FI111714B - Uusi menetelmä formoterolin ja lähisukuisten yhdisteiden valmistamiseksi - Google Patents

Uusi menetelmä formoterolin ja lähisukuisten yhdisteiden valmistamiseksi Download PDF

Info

Publication number
FI111714B
FI111714B FI931333A FI931333A FI111714B FI 111714 B FI111714 B FI 111714B FI 931333 A FI931333 A FI 931333A FI 931333 A FI931333 A FI 931333A FI 111714 B FI111714 B FI 111714B
Authority
FI
Finland
Prior art keywords
eller
compound
med
och
betecknar
Prior art date
Application number
FI931333A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI931333A0 (fi
FI931333A (fi
Inventor
Edib Jakupovic
Jan William Trofast
Lena Katarina Maansson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of FI931333A0 publication Critical patent/FI931333A0/fi
Publication of FI931333A publication Critical patent/FI931333A/fi
Application granted granted Critical
Publication of FI111714B publication Critical patent/FI111714B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
FI931333A 1990-09-26 1993-03-25 Uusi menetelmä formoterolin ja lähisukuisten yhdisteiden valmistamiseksi FI111714B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9003057A SE9003057D0 (sv) 1990-09-26 1990-09-26 New process
SE9003057 1990-09-26
SE9100643 1991-09-25
PCT/SE1991/000643 WO1992005147A1 (en) 1990-09-26 1991-09-25 New process for preparing formoterol and related compounds

Publications (3)

Publication Number Publication Date
FI931333A0 FI931333A0 (fi) 1993-03-25
FI931333A FI931333A (fi) 1993-04-22
FI111714B true FI111714B (fi) 2003-09-15

Family

ID=20380456

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931333A FI111714B (fi) 1990-09-26 1993-03-25 Uusi menetelmä formoterolin ja lähisukuisten yhdisteiden valmistamiseksi

Country Status (28)

Country Link
EP (1) EP0550612B1 (da)
JP (1) JP2801401B2 (da)
KR (1) KR0179639B1 (da)
AT (1) ATE134990T1 (da)
AU (1) AU652386B2 (da)
BG (1) BG61605B1 (da)
CA (1) CA2091343C (da)
CZ (1) CZ284256B6 (da)
DE (1) DE69117768T2 (da)
DK (1) DK0550612T3 (da)
EE (1) EE02979B1 (da)
ES (1) ES2084831T3 (da)
FI (1) FI111714B (da)
GR (1) GR3020134T3 (da)
HK (1) HK52297A (da)
HU (1) HU214054B (da)
IE (1) IE74387B1 (da)
IS (1) IS1684B (da)
LT (1) LT3813B (da)
LV (1) LV10770B (da)
NO (1) NO301709B1 (da)
PL (1) PL166434B1 (da)
PT (1) PT99051B (da)
RU (1) RU2079486C1 (da)
SE (1) SE9003057D0 (da)
SG (1) SG43150A1 (da)
SK (1) SK22793A3 (da)
WO (1) WO1992005147A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6299863B1 (en) 1992-04-03 2001-10-09 Sepracor Inc. Aerosol formulations containing micronized optically pure (R,R) formoterol for bronchodilating therapy
US6866839B2 (en) 1991-04-05 2005-03-15 Sepracor Inc. Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
US5795564A (en) * 1991-04-05 1998-08-18 Sepracor, Inc. Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
US5629200A (en) * 1993-11-18 1997-05-13 Daicel Chemical Industries, Ltd. Production of optically active 2-amino-1-phenylethanol derivatives by asymetrical assimilation
SE9404080L (sv) * 1993-12-28 1995-06-29 Ciba Geigy Ag Förfarande för framställning av en optiskt ren enantiomer av formoterol
AU722859B2 (en) * 1996-11-11 2000-08-10 Sepracor, Inc. Process for the preparation of optically pure isomers of formoterol
US6040344A (en) 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
US6303145B2 (en) 1999-05-10 2001-10-16 Sepracor Inc. (S,R) formoterol methods and compositions
AR028948A1 (es) 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
AU2002252950A1 (en) * 2001-02-22 2002-09-04 Universitatsklinikum Charite Medizinische Fakultat Der Humboldt-Universitat Zu Berlin Protein kinase d inhibitors and protein kinase 2 inhibitors as agents for inhibiting tumour cells and for stimulating angiogenesis
US6472563B1 (en) 2001-11-09 2002-10-29 Sepracor Inc. Formoterol tartrate process and polymorph
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
TW200738634A (en) 2005-08-02 2007-10-16 Astrazeneca Ab New salt
WO2008035380A2 (en) * 2006-09-19 2008-03-27 Natco Pharma Limited An improved process for the preparation of high purity formoterol and its pharmaceutically acceptable salts
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
JP2011501204A (ja) * 2007-10-29 2011-01-06 ジェネリクス・（ユーケー）・リミテッド 新規なクロマトグラフィー方法
EA017627B1 (ru) 2008-05-13 2013-01-30 Астразенека Аб Хинуклидиновые производные в качестве антагонистов мускаринового м3 рецептора
CN101921200B (zh) * 2009-06-16 2014-01-15 上海医药工业研究院 一种n-苄基-1-(4-甲氧基苯基)-2-丙胺的制备方法
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
CN115368250B (zh) * 2022-09-02 2024-07-26 博诺康源(北京)药业科技有限公司 拆分福莫特罗手性中间体的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2366625C2 (da) * 1972-02-05 1988-06-09 Yamanouchi Pharmaceutical Co., Ltd., Tokio/Tokyo, Jp
GB1468156A (en) * 1973-07-19 1977-03-23 Ici Ltd Phenylethylamine derivatives
ES2005492A6 (es) 1987-12-23 1989-03-01 Lasa Lab Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i).

Also Published As

Publication number Publication date
IS1684B (is) 1998-02-24
CA2091343A1 (en) 1992-03-27
NO931058D0 (no) 1993-03-23
FI931333A0 (fi) 1993-03-25
CZ44293A3 (en) 1994-01-19
BG97576A (bg) 1994-03-31
HU9300867D0 (en) 1993-06-28
LT3813B (en) 1996-03-25
WO1992005147A1 (en) 1992-04-02
BG61605B1 (bg) 1998-01-30
IS3756A7 (is) 1992-03-27
GR3020134T3 (en) 1996-08-31
IE913373A1 (en) 1992-04-08
LV10770B (en) 1996-04-20
ATE134990T1 (de) 1996-03-15
ES2084831T3 (es) 1996-05-16
JP2801401B2 (ja) 1998-09-21
AU8652091A (en) 1992-04-15
LTIP1715A (en) 1995-07-25
LV10770A (lv) 1995-08-20
DE69117768T2 (de) 1996-08-29
SG43150A1 (en) 1997-10-17
DE69117768D1 (de) 1996-04-11
SK22793A3 (en) 1993-07-07
PT99051A (pt) 1992-08-31
AU652386B2 (en) 1994-08-25
EE02979B1 (et) 1997-04-15
PL166434B1 (pl) 1995-05-31
KR0179639B1 (ko) 1999-05-15
JPH06501262A (ja) 1994-02-10
HK52297A (en) 1997-05-02
IE74387B1 (en) 1997-07-30
EP0550612B1 (en) 1996-03-06
SE9003057D0 (sv) 1990-09-26
HU214054B (en) 1997-12-29
FI931333A (fi) 1993-04-22
CA2091343C (en) 2002-07-09
DK0550612T3 (da) 1996-07-22
RU2079486C1 (ru) 1997-05-20
PT99051B (pt) 1999-02-26
CZ284256B6 (cs) 1998-10-14
EP0550612A1 (en) 1993-07-14
NO301709B1 (no) 1997-12-01
HUT65912A (en) 1994-07-28
NO931058L (no) 1993-03-23

Similar Documents

Publication Publication Date Title
FI111714B (fi) Uusi menetelmä formoterolin ja lähisukuisten yhdisteiden valmistamiseksi
US5434304A (en) Process for preparing formoterol and related compounds
RU2544856C2 (ru) НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
KR0169134B1 (ko) N-아실-2,3-벤조디아제핀 유도체 및 이 유도체를 함유하는 제약조성물과 이들의 제조방법
FI78684C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara cis, endo-2-azabicyklo-/5.3.0/-dekan-3- karboxylsyraderivat och mellanprodukter.
JP2758502B2 (ja) （−）−リトドリン
FI62528B (fi) Ett nytt foerfarande foer framstaellning av 1-(3,5-dihydroxifenyl)-1-hydroxi-2-(1-metyl-2-(4-hydroxifenyl)-etyl)-aminoetan
JPS5950671B2 (ja) フェニルエタノ−ルアミン誘導体およびその製造法
WO2014008639A1 (zh) 制备茚达特罗的方法
CS236097B1 (en) Acylderivatives of 2-piperazinochinazoline and method of their preparation
JPS6136830B2 (da)
JP2545105B2 (ja) ２−アミノ−６，７−ジメトキシテトラリン−ｎ−アルキル誘導体
HU177107B (en) Process for producing new 1-phenyl-ethanolamine derivatives of antyflogistic activity
IKEDA et al. Total syntheses of bellenamine and its isomers
HU195204B (en) Process for the diastereoselective reduction of 3-amino-1-benzoxepin-5/2/+/-ones
EP0101633B1 (en) Pyridinecarboxylic esters of dopamine and of its n-alkyl derivatives
WO2014008640A1 (zh) 茚达特罗中间体及茚达特罗的合成方法
KR800000540B1 (ko) 아미노-페닐-에탄올 아민의 제조방법
IE67059B1 (en) A process for the preparation of a 1,4-dihydropyridine derivative namely (-)-2-{[2-(aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxy-carbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine and its salts
JPH08500817A (ja) テトラヒドロ−およびペルヒドロイソキノリン−誘導体およびこれを含有する治療剤
GB2067195A (en) 2-aminomethyl-6-halo-phenols their production and pharmaceutical composition containing them
CS247575B1 (cs) Deriváty 1-fenoxy-3-fenoxyethylamino-2-propanolu a způsob jejich přípravy
HU181589B (hu) Eljárás 7,8-dihidroxi-l-(szulfamoilfenil)-2,3,4,5-tetrahidro-lH-3-benzazepin-származékok előállítására

Legal Events

Date Code Title Description
MA Patent expired