FI104718B - [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä - Google Patents

[[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä

Info

Publication number
FI104718B
FI104718B FI981428A FI981428A FI104718B FI 104718 B FI104718 B FI 104718B FI 981428 A FI981428 A FI 981428A FI 981428 A FI981428 A FI 981428A FI 104718 B FI104718 B FI 104718B
Authority
FI
Finland
Prior art keywords
propanedonitrile
levosimendan
oxotetrahydrofuran
hydrazono
azido
Prior art date
Application number
FI981428A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI981428A0 (fi
FI981428A (fi
Inventor
Reijo Baeckstroem
Tuula Heinonen
Tuula Hauta-Aho
Original Assignee
Orion Yhtymae Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oyj filed Critical Orion Yhtymae Oyj
Publication of FI981428A0 publication Critical patent/FI981428A0/fi
Priority to FI981428A priority Critical patent/FI104718B/fi
Priority to ARP990102890A priority patent/AR018879A1/es
Priority to AU47863/99A priority patent/AU755699B2/en
Priority to ES99931312T priority patent/ES2211113T3/es
Priority to YUP-767/00A priority patent/RS49929B/sr
Priority to CA002334864A priority patent/CA2334864C/en
Priority to EA200100055A priority patent/EA002854B1/ru
Priority to MXPA00012436A priority patent/MXPA00012436A/es
Priority to DE69912604T priority patent/DE69912604D1/de
Priority to PCT/FI1999/000539 priority patent/WO1999065888A2/en
Priority to EP99931312A priority patent/EP1087956B1/en
Priority to NZ508557A priority patent/NZ508557A/en
Priority to IL13996499A priority patent/IL139964A/xx
Priority to CZ20004555A priority patent/CZ298659B6/cs
Priority to PL347577A priority patent/PL201772B1/pl
Priority to AT99931312T priority patent/ATE253566T1/de
Priority to SK1872-2000A priority patent/SK284353B6/sk
Priority to CN99807544A priority patent/CN1129590C/zh
Priority to KR1020007014413A priority patent/KR100661772B1/ko
Priority to JP2000554714A priority patent/JP4550279B2/ja
Priority to HU0102020A priority patent/HU229582B1/hu
Priority to IDW20010086A priority patent/ID29239A/id
Priority to BR9911230-2A priority patent/BR9911230A/pt
Priority to US09/719,806 priority patent/US6340764B1/en
Publication of FI981428A publication Critical patent/FI981428A/fi
Application granted granted Critical
Publication of FI104718B publication Critical patent/FI104718B/fi
Priority to ZA200006993A priority patent/ZA200006993B/en
Priority to HR20000866A priority patent/HRP20000866B1/xx
Priority to NO20006444A priority patent/NO325393B1/no
Priority to HK01103183A priority patent/HK1032779A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI981428A 1998-06-18 1998-06-18 [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä FI104718B (fi)

Priority Applications (28)

Application Number Priority Date Filing Date Title
FI981428A FI104718B (fi) 1998-06-18 1998-06-18 [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
ARP990102890A AR018879A1 (es) 1998-06-18 1999-06-16 Compuesto de [[4- (2-azido -3-metil -5- oxotetrahidrofuran -2il) -fenil] -hidrazono] propanodinitrilo de aplicacion en el analisis de cargas de levosimendan, preparaciones de referencia para la determinacion de impurezas genotoxicas utilizando dicho compuesto y metodos analiticos para la determinaci
PL347577A PL201772B1 (pl) 1998-06-18 1999-06-18 Analityczny sposób oznaczania potencjalnie genotoksycznych zanieczyszczeń serii produkcyjnej lewosimendanu, [[4-(2-azydo-3-metylo-5-oksotetrahydrofuran-2-ylo)fenylo]hydrazono]-propanodinitryl, jego zastosowanie i zawierająca go kompozycja odniesienia
CN99807544A CN1129590C (zh) 1998-06-18 1999-06-18 用于左西孟旦批次分析中的参比化合物
YUP-767/00A RS49929B (sr) 1998-06-18 1999-06-18 Referentno jedinjenje za upotrebu u analizi šarži levosimendana
CA002334864A CA2334864C (en) 1998-06-18 1999-06-18 A reference compound for use in the analysis of levosimendan batches
EA200100055A EA002854B1 (ru) 1998-06-18 1999-06-18 Эталонное соединение, применимое для анализа партий левозимендана
MXPA00012436A MXPA00012436A (es) 1998-06-18 1999-06-18 Un compuesto de referencia para utilizarse en el analisis de lotes de levosimendan.
DE69912604T DE69912604D1 (de) 1998-06-18 1999-06-18 Eine referenzverbindung zur verwendung in der analyse von levosimendan-chargen
PCT/FI1999/000539 WO1999065888A2 (en) 1998-06-18 1999-06-18 A reference compound for use in the analysis of levosimendan batches
EP99931312A EP1087956B1 (en) 1998-06-18 1999-06-18 A reference compound for use in the analysis of levosimendan batches
NZ508557A NZ508557A (en) 1998-06-18 1999-06-18 The reference compound [[4-(2-azido-3-methyl-5-oxotetrahydrofuran-2-yl)phenyl]hydrazono]propanedinitrile and its use as a reference compound in the determination of potentially genotoxic impurities in samples of a levosimendan batch
IL13996499A IL139964A (en) 1998-06-18 1999-06-18 Reference compound for use in the analysis of levosimendan batches
CZ20004555A CZ298659B6 (cs) 1998-06-18 1999-06-18 ((4-(2-Azido-3-methyl-5-oxotetrahydrofuran-2-yl)fenyl)hydrazono)propandinitril a zpusob a referencní prípravek pro stanovení potenciálne genotoxických necistot ve vzorcích šarže levosimendanu s jeho použitím
AU47863/99A AU755699B2 (en) 1998-06-18 1999-06-18 A reference compound for use in the analysis of levosimendan batches
AT99931312T ATE253566T1 (de) 1998-06-18 1999-06-18 Eine referenzverbindung zur verwendung in der analyse von levosimendan-chargen
SK1872-2000A SK284353B6 (sk) 1998-06-18 1999-06-18 Referenčná zlúčenina na použitie v analýze šarží levosimendanu
ES99931312T ES2211113T3 (es) 1998-06-18 1999-06-18 Compuesto de referencia de utilidad en el analisis de lotes de levosimendan.
KR1020007014413A KR100661772B1 (ko) 1998-06-18 1999-06-18 레보시멘단 배취 분석용 기준 화합물
JP2000554714A JP4550279B2 (ja) 1998-06-18 1999-06-18 レボシメンダンバッチの分析に用いるための対照化合物
HU0102020A HU229582B1 (en) 1998-06-18 1999-06-18 Compound for use as a reference in the analysis of levosimendan samples
IDW20010086A ID29239A (id) 1998-06-18 1999-06-18 Satu senyawa referensi untuk digunakan dalam analisa kumpulan-kumpulan levosimendan
BR9911230-2A BR9911230A (pt) 1998-06-18 1999-06-18 Composto de referência para uso na análise de bateladas de levosimendan
US09/719,806 US6340764B1 (en) 1998-06-18 1999-06-18 Reference compound for use in the analysis of levosimendan batches
ZA200006993A ZA200006993B (en) 1998-06-18 2000-11-28 A reference compound for use in the analysis of levosimendan batches.
HR20000866A HRP20000866B1 (en) 1998-06-18 2000-12-15 A reference compound for use in the analysis of levosimendan batches
NO20006444A NO325393B1 (no) 1998-06-18 2000-12-15 Forbindelse, referansepreparat som inneholder forbindelsen, anvendelse av forbindelsen til a bestemme genotoksiske urenheter og fremgangsmater derav
HK01103183A HK1032779A1 (en) 1998-06-18 2001-05-05 A reference compound for use in the analysis of levosimendan batches

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI981428A FI104718B (fi) 1998-06-18 1998-06-18 [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä

Publications (3)

Publication Number Publication Date
FI981428A0 FI981428A0 (fi) 1998-06-18
FI981428A FI981428A (fi) 1999-12-19
FI104718B true FI104718B (fi) 2000-03-31

Family

ID=8552039

Family Applications (1)

Application Number Title Priority Date Filing Date
FI981428A FI104718B (fi) 1998-06-18 1998-06-18 [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä

Country Status (28)

Country Link
US (1) US6340764B1 (es)
EP (1) EP1087956B1 (es)
JP (1) JP4550279B2 (es)
KR (1) KR100661772B1 (es)
CN (1) CN1129590C (es)
AR (1) AR018879A1 (es)
AT (1) ATE253566T1 (es)
AU (1) AU755699B2 (es)
BR (1) BR9911230A (es)
CA (1) CA2334864C (es)
CZ (1) CZ298659B6 (es)
DE (1) DE69912604D1 (es)
EA (1) EA002854B1 (es)
ES (1) ES2211113T3 (es)
FI (1) FI104718B (es)
HK (1) HK1032779A1 (es)
HR (1) HRP20000866B1 (es)
HU (1) HU229582B1 (es)
ID (1) ID29239A (es)
IL (1) IL139964A (es)
MX (1) MXPA00012436A (es)
NO (1) NO325393B1 (es)
NZ (1) NZ508557A (es)
PL (1) PL201772B1 (es)
RS (1) RS49929B (es)
SK (1) SK284353B6 (es)
WO (1) WO1999065888A2 (es)
ZA (1) ZA200006993B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105751A1 (en) 2004-04-21 2005-11-10 Teva Pharmaceutical Industries Ltd. Processes for preparing montelukast sodium
FR2877013A1 (fr) * 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
EP1904448B1 (en) * 2005-07-05 2011-02-02 Teva Pharmaceutical Industries, Ltd. Purification of montelukast
CN104230816B (zh) * 2014-09-19 2017-02-15 成都新恒创药业有限公司 一种左西孟旦潜在基因毒性杂质及其制备、检测方法
CN104478809B (zh) * 2014-11-14 2016-08-17 成都新恒创药业有限公司 一种左西孟旦杂质及其制备和检测方法
CN105817632A (zh) * 2015-01-09 2016-08-03 中国科学院宁波材料技术与工程研究所 片状粉末的制备装置及方法
CN105784895B (zh) * 2015-10-30 2018-05-22 成都欣捷高新技术开发有限公司 一种用高效液相色谱仪检测左西孟旦中杂质的方法
CN111474289A (zh) * 2019-10-31 2020-07-31 武汉嘉诺康医药技术有限公司 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法
AU2020408323A1 (en) 2019-12-16 2022-08-11 Tenax Therapeutics, Inc. Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (PH-HF-pEF)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB383449A (en) * 1931-12-12 1932-11-17 Percy Charles Barton Improvements relating to masts, poles, or like supports and their manufacture
GB565546A (en) * 1943-04-13 1944-11-15 Leslie Frederick Reeve A pneumatically operated pickup unit for use in electric organs and the like
FI894035A (fi) * 1988-09-07 1990-03-08 Orion Yhtymae Oy Foerfarande foer framstaellning av nya substituerade pyridazinoner.
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB2266841A (en) * 1992-05-06 1993-11-17 Orion Yhtymae Oy Compounds for use as anti-ischemic medicaments
GB9606474D0 (en) 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
GB9614098D0 (en) * 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
GB9915179D0 (en) * 1999-06-29 1999-09-01 Orion Corp A method for the treatment or prevention of coronary graft vasospasm

Also Published As

Publication number Publication date
HU229582B1 (en) 2014-02-28
SK284353B6 (sk) 2005-02-04
YU76700A (sh) 2002-11-15
AU4786399A (en) 2000-01-05
HRP20000866B1 (en) 2009-02-28
PL347577A1 (en) 2002-04-08
NZ508557A (en) 2002-05-31
CA2334864A1 (en) 1999-12-23
JP2002518383A (ja) 2002-06-25
HK1032779A1 (en) 2001-08-03
HUP0102020A3 (en) 2002-04-29
PL201772B1 (pl) 2009-05-29
NO325393B1 (no) 2008-04-21
WO1999065888A3 (en) 2000-01-27
CN1306527A (zh) 2001-08-01
CA2334864C (en) 2008-01-15
CZ20004555A3 (en) 2001-05-16
CZ298659B6 (cs) 2007-12-12
DE69912604D1 (de) 2003-12-11
BR9911230A (pt) 2001-03-06
NO20006444L (no) 2000-12-15
US6340764B1 (en) 2002-01-22
ID29239A (id) 2001-08-16
FI981428A0 (fi) 1998-06-18
KR20010072622A (ko) 2001-07-31
EA002854B1 (ru) 2002-10-31
ES2211113T3 (es) 2004-07-01
HUP0102020A2 (hu) 2001-12-28
IL139964A0 (en) 2002-02-10
KR100661772B1 (ko) 2006-12-28
ATE253566T1 (de) 2003-11-15
HRP20000866A2 (en) 2001-12-31
WO1999065888A2 (en) 1999-12-23
AR018879A1 (es) 2001-12-12
RS49929B (sr) 2008-09-29
CN1129590C (zh) 2003-12-03
EA200100055A1 (ru) 2001-06-25
JP4550279B2 (ja) 2010-09-22
EP1087956B1 (en) 2003-11-05
SK18722000A3 (sk) 2001-09-11
ZA200006993B (en) 2002-02-28
AU755699B2 (en) 2002-12-19
NO20006444D0 (no) 2000-12-15
IL139964A (en) 2003-07-06
EP1087956A2 (en) 2001-04-04
FI981428A (fi) 1999-12-19
MXPA00012436A (es) 2002-06-04

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