FI111256B - Menetelmä terapeuttisesti käyttökelpoisten asyyliaminoindolijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten asyyliaminoindolijohdannaisten valmistamiseksi Download PDF

Info

Publication number
FI111256B
FI111256B FI931613A FI931613A FI111256B FI 111256 B FI111256 B FI 111256B FI 931613 A FI931613 A FI 931613A FI 931613 A FI931613 A FI 931613A FI 111256 B FI111256 B FI 111256B
Authority
FI
Finland
Prior art keywords
alkyl
compounds
aryl
formula
hydrogen
Prior art date
Application number
FI931613A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI931613A0 (fi
FI931613A (fi
Inventor
John E Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI931613A0 publication Critical patent/FI931613A0/fi
Publication of FI931613A publication Critical patent/FI931613A/fi
Application granted granted Critical
Publication of FI111256B publication Critical patent/FI111256B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Soft Magnetic Materials (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pyrrole Compounds (AREA)
FI931613A 1992-04-10 1993-04-08 Menetelmä terapeuttisesti käyttökelpoisten asyyliaminoindolijohdannaisten valmistamiseksi FI111256B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86638292A 1992-04-10 1992-04-10
US86638292 1992-04-10

Publications (3)

Publication Number Publication Date
FI931613A0 FI931613A0 (fi) 1993-04-08
FI931613A FI931613A (fi) 1993-10-11
FI111256B true FI111256B (fi) 2003-06-30

Family

ID=25347493

Family Applications (2)

Application Number Title Priority Date Filing Date
FI931613A FI111256B (fi) 1992-04-10 1993-04-08 Menetelmä terapeuttisesti käyttökelpoisten asyyliaminoindolijohdannaisten valmistamiseksi
FI20010214A FI20010214A (fi) 1992-04-10 2001-02-05 Asyyliaminoindolijohdannaisia

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20010214A FI20010214A (fi) 1992-04-10 2001-02-05 Asyyliaminoindolijohdannaisia

Country Status (31)

Country Link
US (1) US5498626A (ja)
EP (1) EP0635015B1 (ja)
JP (1) JP2544704B2 (ja)
KR (1) KR0179074B1 (ja)
CN (1) CN1038506C (ja)
AT (1) ATE148465T1 (ja)
AU (1) AU670270B2 (ja)
BR (1) BR9306221A (ja)
CA (1) CA2132706C (ja)
CZ (1) CZ282653B6 (ja)
DE (1) DE69307875T2 (ja)
DK (1) DK0635015T3 (ja)
EG (1) EG20466A (ja)
ES (1) ES2097496T3 (ja)
FI (2) FI111256B (ja)
GR (1) GR3022767T3 (ja)
HR (1) HRP930753B1 (ja)
HU (1) HUT64060A (ja)
IL (1) IL105309A0 (ja)
MX (1) MX9301996A (ja)
MY (1) MY115278A (ja)
NO (1) NO309860B1 (ja)
NZ (1) NZ251047A (ja)
PL (1) PL172232B1 (ja)
RU (1) RU2110516C1 (ja)
SK (1) SK278182B6 (ja)
TW (1) TW394769B (ja)
UA (1) UA34452C2 (ja)
WO (1) WO1993021180A1 (ja)
YU (1) YU48916B (ja)
ZA (1) ZA932536B (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
JP2644088B2 (ja) 1992-04-07 1997-08-25 フアイザー・インコーポレイテツド ５−ｈｔ１作動薬としてのインドール誘導体
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
AU686654B2 (en) * 1993-08-31 1998-02-12 Pfizer Inc. 5-arylindole derivatives
GB9402011D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
GB9402016D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
US5965582A (en) * 1994-08-03 1999-10-12 Asta Medica Aktiengesellschaft N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420503D0 (en) * 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
AU3170099A (en) * 1998-04-16 1999-11-08 Yamanouchi Pharmaceutical Co., Ltd. Remedies for obesity
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
EP1594490A4 (en) * 2003-01-22 2006-03-22 Gtx Inc TREATMENT OF WOMEN ANDROGEN DISEASE ASSOCIATED DISORDERS (ADIF) USING ANDROGENIC RECEPTOR MODULATORS (SARM)
AU2008332880C1 (en) * 2007-12-07 2012-07-19 Pfizer Inc. Tosylate salt of trans-N-isobutyl-3-fluoro-3- [3-fluoro-4- (pyrrolidin-1-yl-methyl) -phenyl] cyclobut anecarboxamide
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
NZ197998A (en) * 1980-08-12 1985-08-16 Glaxo Group Ltd 5-amino(methyl)-1h-indol-3-ylalkaneamines
BE889931A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
NZ238424A (en) * 1990-06-07 1993-12-23 Wellcome Found 3,5-substituted indole derivatives; medicaments and preparatory processes.
HUT64326A (en) * 1990-10-15 1993-12-28 Pfizer Process for production indole derivatives and pharmaceutical preparations containing these compounds
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
KR0184911B1 (ko) * 1991-11-25 1999-05-01 알렌 제이. 스피겔 인돌유도체

Also Published As

Publication number Publication date
AU670270B2 (en) 1996-07-11
MX9301996A (es) 1994-03-31
HU9301048D0 (en) 1993-06-28
NO309860B1 (no) 2001-04-09
CZ282653B6 (cs) 1997-08-13
JPH07501831A (ja) 1995-02-23
YU48916B (sh) 2002-11-15
HRP930753A2 (en) 1994-10-31
CA2132706C (en) 1998-08-04
CA2132706A1 (en) 1993-10-28
CN1080288A (zh) 1994-01-05
BR9306221A (pt) 1998-06-30
IL105309A0 (en) 1993-08-18
WO1993021180A1 (en) 1993-10-28
EP0635015B1 (en) 1997-01-29
US5498626A (en) 1996-03-12
NO943803D0 (no) 1994-10-07
EP0635015A1 (en) 1995-01-25
CN1038506C (zh) 1998-05-27
SK278182B6 (en) 1996-03-06
DE69307875T2 (de) 1997-05-22
ZA932536B (en) 1994-10-08
FI20010214A (fi) 2001-02-05
YU25593A (sh) 1996-10-09
NZ251047A (en) 1996-09-25
DE69307875D1 (de) 1997-03-13
GR3022767T3 (en) 1997-06-30
FI931613A0 (fi) 1993-04-08
EG20466A (en) 1999-05-31
JP2544704B2 (ja) 1996-10-16
RU2110516C1 (ru) 1998-05-10
KR0179074B1 (ko) 1999-03-20
ES2097496T3 (es) 1997-04-01
CZ247794A3 (en) 1995-07-12
SK120794A3 (en) 1995-05-10
KR950700903A (ko) 1995-02-20
UA34452C2 (uk) 2001-03-15
AU3782193A (en) 1993-11-18
DK0635015T3 (da) 1997-03-17
RU94045902A (ru) 1996-08-27
FI931613A (fi) 1993-10-11
MY115278A (en) 2003-05-31
ATE148465T1 (de) 1997-02-15
PL172232B1 (pl) 1997-08-29
HUT64060A (en) 1993-11-29
HRP930753B1 (en) 2000-10-31
NO943803L (no) 1994-10-07
TW394769B (en) 2000-06-21

Similar Documents

Publication Publication Date Title
FI111256B (fi) Menetelmä terapeuttisesti käyttökelpoisten asyyliaminoindolijohdannaisten valmistamiseksi
EP0716649B1 (en) 5-arylindole derivatives
US6387937B1 (en) Indole derivatives
IL99701A (en) History of indole and a pharmaceutical preparation containing them
WO1994010171A1 (en) 5-arylindole derivatives and their use as serotonin (5-ht1) agonists
EP0629199B1 (en) Indole derivatives as 5-ht1 agonists
KR19980703032A (ko) 태키키닌 수용체 길항제로서의 헤테로사이클릭 치환된 피페라지논 유도체
US5994352A (en) 5-arylindole derivatives
MXPA97006872A (en) Derivatives of piperazinone substituted by heterociclico as antagonists of taquiquin receptor

Legal Events

Date Code Title Description
MA Patent expired