FI109538B - Menetelmä antituumorisen aktiivisuuden omaavien 2-aminoalkyyli-5-aminoalkyyliamino-substituoitujen isokino[8,7,6-cd] ja [5,6,7-cd]indatsoli-6(2H)-onien valmistamiseksi - Google Patents

Menetelmä antituumorisen aktiivisuuden omaavien 2-aminoalkyyli-5-aminoalkyyliamino-substituoitujen isokino[8,7,6-cd] ja [5,6,7-cd]indatsoli-6(2H)-onien valmistamiseksi Download PDF

Info

Publication number
FI109538B
FI109538B FI951023A FI951023A FI109538B FI 109538 B FI109538 B FI 109538B FI 951023 A FI951023 A FI 951023A FI 951023 A FI951023 A FI 951023A FI 109538 B FI109538 B FI 109538B
Authority
FI
Finland
Prior art keywords
amino
ethyl
isoquino
indazole
dimethylamino
Prior art date
Application number
FI951023A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI951023A (fi
FI951023A0 (fi
Inventor
Silvano Spinelli
Ernesto Menta
Ambrogio Oliva
A Paul Krapcho
Original Assignee
Univ Vermont
Novuspharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/103,641 external-priority patent/US5519029A/en
Application filed by Univ Vermont, Novuspharma Spa filed Critical Univ Vermont
Publication of FI951023A0 publication Critical patent/FI951023A0/fi
Publication of FI951023A publication Critical patent/FI951023A/fi
Application granted granted Critical
Publication of FI109538B publication Critical patent/FI109538B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI951023A 1992-09-08 1995-03-06 Menetelmä antituumorisen aktiivisuuden omaavien 2-aminoalkyyli-5-aminoalkyyliamino-substituoitujen isokino[8,7,6-cd] ja [5,6,7-cd]indatsoli-6(2H)-onien valmistamiseksi FI109538B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US94160792A 1992-09-08 1992-09-08
US94160792 1992-09-08
US08/103,641 US5519029A (en) 1992-09-08 1993-08-11 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
US10364193 1993-08-11
US9308241 1993-09-08
PCT/US1993/008241 WO1994006795A1 (en) 1992-09-08 1993-09-08 2-aminoalkyl-5-aminoalkylamino substituted isoquinoindazole-6-(2h)-ones with antitumour activity

Publications (3)

Publication Number Publication Date
FI951023A0 FI951023A0 (fi) 1995-03-06
FI951023A FI951023A (fi) 1995-03-31
FI109538B true FI109538B (fi) 2002-08-30

Family

ID=26800681

Family Applications (1)

Application Number Title Priority Date Filing Date
FI951023A FI109538B (fi) 1992-09-08 1995-03-06 Menetelmä antituumorisen aktiivisuuden omaavien 2-aminoalkyyli-5-aminoalkyyliamino-substituoitujen isokino[8,7,6-cd] ja [5,6,7-cd]indatsoli-6(2H)-onien valmistamiseksi

Country Status (17)

Country Link
EP (1) EP0662076B1 (da)
JP (1) JP3497168B2 (da)
CN (1) CN1051549C (da)
AT (1) ATE200491T1 (da)
AU (1) AU680431B2 (da)
CZ (1) CZ288366B6 (da)
DE (1) DE69330131T2 (da)
DK (1) DK0662076T3 (da)
ES (1) ES2155452T3 (da)
FI (1) FI109538B (da)
GR (1) GR3036175T3 (da)
HU (1) HU220616B1 (da)
NO (1) NO302618B1 (da)
PT (1) PT662076E (da)
RU (1) RU2130937C1 (da)
SG (1) SG52494A1 (da)
WO (1) WO1994006795A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5596097A (en) * 1994-03-08 1997-01-21 The University Of Vermont Hetero-annulated indazoles
WO1997002267A1 (en) * 1995-07-06 1997-01-23 University Of Vermont New pyrido-thiopyranoindazoles with antitumor activity
IT1277576B1 (it) * 1995-09-13 1997-11-11 Boehringer Mannheim Italia 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale
IT1286509B1 (it) * 1996-11-29 1998-07-15 Boehringer Mannheim Italia Derivati 2, 3, 4, 7-tetraidropiridoindazolo-(1,4)benzodiazepinici aventi attivita' antitumorale
US6747039B2 (en) 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69211A (en) * 1982-07-23 1987-01-30 Warner Lambert Co Substituted anthra(1,9-cd)pyrazol-6(2h)-ones,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI951023A (fi) 1995-03-31
CZ288366B6 (en) 2001-06-13
RU95110932A (ru) 1996-12-27
ES2155452T3 (es) 2001-05-16
JP3497168B2 (ja) 2004-02-16
RU2130937C1 (ru) 1999-05-27
NO950877L (no) 1995-05-08
DK0662076T3 (da) 2001-05-07
HU220616B1 (hu) 2002-03-28
ATE200491T1 (de) 2001-04-15
GR3036175T3 (en) 2001-10-31
AU4844193A (en) 1994-04-12
EP0662076B1 (en) 2001-04-11
EP0662076A1 (en) 1995-07-12
CZ59895A3 (en) 1995-11-15
DE69330131D1 (de) 2001-05-17
AU680431B2 (en) 1997-07-31
DE69330131T2 (de) 2001-08-30
HUT70145A (en) 1995-09-28
NO950877D0 (no) 1995-03-07
FI951023A0 (fi) 1995-03-06
PT662076E (pt) 2001-09-28
WO1994006795A1 (en) 1994-03-31
SG52494A1 (en) 1998-09-28
CN1101046A (zh) 1995-04-05
CN1051549C (zh) 2000-04-19
NO302618B1 (no) 1998-03-30
HU9500676D0 (en) 1995-04-28
JPH08503933A (ja) 1996-04-30

Similar Documents

Publication Publication Date Title
FI113765B (fi) Menetelmä uusien antiproliferatiivisten 5-substituoitujen kinatsoliiniyhdisteiden valmistamiseksi
JP7039802B2 (ja) Ｒｈｏ－関連プロテインキナーゼ阻害剤、ｒｈｏ－関連プロテインキナーゼ阻害剤を含む医薬組成物、当該医薬組成物の調製方法及び使用
FI103575B (fi) Menetelmä terapeuttisesti vaikuttavien 6,9-bis(amino)bentso(g)isokinol iini-5,10-dionien valmistamiseksi
FI109538B (fi) Menetelmä antituumorisen aktiivisuuden omaavien 2-aminoalkyyli-5-aminoalkyyliamino-substituoitujen isokino[8,7,6-cd] ja [5,6,7-cd]indatsoli-6(2H)-onien valmistamiseksi
WO2004033423A2 (en) Anticancer compounds
AU738823B2 (en) New camptothecin derivatives
KR100269832B1 (ko) 종양치료 활성을 지닌 2-아미노알킬-5-아미노알킬아미노 치환된 이소퀴노인다졸-6-(2h)-온 이를 포함하는 약제학적 조성물 및 이의 제조방법
CN116789647A (zh) 作为parp7抑制剂的化合物
JPH07267936A (ja) 抗腫瘍組成物および治療法
WO2016110237A1 (zh) α-咔啉类化合物，其制备方法以及用途
EP0750619B1 (en) Hetero-annulated indazoles
CA2143853C (en) 2-aminoalkyl-5-aminoalkylamino substituted isoquinoindazole-6-(2h)-ones with antitumour activity
US5604246A (en) 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
WO1998023614A1 (fr) Nouveaux derives du phenanthridinium
CN116529252A (zh) 用于持续释放治疗剂的前药及其用途
KR19990044614A (ko) 항암제로서의 2-[2-[(2-하이드록시에틸)아미노]에틸]-5-[(2-메틸아미노)에틸]아미노]인다졸로[4,3-ｇｈ]이소퀴놀린-6(2Ｈ)-온
JP5198447B2 (ja) 抗腫瘍活性を有するカンプトテシン誘導体
KR19990028765A (ko) 항종양 활성을 지닌 신규한 피리도-티오피라노인다졸
NO180302B (no) 6,9-bis(substituerte-amino)benzo[gÅisokinolin-5,10-dioner
WO1998025910A1 (en) NEW DERIVATIVES OF 6-[(AMINOALKYL)AMINO]-7H-BENZO[e]-PERIMIDIN-7-ONE, METHOD OF THEIR PREPARATION, AND THEIR USE AS A MEDICAMENT
JPH07316162A (ja) 三環式化合物

Legal Events

Date Code Title Description
FD Application lapsed