DK0702721T3 - Fremgangsmåde til fremstilling af fusionsproteiner, der omfatter ScFv fragmenter, ved hjælp af en transformeret skimmelsvamp - Google Patents

Fremgangsmåde til fremstilling af fusionsproteiner, der omfatter ScFv fragmenter, ved hjælp af en transformeret skimmelsvamp

Info

Publication number
DK0702721T3
DK0702721T3 DK94920443T DK94920443T DK0702721T3 DK 0702721 T3 DK0702721 T3 DK 0702721T3 DK 94920443 T DK94920443 T DK 94920443T DK 94920443 T DK94920443 T DK 94920443T DK 0702721 T3 DK0702721 T3 DK 0702721T3
Authority
DK
Denmark
Prior art keywords
gene
aspergillus
present
scfv
mould
Prior art date
Application number
DK94920443T
Other languages
English (en)
Inventor
Leon Gerardus Joseph Frenken
Gorcom Robert F M Van
Johanna G M Hessing
Den Hondel Cornelis Antoni Van
Wouter Musters
Johannes Mariaa Verbakel
Cornelis Theodorus Verrips
Original Assignee
Unilever Nv
Tno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Nv, Tno filed Critical Unilever Nv
Application granted granted Critical
Publication of DK0702721T3 publication Critical patent/DK0702721T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK94920443T 1993-06-09 1994-06-09 Fremgangsmåde til fremstilling af fusionsproteiner, der omfatter ScFv fragmenter, ved hjælp af en transformeret skimmelsvamp DK0702721T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP93201661 1993-06-09
EP93201660 1993-06-09
EP93201706 1993-06-14
PCT/EP1994/001906 WO1994029457A2 (en) 1993-06-09 1994-06-09 Process for producing fusion proteins comprising scfv fragments by a transformed mould

Publications (1)

Publication Number Publication Date
DK0702721T3 true DK0702721T3 (da) 2001-05-21

Family

ID=27235312

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94920443T DK0702721T3 (da) 1993-06-09 1994-06-09 Fremgangsmåde til fremstilling af fusionsproteiner, der omfatter ScFv fragmenter, ved hjælp af en transformeret skimmelsvamp

Country Status (10)

Country Link
EP (1) EP0702721B1 (da)
JP (1) JPH08511160A (da)
AT (1) ATE198490T1 (da)
AU (1) AU7123494A (da)
CA (1) CA2162878A1 (da)
DE (1) DE69426527T2 (da)
DK (1) DK0702721T3 (da)
ES (1) ES2155854T3 (da)
FI (1) FI114870B (da)
WO (1) WO1994029457A2 (da)

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MX343085B (es) 2010-11-08 2016-10-24 Novartis Ag Polipeptidos que se enlazan a cxcr2.
CN103917560B (zh) 2011-03-28 2017-05-24 埃博灵克斯股份有限公司 双特异性抗‑cxcr7免疫球蛋白单可变结构域
UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
WO2012175740A1 (en) 2011-06-23 2012-12-27 Ablynx Nv Immunoglobulin single variable domains directed against ige
JP6219287B2 (ja) 2011-09-30 2017-10-25 アブリンクス エン．ヴェー． ｃ−Ｍｅｔに関連する生物学的物質
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
WO2014087010A1 (en) 2012-12-07 2014-06-12 Ablynx N.V. IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
CN105531287B (zh) * 2013-05-29 2020-01-21 维拜昂公司 改变亨廷顿蛋白突变体降解的单链胞内抗体
NL2013661B1 (en) 2014-10-21 2016-10-05 Ablynx Nv KV1.3 Binding immunoglobulins.
PL3233910T3 (pl) 2014-12-19 2020-06-01 Ablynx N.V. Dimery nanociał połączone cysteiną
CA2985700C (en) 2015-05-13 2022-06-28 Ablynx N.V. T cell recruiting polypeptides based on cd3 reactivity
HUE045437T2 (hu) 2015-05-13 2019-12-30 Ablynx Nv TCR-alfa-béta reaktivitásán alapulva T-sejtet toborzó polipeptidek
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
AU2017228474C1 (en) 2016-03-04 2024-03-28 Abmuno Therapeutics Llc Antibodies to TIGIT
US10968281B2 (en) 2016-10-14 2021-04-06 Institut Curie Anti-LSP1 antibody
WO2018091606A1 (en) 2016-11-16 2018-05-24 Ablynx Nv T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta
US11666657B2 (en) 2017-05-16 2023-06-06 Universite De Strasbourg Protein-drug conjugates and their use in the treatment of cancers
TWI811220B (zh) 2017-06-02 2023-08-11 比利時商艾伯林克斯公司 結合聚集蛋白聚糖之免疫球蛋白
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WO2019020728A1 (en) 2017-07-28 2019-01-31 Institut Curie NEW SUBOPHAVIATES OF FIBROBLASTS ASSOCIATED WITH CANCER AS PROGNOSTIC MARKERS FOR IMMUNOTHERAPY TREATMENTS
WO2019162521A1 (en) 2018-02-26 2019-08-29 Ablynx Nv Improved nucleotide sequences encoding peptide linkers
KR101875564B1 (ko) * 2018-05-24 2018-07-09 국민대학교산학협력단 포도당 및 글리세롤을 이용한 유가식 배양을 통한 리시놀레산으로 오메가-하이드록시운덱-9-에논산의 생물전환공정
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WO2020245663A1 (en) 2019-06-01 2020-12-10 Institut Pasteur Nanobody-based ns1 assay for the specific diagnosis of acute zika virus infection
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IL303740A (en) 2020-12-18 2023-08-01 Sanofi Sa Polypeptides that recruit T cells based on reactivity to alpha/beta receptors
EP4337691A1 (en) 2021-05-12 2024-03-20 Université de Strasbourg Single domain antibody specific for phosphorylated h2ax and its uses
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Also Published As

Publication number Publication date
CA2162878A1 (en) 1994-12-22
WO1994029457A3 (en) 1995-03-09
ES2155854T3 (es) 2001-06-01
ATE198490T1 (de) 2001-01-15
JPH08511160A (ja) 1996-11-26
FI955446A (fi) 1995-12-11
DE69426527T2 (de) 2001-08-30
EP0702721A1 (en) 1996-03-27
AU7123494A (en) 1995-01-03
FI955446A0 (fi) 1995-11-13
EP0702721B1 (en) 2001-01-03
WO1994029457A2 (en) 1994-12-22
FI114870B (fi) 2005-01-14
DE69426527D1 (de) 2001-02-08

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