NO2001003I1 - Gadovist - Google Patents

Gadovist

Info

Publication number
NO2001003I1
NO2001003I1 NO2001003C NO2001003C NO2001003I1 NO 2001003 I1 NO2001003 I1 NO 2001003I1 NO 2001003 C NO2001003 C NO 2001003C NO 2001003 C NO2001003 C NO 2001003C NO 2001003 I1 NO2001003 I1 NO 2001003I1
Authority
NO
Norway
Prior art keywords
gadovist
Prior art date
Application number
NO2001003C
Other languages
English (en)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE4009119A priority Critical patent/DE4009119A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO2001003I1 publication Critical patent/NO2001003I1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/101Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/836Chelate
NO2001003C 1990-03-19 2001-02-14 Gadovist NO2001003I1 (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE4009119A DE4009119A1 (de) 1990-03-19 1990-03-19 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (1)

Publication Number Publication Date
NO2001003I1 true NO2001003I1 (no) 2001-03-05

Family

ID=6402765

Family Applications (2)

Application Number Title Priority Date Filing Date
NO911063A NO179610C (no) 1990-03-19 1991-03-18 1,4,7,10-tetraazacyklododekanbutyltrioler, gadoliniumkompleks og diagnostisk middel som inneholder slike forbindelser, samt anvendelse derav for fremstilling av diagnostiske midler
NO2001003C NO2001003I1 (no) 1990-03-19 2001-02-14 Gadovist

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO911063A NO179610C (no) 1990-03-19 1991-03-18 1,4,7,10-tetraazacyklododekanbutyltrioler, gadoliniumkompleks og diagnostisk middel som inneholder slike forbindelser, samt anvendelse derav for fremstilling av diagnostiske midler

Country Status (17)

Country Link
US (4) US5980864A (no)
EP (1) EP0448191B1 (no)
JP (1) JP2968367B2 (no)
AT (1) AT124405T (no)
AU (1) AU647091B2 (no)
CA (1) CA2038493C (no)
DE (3) DE4009119A1 (no)
DK (1) DK0448191T3 (no)
ES (1) ES2074219T3 (no)
FI (1) FI109695B (no)
HK (1) HK1002811A1 (no)
HU (1) HU215964B (no)
IE (1) IE67643B1 (no)
IL (1) IL97592A (no)
NO (2) NO179610C (no)
NZ (1) NZ237461A (no)
PT (1) PT97065B (no)

Families Citing this family (42)

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US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
US5362476A (en) * 1984-10-18 1994-11-08 Board Of Regents, The University Of Texas System Alkyl phosphonate polyazamacrocyclic cheates for MRI
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
DE19652387A1 (de) * 1996-12-04 1998-06-10 Schering Ag Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
US20030017941A1 (en) * 1997-03-07 2003-01-23 The Procter & Gamble Company Catalysts and methods for catalytic oxidation
US20040048763A1 (en) * 2002-08-27 2004-03-11 The Procter & Gamble Co. Bleach compositions
US20050192195A1 (en) * 2002-08-27 2005-09-01 Busch Daryle H. Catalysts and methods for catalytic oxidation
ZA9801883B (en) * 1997-03-07 1998-09-01 Univ Kansas Catalysts and methods for catalytic oxidation
CA2283163C (en) 1997-03-07 2006-10-31 The Procter & Gamble Company Bleach compositions comprising a transition metal bleach catalyst incorporating a cross-bridged macropolycyclic ligand and an oxygen bleach
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
DE19816370B4 (de) * 1998-04-03 2004-09-09 Schering Ag Substituierte Mangan-D02A-Komplexe, diese enthaltende diagnostische Mittel und ihre Verwendung
EP1088559A3 (de) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
DE10064467C2 (de) * 2000-12-15 2002-10-31 Schering Ag Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
US7011816B2 (en) * 2001-12-26 2006-03-14 Immunomedics, Inc. Labeling targeting agents with gallium-68 and gallium-67
WO2004006934A2 (de) * 2002-07-10 2004-01-22 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecane als modulatoren des guanin-nukleotid bindenden roteins zur behandlung von tumoren
US20060239913A1 (en) * 2003-06-25 2006-10-26 Marc Port Peptide conjugate for magnetic resonance imaging
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
AT429933T (de) * 2004-07-02 2009-05-15 Bracco Imaging Spa 1,4-bis(carboxymethyl)-6-
US20080125344A1 (en) * 2006-11-28 2008-05-29 Daryle Hadley Busch Bleach compositions
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
WO2011054480A1 (de) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
EP2327395A1 (en) 2009-11-23 2011-06-01 Bracco Imaging S.p.A Process for the preparation of gadobenate dimeglumine complex in a solid form
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
EP2457594A1 (en) 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
PE20141325A1 (es) 2011-04-21 2014-10-08 Bayer Ip Gmbh Preparacion de gadobutrol de alta pureza
CA3002897A1 (en) 2015-12-10 2017-06-15 Bracco Imaging Spa Dimeric contrast agents
CN109963838A (zh) 2016-12-12 2019-07-02 伯拉考成像股份公司 二聚造影剂
CN108779082A (zh) 2016-04-13 2018-11-09 伯拉考成像股份公司 造影剂
MX2019003540A (es) 2016-09-27 2019-08-14 Bayer Pharma AG Metodo para producir la forma cristalina de modificacion a de calcobutrol.
WO2018069179A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
WO2018069176A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
EP3392254A1 (en) * 2017-04-20 2018-10-24 Koninklijke Philips N.V. Compounds for use in the diagnosis of a disease
KR101971435B1 (ko) 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1491129A (en) * 1975-06-04 1977-11-09 Guerbet Sa Iodo-benzene derivatives and an x-ray contrast medium containing them
US4284620A (en) * 1979-03-23 1981-08-18 Mallinckrodt, Inc. N-(2-Hydroxyethyl)-2,4,6-triiodo-3,5-bis-(2-keto-L-gulonamido)benzamide and radiological compositions containing same
NO161560C (no) * 1980-04-17 1989-09-06 Univ California Symmetriske trijodisoftaldiamid-derivater og roentgenkontrastmidler inneholdende disse.
DE3150916C2 (no) * 1981-12-18 1990-11-22 Schering Ag, 1000 Berlin Und 4709 Bergkamen, De
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
MX174467B (es) * 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
IT1224416B (it) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
WO1992021017A1 (en) * 1991-05-23 1992-11-26 Unger Evan C Liposoluble compounds for magnetic resonance imaging
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents

Also Published As

Publication number Publication date
US6399043B1 (en) 2002-06-04
JP2968367B2 (ja) 1999-10-25
AU647091B2 (en) 1994-03-17
FI109695B (fi) 2002-09-30
PT97065B (pt) 1998-07-31
JPH05320146A (ja) 1993-12-03
ES2074219T3 (es) 1995-09-01
NO911063L (no) 1991-09-20
EP0448191A1 (de) 1991-09-25
IE910902A1 (en) 1991-09-25
NO179610B (no) 1996-08-05
DK0448191T3 (da) 1995-11-20
IL97592A (en) 1995-10-31
AU7361091A (en) 1991-09-19
DE4009119A1 (de) 1991-09-26
AT124405T (de) 1995-07-15
FI911330A0 (fi) 1991-03-19
US20060078503A1 (en) 2006-04-13
PT97065A (pt) 1991-10-31
HK1002811A1 (en) 1998-09-18
FI109695B1 (no)
NO179610C (no) 1996-11-13
HUT60478A (en) 1992-09-28
US5980864A (en) 1999-11-09
HU910874D0 (en) 1991-09-30
DE59105815D1 (de) 1995-08-03
FI911330A (fi) 1991-09-20
FI911330D0 (no)
NZ237461A (en) 1993-12-23
US6951639B2 (en) 2005-10-04
CA2038493A1 (en) 1991-09-20
NO911063D0 (no) 1991-03-18
CA2038493C (en) 2002-07-02
EP0448191B1 (de) 1995-06-28
US20020176823A1 (en) 2002-11-28
IE67643B1 (en) 1996-04-17
HU215964B (hu) 1999-03-29
DE10075007I2 (de) 2003-06-12
IL97592D0 (en) 1992-06-21

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