FI108643B - Stereoselektiivinen glykosylaatiomenetelmä beta-anomeerilla rikastetun nukleosidin valmistamiseksi - Google Patents

Stereoselektiivinen glykosylaatiomenetelmä beta-anomeerilla rikastetun nukleosidin valmistamiseksi Download PDF

Info

Publication number
FI108643B
FI108643B FI932869A FI932869A FI108643B FI 108643 B FI108643 B FI 108643B FI 932869 A FI932869 A FI 932869A FI 932869 A FI932869 A FI 932869A FI 108643 B FI108643 B FI 108643B
Authority
FI
Finland
Prior art keywords
group
anomer
nhw
alkyl
deoxy
Prior art date
Application number
FI932869A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI932869A0 (fi
FI932869A (fi
Inventor
Charles David Jones
Larry Wayne Hertel
Cora Sue Grossman
Ta-Sen Chou
Laurie Michelle Poteet
Douglas Patton Kjell
Richard Elmer Holmes
Thomas Edward Mabry
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27583678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI108643(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/902,312 external-priority patent/US5371210A/en
Priority claimed from US08/044,345 external-priority patent/US5594124A/en
Priority claimed from US08/044,343 external-priority patent/US5401838A/en
Priority claimed from US08/044,996 external-priority patent/US5821357A/en
Priority claimed from US08/044,312 external-priority patent/US5426183A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI932869A0 publication Critical patent/FI932869A0/fi
Publication of FI932869A publication Critical patent/FI932869A/fi
Application granted granted Critical
Publication of FI108643B publication Critical patent/FI108643B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FI932869A 1992-06-22 1993-06-21 Stereoselektiivinen glykosylaatiomenetelmä beta-anomeerilla rikastetun nukleosidin valmistamiseksi FI108643B (fi)

Applications Claiming Priority (24)

Application Number Priority Date Filing Date Title
US90215092A 1992-06-22 1992-06-22
US90211292A 1992-06-22 1992-06-22
US90213592A 1992-06-22 1992-06-22
US90230292A 1992-06-22 1992-06-22
US90231392A 1992-06-22 1992-06-22
US90215092 1992-06-22
US07/902,312 US5371210A (en) 1992-06-22 1992-06-22 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US90231392 1992-06-22
US90211292 1992-06-22
US90213592 1992-06-22
US90230292 1992-06-22
US90231292 1992-06-22
US4431593A 1993-04-07 1993-04-07
US4430993A 1993-04-07 1993-04-07
US08/044,345 US5594124A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US4434593 1993-04-07
US4431593 1993-04-07
US08/044,343 US5401838A (en) 1992-06-22 1993-04-07 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US4434393 1993-04-07
US4430993 1993-04-07
US4431293 1993-04-07
US08/044,996 US5821357A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US08/044,312 US5426183A (en) 1992-06-22 1993-04-07 Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US4499693 1993-04-07

Publications (3)

Publication Number Publication Date
FI932869A0 FI932869A0 (fi) 1993-06-21
FI932869A FI932869A (fi) 1993-12-23
FI108643B true FI108643B (fi) 2002-02-28

Family

ID=27583678

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932869A FI108643B (fi) 1992-06-22 1993-06-21 Stereoselektiivinen glykosylaatiomenetelmä beta-anomeerilla rikastetun nukleosidin valmistamiseksi

Country Status (20)

Country Link
EP (1) EP0577303B1 (es)
JP (1) JP3313191B2 (es)
KR (1) KR100252452B1 (es)
AT (1) ATE158799T1 (es)
BR (1) BR9302434A (es)
CA (1) CA2098881C (es)
CY (1) CY2067A (es)
DE (1) DE69314239C5 (es)
DK (1) DK0577303T3 (es)
ES (1) ES2107624T3 (es)
FI (1) FI108643B (es)
GR (1) GR3025689T3 (es)
HU (2) HUT64358A (es)
IL (1) IL106071A (es)
MX (1) MX9303707A (es)
MY (1) MY115775A (es)
NO (1) NO180235B3 (es)
NZ (1) NZ247939A (es)
PL (1) PL172348B1 (es)
UA (1) UA41261C2 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US5637688A (en) 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
AU1289697A (en) 1995-12-13 1997-07-03 Eli Lilly And Company Alpha, alpha-difluoro-beta-hydroxy thiol esters and their synthesis
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
AU2001238516B2 (en) 2000-02-18 2005-08-04 Southern Research Institute Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H- purin-6-amine
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
ES2306783T3 (es) * 2001-08-02 2008-11-16 Ilex Oncology, Inc. Procedimiento para preparar nucleosidos purinicos.
CA2472581C (en) 2002-01-15 2012-06-26 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
WO2004041203A2 (en) 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
JP4599295B2 (ja) * 2003-05-22 2010-12-15 独立行政法人科学技術振興機構 α−選択的グリコシル化反応方法
WO2006070985A1 (en) 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
KR20070112774A (ko) * 2005-03-04 2007-11-27 다브르 파마 리미티드 베타―아노머가 많은２１데옥시，２１，２１－디플루오로－ｄ－리보푸라노실뉴클레오시드의 제조를 위한 중간체 및 제조 방법
NZ563995A (en) * 2005-06-03 2010-01-29 Scinopharm Taiwan Ltd Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
CA2670099A1 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
WO2008064132A2 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
TW200942231A (en) 2008-01-11 2009-10-16 Reata Pharmaceuticals Inc Synthetic triterpenoids and methods of use in the treatment of disease
CN104250280A (zh) 2008-04-18 2014-12-31 里亚塔医药公司 抗氧化剂炎症调节剂:c-17同系化齐墩果酸衍生物
TW201004627A (en) 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
WO2009129545A1 (en) 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
JP5564490B2 (ja) 2008-04-18 2014-07-30 リアタ ファーマシューティカルズ インコーポレイテッド 抗炎症性ファルマコアを含む化合物および使用法
NZ588710A (en) 2008-04-18 2012-12-21 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
JP6042527B2 (ja) 2012-04-04 2016-12-14 ハロザイム インコーポレイテッド 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
KR20150141968A (ko) * 2013-03-15 2015-12-21 에피제네틱스 파마 엘엘씨 플루오르화된 피리미딘 유사체 및 그의 사용 방법
CN110831605A (zh) 2017-04-26 2020-02-21 托马斯·I.·卡尔曼 多靶标的核苷衍生物
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents
DE3856527T2 (de) * 1987-08-28 2002-10-31 Eli Lilly And Co., Indianapolis Stereoselektives Verfahren zur Herstellung von geschützten 2',2'-difluorlactonen
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
GB8816345D0 (en) * 1988-07-08 1988-08-10 Hoffmann La Roche Purine derivatives
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
CA2079796A1 (en) * 1990-04-04 1991-10-05 Jo Klaveness Nucleoside derivatives
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Also Published As

Publication number Publication date
HU0201196D0 (es) 2002-06-29
JP3313191B2 (ja) 2002-08-12
KR940005658A (ko) 1994-03-22
HU9301822D0 (en) 1993-09-28
CA2098881A1 (en) 1993-12-23
UA41261C2 (uk) 2001-09-17
EP0577303B1 (en) 1997-10-01
GR3025689T3 (en) 1998-03-31
CY2067A (en) 1993-06-21
MX9303707A (es) 1994-06-30
NO180235C (no) 1997-03-12
DK0577303T3 (da) 1997-10-27
ATE158799T1 (de) 1997-10-15
MY115775A (en) 2003-09-30
NO180235B (no) 1996-12-02
NO932288A (no) 1993-12-23
FI932869A0 (fi) 1993-06-21
DE69314239D1 (de) 1997-11-06
HU223837B1 (hu) 2005-02-28
DE69314239T2 (de) 1998-02-19
IL106071A (en) 2006-08-20
HUT64358A (en) 1993-12-28
PL299415A1 (en) 1994-03-07
PL172348B1 (pl) 1997-09-30
JPH06157570A (ja) 1994-06-03
EP0577303A1 (en) 1994-01-05
CA2098881C (en) 2005-06-07
NO932288D0 (no) 1993-06-21
KR100252452B1 (en) 2000-04-15
NO180235B3 (no) 2007-10-01
FI932869A (fi) 1993-12-23
NZ247939A (en) 1996-02-27
IL106071A0 (en) 1993-10-20
ES2107624T3 (es) 1997-12-01
BR9302434A (pt) 1994-02-16
DE69314239C5 (de) 2012-11-29

Similar Documents

Publication Publication Date Title
FI108643B (fi) Stereoselektiivinen glykosylaatiomenetelmä beta-anomeerilla rikastetun nukleosidin valmistamiseksi
US5401838A (en) Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5426183A (en) Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5371210A (en) Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5744597A (en) Stereoselective anion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5821357A (en) Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
JP2008531680A (ja) βアノマーが富化された２１−デオキシ−２１，２１−ジフルオロ−Ｄ−リボフラノシルヌクレオシドの調製のための中間体と方法
US5594124A (en) Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US8648188B2 (en) Preparation of 2-chloro-9-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-adenine
MXPA05006865A (es) Proceso para la produccion de profarmacos 3'-nucleosidos.
Bobkov et al. Phosphoramidite building blocks for efficient incorporation of 2′-O-aminoethoxy (and propoxy) methyl nucleosides into oligonucleotides
WO2006070985A1 (en) METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
US8586729B2 (en) Synthesis of decitabine
KR20060035652A (ko) β-Ｌ-2-데옥시 뉴클레오시드의 합성
AU2002303187B2 (en) Process for the preparation of 2'-HALO-Beta-L-arabinofuranosyl nucleosides
EP0640614B1 (en) Stereoselective process for preparing beta-anomer enriched 2-deoxy-2, 2-difluoro-d-ribofuranosyl-3, 5-hydroxy protected-1-alkyl and aryl sulfonate intermediates
JP4802712B2 (ja) リボ核酸化合物及びオリゴ核酸化合物の液相合成法
RU2131880C1 (ru) Способ получения обогащенных бета-аномером нуклеозидов
AU659009B2 (en) Stereoselective glycosylation process
JP5599078B2 (ja) アデノシンテトラホスフェート化合物の製造法
AU659008B2 (en) Stereoselective anion glycosylation process
CZ291165B6 (cs) Způsob stereoselektivní glykosylace
WO2001085220A1 (en) Labeled nucleosides and method for their preparation

Legal Events

Date Code Title Description
MA Patent expired