FI112866B - Menetelmä uusien, terapeuttisesti käyttökelpoisten, heksahydro-8-hydroksi-2,6-metano-2H-kinolitsiinien amidijohdannaisten valmistamiseksi sekä menetelmässä käytettävät välituotteet - Google Patents
Menetelmä uusien, terapeuttisesti käyttökelpoisten, heksahydro-8-hydroksi-2,6-metano-2H-kinolitsiinien amidijohdannaisten valmistamiseksi sekä menetelmässä käytettävät välituotteet Download PDFInfo
- Publication number
- FI112866B FI112866B FI922695A FI922695A FI112866B FI 112866 B FI112866 B FI 112866B FI 922695 A FI922695 A FI 922695A FI 922695 A FI922695 A FI 922695A FI 112866 B FI112866 B FI 112866B
- Authority
- FI
- Finland
- Prior art keywords
- methano
- formula
- trans
- octahydro
- quinolizin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP91401550 | 1991-06-11 | ||
| EP91401550A EP0517984A1 (de) | 1991-06-11 | 1991-06-11 | Amidanaloge-Derivate von methanoverbrückten Chinolizinen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI922695A0 FI922695A0 (fi) | 1992-06-10 |
| FI922695A FI922695A (fi) | 1992-12-12 |
| FI112866B true FI112866B (fi) | 2004-01-30 |
Family
ID=8208580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI922695A FI112866B (fi) | 1991-06-11 | 1992-06-10 | Menetelmä uusien, terapeuttisesti käyttökelpoisten, heksahydro-8-hydroksi-2,6-metano-2H-kinolitsiinien amidijohdannaisten valmistamiseksi sekä menetelmässä käytettävät välituotteet |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP0517984A1 (de) |
| JP (1) | JP3377227B2 (de) |
| KR (1) | KR100234926B1 (de) |
| AT (1) | ATE214392T1 (de) |
| AU (1) | AU649836B2 (de) |
| CA (1) | CA2070573C (de) |
| DE (1) | DE69232473T2 (de) |
| DK (1) | DK0518767T3 (de) |
| ES (1) | ES2173863T3 (de) |
| FI (1) | FI112866B (de) |
| HU (1) | HU212735B (de) |
| IE (1) | IE921874A1 (de) |
| IL (1) | IL102132A (de) |
| NO (1) | NO305124B1 (de) |
| NZ (1) | NZ243031A (de) |
| PT (1) | PT518767E (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508287A (en) * | 1992-02-24 | 1996-04-16 | Merrell Pharmaceuticals Inc. | 2,6-methano-2H-quinolizin derivative as 5-HT3 -receptor antagonist |
| KR100287933B1 (ko) * | 1992-02-24 | 2001-05-02 | 슈테펜엘.네스비트 | 5-ht3-수용체 길항제로서의 2,6-메타노-2h-퀴놀리진 유도체,이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| GB9214184D0 (en) * | 1992-07-03 | 1992-08-12 | Smithkline Beecham Plc | Pharmaceuticals |
| FR2765107B1 (fr) * | 1997-06-26 | 2000-03-24 | Sanofi Sa | Utilisation d'un antagoniste specifique des recepteurs 5ht2 pour la preparation de medicaments utiles dans le traitement du syndrome d'apnee du sommeil |
| PT1030667E (pt) | 1997-11-14 | 2005-06-30 | Akzo Nobel Nv | Utilizacao de mirtazapina para o fabrico de um medicamento para o tratamento de apenas do sono |
| PT1066036E (pt) | 1998-02-27 | 2006-09-29 | Univ Illinois | Agentes com actividade relacionada com serotonina para o tratamento da apneia do sono |
| US7160898B2 (en) | 2001-12-14 | 2007-01-09 | Board Of Trustees Of The University Of Illinois | Pharmacological treatment for sleep apnea |
| WO2003035005A2 (en) | 2001-10-26 | 2003-05-01 | University Of Connecticut | Heteroindanes: a new class of potent cannabimimetic ligands |
| EP1833467B1 (de) | 2004-12-20 | 2016-08-03 | Collegium Pharmaceutical, Inc. | Pharmazeutische zusammensetzungen gegen schlafstörungen |
| US7608714B2 (en) * | 2006-01-05 | 2009-10-27 | TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság | Production of dolasetron |
| CN101774971B (zh) * | 2010-02-10 | 2011-07-27 | 山东众诚药业股份有限公司 | 高纯度1-甲基吲唑-3-羧酸的生产方法 |
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB219363A (en) * | 1923-03-24 | 1924-07-24 | Abraham Preston | Improvements in or in connection with bed couches |
| EP0498466B1 (de) * | 1985-04-27 | 2002-07-24 | F. Hoffmann-La Roche Ag | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
| EP0330788A1 (de) * | 1988-03-01 | 1989-09-06 | Merrell Dow Pharmaceuticals Inc. | Verwendung von Chinolizin- und Chinolizinon-Derivaten zur Herstellung von Arzneimitteln zur Behandlung von Herz-Arrhythmie |
| GB8829079D0 (en) * | 1988-12-13 | 1989-01-25 | Beecham Group Plc | Novel compounds |
-
1991
- 1991-06-11 EP EP91401550A patent/EP0517984A1/de not_active Withdrawn
-
1992
- 1992-06-05 AU AU18037/92A patent/AU649836B2/en not_active Expired
- 1992-06-05 CA CA002070573A patent/CA2070573C/en not_active Expired - Lifetime
- 1992-06-05 NZ NZ243031A patent/NZ243031A/en not_active IP Right Cessation
- 1992-06-08 IL IL10213292A patent/IL102132A/en not_active IP Right Cessation
- 1992-06-10 NO NO922270A patent/NO305124B1/no not_active IP Right Cessation
- 1992-06-10 FI FI922695A patent/FI112866B/fi not_active IP Right Cessation
- 1992-06-10 KR KR1019920010016A patent/KR100234926B1/ko not_active IP Right Cessation
- 1992-06-10 HU HU9201939A patent/HU212735B/hu unknown
- 1992-06-11 DK DK92401618T patent/DK0518767T3/da active
- 1992-06-11 JP JP17598392A patent/JP3377227B2/ja not_active Expired - Lifetime
- 1992-06-11 ES ES92401618T patent/ES2173863T3/es not_active Expired - Lifetime
- 1992-06-11 AT AT92401618T patent/ATE214392T1/de active
- 1992-06-11 EP EP92401618A patent/EP0518767B1/de not_active Expired - Lifetime
- 1992-06-11 DE DE69232473T patent/DE69232473T2/de not_active Expired - Lifetime
- 1992-06-11 PT PT92401618T patent/PT518767E/pt unknown
- 1992-07-01 IE IE187492A patent/IE921874A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL102132A0 (en) | 1993-01-14 |
| FI922695A0 (fi) | 1992-06-10 |
| DE69232473T2 (de) | 2002-11-21 |
| IL102132A (en) | 1996-10-31 |
| NO305124B1 (no) | 1999-04-06 |
| ATE214392T1 (de) | 2002-03-15 |
| EP0518767A2 (de) | 1992-12-16 |
| ES2173863T3 (es) | 2002-11-01 |
| HU9201939D0 (en) | 1992-08-28 |
| AU1803792A (en) | 1992-12-24 |
| DK0518767T3 (da) | 2002-07-01 |
| EP0518767A3 (en) | 1993-05-05 |
| KR100234926B1 (ko) | 1999-12-15 |
| NO922270D0 (no) | 1992-06-10 |
| JPH05202044A (ja) | 1993-08-10 |
| KR930000518A (ko) | 1993-01-15 |
| DE69232473D1 (de) | 2002-04-18 |
| FI922695A (fi) | 1992-12-12 |
| HU212735B (en) | 1996-10-28 |
| NZ243031A (en) | 1994-02-25 |
| NO922270L (no) | 1992-12-14 |
| JP3377227B2 (ja) | 2003-02-17 |
| EP0517984A1 (de) | 1992-12-16 |
| CA2070573C (en) | 2003-04-15 |
| CA2070573A1 (en) | 1992-12-12 |
| HUT61549A (en) | 1993-01-28 |
| EP0518767B1 (de) | 2002-03-13 |
| AU649836B2 (en) | 1994-06-02 |
| IE921874A1 (en) | 1992-12-16 |
| PT518767E (pt) | 2002-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer of assignment of patent |
Owner name: AVENTIS INC. Free format text: AVENTIS INC. |
|
| PC | Transfer of assignment of patent |
Owner name: AVENTISUB II INC. Free format text: AVENTISUB II INC. |
|
| MA | Patent expired |