FI109695B - Diagnostisia 1,4,7,10-tetra-atsasyklododekaanibutyylitrioleja, niiden käyttö diagnostisina aineina ja menetelmä niiden valmistamiseksi - Google Patents

Diagnostisia 1,4,7,10-tetra-atsasyklododekaanibutyylitrioleja, niiden käyttö diagnostisina aineina ja menetelmä niiden valmistamiseksi Download PDF

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Publication number
FI109695B
FI109695B FI911330A FI911330A FI109695B FI 109695 B FI109695 B FI 109695B FI 911330 A FI911330 A FI 911330A FI 911330 A FI911330 A FI 911330A FI 109695 B FI109695 B FI 109695B
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FI
Finland
Prior art keywords
general formula
group
metal
tetraazacyclododecane
order numbers
Prior art date
Application number
FI911330A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI911330A0 (fi
FI911330A (fi
Inventor
Heinz Gries
Hanns-Joachim Weinmann
Gabriele Schuhmann-Giampieri
Wolf-Ruediger Press
Johannes Platzek
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of FI911330A0 publication Critical patent/FI911330A0/fi
Publication of FI911330A publication Critical patent/FI911330A/fi
Application granted granted Critical
Publication of FI109695B publication Critical patent/FI109695B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI911330A 1990-03-19 1991-03-19 Diagnostisia 1,4,7,10-tetra-atsasyklododekaanibutyylitrioleja, niiden käyttö diagnostisina aineina ja menetelmä niiden valmistamiseksi FI109695B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4009119A DE4009119A1 (de) 1990-03-19 1990-03-19 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4009119 1990-03-19

Publications (3)

Publication Number Publication Date
FI911330A0 FI911330A0 (fi) 1991-03-19
FI911330A FI911330A (fi) 1991-09-20
FI109695B true FI109695B (fi) 2002-09-30

Family

ID=6402765

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911330A FI109695B (fi) 1990-03-19 1991-03-19 Diagnostisia 1,4,7,10-tetra-atsasyklododekaanibutyylitrioleja, niiden käyttö diagnostisina aineina ja menetelmä niiden valmistamiseksi

Country Status (17)

Country Link
US (4) US5980864A (ja)
EP (1) EP0448191B1 (ja)
JP (1) JP2968367B2 (ja)
AT (1) ATE124405T1 (ja)
AU (1) AU647091B2 (ja)
CA (1) CA2038493C (ja)
DE (3) DE4009119A1 (ja)
DK (1) DK0448191T3 (ja)
ES (1) ES2074219T3 (ja)
FI (1) FI109695B (ja)
HK (1) HK1002811A1 (ja)
HU (1) HU215964B (ja)
IE (1) IE67643B1 (ja)
IL (1) IL97592A (ja)
NO (2) NO179610C (ja)
NZ (1) NZ237461A (ja)
PT (1) PT97065B (ja)

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DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
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DE19652387A1 (de) * 1996-12-04 1998-06-10 Schering Ag Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
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DE10064467C2 (de) * 2000-12-15 2002-10-31 Schering Ag Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
US7011816B2 (en) * 2001-12-26 2006-03-14 Immunomedics, Inc. Labeling targeting agents with gallium-68 and gallium-67
WO2004006934A2 (de) * 2002-07-10 2004-01-22 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecane als modulatoren des guanin-nukleotid bindenden roteins zur behandlung von tumoren
US20040048763A1 (en) * 2002-08-27 2004-03-11 The Procter & Gamble Co. Bleach compositions
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KR102167614B1 (ko) * 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
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Also Published As

Publication number Publication date
NO179610C (no) 1996-11-13
JP2968367B2 (ja) 1999-10-25
HU215964B (hu) 1999-03-29
DK0448191T3 (da) 1995-11-20
HU910874D0 (en) 1991-09-30
US20060078503A1 (en) 2006-04-13
CA2038493A1 (en) 1991-09-20
NZ237461A (en) 1993-12-23
EP0448191A1 (de) 1991-09-25
DE4009119A1 (de) 1991-09-26
US6399043B1 (en) 2002-06-04
NO911063L (no) 1991-09-20
IL97592A (en) 1995-10-31
NO911063D0 (no) 1991-03-18
DE10075007I2 (de) 2003-06-12
IL97592A0 (en) 1992-06-21
CA2038493C (en) 2002-07-02
AU7361091A (en) 1991-09-19
ES2074219T3 (es) 1995-09-01
FI911330A0 (fi) 1991-03-19
PT97065A (pt) 1991-10-31
HUT60478A (en) 1992-09-28
US6951639B2 (en) 2005-10-04
EP0448191B1 (de) 1995-06-28
IE67643B1 (en) 1996-04-17
DE59105815D1 (de) 1995-08-03
FI911330A (fi) 1991-09-20
US5980864A (en) 1999-11-09
AU647091B2 (en) 1994-03-17
NO2001003I1 (no) 2001-03-05
HK1002811A1 (en) 1998-09-18
US20020176823A1 (en) 2002-11-28
JPH05320146A (ja) 1993-12-03
PT97065B (pt) 1998-07-31
NO179610B (no) 1996-08-05
IE910902A1 (en) 1991-09-25
ATE124405T1 (de) 1995-07-15

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