FI955446A0 - Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella - Google Patents

Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella

Info

Publication number
FI955446A0
FI955446A0 FI955446A FI955446A FI955446A0 FI 955446 A0 FI955446 A0 FI 955446A0 FI 955446 A FI955446 A FI 955446A FI 955446 A FI955446 A FI 955446A FI 955446 A0 FI955446 A0 FI 955446A0
Authority
FI
Finland
Prior art keywords
gene
aspergillus
scfv
present
mould
Prior art date
Application number
FI955446A
Other languages
English (en)
Swedish (sv)
Other versions
FI955446A (fi
FI114870B (fi
Inventor
Leon Gerardus Joseph Frenken
Gorcom Robert F M Van
Johanna G M Hessing
Den Hondel Cornelis Antoni Van
Wouter Musters
Johannes Maria A Verbakel
Cornelis Theodorus Verrips
Original Assignee
Tno
Unilever Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tno, Unilever Nv filed Critical Tno
Publication of FI955446A0 publication Critical patent/FI955446A0/fi
Publication of FI955446A publication Critical patent/FI955446A/fi
Application granted granted Critical
Publication of FI114870B publication Critical patent/FI114870B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI955446A 1993-06-09 1995-11-13 Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella FI114870B (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP93201660 1993-06-09
EP93201660 1993-06-09
EP93201661 1993-06-09
EP93201661 1993-06-09
EP93201706 1993-06-14
EP93201706 1993-06-14
EP9401906 1994-06-09
PCT/EP1994/001906 WO1994029457A2 (en) 1993-06-09 1994-06-09 Process for producing fusion proteins comprising scfv fragments by a transformed mould

Publications (3)

Publication Number Publication Date
FI955446A0 true FI955446A0 (fi) 1995-11-13
FI955446A FI955446A (fi) 1995-12-11
FI114870B FI114870B (fi) 2005-01-14

Family

ID=27235312

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955446A FI114870B (fi) 1993-06-09 1995-11-13 Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella

Country Status (10)

Country Link
EP (1) EP0702721B1 (fi)
JP (1) JPH08511160A (fi)
AT (1) ATE198490T1 (fi)
AU (1) AU7123494A (fi)
CA (1) CA2162878A1 (fi)
DE (1) DE69426527T2 (fi)
DK (1) DK0702721T3 (fi)
ES (1) ES2155854T3 (fi)
FI (1) FI114870B (fi)
WO (1) WO1994029457A2 (fi)

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EP2365000A3 (en) 2005-05-18 2013-01-16 Ablynx N.V. Improved nanobodiesTM against tumor necrosis factor-alpha
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WO2008074840A2 (en) 2006-12-19 2008-06-26 Ablynx N.V. Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders
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EP2102240A2 (en) * 2007-01-05 2009-09-23 Novozymes A/S Overexpression of the chaperone bip in a heterokaryon
EP2947097A1 (en) 2008-04-07 2015-11-25 Ablynx N.V. Amino acid sequences directed against the Notch pathways and uses thereof
EP2417163B1 (en) 2009-04-10 2019-02-27 Ablynx N.V. Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
EP2427489B1 (en) 2009-05-07 2015-04-22 Novozymes Biopharma DK A/S Method of controlling o-linked glycosylation of antibodies
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WO2012042026A1 (en) 2010-09-30 2012-04-05 Ablynx Nv Biological materials related to c-met
BR112013011003B1 (pt) 2010-11-08 2021-12-07 Novartis Ag Polipeptídeo e seus usos, célula hospedeira transgênica de microrganismo, nanocorpo monovalente, bivalente, multivalente, biparatópico ou multiparatópico, e composição farmacêutica
CA2831415A1 (en) 2011-03-28 2012-10-04 Ablynx Nv Bispecific anti-cxcr7 immunoglobulin single variable domains
UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
EP2723772A1 (en) 2011-06-23 2014-04-30 Ablynx N.V. Immunoglobulin single variable domains directed against ige
CN106046161B (zh) 2011-09-30 2019-09-13 埃博灵克斯股份有限公司 与C-Met相关的生物物质
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
WO2014087010A1 (en) 2012-12-07 2014-06-12 Ablynx N.V. IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
CN105531287B (zh) * 2013-05-29 2020-01-21 维拜昂公司 改变亨廷顿蛋白突变体降解的单链胞内抗体
NL2013661B1 (en) 2014-10-21 2016-10-05 Ablynx Nv KV1.3 Binding immunoglobulins.
US11426468B2 (en) 2014-12-19 2022-08-30 Ablynx N.V. Cysteine linked nanobody dimers
EP4345112A3 (en) 2015-05-13 2024-06-26 Ablynx N.V. T cell recruiting polypeptides based on cd3 reactivity
CA2985698C (en) 2015-05-13 2023-02-28 Ablynx N.V. T cell recruiting polypeptides based on tcr alpha/beta reactivity
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
MY191649A (en) 2016-03-04 2022-07-05 Jn Biosciences Llc Antibodies to tigit
WO2018069480A1 (en) 2016-10-14 2018-04-19 Institut Curie New anti-lsp1 antibody
KR102665596B1 (ko) 2016-11-16 2024-05-14 아블린쓰 엔.브이. Cd123 및 tcr 알파/베타에 결합할 수 있는 t 세포 동원 폴리펩티드
EP3624854A1 (en) 2017-05-16 2020-03-25 Université de Strasbourg Protein-drug conjugates and their use in the treatment of cancers
US20200190216A1 (en) 2017-06-02 2020-06-18 Merck Patent Gmbh Mmp13 binding immunoglobulins
AU2018277102A1 (en) 2017-06-02 2019-12-19 Ablynx N.V. Polypeptides binding ADAMTS5, MMP13 and Aggrecan
MX2019014400A (es) 2017-06-02 2020-02-10 Merck Patent Gmbh Inmunoglobulinas que se unen a adamts.
BR112019025392A2 (pt) 2017-06-02 2020-07-07 Ablynx N.V. imunoglobulinas de ligação ao agrecano
US20200371105A1 (en) 2017-07-28 2020-11-26 Institut Curie New subpopulations of cancer associated fibroblasts as prognosis markers for immunotherapy treatments
AR114269A1 (es) 2018-02-26 2020-08-12 Ablynx Nv Secuencias nucleotídicas mejoradas que codifican para péptidos de unión
KR101875564B1 (ko) * 2018-05-24 2018-07-09 국민대학교산학협력단 포도당 및 글리세롤을 이용한 유가식 배양을 통한 리시놀레산으로 오메가-하이드록시운덱-9-에논산의 생물전환공정
EP3636657A1 (en) 2018-10-08 2020-04-15 Ablynx N.V. Chromatography-free antibody purification method
WO2020245663A1 (en) 2019-06-01 2020-12-10 Institut Pasteur Nanobody-based ns1 assay for the specific diagnosis of acute zika virus infection
PE20231078A1 (es) 2020-06-02 2023-07-17 Arcus Biosciences Inc Anticuerpos anti-tigit
EP4263610A1 (en) 2020-12-18 2023-10-25 Ablynx N.V. T cell recruiting polypeptides based on tcr alpha/beta reactivity
WO2022238505A1 (en) 2021-05-12 2022-11-17 Universite De Strasbourg Single domain antibody specific for phosphorylated h2ax and its uses
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WO1993008300A1 (en) * 1991-10-18 1993-04-29 The University Of Calgary Expression-secretion vectors for the production of biologically active fv fragments
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Also Published As

Publication number Publication date
AU7123494A (en) 1995-01-03
ATE198490T1 (de) 2001-01-15
ES2155854T3 (es) 2001-06-01
FI955446A (fi) 1995-12-11
JPH08511160A (ja) 1996-11-26
WO1994029457A2 (en) 1994-12-22
DK0702721T3 (da) 2001-05-21
FI114870B (fi) 2005-01-14
CA2162878A1 (en) 1994-12-22
EP0702721B1 (en) 2001-01-03
DE69426527T2 (de) 2001-08-30
DE69426527D1 (de) 2001-02-08
WO1994029457A3 (en) 1995-03-09
EP0702721A1 (en) 1996-03-27

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