FI110944B - Förfarande för framställning av terapeutiskt användbara pyrrolo-, pyrazolo- och imidazo[2,1-c][1,4]diazepiner - Google Patents

Förfarande för framställning av terapeutiskt användbara pyrrolo-, pyrazolo- och imidazo[2,1-c][1,4]diazepiner Download PDF

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Publication number
FI110944B
FI110944B FI943543A FI943543A FI110944B FI 110944 B FI110944 B FI 110944B FI 943543 A FI943543 A FI 943543A FI 943543 A FI943543 A FI 943543A FI 110944 B FI110944 B FI 110944B
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FI
Finland
Prior art keywords
pyrrolo
benzodiazepine
ylcarbonyl
phenyl
give
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FI943543A
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English (en)
Finnish (fi)
Other versions
FI943543A0 (sv
FI943543A (sv
Inventor
Jay D Albright
Marvin F Reich
Fuk-Wah Sum
Efren Guillermo Delos Santos
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American Cyanamid Co
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Publication of FI943543A0 publication Critical patent/FI943543A0/sv
Publication of FI943543A publication Critical patent/FI943543A/sv
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI943543A 1993-07-29 1994-07-28 Förfarande för framställning av terapeutiskt användbara pyrrolo-, pyrazolo- och imidazo[2,1-c][1,4]diazepiner FI110944B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10000493A 1993-07-29 1993-07-29
US10000493 1993-07-29

Publications (3)

Publication Number Publication Date
FI943543A0 FI943543A0 (sv) 1994-07-28
FI943543A FI943543A (sv) 1995-01-30
FI110944B true FI110944B (sv) 2003-04-30

Family

ID=22277643

Family Applications (3)

Application Number Title Priority Date Filing Date
FI943543A FI110944B (sv) 1993-07-29 1994-07-28 Förfarande för framställning av terapeutiskt användbara pyrrolo-, pyrazolo- och imidazo[2,1-c][1,4]diazepiner
FI20011207A FI113868B (sv) 1993-07-29 2001-06-07 Förfarande för framställning av terapeutiskt användbara pyrrolo [1,2-a] [1,5] bensodiazepiner och [1,2,4] triazolo [4,3-a] [1,5] bensodiazepiner
FI20011206A FI113867B (sv) 1993-07-29 2001-06-07 Förfarande för framställning av terapeutiskt användbara pyrrolo [1,2-a] kinoxaliner

Family Applications After (2)

Application Number Title Priority Date Filing Date
FI20011207A FI113868B (sv) 1993-07-29 2001-06-07 Förfarande för framställning av terapeutiskt användbara pyrrolo [1,2-a] [1,5] bensodiazepiner och [1,2,4] triazolo [4,3-a] [1,5] bensodiazepiner
FI20011206A FI113867B (sv) 1993-07-29 2001-06-07 Förfarande för framställning av terapeutiskt användbara pyrrolo [1,2-a] kinoxaliner

Country Status (29)

Country Link
US (2) US5516774A (sv)
EP (1) EP0636625B1 (sv)
JP (1) JP3782475B2 (sv)
KR (1) KR100347479B1 (sv)
CN (2) CN1039908C (sv)
AT (1) ATE176234T1 (sv)
AU (1) AU683660B2 (sv)
BR (1) BR1100563A (sv)
CA (1) CA2128956C (sv)
CZ (1) CZ291322B6 (sv)
DE (1) DE69416211T2 (sv)
DK (1) DK0636625T3 (sv)
EC (1) ECSP941137A (sv)
ES (1) ES2129090T3 (sv)
FI (3) FI110944B (sv)
GR (1) GR3030069T3 (sv)
HK (1) HK1011363A1 (sv)
HU (1) HU220707B1 (sv)
IL (1) IL110435A (sv)
LV (1) LV12497B (sv)
NO (1) NO301827B1 (sv)
NZ (1) NZ264115A (sv)
PE (1) PE17895A1 (sv)
PH (1) PH31469A (sv)
PL (1) PL178563B1 (sv)
RU (1) RU2126006C1 (sv)
SG (1) SG47522A1 (sv)
SK (1) SK280836B6 (sv)
ZA (1) ZA945603B (sv)

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ZA945603B (en) 1995-03-09
JP3782475B2 (ja) 2006-06-07
CZ291322B6 (cs) 2003-02-12
EP0636625B1 (en) 1999-01-27
LV12497B (lv) 2000-09-20
ES2129090T3 (es) 1999-06-01
CN1039908C (zh) 1998-09-23
NO942816D0 (no) 1994-07-28
CN1205335A (zh) 1999-01-20
AU6877794A (en) 1995-02-09
KR950003295A (ko) 1995-02-16
DK0636625T3 (da) 1999-09-13
CA2128956A1 (en) 1995-01-30
RU2126006C1 (ru) 1999-02-10
FI113867B (sv) 2004-06-30
JPH07157486A (ja) 1995-06-20
PH31469A (en) 1998-11-03
DE69416211D1 (de) 1999-03-11
NO301827B1 (no) 1997-12-15
CN1106812A (zh) 1995-08-16
FI20011207A (sv) 2001-06-07
FI113868B (sv) 2004-06-30
SG47522A1 (en) 1998-04-17
US5516774A (en) 1996-05-14
AU683660B2 (en) 1997-11-20
PL178563B1 (pl) 2000-05-31
PE17895A1 (es) 1995-07-18
US5624923A (en) 1997-04-29
CA2128956C (en) 2004-10-05
EP0636625A3 (en) 1995-05-17
HK1011363A1 (en) 1999-07-09
RU94027583A (ru) 1996-07-20
HU220707B1 (hu) 2002-04-29
CZ179994A3 (en) 1995-02-15
FI943543A0 (sv) 1994-07-28
CN1056374C (zh) 2000-09-13
SK88194A3 (en) 1995-04-12
KR100347479B1 (ko) 2002-12-06
FI943543A (sv) 1995-01-30
NZ264115A (en) 1997-10-24
IL110435A (en) 2003-11-23
EP0636625A2 (en) 1995-02-01
GR3030069T3 (en) 1999-07-30
LV12497A (en) 2000-06-20
ATE176234T1 (de) 1999-02-15
SK280836B6 (sk) 2000-08-14
NO942816L (no) 1995-01-30
HUT71495A (en) 1995-11-28
HU9402219D0 (en) 1994-09-28
FI20011206A (sv) 2001-06-07
ECSP941137A (es) 1995-02-27
BR1100563A (pt) 2000-02-08
IL110435A0 (en) 1994-10-21
PL304498A1 (en) 1995-02-06
DE69416211T2 (de) 1999-09-02

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