IL108689A - Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acid - Google Patents

Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acid

Info

Publication number
IL108689A
IL108689A IL108689A IL10868994A IL108689A IL 108689 A IL108689 A IL 108689A IL 108689 A IL108689 A IL 108689A IL 10868994 A IL10868994 A IL 10868994A IL 108689 A IL108689 A IL 108689A
Authority
IL
Israel
Prior art keywords
acid
heparin
aqueous solution
general formula
nucleophilic
Prior art date
Application number
IL108689A
Other languages
English (en)
Hebrew (he)
Other versions
IL108689A0 (en
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of IL108689A0 publication Critical patent/IL108689A0/xx
Publication of IL108689A publication Critical patent/IL108689A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL108689A 1993-03-29 1994-02-17 Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acid IL108689A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93BO000125A IT1264101B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2

Publications (2)

Publication Number Publication Date
IL108689A0 IL108689A0 (en) 1994-05-30
IL108689A true IL108689A (en) 1998-03-10

Family

ID=11338858

Family Applications (1)

Application Number Title Priority Date Filing Date
IL108689A IL108689A (en) 1993-03-29 1994-02-17 Process for the synthesis of semi-synthetic glycosaminoglycans when the structure of heparin or heparin differs in position 2 of the a-L-Iduro acid

Country Status (18)

Country Link
US (1) US5405949A (ja)
EP (1) EP0618234B1 (ja)
JP (1) JP2731721B2 (ja)
KR (1) KR100194122B1 (ja)
AT (1) ATE154039T1 (ja)
AU (1) AU664939B2 (ja)
CA (1) CA2114862C (ja)
DE (1) DE69403537T2 (ja)
DK (1) DK0618234T3 (ja)
ES (1) ES2102087T3 (ja)
FI (1) FI105101B (ja)
GR (1) GR3024416T3 (ja)
IL (1) IL108689A (ja)
IT (1) IT1264101B1 (ja)
NO (1) NO305994B1 (ja)
NZ (1) NZ250815A (ja)
TW (1) TW266215B (ja)
ZA (1) ZA94970B (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
CA2435637A1 (en) 2001-01-23 2002-08-01 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
KR100855331B1 (ko) 2001-09-12 2008-09-04 시그마타우 리서치 스위츠랜드 에스.에이 혈관형성 억제 활성을 가지며 응고억제 효과는 없는,헤파라나제 억제제로서 부분적으로 탈황산화된글리코스아미노글리칸의 유도체
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
WO2017154938A1 (ja) * 2016-03-09 2017-09-14 株式会社糖鎖工学研究所 硫酸基および／またはリン酸基を有する糖の製造方法
CN114901702B (zh) * 2019-12-27 2024-01-09 深圳市海普瑞药业集团股份有限公司 一种糖胺聚糖衍生物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5011919A (en) * 1989-01-30 1991-04-30 Ajorca S.A. Modified heparins and obtention process
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
BE1006134A6 (fr) * 1992-08-25 1994-05-24 Syntex Sa Procede de preparation de derives 2-desoxy-2-amino hexuronyles d'heparine, derives tels qu'ainsi obtenus et leur utilisation.

Also Published As

Publication number Publication date
FI105101B (fi) 2000-06-15
GR3024416T3 (en) 1997-11-28
ITBO930125A1 (it) 1994-09-29
CA2114862C (en) 1999-05-25
NO305994B1 (no) 1999-08-30
EP0618234B1 (en) 1997-06-04
TW266215B (ja) 1995-12-21
EP0618234A1 (en) 1994-10-05
NZ250815A (en) 1996-02-27
ES2102087T3 (es) 1997-07-16
AU664939B2 (en) 1995-12-07
AU5508594A (en) 1994-10-06
KR100194122B1 (ko) 1999-06-15
KR940021582A (ko) 1994-10-19
ATE154039T1 (de) 1997-06-15
JPH06298805A (ja) 1994-10-25
ZA94970B (en) 1994-08-24
IT1264101B1 (it) 1996-09-10
ITBO930125A0 (it) 1993-03-29
FI941431A0 (fi) 1994-03-28
JP2731721B2 (ja) 1998-03-25
FI941431A (fi) 1994-09-30
NO941128D0 (no) 1994-03-28
CA2114862A1 (en) 1994-09-30
US5405949A (en) 1995-04-11
IL108689A0 (en) 1994-05-30
DE69403537D1 (de) 1997-07-10
NO941128L (no) 1994-09-30
DE69403537T2 (de) 1997-09-18
DK0618234T3 (da) 1997-08-25

Similar Documents

Publication Publication Date Title
EP0565863B1 (en) Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-L-iduronic-2-0-sulfate acid modified in position 2
EP0565862B1 (en) Semi-synthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3
US5410039A (en) Process for the synthesis of glycosaminoglycans containing α-L-galacturonic acid substituted with nucleophilic groups in position 3
EP0618234B1 (en) Process for the synthesis of semisynthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-0-sulfate acid
Baumann et al. Concepts for preparation of novel regioselective modified cellulose derivatives sulfated, aminated, carboxylated and acetylated for hemocompatible ultrathin coatings on biomaterials
CN115417937A (zh) 一种含双抗凝血酶结合序列的肝素十二糖及其制备方法与应用
Hirano et al. 13C-nmr analysis of some sulphate derivatives of chitosan

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH1 Patent not in force