FI114870B - Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella - Google Patents
Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella Download PDFInfo
- Publication number
- FI114870B FI114870B FI955446A FI955446A FI114870B FI 114870 B FI114870 B FI 114870B FI 955446 A FI955446 A FI 955446A FI 955446 A FI955446 A FI 955446A FI 114870 B FI114870 B FI 114870B
- Authority
- FI
- Finland
- Prior art keywords
- ser
- scfv
- fragment
- gly
- thr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93201660 | 1993-06-09 | ||
| EP93201660 | 1993-06-09 | ||
| EP93201661 | 1993-06-09 | ||
| EP93201661 | 1993-06-09 | ||
| EP93201706 | 1993-06-14 | ||
| EP93201706 | 1993-06-14 | ||
| PCT/EP1994/001906 WO1994029457A2 (en) | 1993-06-09 | 1994-06-09 | Process for producing fusion proteins comprising scfv fragments by a transformed mould |
| EP9401906 | 1994-06-09 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI955446A0 FI955446A0 (fi) | 1995-11-13 |
| FI955446A FI955446A (fi) | 1995-12-11 |
| FI114870B true FI114870B (fi) | 2005-01-14 |
Family
ID=27235312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI955446A FI114870B (fi) | 1993-06-09 | 1995-11-13 | Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0702721B1 (ja) |
| JP (1) | JPH08511160A (ja) |
| AT (1) | ATE198490T1 (ja) |
| AU (1) | AU7123494A (ja) |
| CA (1) | CA2162878A1 (ja) |
| DE (1) | DE69426527T2 (ja) |
| DK (1) | DK0702721T3 (ja) |
| ES (1) | ES2155854T3 (ja) |
| FI (1) | FI114870B (ja) |
| WO (1) | WO1994029457A2 (ja) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9504344D0 (en) * | 1995-03-03 | 1995-04-19 | Unilever Plc | Antibody fragment production |
| CA2221271A1 (en) * | 1995-05-18 | 1996-11-21 | Genencor International, Inc. | Expression of glycosyltransferase in aspergillus |
| AU8437398A (en) | 1997-06-13 | 1998-12-30 | Unilever Plc | Bleaching enzymes |
| EP0954978B1 (en) | 1998-03-12 | 2011-11-30 | VHsquared Limited | New products comprising inactivated yeasts or moulds provided with active antibodies |
| ATE535154T1 (de) | 1998-03-12 | 2011-12-15 | Vhsquared Ltd | Produkten die inaktivierte hefen oder schimmel enthalten, die auf ihrer aussenoberfläche aktive antikörper haben |
| CA2379214A1 (en) | 1999-07-27 | 2001-02-01 | Unilever Plc | Bleaching detergent compositions |
| EP1368380B1 (en) | 2000-12-19 | 2009-09-02 | Unilever N.V. | Stabilisation of heavy chain Camelid antibodies with potassium salts |
| BR0307216A (pt) * | 2002-01-28 | 2005-12-20 | Medarex Inc | Anticorpos monoclonais humanos para antìgeno de membrana especìfica de próstata (psma) |
| MX2007014359A (es) | 2005-05-18 | 2008-02-06 | Ablynx Nv | Nanobodiestm (nanocuerpos) mejorados contra el factor alfa de necrosis del tumor. |
| SI2444424T1 (sl) | 2005-05-20 | 2018-10-30 | Ablynx N.V. | Izboljšana protitelesa (TM) za zdravljenje z agregacijo posredovanih motenj |
| WO2008074840A2 (en) | 2006-12-19 | 2008-06-26 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders |
| US20100062004A1 (en) | 2006-12-19 | 2010-03-11 | Ablynx N.V. | Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders |
| US20100062491A1 (en) * | 2007-01-05 | 2010-03-11 | Novozymes A/S | Overexpression of the Chaperone BIP in a Heterokaryon |
| CN102056945A (zh) | 2008-04-07 | 2011-05-11 | 埃博灵克斯股份有限公司 | 针对Notch途径的单可变结构域 |
| MX2011010681A (es) | 2009-04-10 | 2012-01-20 | Ablynx Nv | Secuencias mejoradas de aminoacidos dirigidas contra il-6r y polipeptidos que comprenden el mismo para el tratamiento de enfermedades y trastornos relacionados con il-6r. |
| EP2427489B1 (en) | 2009-05-07 | 2015-04-22 | Novozymes Biopharma DK A/S | Method of controlling o-linked glycosylation of antibodies |
| JP6081196B2 (ja) | 2009-06-05 | 2017-03-01 | アブリンクス エン．ヴェー． | 気道感染症の予防及び／又は治療のためのヒト呼吸器合胞体ウイルス（ｈＲＳＶ）に指向性を有する改良アミノ酸配列及びこれを含むポリペプチド |
| EP2507262A1 (en) | 2009-11-30 | 2012-10-10 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
| US8962807B2 (en) | 2009-12-14 | 2015-02-24 | Ablynx N.V. | Single variable domain antibodies against OX40L, constructs and therapeutic use |
| WO2011083141A2 (en) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Method for generation of immunoglobulin sequences by using lipoprotein particles |
| US9120855B2 (en) | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
| US8937164B2 (en) | 2010-03-26 | 2015-01-20 | Ablynx N.V. | Biological materials related to CXCR7 |
| EP3546483A1 (en) | 2010-05-20 | 2019-10-02 | Ablynx N.V. | Biological materials related to her3 |
| WO2012042026A1 (en) | 2010-09-30 | 2012-04-05 | Ablynx Nv | Biological materials related to c-met |
| EA037063B1 (ru) | 2010-11-08 | 2021-02-01 | Аблинкс Н.В. | Cxcr2-связывающие полипептиды |
| CN103917560B (zh) | 2011-03-28 | 2017-05-24 | 埃博灵克斯股份有限公司 | 双特异性抗‑cxcr7免疫球蛋白单可变结构域 |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| IN2014CN00437A (ja) | 2011-06-23 | 2015-04-03 | Ablynx Nv | |
| CN106046161B (zh) | 2011-09-30 | 2019-09-13 | 埃博灵克斯股份有限公司 | 与C-Met相关的生物物质 |
| US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| CN105531287B (zh) * | 2013-05-29 | 2020-01-21 | 维拜昂公司 | 改变亨廷顿蛋白突变体降解的单链胞内抗体 |
| NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
| US11426468B2 (en) | 2014-12-19 | 2022-08-30 | Ablynx N.V. | Cysteine linked nanobody dimers |
| CN114920848A (zh) | 2015-05-13 | 2022-08-19 | 埃博灵克斯股份有限公司 | 基于cd3反应性的t细胞募集多肽 |
| EP3294768B1 (en) | 2015-05-13 | 2019-08-21 | Ablynx N.V. | T cell recruiting polypeptides based on tcr alpha/beta reactivity |
| WO2017013270A1 (en) | 2015-07-23 | 2017-01-26 | Universite De Strasbourg | Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy |
| WO2017152088A1 (en) | 2016-03-04 | 2017-09-08 | JN Biosciences, LLC | Antibodies to tigit |
| US10968281B2 (en) | 2016-10-14 | 2021-04-06 | Institut Curie | Anti-LSP1 antibody |
| CN117700549A (zh) | 2016-11-16 | 2024-03-15 | 埃博灵克斯股份有限公司 | 能够结合CD123和TCRα/β的T细胞募集多肽 |
| US11666657B2 (en) | 2017-05-16 | 2023-06-06 | Universite De Strasbourg | Protein-drug conjugates and their use in the treatment of cancers |
| SG10202113337YA (en) | 2017-06-02 | 2021-12-30 | Ablynx Nv | Aggrecan binding immunoglobulins |
| EP4272822A3 (en) | 2017-06-02 | 2024-03-27 | Merck Patent GmbH | Adamts binding immunoglobulins |
| JP7249961B2 (ja) | 2017-06-02 | 2023-03-31 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ａｄａｍｔｓ５、ｍｍｐ１３およびアグリカンに結合するポリペプチド |
| KR20200015601A (ko) | 2017-06-02 | 2020-02-12 | 메르크 파텐트 게엠베하 | Mmp13 결합성 면역글로불린 |
| EP3658915A1 (en) | 2017-07-28 | 2020-06-03 | Institut Curie | New subpopulations of cancer associated fibroblasts as prognosis markers for immunotherapy treatments |
| US20200392512A1 (en) | 2018-02-26 | 2020-12-17 | Ablynx N.V. | Nucleotide sequences encoding peptide linkers |
| KR101875564B1 (ko) * | 2018-05-24 | 2018-07-09 | 국민대학교산학협력단 | 포도당 및 글리세롤을 이용한 유가식 배양을 통한 리시놀레산으로 오메가-하이드록시운덱-9-에논산의 생물전환공정 |
| EP3636657A1 (en) | 2018-10-08 | 2020-04-15 | Ablynx N.V. | Chromatography-free antibody purification method |
| WO2020245663A1 (en) | 2019-06-01 | 2020-12-10 | Institut Pasteur | Nanobody-based ns1 assay for the specific diagnosis of acute zika virus infection |
| AR122493A1 (es) | 2020-06-02 | 2022-09-14 | Arcus Biosciences Inc | Anticuerpos anti-tigit |
| IL303740A (en) | 2020-12-18 | 2023-08-01 | Sanofi Sa | Polypeptides that recruit T cells based on reactivity to alpha/beta receptors |
| EP4337691A1 (en) | 2021-05-12 | 2024-03-20 | Université de Strasbourg | Single domain antibody specific for phosphorylated h2ax and its uses |
| WO2023151894A1 (en) | 2022-02-11 | 2023-08-17 | Henkel Ag & Co. Kgaa | Process for the synthesis of alpha-methylene-gamma-butyrolactone |
| WO2024023271A1 (en) | 2022-07-27 | 2024-02-01 | Ablynx Nv | Polypeptides binding to a specific epitope of the neonatal fc receptor |
| WO2024083843A1 (en) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU657911B2 (en) * | 1990-07-16 | 1995-03-30 | Roal Oy | Immunoglobulin production by (Trichoderma) |
| WO1993008300A1 (en) * | 1991-10-18 | 1993-04-29 | The University Of Calgary | Expression-secretion vectors for the production of biologically active fv fragments |
| IT1270866B (it) * | 1993-03-10 | 1997-05-13 | Eniricerche Spa | Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis |
-
1994
- 1994-06-09 DK DK94920443T patent/DK0702721T3/da active
- 1994-06-09 JP JP7501340A patent/JPH08511160A/ja active Pending
- 1994-06-09 WO PCT/EP1994/001906 patent/WO1994029457A2/en active IP Right Grant
- 1994-06-09 EP EP94920443A patent/EP0702721B1/en not_active Expired - Lifetime
- 1994-06-09 ES ES94920443T patent/ES2155854T3/es not_active Expired - Lifetime
- 1994-06-09 AT AT94920443T patent/ATE198490T1/de not_active IP Right Cessation
- 1994-06-09 CA CA002162878A patent/CA2162878A1/en not_active Abandoned
- 1994-06-09 AU AU71234/94A patent/AU7123494A/en not_active Abandoned
- 1994-06-09 DE DE69426527T patent/DE69426527T2/de not_active Expired - Fee Related
-
1995
- 1995-11-13 FI FI955446A patent/FI114870B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI955446A (fi) | 1995-12-11 |
| WO1994029457A3 (en) | 1995-03-09 |
| FI955446A0 (fi) | 1995-11-13 |
| EP0702721A1 (en) | 1996-03-27 |
| CA2162878A1 (en) | 1994-12-22 |
| DE69426527D1 (de) | 2001-02-08 |
| EP0702721B1 (en) | 2001-01-03 |
| WO1994029457A2 (en) | 1994-12-22 |
| DE69426527T2 (de) | 2001-08-30 |
| DK0702721T3 (da) | 2001-05-21 |
| JPH08511160A (ja) | 1996-11-26 |
| ES2155854T3 (es) | 2001-06-01 |
| ATE198490T1 (de) | 2001-01-15 |
| AU7123494A (en) | 1995-01-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI114870B (fi) | Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella | |
| JP3691055B2 (ja) | 特異的結合力をもつ固定化タンパク質並びに各種プロセス・物品におけるそれらの使用 | |
| US6590078B2 (en) | DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi | |
| JP3542604B2 (ja) | Ｙａｐ３シグナルペプチドをコードするｄｎａ構築体 | |
| Frenken et al. | Recent advances in the large-scale production of antibody fragments using lower eukaryotic microorganisms | |
| US5965384A (en) | Methods for producing Humicola lipases in aspergillus | |
| JP2609446B2 (ja) | スーパーオキシドジスムターゼ遺伝子 | |
| CZ284251B6 (cs) | Způsob výroby heterologního proteinu v transformované buňce | |
| HU221118B1 (en) | Synthetic leader peptide sequences | |
| EP2607486B1 (en) | KEX2 cleavage regions of recombinant fusion proteins | |
| HU211600A9 (en) | Yeast expressing system | |
| US8198046B2 (en) | KEX2 cleavage regions of recombinant fusion proteins | |
| US5612198A (en) | Production of insulin-like growth factor-1 in methylotrophic yeast cells | |
| CA2146240C (en) | Increased production of secreted proteins by recombinant eukaryotic cells | |
| US5171673A (en) | Expression of heterologous dna using the bacillus coagulans amylase gene | |
| JP2000501617A (ja) | 酵母細胞におけるｎ末端を伸長されたタンパクの発現のためのベクター | |
| WO1994008024A9 (en) | Increased production of secreted proteins by recombinant eukaryotic cells | |
| AU734541B2 (en) | Increased production of secreted proteins by recombinant yeast cells | |
| JPH04229188A (ja) | 融合タンパク質の試験管内プロセシング | |
| FI97549C (fi) | Menetelmä vierasproteiinien valmistamiseksi Streptomycessoluissa | |
| AU620568B2 (en) | The expression of antibody fragments in protease deficient bacterial host cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Ref document number: 114870 Country of ref document: FI |
|
| MA | Patent expired |