TW222616B - - Google Patents

Info

Publication number
TW222616B
TW222616B TW081106574A TW81106574A TW222616B TW 222616 B TW222616 B TW 222616B TW 081106574 A TW081106574 A TW 081106574A TW 81106574 A TW81106574 A TW 81106574A TW 222616 B TW222616 B TW 222616B
Authority
TW
Taiwan
Prior art keywords
disclosed
novel
amino
organisms
deoxytetracyclines
Prior art date
Application number
TW081106574A
Other languages
English (en)
Chinese (zh)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of TW222616B publication Critical patent/TW222616B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Peptides Or Proteins (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Luminescent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Moulding By Coating Moulds (AREA)
  • Tires In General (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
TW081106574A 1991-10-04 1992-08-19 TW222616B (OSRAM)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Publications (1)

Publication Number Publication Date
TW222616B true TW222616B (OSRAM) 1994-04-21

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081106574A TW222616B (OSRAM) 1991-10-04 1992-08-19

Country Status (24)

Country Link
US (3) US5281628A (OSRAM)
EP (1) EP0535346B1 (OSRAM)
JP (1) JP3183729B2 (OSRAM)
KR (1) KR100261528B1 (OSRAM)
CN (1) CN1053182C (OSRAM)
AT (1) ATE129697T1 (OSRAM)
AU (1) AU651734B2 (OSRAM)
CA (1) CA2079703C (OSRAM)
CZ (1) CZ285015B6 (OSRAM)
DE (1) DE69205792T2 (OSRAM)
DK (1) DK0535346T3 (OSRAM)
ES (1) ES2081005T3 (OSRAM)
FI (1) FI111716B (OSRAM)
GR (1) GR3017978T3 (OSRAM)
HU (2) HU211214B (OSRAM)
IL (1) IL103319A (OSRAM)
MX (1) MX9205573A (OSRAM)
NO (1) NO300129B1 (OSRAM)
NZ (1) NZ244556A (OSRAM)
PH (1) PH30343A (OSRAM)
PL (2) PL170939B1 (OSRAM)
SK (1) SK281113B6 (OSRAM)
TW (1) TW222616B (OSRAM)
ZA (1) ZA927608B (OSRAM)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
DK0643775T3 (da) * 1992-05-28 2004-09-06 Ct For Molecular Biology And M Quinonderivater til forbedring af cellebioenergi
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
AU1279095A (en) * 1994-02-17 1995-09-04 Pfizer Inc. 9-(substituted amino)-alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
AU753370B2 (en) * 1998-01-23 2002-10-17 Trustees Of Tufts College Pharmaceutically active compounds and methods of use thereof
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
ATE323671T1 (de) * 1999-09-14 2006-05-15 Tufts College Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien
US6686365B2 (en) * 2000-02-04 2004-02-03 Eli Lilly And Company Pharmaceutical composition
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
HRP20030090A2 (en) * 2000-07-07 2005-08-31 Paratek Pharmaceuticals Trustees Of Tufts College 7-substituted tetracycline compounds
IL153639A0 (en) * 2000-07-07 2003-07-06 Tufts College 9-substituted minocycline compounds
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
CZ20032780A3 (cs) * 2001-03-13 2004-01-14 Paratek Pharmaceuticals, Inc. 7,9- Substituované tetracyklinové sloučeniny
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2301550A1 (en) 2001-07-13 2011-03-30 Paratek Pharmaceuticals, Inc. Tetracycline compounds having target therapeutic activities
WO2003055441A2 (en) * 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
AU2003235759A1 (en) * 2002-01-08 2003-07-24 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
KR101093842B1 (ko) * 2002-03-08 2011-12-13 파라테크 파마슈티컬스, 인크. 아미노-메틸 치환된 테트라시클린 화합물
AU2003218243B2 (en) 2002-03-21 2010-04-01 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EA200900540A1 (ru) 2002-07-12 2009-12-30 Пэрэтек Фамэсьютикэлс, Инк. Замещённые соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
WO2004060425A2 (en) * 2002-12-27 2004-07-22 Angiotech International Ag Compositions and methods of using collagen and mmpi
US20050143352A1 (en) 2003-07-09 2005-06-30 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2332904A3 (en) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
EP2284151A3 (en) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2301916A3 (en) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
WO2006084265A1 (en) * 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
EP1910273A2 (en) * 2005-07-21 2008-04-16 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
CA2631632A1 (en) * 2005-12-22 2007-07-05 Wyeth Methods of treating gastrointestinal tract infections with tigecycline
EP1965770A2 (en) * 2005-12-22 2008-09-10 Wyeth a Corporation of the State of Delaware Oral formulations comprising tigecycline
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
EP2426104A1 (en) * 2006-04-24 2012-03-07 Teva Pharmaceutical Industries Ltd. Tigecycline crystalline form and process for preparation thereof
WO2007133678A1 (en) * 2006-05-10 2007-11-22 Teva Pharmaceutical Industries Ltd. Methods for reducing 7/9-nitrotetracycline derivatives
EP2029749A2 (en) 2006-05-15 2009-03-04 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
MX2008009520A (es) 2006-11-29 2009-02-26 Teva Pharma Formas cristalinas de tigeciclina y procesos de preparacion de ellas.
WO2008066908A1 (en) * 2006-11-30 2008-06-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
US20080214869A1 (en) * 2007-03-01 2008-09-04 Sergei Fine Processes for purification of tigecycline
MY153749A (en) 2007-11-29 2015-03-13 Actelion Pharmaceuticals Ltd Phosphonic acid derivates and their use as p2y12 receptor antagonists
WO2010032219A1 (en) * 2008-09-18 2010-03-25 Ranbaxy Laboratories Limited Process for the preparation of tigecycline
WO2010114680A1 (en) * 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
ES2469829T3 (es) * 2009-11-26 2014-06-20 Sandoz Ag Reacción de compuestos orgánicos con bajas cantidades de hidrógeno

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE26271E (en) * 1967-09-26 Reductive alkylation process
US2482055A (en) * 1948-02-11 1949-09-13 American Cyanamid Co Aureomycin and preparation of same
US2997471A (en) * 1958-08-18 1961-08-22 Bristol Myers Co Tetracycline derivatives
US3007965A (en) * 1959-02-13 1961-11-07 American Cyanamid Co New tetracyclines produced by streptomyces aureofaciens
US3043875A (en) * 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (OSRAM) * 1960-05-23 1966-05-25
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3148212A (en) 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
US3360557A (en) * 1963-05-10 1967-12-26 American Cyanamid Co 9-hydroxytetracyclines and a process of preparing same
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3397230A (en) * 1966-03-14 1968-08-13 American Cyanamid Co Nitration of tetracyclines
US3341585A (en) * 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
US3373198A (en) * 1967-04-27 1968-03-12 American Cyanamid Co Substituted 5a, 11a-dehydro-6-epitetracyclines
US3360561A (en) * 1967-06-19 1967-12-26 American Cyanamid Co Nitration of tetracyclines
US3518306A (en) * 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
CA999855A (en) * 1972-09-18 1976-11-16 Societa' Farmaceutici Italia S.P.A. Process for the preparation of tetracyclines derivatives in the 7 position
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
JPH04295458A (ja) * 1991-03-22 1992-10-20 Fuji Photo Film Co Ltd 光照射により酸を発生する化合物
US5141960A (en) * 1991-06-25 1992-08-25 G. D. Searle & Co. Tricyclic glycinamide derivatives as anti-convulsants
US5258398A (en) * 1991-12-16 1993-11-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic diaminoalkanoic acid derivatives

Also Published As

Publication number Publication date
EP0535346B1 (en) 1995-11-02
NO923856L (no) 1993-04-05
FI111716B (fi) 2003-09-15
NO923856D0 (no) 1992-10-02
PL170939B1 (pl) 1997-02-28
AU651734B2 (en) 1994-07-28
CA2079703A1 (en) 1993-04-05
JPH05239006A (ja) 1993-09-17
IL103319A0 (en) 1993-03-15
FI924453L (fi) 1993-04-05
HU211922A9 (en) 1996-01-29
HU211214B (en) 1995-11-28
DE69205792D1 (de) 1995-12-07
ATE129697T1 (de) 1995-11-15
US5326759A (en) 1994-07-05
MX9205573A (es) 1993-05-01
DE69205792T2 (de) 1996-06-20
PL296140A1 (en) 1993-11-02
EP0535346A1 (en) 1993-04-07
CA2079703C (en) 2004-07-20
DK0535346T3 (da) 1995-12-04
ES2081005T3 (es) 1996-02-16
IL103319A (en) 1996-07-23
GR3017978T3 (en) 1996-02-29
PH30343A (en) 1997-04-02
CN1071415A (zh) 1993-04-28
PL170933B1 (pl) 1997-02-28
SK281113B6 (sk) 2000-12-11
AU2618292A (en) 1993-04-08
CZ297292A3 (en) 1993-04-14
ZA927608B (en) 1993-04-13
NZ244556A (en) 1994-06-27
CZ285015B6 (cs) 1999-05-12
HUT64298A (en) 1993-12-28
JP3183729B2 (ja) 2001-07-09
KR100261528B1 (ko) 2000-07-15
HK1000319A1 (en) 1998-02-27
KR930007895A (ko) 1993-05-20
HU9203143D0 (en) 1992-12-28
FI924453A0 (fi) 1992-10-02
US5281628A (en) 1994-01-25
SK297292A3 (en) 1994-12-07
CN1053182C (zh) 2000-06-07
NO300129B1 (no) 1997-04-14
US5401863A (en) 1995-03-28

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