FI924453A0 - Nya 9-amino-7-(substituerad)-6-demetyl-6-deoxitetracykliner - Google Patents

Nya 9-amino-7-(substituerad)-6-demetyl-6-deoxitetracykliner

Info

Publication number
FI924453A0
FI924453A0 FI924453A FI924453A FI924453A0 FI 924453 A0 FI924453 A0 FI 924453A0 FI 924453 A FI924453 A FI 924453A FI 924453 A FI924453 A FI 924453A FI 924453 A0 FI924453 A0 FI 924453A0
Authority
FI
Finland
Prior art keywords
amino
deoxitetracykliner
demetyl
nya
substitute
Prior art date
Application number
FI924453A
Other languages
English (en)
Other versions
FI924453A (fi
FI111716B (fi
Inventor
Joseph J Hlavka
Phaik-Eng Sum
Yakov Gluzman
Ving J Lee
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FI924453A0 publication Critical patent/FI924453A0/fi
Publication of FI924453A publication Critical patent/FI924453A/fi
Application granted granted Critical
Publication of FI111716B publication Critical patent/FI111716B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Luminescent Compositions (AREA)
  • Moulding By Coating Moulds (AREA)
  • Tires In General (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI924453A 1991-10-04 1992-10-02 Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi FI111716B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US77169791 1991-10-04

Publications (3)

Publication Number Publication Date
FI924453A0 true FI924453A0 (fi) 1992-10-02
FI924453A FI924453A (fi) 1993-04-05
FI111716B FI111716B (fi) 2003-09-15

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924453A FI111716B (fi) 1991-10-04 1992-10-02 Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi

Country Status (25)

Country Link
US (3) US5281628A (fi)
EP (1) EP0535346B1 (fi)
JP (1) JP3183729B2 (fi)
KR (1) KR100261528B1 (fi)
CN (1) CN1053182C (fi)
AT (1) ATE129697T1 (fi)
AU (1) AU651734B2 (fi)
CA (1) CA2079703C (fi)
CZ (1) CZ285015B6 (fi)
DE (1) DE69205792T2 (fi)
DK (1) DK0535346T3 (fi)
ES (1) ES2081005T3 (fi)
FI (1) FI111716B (fi)
GR (1) GR3017978T3 (fi)
HK (1) HK1000319A1 (fi)
HU (2) HU211214B (fi)
IL (1) IL103319A (fi)
MX (1) MX9205573A (fi)
NO (1) NO300129B1 (fi)
NZ (1) NZ244556A (fi)
PH (1) PH30343A (fi)
PL (2) PL170939B1 (fi)
SK (1) SK281113B6 (fi)
TW (1) TW222616B (fi)
ZA (1) ZA927608B (fi)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
DK0643775T3 (da) * 1992-05-28 2004-09-06 Ct For Molecular Biology And M Quinonderivater til forbedring af cellebioenergi
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
CA2183565A1 (en) * 1994-02-17 1995-08-24 Wei-Guo Su 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
IL137445A0 (en) * 1998-01-23 2001-07-24 Tufts College Pharmaceutically active compounds and methods of use thereof
DE60027465T2 (de) * 1999-09-14 2007-02-01 The Trustees Of Tufts College, Medford Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6686365B2 (en) * 2000-02-04 2004-02-03 Eli Lilly And Company Pharmaceutical composition
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
SI1301467T1 (sl) * 2000-07-07 2007-02-28 Tufts College 9-substituirane minociklinske spojine
CN1450989A (zh) * 2000-07-07 2003-10-22 塔夫茨大学信托人 7－取代的四环素化合物
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
DE60135387D1 (de) * 2001-03-13 2008-09-25 Paratek Pharm Innc 7,9 substituierte tetracyclinverbindungen
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2332549A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Novel tetracyclines and their use in medicine
WO2003055441A2 (en) * 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
WO2003057169A2 (en) * 2002-01-08 2003-07-17 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
CN102531948A (zh) * 2002-03-08 2012-07-04 帕拉特克药品公司 氨基-甲基取代的四环素类化合物
AU2003218243B2 (en) 2002-03-21 2010-04-01 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
KR101148415B1 (ko) 2002-07-12 2012-05-21 파라테크 파마슈티컬스, 인크. 3, 10, 및 12ａ 치환된 테트라시클린 화합물
CN1732023A (zh) * 2002-12-27 2006-02-08 血管技术国际股份公司 组合物和使用collajolie的方法
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2298322A3 (en) * 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
CA2553510C (en) * 2004-01-15 2012-09-25 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
CA2585418A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP2284156A3 (en) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US8088755B2 (en) * 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
KR20080080205A (ko) * 2005-12-22 2008-09-02 와이어쓰 티게사이클린을 포함하는 경구 제형
JP2009521456A (ja) * 2005-12-22 2009-06-04 ワイス チゲサイクリンでの胃腸管感染症の治療法
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
ES2528202T3 (es) * 2006-04-24 2015-02-05 Teva Pharmaceutical Industries Ltd. Una forma cristalina de tigeciclina y procesos para su preparación
CN101437788A (zh) * 2006-05-10 2009-05-20 特瓦制药工业有限公司 还原7/9-硝基四环素衍生物的方法
JP2009537139A (ja) 2006-05-15 2009-10-29 パラテック ファーマシューティカルズ インコーポレイテッド 置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を制御する方法
MX2008009520A (es) 2006-11-29 2009-02-26 Teva Pharma Formas cristalinas de tigeciclina y procesos de preparacion de ellas.
WO2008066908A1 (en) * 2006-11-30 2008-06-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
DK2225253T3 (da) 2007-11-29 2012-08-27 Actelion Pharmaceuticals Ltd Phosphonsyrederivater og deres anvendelse som p2y12- receptorantagonister
WO2010032219A1 (en) * 2008-09-18 2010-03-25 Ranbaxy Laboratories Limited Process for the preparation of tigecycline
JP2012520305A (ja) * 2009-03-12 2012-09-06 ワイス・エルエルシー テトラサイクリンのニトロ化
PL2327676T3 (pl) * 2009-11-26 2014-08-29 Sandoz Ag Reakcja związków organicznych z małymi ilościami wodoru

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USRE26271E (en) * 1967-09-26 Reductive alkylation process
US2482055A (en) * 1948-02-11 1949-09-13 American Cyanamid Co Aureomycin and preparation of same
US2997471A (en) * 1958-08-18 1961-08-22 Bristol Myers Co Tetracycline derivatives
US3007965A (en) * 1959-02-13 1961-11-07 American Cyanamid Co New tetracyclines produced by streptomyces aureofaciens
US3043875A (en) * 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (fi) * 1960-05-23 1966-05-25
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3148212A (en) 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
US3360557A (en) * 1963-05-10 1967-12-26 American Cyanamid Co 9-hydroxytetracyclines and a process of preparing same
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3397230A (en) * 1966-03-14 1968-08-13 American Cyanamid Co Nitration of tetracyclines
US3341585A (en) * 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
US3373198A (en) * 1967-04-27 1968-03-12 American Cyanamid Co Substituted 5a, 11a-dehydro-6-epitetracyclines
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US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
JPH04295458A (ja) * 1991-03-22 1992-10-20 Fuji Photo Film Co Ltd 光照射により酸を発生する化合物
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Also Published As

Publication number Publication date
CZ285015B6 (cs) 1999-05-12
FI924453A (fi) 1993-04-05
KR100261528B1 (ko) 2000-07-15
AU2618292A (en) 1993-04-08
TW222616B (fi) 1994-04-21
HU9203143D0 (en) 1992-12-28
CN1071415A (zh) 1993-04-28
GR3017978T3 (en) 1996-02-29
HK1000319A1 (en) 1998-02-27
PH30343A (en) 1997-04-02
DE69205792T2 (de) 1996-06-20
US5326759A (en) 1994-07-05
KR930007895A (ko) 1993-05-20
PL170933B1 (pl) 1997-02-28
IL103319A (en) 1996-07-23
AU651734B2 (en) 1994-07-28
CA2079703A1 (en) 1993-04-05
HUT64298A (en) 1993-12-28
ES2081005T3 (es) 1996-02-16
IL103319A0 (en) 1993-03-15
PL296140A1 (en) 1993-11-02
EP0535346B1 (en) 1995-11-02
MX9205573A (es) 1993-05-01
CZ297292A3 (en) 1993-04-14
HU211922A9 (en) 1996-01-29
NO923856L (no) 1993-04-05
US5401863A (en) 1995-03-28
DE69205792D1 (de) 1995-12-07
NO300129B1 (no) 1997-04-14
US5281628A (en) 1994-01-25
EP0535346A1 (en) 1993-04-07
ATE129697T1 (de) 1995-11-15
DK0535346T3 (da) 1995-12-04
CA2079703C (en) 2004-07-20
SK297292A3 (en) 1994-12-07
NZ244556A (en) 1994-06-27
PL170939B1 (pl) 1997-02-28
SK281113B6 (sk) 2000-12-11
CN1053182C (zh) 2000-06-07
NO923856D0 (no) 1992-10-02
FI111716B (fi) 2003-09-15
ZA927608B (en) 1993-04-13
JP3183729B2 (ja) 2001-07-09
HU211214B (en) 1995-11-28
JPH05239006A (ja) 1993-09-17

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