FI964772A - (a)-annelloidut pyrrolijohdannaiset ja niiden käyttö farmasiassa - Google Patents

(a)-annelloidut pyrrolijohdannaiset ja niiden käyttö farmasiassa Download PDF

Info

Publication number
FI964772A
FI964772A FI964772A FI964772A FI964772A FI 964772 A FI964772 A FI 964772A FI 964772 A FI964772 A FI 964772A FI 964772 A FI964772 A FI 964772A FI 964772 A FI964772 A FI 964772A
Authority
FI
Finland
Prior art keywords
pct
pharmacin
annealed
pyrrole derivatives
sec
Prior art date
Application number
FI964772A
Other languages
English (en)
Swedish (sv)
Other versions
FI964772A0 (fi
FI113966B (fi
Inventor
Stefan Laufer
Hans Guenther Striegel
Gerd Dannhardt
Original Assignee
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merckle Gmbh filed Critical Merckle Gmbh
Publication of FI964772A0 publication Critical patent/FI964772A0/fi
Publication of FI964772A publication Critical patent/FI964772A/fi
Application granted granted Critical
Publication of FI113966B publication Critical patent/FI113966B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
FI964772A 1994-06-01 1996-11-29 Pyrrolo [2,1-b] imidatsoli-, ja -tiatsoli- ja pyrrolo [2,1-b] -1,3-tiatsiinijohdannaiset ja niiden käyttö farmasiassa ja välituotteina FI113966B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4419315A DE4419315A1 (de) 1994-06-01 1994-06-01 Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419315 1994-06-01
EP9502078 1995-05-31
PCT/EP1995/002078 WO1995032971A1 (de) 1994-06-01 1995-05-31 [a]-ANNELIERTE PYRROLDERIVATE UND DEREN ANWENDUNG IN DER PHARMAZIE

Publications (3)

Publication Number Publication Date
FI964772A0 FI964772A0 (fi) 1996-11-29
FI964772A true FI964772A (fi) 1997-01-27
FI113966B FI113966B (fi) 2004-07-15

Family

ID=6519632

Family Applications (1)

Application Number Title Priority Date Filing Date
FI964772A FI113966B (fi) 1994-06-01 1996-11-29 Pyrrolo [2,1-b] imidatsoli-, ja -tiatsoli- ja pyrrolo [2,1-b] -1,3-tiatsiinijohdannaiset ja niiden käyttö farmasiassa ja välituotteina

Country Status (13)

Country Link
US (1) US5939415A (fi)
EP (1) EP0804437B1 (fi)
JP (1) JP3569823B2 (fi)
KR (1) KR100378882B1 (fi)
AT (1) ATE304543T1 (fi)
AU (1) AU2672995A (fi)
CA (1) CA2191745A1 (fi)
DE (2) DE4419315A1 (fi)
DK (1) DK0804437T3 (fi)
ES (1) ES2248798T3 (fi)
FI (1) FI113966B (fi)
NO (1) NO311222B1 (fi)
WO (1) WO1995032971A1 (fi)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4246268B2 (ja) * 1997-01-22 2009-04-02 チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド α−アミノケトンに基づく光活性化可能な窒素含有塩基
US6878738B1 (en) 1999-11-23 2005-04-12 Merckle Gmbh Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use
DE10001166A1 (de) * 2000-01-13 2001-07-19 Merckle Gmbh Anellierte Pyrrolverbindungen, diese enthaltende pharmazeutische Mittel und deren Verwendung
DE50101761D1 (de) * 2000-01-28 2004-04-29 Merckle Gmbh Verfahren zur herstellung von 6-(4-chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-yl-essigsäure
DE10004157A1 (de) 2000-02-01 2001-08-02 Merckle Gmbh Chem Pharm Fabrik 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie
DE10141285A1 (de) 2001-08-23 2003-03-27 Merckle Gmbh Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
BR0212244A (pt) 2001-08-30 2004-10-05 Merckle Gmbh Uso de um ou mais do que um composto e seus isÈmeros ópticos, derivados e sais fisiologicamente aceitáveis, composição farmacêutica, e, método de tratamento ou de prevenção da degeneração ou da destruição de cartilagem articular e/ou de osso subcondral em uma ou mais articulações de um mamìfero
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
EA016558B1 (ru) * 2003-06-17 2012-05-30 Арена Фармасьютикалз, Инк. Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором
HUE028976T2 (en) * 2003-06-17 2017-02-28 Arena Pharm Inc 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
WO2005042490A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
JP5270167B2 (ja) 2004-12-21 2013-08-21 アリーナ ファーマシューティカルズ， インコーポレイテッド （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形
CN102631349A (zh) 2004-12-23 2012-08-15 艾尼纳制药公司 5HT2c受体调节剂组合物和使用方法
DE102005012971A1 (de) * 2005-03-21 2006-09-28 Merckle Gmbh Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
JP5199997B2 (ja) 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
CN101547892B (zh) * 2006-12-05 2014-08-20 艾尼纳制药公司 制备(r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的方法和其中间体
JP5491421B2 (ja) * 2008-03-04 2014-05-14 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
EP2611433A2 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
SG188362A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Modified-release dosage forms of 5-ht2c agonists useful for weight management
US8999970B2 (en) 2010-09-01 2015-04-07 Arena Pharmaceuticals, Inc. Administration of an anti-obesity compound to individuals with renal impairment
SG10201506870PA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Salts of lorcaserin with optically active acids
KR20150070249A (ko) 2012-10-09 2015-06-24 아레나 파마슈티칼스, 인크. 체중 관리 방법
KR20150143104A (ko) 2014-06-13 2015-12-23 이경희 원적외선을 이용한 건식 발 온열기

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU417424A1 (fi) * 1972-02-03 1974-02-28
GB1461592A (en) * 1973-04-25 1977-01-13 Agfa Gevaert Specially sensitized direct positive silver halide emulsions
US3920672A (en) * 1974-08-22 1975-11-18 Syntex Inc Thiacycl (2.2.2.)azine carboxylic acids
US4536512A (en) * 1982-10-08 1985-08-20 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents
US4539400A (en) * 1983-01-13 1985-09-03 Rhone-Poulenc Sante Pyridin-3-yl substituted ortho-fused pyrrole derivatives
FR2557111B1 (fr) * 1983-12-21 1986-04-11 Rhone Poulenc Sante Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent
US5260451A (en) * 1989-05-11 1993-11-09 Merckle Gmbh Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE3915450A1 (de) * 1989-05-11 1990-11-15 Gerd Prof Dr Dannhardt Substituierte pyrrolverbindungen und deren anwendung in der pharmazie
DE69419327D1 (de) * 1993-01-21 1999-08-12 Konishiroku Photo Ind Ein farbphotographisches Silberhalogenidmaterial
US5552422A (en) * 1995-01-11 1996-09-03 Merck Frosst Canada, Inc. Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents

Also Published As

Publication number Publication date
DK0804437T3 (da) 2005-11-14
CA2191745A1 (en) 1995-12-07
KR970703345A (ko) 1997-07-03
NO965094D0 (no) 1996-11-29
ATE304543T1 (de) 2005-09-15
JP3569823B2 (ja) 2004-09-29
NO311222B1 (no) 2001-10-29
KR100378882B1 (ko) 2003-08-02
FI964772A0 (fi) 1996-11-29
ES2248798T3 (es) 2006-03-16
NO965094L (no) 1996-12-11
DE4419315A1 (de) 1995-12-07
WO1995032971A1 (de) 1995-12-07
EP0804437A1 (de) 1997-11-05
JPH10506369A (ja) 1998-06-23
DE59511017D1 (de) 2005-10-20
FI113966B (fi) 2004-07-15
AU2672995A (en) 1995-12-21
EP0804437B1 (de) 2005-09-14
US5939415A (en) 1999-08-17

Similar Documents

Publication Publication Date Title
FI964772A (fi) (a)-annelloidut pyrrolijohdannaiset ja niiden käyttö farmasiassa
FI964773A (fi) (a)-annelloidut pyrrolijohdannaiset ja niiden käyttö farmasiassa
FI964771A0 (fi) (a)-annelloidut pyrrolijohdannaiset ja niiden käyttö farmasiassa
NO952132L (no) Farmakologiske aktive pyridin-derivater og deres fremstilling
NO306346B1 (no) N-substituerte azabicykloalkanderivater, anvendelse derav og farmasöytisk preparat
DK0723544T3 (da) Alkoxyalkylcarbamater af imidazo[1,2-a]pyridiner
ES2135769T3 (es) Derivados de isotiourea como inhibidores de no-sintasa.
NO306400B1 (no) N-substituerte azabicykloheptan-derivater, anvendelse derav og farmasöytisk preparat
ES2094545T3 (es) Derivados n-substituidos del 3-azabiciclo(3.2.0)heptano, como neurolepticos etc..
ES2155476T3 (es) Aril-tio-alquil-tio-piridinas sustituidas.
FI962301A0 (fi) Substituoidut aminoalkyyliaminopyridiinit