FI109792B - Menetelmä bakkatiini-III- ja 10-desasetyylibakkatiini-III-johdannaisten valmistamiseksi - Google Patents

Menetelmä bakkatiini-III- ja 10-desasetyylibakkatiini-III-johdannaisten valmistamiseksi Download PDF

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Publication number
FI109792B
FI109792B FI940075A FI940075A FI109792B FI 109792 B FI109792 B FI 109792B FI 940075 A FI940075 A FI 940075A FI 940075 A FI940075 A FI 940075A FI 109792 B FI109792 B FI 109792B
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FI
Finland
Prior art keywords
general formula
radical
preparation
acetyl
protecting group
Prior art date
Application number
FI940075A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI940075A0 (fi
FI940075A (fi
Inventor
Augustin Hittinger
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of FI940075A0 publication Critical patent/FI940075A0/fi
Publication of FI940075A publication Critical patent/FI940075A/fi
Application granted granted Critical
Publication of FI109792B publication Critical patent/FI109792B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
FI940075A 1991-07-10 1994-01-07 Menetelmä bakkatiini-III- ja 10-desasetyylibakkatiini-III-johdannaisten valmistamiseksi FI109792B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9108673A FR2678930B1 (fr) 1991-07-10 1991-07-10 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
FR9108673 1991-07-10
FR9200649 1992-07-08
PCT/FR1992/000649 WO1993001179A1 (fr) 1991-07-10 1992-07-08 Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

Publications (3)

Publication Number Publication Date
FI940075A0 FI940075A0 (fi) 1994-01-07
FI940075A FI940075A (fi) 1994-01-07
FI109792B true FI109792B (fi) 2002-10-15

Family

ID=9414931

Family Applications (1)

Application Number Title Priority Date Filing Date
FI940075A FI109792B (fi) 1991-07-10 1994-01-07 Menetelmä bakkatiini-III- ja 10-desasetyylibakkatiini-III-johdannaisten valmistamiseksi

Country Status (25)

Country Link
US (1) US5578739A (es)
EP (2) EP0593641B1 (es)
JP (1) JP3085710B2 (es)
KR (1) KR100206458B1 (es)
AT (1) ATE132145T1 (es)
AU (1) AU662346B2 (es)
CA (1) CA2111319C (es)
CZ (1) CZ281288B6 (es)
DE (1) DE69207194T2 (es)
DK (1) DK0593641T3 (es)
ES (1) ES2081120T3 (es)
FI (1) FI109792B (es)
FR (1) FR2678930B1 (es)
GR (1) GR3018543T3 (es)
HU (1) HU217115B (es)
IE (1) IE73637B1 (es)
MX (1) MX9204029A (es)
NO (2) NO934485D0 (es)
NZ (1) NZ243491A (es)
PL (1) PL169780B1 (es)
RU (1) RU2088578C1 (es)
SK (1) SK281560B6 (es)
WO (1) WO1993001179A1 (es)
YU (1) YU49175B (es)
ZA (1) ZA925098B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
CA2111527C (en) * 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
CA2129288C (en) * 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
FR2718135B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation d'hydroxy-7 taxanes.
US5580899A (en) * 1995-01-09 1996-12-03 The Liposome Company, Inc. Hydrophobic taxane derivatives
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
US6051600A (en) * 1995-09-12 2000-04-18 Mayhew; Eric Liposomal hydrolysis-promoting hydrophobic taxane derivatives
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
FR2742751B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
AU739303B2 (en) 1997-08-21 2001-10-11 Florida State University Method for the synthesis of taxanes
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
EP1068192B1 (en) * 1998-01-14 2002-06-12 Bristol-Myers Squibb Company Novel crystalline complexes of baccatin iii with imidazole, 2-methylimidazole or isopropanol
WO1999057105A1 (en) 1998-05-01 1999-11-11 Napro Biotherapeutics, Inc. Methods and useful intermediates for paclitaxel synthesis from c-7, c-10 di-cbz baccatin iii
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
IT1319168B1 (it) * 2000-03-17 2003-09-26 Indena Spa Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.
MX2008012013A (es) 2006-03-23 2008-10-03 Novartis Ag Tratamiento con anticuerpo antigeno de celulas neoplasicas.
DE102008013929B3 (de) * 2008-03-12 2009-04-09 Wieland-Werke Ag Verdampferrohr mit optimierten Hinterschneidungen am Nutengrund
CN101531645B (zh) * 2009-04-29 2012-08-22 深圳万乐药业有限公司 一种多西他赛的合成方法
CN104582732A (zh) 2012-06-15 2015-04-29 布里格姆及妇女医院股份有限公司 治疗癌症的组合物及其制造方法
CA2944401A1 (en) 2014-04-03 2015-10-08 Invictus Oncology Pvt. Ltd. Supramolecular combinatorial therapeutics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol

Also Published As

Publication number Publication date
ZA925098B (en) 1993-04-28
US5578739A (en) 1996-11-26
HUT66018A (en) 1994-08-29
FR2678930B1 (fr) 1995-01-13
HU9400062D0 (en) 1994-05-30
FI940075A0 (fi) 1994-01-07
NO934485L (no) 1993-12-08
YU68792A (sh) 1995-10-03
HU217115B (hu) 1999-11-29
CA2111319C (fr) 2003-04-08
IE922234A1 (en) 1993-01-13
FR2678930A1 (fr) 1993-01-15
AU2328092A (en) 1993-02-11
EP0593641A1 (fr) 1994-04-27
CZ3194A3 (en) 1994-04-13
AU662346B2 (en) 1995-08-31
JPH06509082A (ja) 1994-10-13
FI940075A (fi) 1994-01-07
PL169780B1 (pl) 1996-08-30
GR3018543T3 (en) 1996-03-31
SK281560B6 (sk) 2001-05-10
JP3085710B2 (ja) 2000-09-11
CA2111319A1 (fr) 1993-01-21
CZ281288B6 (cs) 1996-08-14
ES2081120T3 (es) 1996-02-16
EP0593641B1 (fr) 1995-12-27
NO302521B1 (no) 1998-03-16
RU2088578C1 (ru) 1997-08-27
YU49175B (sh) 2004-07-15
DE69207194D1 (de) 1996-02-08
IE73637B1 (en) 1997-06-18
DE69207194T2 (de) 1996-09-05
MX9204029A (es) 1993-01-01
DK0593641T3 (da) 1996-01-29
EP0522958A1 (fr) 1993-01-13
WO1993001179A1 (fr) 1993-01-21
SK1794A3 (en) 1994-11-09
NO934485D0 (no) 1993-12-08
ATE132145T1 (de) 1996-01-15
NZ243491A (en) 1995-05-26
KR100206458B1 (ko) 1999-07-01

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