FI105101B - Menetelmä hepariini- tai heparaanirakenteen omaavien puolisynteettisten glykoaminoglykaanien valmistamiseksi - Google Patents

Menetelmä hepariini- tai heparaanirakenteen omaavien puolisynteettisten glykoaminoglykaanien valmistamiseksi Download PDF

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Publication number
FI105101B
FI105101B FI941431A FI941431A FI105101B FI 105101 B FI105101 B FI 105101B FI 941431 A FI941431 A FI 941431A FI 941431 A FI941431 A FI 941431A FI 105101 B FI105101 B FI 105101B
Authority
FI
Finland
Prior art keywords
heparin
acid
glycosaminoglycans
nucleophilic
aqueous solution
Prior art date
Application number
FI941431A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI941431A (fi
FI941431A0 (fi
Inventor
Fabrizio Ungarelli
Silvano Piani
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of FI941431A0 publication Critical patent/FI941431A0/fi
Publication of FI941431A publication Critical patent/FI941431A/fi
Application granted granted Critical
Publication of FI105101B publication Critical patent/FI105101B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI941431A 1993-03-29 1994-03-28 Menetelmä hepariini- tai heparaanirakenteen omaavien puolisynteettisten glykoaminoglykaanien valmistamiseksi FI105101B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT93BO000125A IT1264101B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
ITBO930125 1993-03-29

Publications (3)

Publication Number Publication Date
FI941431A0 FI941431A0 (fi) 1994-03-28
FI941431A FI941431A (fi) 1994-09-30
FI105101B true FI105101B (fi) 2000-06-15

Family

ID=11338858

Family Applications (1)

Application Number Title Priority Date Filing Date
FI941431A FI105101B (fi) 1993-03-29 1994-03-28 Menetelmä hepariini- tai heparaanirakenteen omaavien puolisynteettisten glykoaminoglykaanien valmistamiseksi

Country Status (18)

Country Link
US (1) US5405949A (ja)
EP (1) EP0618234B1 (ja)
JP (1) JP2731721B2 (ja)
KR (1) KR100194122B1 (ja)
AT (1) ATE154039T1 (ja)
AU (1) AU664939B2 (ja)
CA (1) CA2114862C (ja)
DE (1) DE69403537T2 (ja)
DK (1) DK0618234T3 (ja)
ES (1) ES2102087T3 (ja)
FI (1) FI105101B (ja)
GR (1) GR3024416T3 (ja)
IL (1) IL108689A (ja)
IT (1) IT1264101B1 (ja)
NO (1) NO305994B1 (ja)
NZ (1) NZ250815A (ja)
TW (1) TW266215B (ja)
ZA (1) ZA94970B (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
US6846917B2 (en) 2001-01-23 2005-01-25 Massachusetts Institute Of Technology Solid- and solution-phase synthesis of heparin and other glycosaminoglycans
EP2343077B1 (en) 2001-09-12 2013-07-17 SIGMA-TAU Research Switzerland S.A. Derivatives of totally N-desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
JP7401882B2 (ja) * 2016-03-09 2023-12-20 株式会社糖鎖工学研究所 硫酸基を有する糖の製造方法
CN114901702B (zh) * 2019-12-27 2024-01-09 深圳市海普瑞药业集团股份有限公司 一种糖胺聚糖衍生物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5011919A (en) * 1989-01-30 1991-04-30 Ajorca S.A. Modified heparins and obtention process
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
BE1006134A6 (fr) * 1992-08-25 1994-05-24 Syntex Sa Procede de preparation de derives 2-desoxy-2-amino hexuronyles d'heparine, derives tels qu'ainsi obtenus et leur utilisation.

Also Published As

Publication number Publication date
KR940021582A (ko) 1994-10-19
DE69403537D1 (de) 1997-07-10
GR3024416T3 (en) 1997-11-28
CA2114862A1 (en) 1994-09-30
JPH06298805A (ja) 1994-10-25
KR100194122B1 (ko) 1999-06-15
ES2102087T3 (es) 1997-07-16
IT1264101B1 (it) 1996-09-10
ITBO930125A0 (it) 1993-03-29
NO941128D0 (no) 1994-03-28
DE69403537T2 (de) 1997-09-18
ZA94970B (en) 1994-08-24
IL108689A0 (en) 1994-05-30
NO305994B1 (no) 1999-08-30
EP0618234A1 (en) 1994-10-05
ATE154039T1 (de) 1997-06-15
IL108689A (en) 1998-03-10
ITBO930125A1 (it) 1994-09-29
DK0618234T3 (da) 1997-08-25
JP2731721B2 (ja) 1998-03-25
FI941431A (fi) 1994-09-30
US5405949A (en) 1995-04-11
AU5508594A (en) 1994-10-06
AU664939B2 (en) 1995-12-07
CA2114862C (en) 1999-05-25
NZ250815A (en) 1996-02-27
FI941431A0 (fi) 1994-03-28
EP0618234B1 (en) 1997-06-04
TW266215B (ja) 1995-12-21
NO941128L (no) 1994-09-30

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