FI111716B - Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi - Google Patents
Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi Download PDFInfo
- Publication number
- FI111716B FI111716B FI924453A FI924453A FI111716B FI 111716 B FI111716 B FI 111716B FI 924453 A FI924453 A FI 924453A FI 924453 A FI924453 A FI 924453A FI 111716 B FI111716 B FI 111716B
- Authority
- FI
- Finland
- Prior art keywords
- group
- amino
- dimethylamino
- dioxo
- tetrahydroxy
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- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
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- IVFLPPKNEWVNFG-UHFFFAOYSA-N tetracene-1-carboxamide Chemical compound C1=CC=C2C=C(C=C3C(C(=O)N)=CC=CC3=C3)C3=CC2=C1 IVFLPPKNEWVNFG-UHFFFAOYSA-N 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- GZNAASVAJNXPPW-UHFFFAOYSA-M tin(4+) chloride dihydrate Chemical compound O.O.[Cl-].[Sn+4] GZNAASVAJNXPPW-UHFFFAOYSA-M 0.000 description 1
- FWPIDFUJEMBDLS-UHFFFAOYSA-L tin(II) chloride dihydrate Substances O.O.Cl[Sn]Cl FWPIDFUJEMBDLS-UHFFFAOYSA-L 0.000 description 1
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- PTMFUWGXPRYYMC-UHFFFAOYSA-N triethylazanium;formate Chemical compound OC=O.CCN(CC)CC PTMFUWGXPRYYMC-UHFFFAOYSA-N 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Seasonings (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Pyridine Compounds (AREA)
- Luminescent Compositions (AREA)
- Moulding By Coating Moulds (AREA)
- Tires In General (AREA)
- Spinning Or Twisting Of Yarns (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77169791 | 1991-10-04 | ||
| US07/771,697 US5281628A (en) | 1991-10-04 | 1991-10-04 | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI924453A0 FI924453A0 (fi) | 1992-10-02 |
| FI924453L FI924453L (fi) | 1993-04-05 |
| FI111716B true FI111716B (fi) | 2003-09-15 |
Family
ID=25092681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI924453A FI111716B (fi) | 1991-10-04 | 1992-10-02 | Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US5281628A (OSRAM) |
| EP (1) | EP0535346B1 (OSRAM) |
| JP (1) | JP3183729B2 (OSRAM) |
| KR (1) | KR100261528B1 (OSRAM) |
| CN (1) | CN1053182C (OSRAM) |
| AT (1) | ATE129697T1 (OSRAM) |
| AU (1) | AU651734B2 (OSRAM) |
| CA (1) | CA2079703C (OSRAM) |
| CZ (1) | CZ285015B6 (OSRAM) |
| DE (1) | DE69205792T2 (OSRAM) |
| DK (1) | DK0535346T3 (OSRAM) |
| ES (1) | ES2081005T3 (OSRAM) |
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| GR (1) | GR3017978T3 (OSRAM) |
| HK (1) | HK1000319A1 (OSRAM) |
| HU (2) | HU211214B (OSRAM) |
| IL (1) | IL103319A (OSRAM) |
| MX (1) | MX9205573A (OSRAM) |
| NO (1) | NO300129B1 (OSRAM) |
| NZ (1) | NZ244556A (OSRAM) |
| PH (1) | PH30343A (OSRAM) |
| PL (2) | PL170933B1 (OSRAM) |
| SK (1) | SK281113B6 (OSRAM) |
| TW (1) | TW222616B (OSRAM) |
| ZA (1) | ZA927608B (OSRAM) |
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| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| KR101083571B1 (ko) * | 2000-07-07 | 2011-11-14 | 파라테크 파마슈티컬스, 인크. | 7-치환 테트라사이클린 화합물 |
| ATE544745T1 (de) * | 2000-07-07 | 2012-02-15 | Tufts College | 9-substituierte minocyclinverbindungen |
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| PL2016045T3 (pl) * | 2006-04-24 | 2015-04-30 | Teva Pharma | Krystaliczna postać tygecykliny i sposoby jej otrzymywania |
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| USRE26271E (en) * | 1967-09-26 | Reductive alkylation process | ||
| US2482055A (en) * | 1948-02-11 | 1949-09-13 | American Cyanamid Co | Aureomycin and preparation of same |
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| US3043875A (en) * | 1959-10-22 | 1962-07-10 | Pfizer & Co C | Halogenated tetracycline derivatives and processes for their preparation |
| FR1430859A (OSRAM) * | 1960-05-23 | 1966-05-25 | ||
| US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
| US3148212A (en) | 1961-12-22 | 1964-09-08 | American Cyanamid Co | Reductive alkylation process |
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| US3373198A (en) * | 1967-04-27 | 1968-03-12 | American Cyanamid Co | Substituted 5a, 11a-dehydro-6-epitetracyclines |
| US3360561A (en) * | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
| US3518306A (en) * | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
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| US5064821A (en) * | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
| US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US5202449A (en) * | 1987-07-28 | 1993-04-13 | Nippon Kayaku Kabushiki Kaisha | Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline |
| JPH04295458A (ja) * | 1991-03-22 | 1992-10-20 | Fuji Photo Film Co Ltd | 光照射により酸を発生する化合物 |
| US5141960A (en) * | 1991-06-25 | 1992-08-25 | G. D. Searle & Co. | Tricyclic glycinamide derivatives as anti-convulsants |
| US5258398A (en) * | 1991-12-16 | 1993-11-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Antithrombotic diaminoalkanoic acid derivatives |
-
1991
- 1991-10-04 US US07/771,697 patent/US5281628A/en not_active Expired - Lifetime
-
1992
- 1992-08-18 ES ES92114054T patent/ES2081005T3/es not_active Expired - Lifetime
- 1992-08-18 DE DE69205792T patent/DE69205792T2/de not_active Expired - Fee Related
- 1992-08-18 DK DK92114054.7T patent/DK0535346T3/da active
- 1992-08-18 EP EP92114054A patent/EP0535346B1/en not_active Expired - Lifetime
- 1992-08-18 AT AT92114054T patent/ATE129697T1/de not_active IP Right Cessation
- 1992-08-19 TW TW081106574A patent/TW222616B/zh active
- 1992-09-28 JP JP28114692A patent/JP3183729B2/ja not_active Expired - Fee Related
- 1992-09-29 SK SK2972-92A patent/SK281113B6/sk unknown
- 1992-09-29 CZ CS922972A patent/CZ285015B6/cs not_active IP Right Cessation
- 1992-09-30 NZ NZ244556A patent/NZ244556A/xx unknown
- 1992-09-30 MX MX9205573A patent/MX9205573A/es not_active IP Right Cessation
- 1992-10-01 IL IL10331992A patent/IL103319A/en not_active IP Right Cessation
- 1992-10-02 AU AU26182/92A patent/AU651734B2/en not_active Ceased
- 1992-10-02 PL PL92296140A patent/PL170933B1/pl not_active IP Right Cessation
- 1992-10-02 CA CA002079703A patent/CA2079703C/en not_active Expired - Fee Related
- 1992-10-02 ZA ZA927608A patent/ZA927608B/xx unknown
- 1992-10-02 KR KR1019920018123A patent/KR100261528B1/ko not_active Expired - Fee Related
- 1992-10-02 PL PL92310696A patent/PL170939B1/pl not_active IP Right Cessation
- 1992-10-02 FI FI924453A patent/FI111716B/fi active
- 1992-10-02 PH PH45040A patent/PH30343A/en unknown
- 1992-10-02 NO NO923856A patent/NO300129B1/no not_active IP Right Cessation
- 1992-10-02 HU HU9203143A patent/HU211214B/hu not_active IP Right Cessation
- 1992-10-04 CN CN92111456A patent/CN1053182C/zh not_active Expired - Fee Related
-
1993
- 1993-11-01 US US08/146,666 patent/US5326759A/en not_active Expired - Lifetime
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1994
- 1994-03-29 US US08/219,568 patent/US5401863A/en not_active Expired - Lifetime
-
1995
- 1995-06-29 HU HU95P/P00602P patent/HU211922A9/hu unknown
- 1995-11-08 GR GR950402164T patent/GR3017978T3/el unknown
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1997
- 1997-10-04 HK HK97101881A patent/HK1000319A1/en not_active IP Right Cessation
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