CA2079703A1 - Novel 9-amino-7-substituted-6-demethyl-6-deoxytetracyclines - Google Patents

Novel 9-amino-7-substituted-6-demethyl-6-deoxytetracyclines

Info

Publication number
CA2079703A1
CA2079703A1 CA002079703A CA2079703A CA2079703A1 CA 2079703 A1 CA2079703 A1 CA 2079703A1 CA 002079703 A CA002079703 A CA 002079703A CA 2079703 A CA2079703 A CA 2079703A CA 2079703 A1 CA2079703 A1 CA 2079703A1
Authority
CA
Canada
Prior art keywords
novel
amino
deoxytetracyclines
substituted
demethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002079703A
Other languages
French (fr)
Other versions
CA2079703C (en
Inventor
Joseph J. Hlavka
Phaik-Eng Sum
Yakov Gluzman
Ving J. Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2079703A1 publication Critical patent/CA2079703A1/en
Application granted granted Critical
Publication of CA2079703C publication Critical patent/CA2079703C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Moulding By Coating Moulds (AREA)
  • Tires In General (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Novel 9-amino-7-(substituted amino)-6-de-methyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.
CA002079703A 1991-10-04 1992-10-02 Novel 9-amino-7-substituted-6-demethyl-6-deoxytetracyclines Expired - Fee Related CA2079703C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US07/771,697 1991-10-04

Publications (2)

Publication Number Publication Date
CA2079703A1 true CA2079703A1 (en) 1993-04-05
CA2079703C CA2079703C (en) 2004-07-20

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002079703A Expired - Fee Related CA2079703C (en) 1991-10-04 1992-10-02 Novel 9-amino-7-substituted-6-demethyl-6-deoxytetracyclines

Country Status (24)

Country Link
US (3) US5281628A (en)
EP (1) EP0535346B1 (en)
JP (1) JP3183729B2 (en)
KR (1) KR100261528B1 (en)
CN (1) CN1053182C (en)
AT (1) ATE129697T1 (en)
AU (1) AU651734B2 (en)
CA (1) CA2079703C (en)
CZ (1) CZ285015B6 (en)
DE (1) DE69205792T2 (en)
DK (1) DK0535346T3 (en)
ES (1) ES2081005T3 (en)
FI (1) FI111716B (en)
GR (1) GR3017978T3 (en)
HU (2) HU211214B (en)
IL (1) IL103319A (en)
MX (1) MX9205573A (en)
NO (1) NO300129B1 (en)
NZ (1) NZ244556A (en)
PH (1) PH30343A (en)
PL (2) PL170933B1 (en)
SK (1) SK281113B6 (en)
TW (1) TW222616B (en)
ZA (1) ZA927608B (en)

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US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5981601A (en) * 1992-05-28 1999-11-09 Centre For Molecular Biology And Medicine Method for enhancing cellular bioenergy
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
MX9603508A (en) * 1994-02-17 1997-03-29 Pfizer ANALOGS OF DOXICICLINE.
WO1999037307A1 (en) * 1998-01-23 1999-07-29 Trustees Of Tufts College Pharmaceutically active compounds and methods of use thereof
EP2327686A3 (en) * 1999-09-14 2012-08-22 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6686365B2 (en) * 2000-02-04 2004-02-03 Eli Lilly And Company Pharmaceutical composition
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
EP2308832B8 (en) * 2000-07-07 2019-04-24 Trustees Of Tufts College 9-substituted minocycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
KR101083571B1 (en) * 2000-07-07 2011-11-14 파라테크 파마슈티컬스, 인크. 7-substituted tetracycline compounds
EA201000388A1 (en) * 2001-03-13 2010-10-29 Пэрэтек Фамэсьютикэлс, Инк. SUBSTITUTED TETRACYCLINE COMPOUNDS (OPTIONS), PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF TETRACYCLINE-SENSITIVE CONDITION OF THE SUBJECT
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
AU2002318238A1 (en) 2001-07-13 2003-01-29 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
WO2003055441A2 (en) * 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
EP2311797A1 (en) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
JP2005526754A (en) * 2002-03-08 2005-09-08 パラテック ファーマシューティカルズ インコーポレイテッド Aminomethyl-substituted tetracycline compounds
CN1653037A (en) 2002-03-21 2005-08-10 帕拉特克药品公司 Substituted Tetracycline Compounds
EP2345637A3 (en) 2002-07-12 2012-02-15 Paratek Pharmaceuticals, Inc. 3, 10, and 12a substituted tetracycline compounds
AU2003300379A1 (en) * 2002-12-27 2004-07-29 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collagen and MMPI
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
WO2005009943A2 (en) * 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP1716101A1 (en) * 2004-01-15 2006-11-02 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
EP2284152A3 (en) 2004-10-25 2011-10-05 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2301912A3 (en) 2004-10-25 2012-07-11 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
US8088755B2 (en) * 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057033A1 (en) * 2005-05-27 2007-11-14 Wyeth Corp TIGECICLINE AND METHODS TO PREPARE 9-NITROMINOCICLINE
AR057034A1 (en) * 2005-05-27 2007-11-14 Wyeth Corp METHODS TO PURIFY TIGECICLINE
AR057032A1 (en) * 2005-05-27 2007-11-14 Wyeth Corp TIGECICLINE AND PREPARATION METHODS
AR057324A1 (en) * 2005-05-27 2007-11-28 Wyeth Corp TIGECICLINE AND METHODS TO PREPARE 9-AMINOMINOCICLINE
JP2009502809A (en) * 2005-07-21 2009-01-29 パラテック ファーマシューティカルズ インコーポレイテッド 10-Substituted Tetracycline and Method of Use
AU2006331688A1 (en) * 2005-12-22 2007-07-05 Wyeth Oral formulations comprising tigecycline
EP1962860A1 (en) * 2005-12-22 2008-09-03 Wyeth Methods of treating gastrointestinal tract infections with tigecycline
WO2007120913A2 (en) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
PL2016045T3 (en) * 2006-04-24 2015-04-30 Teva Pharma A tigecycline crystalline form and processes for its preparation
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
BRPI0702886A2 (en) * 2006-05-10 2011-03-15 Teva Pharmaceutical Ind Ltda process for reducing 7-or 9-nitrotetracycline into its corresponding 7-or 9-aminotetracycline
EP2026776A2 (en) 2006-05-15 2009-02-25 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
WO2008066935A2 (en) 2006-11-29 2008-06-05 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
WO2008066908A1 (en) * 2006-11-30 2008-06-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
EP2114865A1 (en) * 2007-03-01 2009-11-11 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
PT2225253E (en) 2007-11-29 2012-09-19 Actelion Pharmaceuticals Ltd Phosphonic acid derivates and their use as p2y12 receptor antagonists
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Also Published As

Publication number Publication date
KR930007895A (en) 1993-05-20
CZ297292A3 (en) 1993-04-14
PL296140A1 (en) 1993-11-02
GR3017978T3 (en) 1996-02-29
AU2618292A (en) 1993-04-08
TW222616B (en) 1994-04-21
US5326759A (en) 1994-07-05
HUT64298A (en) 1993-12-28
ATE129697T1 (en) 1995-11-15
KR100261528B1 (en) 2000-07-15
US5401863A (en) 1995-03-28
HK1000319A1 (en) 1998-02-27
SK297292A3 (en) 1994-12-07
FI924453A0 (en) 1992-10-02
DE69205792D1 (en) 1995-12-07
PL170933B1 (en) 1997-02-28
ZA927608B (en) 1993-04-13
US5281628A (en) 1994-01-25
NZ244556A (en) 1994-06-27
CN1053182C (en) 2000-06-07
EP0535346A1 (en) 1993-04-07
FI924453L (en) 1993-04-05
JP3183729B2 (en) 2001-07-09
CN1071415A (en) 1993-04-28
HU9203143D0 (en) 1992-12-28
HU211214B (en) 1995-11-28
MX9205573A (en) 1993-05-01
DK0535346T3 (en) 1995-12-04
IL103319A0 (en) 1993-03-15
HU211922A9 (en) 1996-01-29
NO923856L (en) 1993-04-05
FI111716B (en) 2003-09-15
EP0535346B1 (en) 1995-11-02
PL170939B1 (en) 1997-02-28
DE69205792T2 (en) 1996-06-20
IL103319A (en) 1996-07-23
ES2081005T3 (en) 1996-02-16
NO923856D0 (en) 1992-10-02
NO300129B1 (en) 1997-04-14
CA2079703C (en) 2004-07-20
PH30343A (en) 1997-04-02
CZ285015B6 (en) 1999-05-12
AU651734B2 (en) 1994-07-28
SK281113B6 (en) 2000-12-11
JPH05239006A (en) 1993-09-17

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