FI113966B - Pyrrolo [2,1-b] imidatsoli-, ja -tiatsoli- ja pyrrolo [2,1-b] -1,3-tiatsiinijohdannaiset ja niiden käyttö farmasiassa ja välituotteina - Google Patents

Pyrrolo [2,1-b] imidatsoli-, ja -tiatsoli- ja pyrrolo [2,1-b] -1,3-tiatsiinijohdannaiset ja niiden käyttö farmasiassa ja välituotteina Download PDF

Info

Publication number
FI113966B
FI113966B FI964772A FI964772A FI113966B FI 113966 B FI113966 B FI 113966B FI 964772 A FI964772 A FI 964772A FI 964772 A FI964772 A FI 964772A FI 113966 B FI113966 B FI 113966B
Authority
FI
Finland
Prior art keywords
phenyl
pyrrolo
formula
thiazole
compounds
Prior art date
Application number
FI964772A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI964772A0 (fi
FI964772A (fi
Inventor
Stefan Laufer
Hans Guenther Striegel
Gerd Dannhardt
Original Assignee
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merckle Gmbh filed Critical Merckle Gmbh
Publication of FI964772A0 publication Critical patent/FI964772A0/fi
Publication of FI964772A publication Critical patent/FI964772A/fi
Application granted granted Critical
Publication of FI113966B publication Critical patent/FI113966B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI964772A 1994-06-01 1996-11-29 Pyrrolo [2,1-b] imidatsoli-, ja -tiatsoli- ja pyrrolo [2,1-b] -1,3-tiatsiinijohdannaiset ja niiden käyttö farmasiassa ja välituotteina FI113966B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4419315A DE4419315A1 (de) 1994-06-01 1994-06-01 Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419315 1994-06-01
PCT/EP1995/002078 WO1995032971A1 (de) 1994-06-01 1995-05-31 [a]-ANNELIERTE PYRROLDERIVATE UND DEREN ANWENDUNG IN DER PHARMAZIE
EP9502078 1995-05-31

Publications (3)

Publication Number Publication Date
FI964772A0 FI964772A0 (fi) 1996-11-29
FI964772A FI964772A (fi) 1997-01-27
FI113966B true FI113966B (fi) 2004-07-15

Family

ID=6519632

Family Applications (1)

Application Number Title Priority Date Filing Date
FI964772A FI113966B (fi) 1994-06-01 1996-11-29 Pyrrolo [2,1-b] imidatsoli-, ja -tiatsoli- ja pyrrolo [2,1-b] -1,3-tiatsiinijohdannaiset ja niiden käyttö farmasiassa ja välituotteina

Country Status (13)

Country Link
US (1) US5939415A (no)
EP (1) EP0804437B1 (no)
JP (1) JP3569823B2 (no)
KR (1) KR100378882B1 (no)
AT (1) ATE304543T1 (no)
AU (1) AU2672995A (no)
CA (1) CA2191745A1 (no)
DE (2) DE4419315A1 (no)
DK (1) DK0804437T3 (no)
ES (1) ES2248798T3 (no)
FI (1) FI113966B (no)
NO (1) NO311222B1 (no)
WO (1) WO1995032971A1 (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032756A1 (en) * 1997-01-22 1998-07-30 Ciba Specialty Chemicals Holding Inc. Substituted aminoalkylidenamino triazines as herbicides
JP2003505390A (ja) 1999-11-23 2003-02-12 メルクル・ゲーエムベーハー 抗炎症薬用のピロリジンのオキソ及びヒドロキシ誘導体、並びにその使用方法
DE10001166A1 (de) * 2000-01-13 2001-07-19 Merckle Gmbh Anellierte Pyrrolverbindungen, diese enthaltende pharmazeutische Mittel und deren Verwendung
EA004938B1 (ru) * 2000-01-28 2004-10-28 Меркле Гмбх Способ получения 6-(4-хлорфенил)-2,2-диметил-7-фенил-2,3-дигидро-1h-пирролизин-5-илуксусной кислоты
DE10004157A1 (de) * 2000-02-01 2001-08-02 Merckle Gmbh Chem Pharm Fabrik 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie
DE10141285A1 (de) 2001-08-23 2003-03-27 Merckle Gmbh Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
US7425573B2 (en) 2001-08-30 2008-09-16 Merckle Gmbh Use of annellated pyrrole compounds in the treatment of articular cartilage or subchondral bone degeneration
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
SI2332921T1 (sl) 2003-06-17 2016-06-30 Arena Pharmaceuticals, Inc. 8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazapin hidroklorid
CN101274911B (zh) * 2003-06-17 2011-01-26 艾尼纳制药公司 用于治疗5ht2c受体相关病症的苯并氮杂卓衍生物
WO2005042490A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2005042491A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
JP5270167B2 (ja) 2004-12-21 2013-08-21 アリーナ ファーマシューティカルズ， インコーポレイテッド （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形
KR20130087622A (ko) * 2004-12-23 2013-08-06 아레나 파마슈티칼스, 인크. 5ｈｔ２ｃ 수용체 조정물질 조성물 및 그의 사용 방법
DE102005012971A1 (de) 2005-03-21 2006-09-28 Merckle Gmbh Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
CN101466684B (zh) * 2006-04-03 2012-06-20 艾尼纳制药公司 8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备工艺和其相关中间体
WO2008070111A2 (en) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
WO2009111004A1 (en) * 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
NZ630494A (en) 2010-09-01 2016-05-27 Arena Pharm Inc Administration of lorcaserin to individuals with renal impairment
SG188362A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Modified-release dosage forms of 5-ht2c agonists useful for weight management
SG10201506870PA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Salts of lorcaserin with optically active acids
SG188361A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Non-hygroscopic salts of 5-ht2c agonists
KR20150070249A (ko) 2012-10-09 2015-06-24 아레나 파마슈티칼스, 인크. 체중 관리 방법
KR20150143104A (ko) 2014-06-13 2015-12-23 이경희 원적외선을 이용한 건식 발 온열기

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU417424A1 (no) * 1972-02-03 1974-02-28
GB1461592A (en) * 1973-04-25 1977-01-13 Agfa Gevaert Specially sensitized direct positive silver halide emulsions
US3920672A (en) * 1974-08-22 1975-11-18 Syntex Inc Thiacycl (2.2.2.)azine carboxylic acids
US4536512A (en) * 1982-10-08 1985-08-20 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents
DD216021A5 (de) * 1983-01-13 1984-11-28 Rhone Poulenc Sante Verfahren zur herstellung eines neuen pyrrolderivates
FR2557111B1 (fr) * 1983-12-21 1986-04-11 Rhone Poulenc Sante Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent
DE3915450A1 (de) * 1989-05-11 1990-11-15 Gerd Prof Dr Dannhardt Substituierte pyrrolverbindungen und deren anwendung in der pharmazie
US5260451A (en) * 1989-05-11 1993-11-09 Merckle Gmbh Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE69419327D1 (de) * 1993-01-21 1999-08-12 Konishiroku Photo Ind Ein farbphotographisches Silberhalogenidmaterial
US5552422A (en) * 1995-01-11 1996-09-03 Merck Frosst Canada, Inc. Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents

Also Published As

Publication number Publication date
EP0804437B1 (de) 2005-09-14
EP0804437A1 (de) 1997-11-05
WO1995032971A1 (de) 1995-12-07
JP3569823B2 (ja) 2004-09-29
KR100378882B1 (ko) 2003-08-02
ATE304543T1 (de) 2005-09-15
DK0804437T3 (da) 2005-11-14
FI964772A0 (fi) 1996-11-29
JPH10506369A (ja) 1998-06-23
ES2248798T3 (es) 2006-03-16
US5939415A (en) 1999-08-17
NO311222B1 (no) 2001-10-29
NO965094L (no) 1996-12-11
DE59511017D1 (de) 2005-10-20
FI964772A (fi) 1997-01-27
AU2672995A (en) 1995-12-21
NO965094D0 (no) 1996-11-29
KR970703345A (ko) 1997-07-03
CA2191745A1 (en) 1995-12-07
DE4419315A1 (de) 1995-12-07

Similar Documents

Publication Publication Date Title
FI113966B (fi) Pyrrolo [2,1-b] imidatsoli-, ja -tiatsoli- ja pyrrolo [2,1-b] -1,3-tiatsiinijohdannaiset ja niiden käyttö farmasiassa ja välituotteina
FI114099B (fi) Pyrrolitsiini- ja pyrrolo[2,1-b] tiatsolijohdannaiset ja niiden käyttö farmasiassa
KR101081446B1 (ko) 2-치환페닐-5,7-디알킬-3,7-디하이드로피롤[2,3-ｄ]피리미딘-4-온유도체, 그의 제법 및 약학적 용도
US5686442A (en) Tricyclic benzazepine and benzothiazepine derivatives
CH674368A5 (no)
FI79319B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tricykliska oxindolkarboxamidderivat.
FI95259B (fi) Menetelmä farmaseuttisesti aktiivisten 7-substituoitu-2-amino-3,5-dihydro-4H-pyrrolo/3,2-d/pyrimidin-4-onien valmistamiseksi
JP2003525227A (ja) ４−ピリジル−および２，４−ピリミジニル−置換ピロール誘導体および薬学におけるそれらの利用法
HUT62888A (en) Process for producing new oxazole derivatives and pharmaceutical compositions comprising same
IE47902B1 (en) Thiazolidine-2,4-dione derivatives
KR20000075641A (ko) 세로토닌-2 수용체 길항작용 및 알파 1-저해 작용을 갖는 피롤로티아진 및 피롤로티아제핀 화합물
AU616608B2 (en) 4,5,6,7-tetrasubstituted benzoxazolones
US4927970A (en) Substituted 3-cyclobutene-1,2-dione intermediates
JPH04221386A (ja) ４Ｈ−ピロロ［１，２−ａ］チエノ［２，３−ｆ］［１，４］ジアゼピンの新規誘導体、それらの製造方法及びこれらを含有する医薬品組成物
Peesapati et al. THIOPHENO [3, 2][1] BENZAZEPINE, BENZO [3, 4] CYCLOHEPTA [2, 1-b] THIOPHENES, THIAZOLO [5, 4-d][1] BENZAZEPINE AND BENZO [3, 4] CYCLOHEPTA [2, 1-d] THIAZOLES
KR20000075642A (ko) 세로토닌-2 수용체 길항작용 및 알파 1-저해 작용을 갖는 피롤로티아진 및 피롤로티아제핀 화합물
CA2396413A1 (en) Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof
EP0966473B1 (fr) Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant
FR2539131A1 (fr) Nouvelles carboxy-thiazolo(3,2-a)pyrimidines substituees utiles notamment comme antiallergiques et leurs procedes de fabrication
Boulouard et al. Pyirolothieno [1, 4] diazepines. Part IV. First synthesis of pyrrolo‐[1, 2‐a] thieno [2, 3‐f][1, 4] diazepine Derivatives
JP2000191663A (ja) 縮合ピリダジン誘導体の製造法
Binder et al. Synthesis of thienoimidazothiazoles
JPH06293640A (ja) 肝疾患治療剤および１，３−ベンゾキサチオール誘導体
Erker et al. Studies on the chemistry of thienoannelated O, N‐and S, N‐containing heterocycles. 24 [1]. Synthesis of imidazo [1, 5‐d] thieno [2, 3‐b][1, 4]‐thiazine derivatives as potential receptor ligands
JPH0120155B2 (no)