FI111250B - Menetelmä terapeuttisesti käyttökelpoisen N-metyyli-3-fenyyli-3-(2-metyylitiofenoksi)propyyliamiinin valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisen N-metyyli-3-fenyyli-3-(2-metyylitiofenoksi)propyyliamiinin valmistamiseksi Download PDF

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Publication number
FI111250B
FI111250B FI924305A FI924305A FI111250B FI 111250 B FI111250 B FI 111250B FI 924305 A FI924305 A FI 924305A FI 924305 A FI924305 A FI 924305A FI 111250 B FI111250 B FI 111250B
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FI
Finland
Prior art keywords
phenyl
compound
methylthiophenoxy
formula
methyl
Prior art date
Application number
FI924305A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924305L (fi
FI924305A0 (fi
Inventor
David Taiwai Wong
David Wayne Robertson
Donald Richard Gehlert
Original Assignee
Lilly Co Eli
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Filing date
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Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI924305A0 publication Critical patent/FI924305A0/fi
Publication of FI924305L publication Critical patent/FI924305L/fi
Application granted granted Critical
Publication of FI111250B publication Critical patent/FI111250B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/29—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Toxicology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FI924305A 1991-09-27 1992-09-25 Menetelmä terapeuttisesti käyttökelpoisen N-metyyli-3-fenyyli-3-(2-metyylitiofenoksi)propyyliamiinin valmistamiseksi FI111250B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76699391 1991-09-27
US07/766,993 US5281624A (en) 1991-09-27 1991-09-27 N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and pharmaceutical use thereof

Publications (3)

Publication Number Publication Date
FI924305A0 FI924305A0 (fi) 1992-09-25
FI924305L FI924305L (fi) 1993-03-28
FI111250B true FI111250B (fi) 2003-06-30

Family

ID=25078150

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924305A FI111250B (fi) 1991-09-27 1992-09-25 Menetelmä terapeuttisesti käyttökelpoisen N-metyyli-3-fenyyli-3-(2-metyylitiofenoksi)propyyliamiinin valmistamiseksi

Country Status (23)

Country Link
US (1) US5281624A (enExample)
EP (1) EP0534756A3 (enExample)
JP (2) JP3256291B2 (enExample)
KR (1) KR100221180B1 (enExample)
CN (1) CN1033580C (enExample)
AT (1) ATE124934T1 (enExample)
AU (1) AU655075B2 (enExample)
BR (2) BR9203743A (enExample)
CA (2) CA2079162A1 (enExample)
CZ (1) CZ281817B6 (enExample)
DE (1) DE69203424T2 (enExample)
FI (1) FI111250B (enExample)
HU (1) HU215519B (enExample)
IL (1) IL103277A (enExample)
MX (1) MX9205433A (enExample)
MY (1) MY108304A (enExample)
NO (1) NO178109C (enExample)
NZ (1) NZ244460A (enExample)
RU (1) RU2057120C1 (enExample)
SK (1) SK280480B6 (enExample)
TW (1) TW249225B (enExample)
YU (1) YU87192A (enExample)
ZA (1) ZA927240B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6017965A (en) * 1993-02-08 2000-01-25 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US7087765B2 (en) * 1995-06-07 2006-08-08 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
TW344661B (en) * 1993-11-24 1998-11-11 Lilly Co Eli Pharmaceutical composition for treatment of incontinence
MX9800589A (es) * 1995-07-24 1998-04-30 Lilly Co Eli Tratamiento de desorden de la falta de atencion/hiperactividad.
EP0927034A1 (en) * 1996-09-19 1999-07-07 American Home Products Corporation Method of treating urinary incontinence
US6586427B2 (en) 1998-04-09 2003-07-01 Pharmacia & Upjohn Company Treatments for nervous disorders
BR9909478A (pt) * 1998-04-09 2000-12-19 Upjohn Co Novos tratamentos para vários distúrbios do sistema nervoso
US6342533B1 (en) 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
EP1165487A1 (en) * 1999-04-06 2002-01-02 Sepracor Inc. Derivatives of venlafaxine and methods of preparing and using the same
WO2000071517A1 (en) 1999-05-24 2000-11-30 Mitsubishi Pharma Corporation Phenoxypropylamine compounds
PL196996B1 (pl) * 1999-07-01 2008-02-29 Upjohn Co Zastosowanie optycznie czystej (S,S)-reboksetyny lub jej dopuszczalnej farmaceutycznie soli do wytwarzania leku
US20040034106A1 (en) * 2001-11-06 2004-02-19 Read Holly Ann Treatment of anxiety disorders
WO2003047560A1 (en) * 2001-11-30 2003-06-12 Eli Lilly And Company Use of norepinephrine reuptake inhibitors for the treatment of tic disorders
SK2442004A3 (en) * 2001-12-11 2004-12-01 Lilly Co Eli Use of norepinephrine reuptake inhibitors for the treatment of cognitive failure
WO2004089288A2 (en) * 2003-04-04 2004-10-21 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
US20060241188A1 (en) * 2003-08-27 2006-10-26 Elililly And Company Treatment of pervasive developemental disorders with norepinephrine reuptake inhibitors
ATE399557T1 (de) * 2003-12-12 2008-07-15 Lilly Co Eli Selektive norepinephrin-wiederaufnahmehemmer zur behandlung von hitzewallungen
ITMI20061987A1 (it) * 2006-10-16 2008-04-17 Archimica Srl Processo per la sintesi di arilossipropilammine ed eteroarilossipropilammine.
US11111220B2 (en) * 2017-10-16 2021-09-07 Esteve Pharmaceuticals, S.A. Propanamine derivatives for treating pain and pain related conditions
CN113121394B (zh) * 2019-12-30 2022-11-08 中国药科大学 一种苯氧乙酸类衍生物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194009A (en) * 1974-01-10 1980-03-18 Eli Lilly And Company Aryloxyphenylpropylamines for obtaining a psychotropic effect
US4018895A (en) * 1974-01-10 1977-04-19 Eli Lilly And Company Aryloxyphenylpropylamines in treating depression
US4313896A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Aryloxyphenylpropylamines
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
US4626549A (en) * 1974-01-10 1986-12-02 Eli Lilly And Company Treatment of obesity with aryloxyphenylpropylamines
US4584404A (en) * 1974-01-10 1986-04-22 Eli Lilly And Company Substituted phenoxyphenylproply dimethylamines
CA1337128C (en) * 1988-04-08 1995-09-26 David Wayne Robertson Propanamine derivatives

Also Published As

Publication number Publication date
JPH05238996A (ja) 1993-09-17
DE69203424T2 (de) 1996-01-11
DE69203424D1 (de) 1995-08-17
CZ281817B6 (cs) 1997-02-12
CA2079161A1 (en) 1993-03-28
HU215519B (hu) 1999-01-28
IL103277A (en) 1997-11-20
ATE124934T1 (de) 1995-07-15
HUT65375A (en) 1994-05-02
MX9205433A (es) 1993-03-01
HU9203051D0 (en) 1992-12-28
NO178109C (no) 1996-01-24
NZ244460A (en) 1994-10-26
NO178109B (no) 1995-10-16
EP0534756A2 (en) 1993-03-31
FI924305L (fi) 1993-03-28
SK290892A3 (en) 2000-02-14
EP0534756A3 (en) 1993-06-16
YU87192A (sh) 1995-10-24
NO923710L (no) 1993-03-29
CZ290892A3 (en) 1993-04-14
MY108304A (en) 1996-09-30
CA2079162A1 (en) 1993-03-28
TW249225B (enExample) 1995-06-11
BR1100384A (pt) 1999-08-31
RU2057120C1 (ru) 1996-03-27
CA2079161C (en) 2004-02-17
AU655075B2 (en) 1994-12-01
BR9203743A (pt) 1993-04-20
US5281624A (en) 1994-01-25
CN1033580C (zh) 1996-12-18
JP3256291B2 (ja) 2002-02-12
JPH05201961A (ja) 1993-08-10
FI924305A0 (fi) 1992-09-25
KR930005972A (ko) 1993-04-20
AU2537092A (en) 1993-04-01
IL103277A0 (en) 1993-02-21
NO923710D0 (no) 1992-09-24
SK280480B6 (sk) 2000-02-14
ZA927240B (en) 1994-03-22
CN1071416A (zh) 1993-04-28
KR100221180B1 (ko) 1999-09-15

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