ATE124934T1 - N-alkyl-3-phenyl-3-(2- alkylthiophenoxy)propylamine als norepinephrineinhibitoren. - Google Patents
N-alkyl-3-phenyl-3-(2- alkylthiophenoxy)propylamine als norepinephrineinhibitoren.Info
- Publication number
- ATE124934T1 ATE124934T1 AT92308709T AT92308709T ATE124934T1 AT E124934 T1 ATE124934 T1 AT E124934T1 AT 92308709 T AT92308709 T AT 92308709T AT 92308709 T AT92308709 T AT 92308709T AT E124934 T1 ATE124934 T1 AT E124934T1
- Authority
- AT
- Austria
- Prior art keywords
- propylamines
- phenyl
- alkyl
- alkylthiophenoxy
- norepinephrine inhibitors
- Prior art date
Links
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 title abstract 2
- 229960002748 norepinephrine Drugs 0.000 title abstract 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 125000006308 propyl amino group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/29—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/766,993 US5281624A (en) | 1991-09-27 | 1991-09-27 | N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and pharmaceutical use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE124934T1 true ATE124934T1 (de) | 1995-07-15 |
Family
ID=25078150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92308709T ATE124934T1 (de) | 1991-09-27 | 1992-09-24 | N-alkyl-3-phenyl-3-(2- alkylthiophenoxy)propylamine als norepinephrineinhibitoren. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5281624A (enExample) |
| EP (1) | EP0534756A3 (enExample) |
| JP (2) | JPH05238996A (enExample) |
| KR (1) | KR100221180B1 (enExample) |
| CN (1) | CN1033580C (enExample) |
| AT (1) | ATE124934T1 (enExample) |
| AU (1) | AU655075B2 (enExample) |
| BR (2) | BR9203743A (enExample) |
| CA (2) | CA2079161C (enExample) |
| CZ (1) | CZ281817B6 (enExample) |
| DE (1) | DE69203424T2 (enExample) |
| FI (1) | FI111250B (enExample) |
| HU (1) | HU215519B (enExample) |
| IL (1) | IL103277A (enExample) |
| MX (1) | MX9205433A (enExample) |
| MY (1) | MY108304A (enExample) |
| NO (1) | NO178109C (enExample) |
| NZ (1) | NZ244460A (enExample) |
| RU (1) | RU2057120C1 (enExample) |
| SK (1) | SK280480B6 (enExample) |
| TW (1) | TW249225B (enExample) |
| YU (1) | YU87192A (enExample) |
| ZA (1) | ZA927240B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071970A (en) * | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6017965A (en) * | 1993-02-08 | 2000-01-25 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US7087765B2 (en) * | 1995-06-07 | 2006-08-08 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| TW344661B (en) * | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
| AU709704B2 (en) * | 1995-07-24 | 1999-09-02 | Eli Lilly And Company | Treatment of attention-deficit/hyperactivity disorder |
| KR20010029519A (ko) * | 1996-09-19 | 2001-04-06 | 이곤 이 버그 | 요실금 치료 방법 |
| EP1069900B1 (en) * | 1998-04-09 | 2005-08-10 | Pharmacia & Upjohn Company LLC | Use of reboxetine for the treatment of neuropsychiatric disorders |
| US6586427B2 (en) | 1998-04-09 | 2003-07-01 | Pharmacia & Upjohn Company | Treatments for nervous disorders |
| US6342533B1 (en) | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
| HUP0200898A3 (en) | 1999-04-06 | 2005-09-28 | Sepracor Inc | Derivatives of venlafaxine and methods of preparing and using the same |
| EP1188747B1 (en) | 1999-05-24 | 2005-09-07 | Mitsubishi Pharma Corporation | Phenoxypropylamine compounds |
| ES2246488T3 (es) * | 1999-07-01 | 2006-02-16 | PHARMACIA & UPJOHN COMPANY LLC | Reboxetina para tratar la migraña. |
| US20040034106A1 (en) * | 2001-11-06 | 2004-02-19 | Read Holly Ann | Treatment of anxiety disorders |
| PT1455770E (pt) * | 2001-11-30 | 2007-09-06 | Lilly Co Eli | Uso de inibidores de reabsorção da norepinefrina para o tratamento dos transtornos de tiques. |
| CA2467802A1 (en) * | 2001-12-11 | 2003-06-19 | Eli Lilly And Company | Use of norepinephrine reuptake inhibitors for the treatment of cognitive failure |
| ATE365554T1 (de) * | 2003-04-04 | 2007-07-15 | Dynogen Pharmaceuticals Inc | Methode zur behandlung von erkrankungen der unteren harnwege |
| US20060241188A1 (en) * | 2003-08-27 | 2006-10-26 | Elililly And Company | Treatment of pervasive developemental disorders with norepinephrine reuptake inhibitors |
| CN1889940A (zh) * | 2003-12-12 | 2007-01-03 | 伊莱利利公司 | 热潮红、冲动控制障碍和全身性医学病症引起的人格变化的治疗 |
| ITMI20061987A1 (it) * | 2006-10-16 | 2008-04-17 | Archimica Srl | Processo per la sintesi di arilossipropilammine ed eteroarilossipropilammine. |
| EP3697754A1 (en) * | 2017-10-16 | 2020-08-26 | Esteve Pharmaceuticals, S.A. | Propanamine derivatives for treating pain and pain related conditions |
| CN113121394B (zh) * | 2019-12-30 | 2022-11-08 | 中国药科大学 | 一种苯氧乙酸类衍生物的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4313896A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Aryloxyphenylpropylamines |
| US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
| US4584404A (en) * | 1974-01-10 | 1986-04-22 | Eli Lilly And Company | Substituted phenoxyphenylproply dimethylamines |
| US4194009A (en) * | 1974-01-10 | 1980-03-18 | Eli Lilly And Company | Aryloxyphenylpropylamines for obtaining a psychotropic effect |
| US4626549A (en) * | 1974-01-10 | 1986-12-02 | Eli Lilly And Company | Treatment of obesity with aryloxyphenylpropylamines |
| US4018895A (en) * | 1974-01-10 | 1977-04-19 | Eli Lilly And Company | Aryloxyphenylpropylamines in treating depression |
| ZA892517B (en) * | 1988-04-08 | 1990-12-28 | Lilly Co Eli | Propanamine derivatives |
-
1991
- 1991-09-27 US US07/766,993 patent/US5281624A/en not_active Expired - Lifetime
-
1992
- 1992-09-22 SK SK2908-92A patent/SK280480B6/sk unknown
- 1992-09-22 CZ CS922908A patent/CZ281817B6/cs not_active IP Right Cessation
- 1992-09-22 ZA ZA927240A patent/ZA927240B/xx unknown
- 1992-09-23 NZ NZ244460A patent/NZ244460A/en unknown
- 1992-09-23 MY MYPI92001704A patent/MY108304A/en unknown
- 1992-09-24 IL IL103277A patent/IL103277A/xx not_active IP Right Cessation
- 1992-09-24 DE DE69203424T patent/DE69203424T2/de not_active Expired - Fee Related
- 1992-09-24 EP EP19920308708 patent/EP0534756A3/en not_active Withdrawn
- 1992-09-24 HU HU9203051A patent/HU215519B/hu not_active IP Right Cessation
- 1992-09-24 AT AT92308709T patent/ATE124934T1/de not_active IP Right Cessation
- 1992-09-24 NO NO923710A patent/NO178109C/no unknown
- 1992-09-24 MX MX9205433A patent/MX9205433A/es not_active IP Right Cessation
- 1992-09-25 AU AU25370/92A patent/AU655075B2/en not_active Ceased
- 1992-09-25 JP JP4256333A patent/JPH05238996A/ja not_active Withdrawn
- 1992-09-25 KR KR1019920017511A patent/KR100221180B1/ko not_active Expired - Fee Related
- 1992-09-25 YU YU87192A patent/YU87192A/sh unknown
- 1992-09-25 CA CA002079161A patent/CA2079161C/en not_active Expired - Fee Related
- 1992-09-25 CA CA002079162A patent/CA2079162A1/en not_active Abandoned
- 1992-09-25 RU SU5052706/04A patent/RU2057120C1/ru not_active IP Right Cessation
- 1992-09-25 FI FI924305A patent/FI111250B/fi active
- 1992-09-25 BR BR929203743A patent/BR9203743A/pt not_active Application Discontinuation
- 1992-09-25 JP JP25632792A patent/JP3256291B2/ja not_active Expired - Fee Related
- 1992-09-26 CN CN92111081A patent/CN1033580C/zh not_active Expired - Fee Related
- 1992-11-10 TW TW081108988A patent/TW249225B/zh active
-
1997
- 1997-04-30 BR BR1100384-7A patent/BR1100384A/pt active IP Right Grant
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69203424D1 (de) | N-Alkyl-3-phenyl-3-(2-alkylthiophenoxy)Propylamine als Norepinephrineinhibitoren. | |
| ES2082887T3 (es) | Flupirtina en combinacion con antiparkinsonianos para combatir espasmos musculares. | |
| EA200200766A1 (ru) | Замещенные арилпиразины | |
| PT971713E (pt) | Utilizacao de inibidores da colinesterase para tratamento de desordens da atencao | |
| PT729468E (pt) | Antagonistas nao peptidicos de receptores de taquiquininas | |
| BR9708815B1 (pt) | compostos úteis para prevenção e tratamento de desordens do sistema nervoso central. | |
| FI872601A7 (fi) | Puhdistusjärjestelmiä, jotka sisältävät dispergoitua vesiorgaaninen-pehmitinainetta kovuuden poistamiseksi. | |
| ATE108446T1 (de) | Ringsubstituierte 2-amin-1,2,3,4-tetrahydro- naphthaline. | |
| BR9708027A (pt) | Métodos de tratamento ou prevenção de cistite entersticial | |
| DE3874929D1 (de) | N-silyl-substituierte 1-sila-2-azacyclopentane. | |
| DK0435177T3 (da) | 4-Benzyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-oner samt deres anvendelse som antikonvulsive midler | |
| BR9710901A (pt) | M-todo para o tratamento da doen-a bipolar | |
| IT8322692A0 (it) | Composizioni per il trattamento della ruggine. | |
| ES2192219T3 (es) | Composiciones para la prevencion y tratamiento de trastornos urogenitales, que contienen bismuto. | |
| ATE136884T1 (de) | Neue 2-mercaptomethylen-tetrahydronaphthalin- und -indan-2-carboxamide als enkephalinaseinhibitoren | |
| IT8423581V0 (it) | Dispositivo di guida antiusura per sospensioni primarie di carrelli ferroviari. | |
| FI920186A0 (fi) | Polyaminfenoler som skyddar mot straolning. | |
| SU1455632A1 (ru) | О,о-диэтил-n-(1-пропилтио-2-гидрокси-2-метилпропилиден)-амидотиофосфат, обладающий бактерицидной активностью |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |