NO179610C - 1,4,7,10-tetraazacyklododekanbutyltrioler, gadoliniumkompleks og diagnostisk middel som inneholder slike forbindelser, samt anvendelse derav for fremstilling av diagnostiske midler - Google Patents

1,4,7,10-tetraazacyklododekanbutyltrioler, gadoliniumkompleks og diagnostisk middel som inneholder slike forbindelser, samt anvendelse derav for fremstilling av diagnostiske midler

Info

Publication number
NO179610C
NO179610C NO911063A NO911063A NO179610C NO 179610 C NO179610 C NO 179610C NO 911063 A NO911063 A NO 911063A NO 911063 A NO911063 A NO 911063A NO 179610 C NO179610 C NO 179610C
Authority
NO
Norway
Prior art keywords
tetraazacyclododecan
triols
butyl
compounds
preparation
Prior art date
Application number
NO911063A
Other languages
English (en)
Other versions
NO911063L (no
NO911063D0 (no
NO179610B (no
Inventor
Johannes Platzek
Heinz Gries
Hanns-Joachim Weinmann
Gabriele Schuhmann-Giampieri
Wolf-Rudiger Press
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO911063D0 publication Critical patent/NO911063D0/no
Publication of NO911063L publication Critical patent/NO911063L/no
Publication of NO179610B publication Critical patent/NO179610B/no
Publication of NO179610C publication Critical patent/NO179610C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO911063A 1990-03-19 1991-03-18 1,4,7,10-tetraazacyklododekanbutyltrioler, gadoliniumkompleks og diagnostisk middel som inneholder slike forbindelser, samt anvendelse derav for fremstilling av diagnostiske midler NO179610C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4009119A DE4009119A1 (de) 1990-03-19 1990-03-19 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (4)

Publication Number Publication Date
NO911063D0 NO911063D0 (no) 1991-03-18
NO911063L NO911063L (no) 1991-09-20
NO179610B NO179610B (no) 1996-08-05
NO179610C true NO179610C (no) 1996-11-13

Family

ID=6402765

Family Applications (2)

Application Number Title Priority Date Filing Date
NO911063A NO179610C (no) 1990-03-19 1991-03-18 1,4,7,10-tetraazacyklododekanbutyltrioler, gadoliniumkompleks og diagnostisk middel som inneholder slike forbindelser, samt anvendelse derav for fremstilling av diagnostiske midler
NO2001003C NO2001003I1 (no) 1990-03-19 2001-02-14 Gadovist

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2001003C NO2001003I1 (no) 1990-03-19 2001-02-14 Gadovist

Country Status (17)

Country Link
US (4) US5980864A (no)
EP (1) EP0448191B1 (no)
JP (1) JP2968367B2 (no)
AT (1) ATE124405T1 (no)
AU (1) AU647091B2 (no)
CA (1) CA2038493C (no)
DE (3) DE4009119A1 (no)
DK (1) DK0448191T3 (no)
ES (1) ES2074219T3 (no)
FI (1) FI109695B (no)
HK (1) HK1002811A1 (no)
HU (1) HU215964B (no)
IE (1) IE67643B1 (no)
IL (1) IL97592A (no)
NO (2) NO179610C (no)
NZ (1) NZ237461A (no)
PT (1) PT97065B (no)

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DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
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DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
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WO2004006934A2 (de) * 2002-07-10 2004-01-22 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecane als modulatoren des guanin-nukleotid bindenden roteins zur behandlung von tumoren
US20040048763A1 (en) * 2002-08-27 2004-03-11 The Procter & Gamble Co. Bleach compositions
US20050192195A1 (en) * 2002-08-27 2005-09-01 Busch Daryle H. Catalysts and methods for catalytic oxidation
US20060239913A1 (en) * 2003-06-25 2006-10-26 Marc Port Peptide conjugate for magnetic resonance imaging
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DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
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JP6896733B2 (ja) 2015-12-10 2021-06-30 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 二量体造影剤
KR102703312B1 (ko) 2015-12-10 2024-09-05 브라코 이미징 에스.피.에이. 조영제
EP3442949B1 (en) * 2016-04-13 2022-06-08 Bracco Imaging S.p.A. Contrast agents
AU2017333698B2 (en) 2016-09-27 2020-12-24 Bayer Pharma Aktiengesellschaft Method for producing the crystalline form of modification a of calcobutrol
WO2018069179A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
WO2018069176A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
JP7145156B2 (ja) 2016-12-12 2022-09-30 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 二量体造影剤
EP3392254A1 (en) * 2017-04-20 2018-10-24 Koninklijke Philips N.V. Compounds for use in the diagnosis of a disease
KR101971435B1 (ko) 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
EP4083026A1 (en) 2018-07-10 2022-11-02 Biophore India Pharmaceuticals Pvt. Ltd. Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
KR102167614B1 (ko) * 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
CN114573521B (zh) * 2020-12-01 2023-10-27 威智医药股份有限公司 一种钆布醇及其中间体的制备方法

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Also Published As

Publication number Publication date
US6951639B2 (en) 2005-10-04
CA2038493C (en) 2002-07-02
NZ237461A (en) 1993-12-23
AU7361091A (en) 1991-09-19
IL97592A0 (en) 1992-06-21
NO911063L (no) 1991-09-20
NO2001003I1 (no) 2001-03-05
HU910874D0 (en) 1991-09-30
NO911063D0 (no) 1991-03-18
PT97065A (pt) 1991-10-31
DK0448191T3 (da) 1995-11-20
US20060078503A1 (en) 2006-04-13
US6399043B1 (en) 2002-06-04
US5980864A (en) 1999-11-09
PT97065B (pt) 1998-07-31
EP0448191B1 (de) 1995-06-28
CA2038493A1 (en) 1991-09-20
NO179610B (no) 1996-08-05
HK1002811A1 (en) 1998-09-18
HUT60478A (en) 1992-09-28
JPH05320146A (ja) 1993-12-03
ES2074219T3 (es) 1995-09-01
JP2968367B2 (ja) 1999-10-25
IE67643B1 (en) 1996-04-17
FI911330A (fi) 1991-09-20
AU647091B2 (en) 1994-03-17
IL97592A (en) 1995-10-31
HU215964B (hu) 1999-03-29
DE4009119A1 (de) 1991-09-26
IE910902A1 (en) 1991-09-25
DE10075007I2 (de) 2003-06-12
EP0448191A1 (de) 1991-09-25
US20020176823A1 (en) 2002-11-28
FI109695B (fi) 2002-09-30
ATE124405T1 (de) 1995-07-15
FI911330A0 (fi) 1991-03-19
DE59105815D1 (de) 1995-08-03

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SPCG Granted supplementary protection certificate

Spc suppl protection certif: SPC/NO 2001 003

Filing date: 20010214

Extension date: 20130226

MK1K Patent expired