CA2079703A1 - Novel 9-amino-7-substituted-6-demethyl-6-deoxytetracyclines - Google Patents

Novel 9-amino-7-substituted-6-demethyl-6-deoxytetracyclines

Info

Publication number
CA2079703A1
CA2079703A1 CA002079703A CA2079703A CA2079703A1 CA 2079703 A1 CA2079703 A1 CA 2079703A1 CA 002079703 A CA002079703 A CA 002079703A CA 2079703 A CA2079703 A CA 2079703A CA 2079703 A1 CA2079703 A1 CA 2079703A1
Authority
CA
Canada
Prior art keywords
novel
amino
deoxytetracyclines
substituted
demethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002079703A
Other languages
French (fr)
Other versions
CA2079703C (en
Inventor
Joseph J. Hlavka
Phaik-Eng Sum
Yakov Gluzman
Ving J. Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2079703A1 publication Critical patent/CA2079703A1/en
Application granted granted Critical
Publication of CA2079703C publication Critical patent/CA2079703C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Tires In General (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Moulding By Coating Moulds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Novel 9-amino-7-(substituted amino)-6-de-methyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.
CA002079703A 1991-10-04 1992-10-02 Novel 9-amino-7-substituted-6-demethyl-6-deoxytetracyclines Expired - Fee Related CA2079703C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US07/771,697 1991-10-04

Publications (2)

Publication Number Publication Date
CA2079703A1 true CA2079703A1 (en) 1993-04-05
CA2079703C CA2079703C (en) 2004-07-20

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002079703A Expired - Fee Related CA2079703C (en) 1991-10-04 1992-10-02 Novel 9-amino-7-substituted-6-demethyl-6-deoxytetracyclines

Country Status (24)

Country Link
US (3) US5281628A (en)
EP (1) EP0535346B1 (en)
JP (1) JP3183729B2 (en)
KR (1) KR100261528B1 (en)
CN (1) CN1053182C (en)
AT (1) ATE129697T1 (en)
AU (1) AU651734B2 (en)
CA (1) CA2079703C (en)
CZ (1) CZ285015B6 (en)
DE (1) DE69205792T2 (en)
DK (1) DK0535346T3 (en)
ES (1) ES2081005T3 (en)
FI (1) FI111716B (en)
GR (1) GR3017978T3 (en)
HU (2) HU211214B (en)
IL (1) IL103319A (en)
MX (1) MX9205573A (en)
NO (1) NO300129B1 (en)
NZ (1) NZ244556A (en)
PH (1) PH30343A (en)
PL (2) PL170939B1 (en)
SK (1) SK281113B6 (en)
TW (1) TW222616B (en)
ZA (1) ZA927608B (en)

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US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
WO1995022529A1 (en) * 1994-02-17 1995-08-24 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
AU2466099A (en) * 1998-01-23 1999-08-09 Trustees Of Tufts College Pharmaceutically active compounds and methods of use thereof
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
ES2260051T3 (en) * 1999-09-14 2006-11-01 Trustees Of Tufts College METHOD FOR PREPARING SUBSTITUTED TETRACICLINES WITH CHEMICALS BASED ON TRANSITIONAL METALS.
US6686365B2 (en) * 2000-02-04 2004-02-03 Eli Lilly And Company Pharmaceutical composition
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
CN1690047B (en) * 2000-07-07 2010-10-06 塔夫茨大学信托人 9-substituted minocycline compounds
JP5044084B2 (en) * 2000-07-07 2012-10-10 トラスティーズ・オブ・タフツ・カレッジ 7-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
EP2301914A1 (en) * 2001-03-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7,9-Substituted tetracycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2301915A1 (en) 2001-07-13 2011-03-30 Paratek Pharmaceuticals, Inc. 7-(diethylamino)methyl substituted tetracycline having target therapeutic activities
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
US7056902B2 (en) * 2002-01-08 2006-06-06 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EP2316450A1 (en) * 2002-03-08 2011-05-04 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
CN101712632A (en) 2002-03-21 2010-05-26 帕拉特克药品公司 Substituted tetracycline compounds
CN1700922A (en) 2002-07-12 2005-11-23 帕拉特克药品公司 3, 10, and 12a substituted tetracycline compounds
JP2006516252A (en) * 2002-12-27 2006-06-29 アンジオテック インターナショナル アクツィエン ゲゼルシャフト Compositions and methods using collagen and MMPI
EA200600221A1 (en) * 2003-07-09 2006-06-30 Пэрэтек Фамэсьютикэлс, Инк. SUBSTITUTED TETRACYCLINE COMPOUNDS (OPTIONS), PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OF TETRACYCLINE-SENSITIVE CONDITION IN SUBJECT
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
WO2005070878A1 (en) * 2004-01-15 2005-08-04 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
EP2295419A3 (en) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP1805134B1 (en) 2004-10-25 2012-06-20 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
US8088755B2 (en) 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057324A1 (en) * 2005-05-27 2007-11-28 Wyeth Corp TIGECICLINE AND METHODS TO PREPARE 9-AMINOMINOCICLINE
AR057032A1 (en) * 2005-05-27 2007-11-14 Wyeth Corp TIGECICLINE AND PREPARATION METHODS
AR057034A1 (en) * 2005-05-27 2007-11-14 Wyeth Corp METHODS TO PURIFY TIGECICLINE
AR057033A1 (en) * 2005-05-27 2007-11-14 Wyeth Corp TIGECICLINE AND METHODS TO PREPARE 9-NITROMINOCICLINE
JP2009502809A (en) * 2005-07-21 2009-01-29 パラテック ファーマシューティカルズ インコーポレイテッド 10-Substituted Tetracycline and Method of Use
JP2009521456A (en) * 2005-12-22 2009-06-04 ワイス Treatment of gastrointestinal infections with tigecycline
BRPI0620646A2 (en) * 2005-12-22 2011-11-22 Wyeth Corp pharmaceutical composition comprising tigecycline and its use
EP2007713A2 (en) * 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Isolation of tetracycline derivatives
US7871993B2 (en) * 2006-04-24 2011-01-18 Teva Pharmaceutical Industries Ltd. Tigecycline crystalline forms and processes for preparation thereof
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
CN101437788A (en) * 2006-05-10 2009-05-20 特瓦制药工业有限公司 Methods for reducing 7/9-nitrotetracycline derivatives
US20080118979A1 (en) 2006-05-15 2008-05-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
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MX2008009727A (en) * 2006-11-30 2009-01-09 Teva Pharma Processes for preparation of 9-haloacetamidominocyclines.
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Also Published As

Publication number Publication date
FI111716B (en) 2003-09-15
HU9203143D0 (en) 1992-12-28
NZ244556A (en) 1994-06-27
ATE129697T1 (en) 1995-11-15
HK1000319A1 (en) 1998-02-27
EP0535346A1 (en) 1993-04-07
MX9205573A (en) 1993-05-01
SK281113B6 (en) 2000-12-11
NO923856D0 (en) 1992-10-02
CZ297292A3 (en) 1993-04-14
PH30343A (en) 1997-04-02
US5401863A (en) 1995-03-28
JP3183729B2 (en) 2001-07-09
NO300129B1 (en) 1997-04-14
CN1053182C (en) 2000-06-07
HU211214B (en) 1995-11-28
KR930007895A (en) 1993-05-20
IL103319A0 (en) 1993-03-15
US5281628A (en) 1994-01-25
CZ285015B6 (en) 1999-05-12
PL296140A1 (en) 1993-11-02
TW222616B (en) 1994-04-21
GR3017978T3 (en) 1996-02-29
AU2618292A (en) 1993-04-08
FI924453L (en) 1993-04-05
FI924453A0 (en) 1992-10-02
AU651734B2 (en) 1994-07-28
NO923856L (en) 1993-04-05
PL170933B1 (en) 1997-02-28
ES2081005T3 (en) 1996-02-16
KR100261528B1 (en) 2000-07-15
SK297292A3 (en) 1994-12-07
JPH05239006A (en) 1993-09-17
EP0535346B1 (en) 1995-11-02
DE69205792D1 (en) 1995-12-07
ZA927608B (en) 1993-04-13
DK0535346T3 (en) 1995-12-04
US5326759A (en) 1994-07-05
CA2079703C (en) 2004-07-20
IL103319A (en) 1996-07-23
CN1071415A (en) 1993-04-28
HUT64298A (en) 1993-12-28
DE69205792T2 (en) 1996-06-20
HU211922A9 (en) 1996-01-29
PL170939B1 (en) 1997-02-28

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