AR018879A1 - Compuesto de [[4- (2-azido -3-metil -5- oxotetrahidrofuran -2il) -fenil] -hidrazono] propanodinitrilo de aplicacion en el analisis de cargas de levosimendan, preparaciones de referencia para la determinacion de impurezas genotoxicas utilizando dicho compuesto y metodos analiticos para la determinaci - Google Patents
Compuesto de [[4- (2-azido -3-metil -5- oxotetrahidrofuran -2il) -fenil] -hidrazono] propanodinitrilo de aplicacion en el analisis de cargas de levosimendan, preparaciones de referencia para la determinacion de impurezas genotoxicas utilizando dicho compuesto y metodos analiticos para la determinaciInfo
- Publication number
- AR018879A1 AR018879A1 ARP990102890A ARP990102890A AR018879A1 AR 018879 A1 AR018879 A1 AR 018879A1 AR P990102890 A ARP990102890 A AR P990102890A AR P990102890 A ARP990102890 A AR P990102890A AR 018879 A1 AR018879 A1 AR 018879A1
- Authority
- AR
- Argentina
- Prior art keywords
- determination
- levosimendan
- oxotetrahydrofuran
- azido
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N2030/042—Standards
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se trata de un compuesto de [[4-(2-azido-3-metil]-5-oxotetrahidrofuran-2-il)fenil]hidrozono]propanodinitrilo, de aplicacion en el análisis de cargas delevosimendan caracterizado porque tiene la formula (I) y diaestereomeros del mismo, y al uso delmi smo como compuesto de referencia en la determinacion deimpurezas potencialmente genotoxicas en muestras de levosimendan. La invencion asimismo se refiere a un método analítico para la determinacion de impurezaspotencialmente genotoxicas enmuestras d e levosimendan en donde se emplea (I) como compuesto de referencia. El levosimendan es un medicamento que resulta utilen el tratamiento de la insuficiencia cardíaca.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI981428A FI104718B (fi) | 1998-06-18 | 1998-06-18 | [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä |
Publications (1)
Publication Number | Publication Date |
---|---|
AR018879A1 true AR018879A1 (es) | 2001-12-12 |
Family
ID=8552039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990102890A AR018879A1 (es) | 1998-06-18 | 1999-06-16 | Compuesto de [[4- (2-azido -3-metil -5- oxotetrahidrofuran -2il) -fenil] -hidrazono] propanodinitrilo de aplicacion en el analisis de cargas de levosimendan, preparaciones de referencia para la determinacion de impurezas genotoxicas utilizando dicho compuesto y metodos analiticos para la determinaci |
Country Status (28)
Country | Link |
---|---|
US (1) | US6340764B1 (es) |
EP (1) | EP1087956B1 (es) |
JP (1) | JP4550279B2 (es) |
KR (1) | KR100661772B1 (es) |
CN (1) | CN1129590C (es) |
AR (1) | AR018879A1 (es) |
AT (1) | ATE253566T1 (es) |
AU (1) | AU755699B2 (es) |
BR (1) | BR9911230A (es) |
CA (1) | CA2334864C (es) |
CZ (1) | CZ298659B6 (es) |
DE (1) | DE69912604D1 (es) |
EA (1) | EA002854B1 (es) |
ES (1) | ES2211113T3 (es) |
FI (1) | FI104718B (es) |
HK (1) | HK1032779A1 (es) |
HR (1) | HRP20000866B1 (es) |
HU (1) | HU229582B1 (es) |
ID (1) | ID29239A (es) |
IL (1) | IL139964A (es) |
MX (1) | MXPA00012436A (es) |
NO (1) | NO325393B1 (es) |
NZ (1) | NZ508557A (es) |
PL (1) | PL201772B1 (es) |
RS (1) | RS49929B (es) |
SK (1) | SK284353B6 (es) |
WO (1) | WO1999065888A2 (es) |
ZA (1) | ZA200006993B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA06012220A (es) | 2004-04-21 | 2007-07-18 | Teva Pharma | Procesos para preparar sodio de montelukast. |
FR2877013A1 (fr) * | 2004-10-27 | 2006-04-28 | Assist Publ Hopitaux De Paris | Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez |
US7812168B2 (en) * | 2005-07-05 | 2010-10-12 | Teva Pharmaceutical Industries Ltd. | Purification of montelukast |
CN104230816B (zh) * | 2014-09-19 | 2017-02-15 | 成都新恒创药业有限公司 | 一种左西孟旦潜在基因毒性杂质及其制备、检测方法 |
CN104478809B (zh) * | 2014-11-14 | 2016-08-17 | 成都新恒创药业有限公司 | 一种左西孟旦杂质及其制备和检测方法 |
CN105817632A (zh) * | 2015-01-09 | 2016-08-03 | 中国科学院宁波材料技术与工程研究所 | 片状粉末的制备装置及方法 |
CN105784895B (zh) * | 2015-10-30 | 2018-05-22 | 成都欣捷高新技术开发有限公司 | 一种用高效液相色谱仪检测左西孟旦中杂质的方法 |
CN111474289A (zh) * | 2019-10-31 | 2020-07-31 | 武汉嘉诺康医药技术有限公司 | 一种利用反相色谱分离分析左西孟旦中右西孟旦的方法 |
CA3161960A1 (en) | 2019-12-16 | 2021-06-24 | Tenax Therapeutics, Inc. | Levosimendan for treating pulmonary hypertension with heart failure with preserved ejection fraction (ph-hfpef) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB383449A (en) * | 1931-12-12 | 1932-11-17 | Percy Charles Barton | Improvements relating to masts, poles, or like supports and their manufacture |
GB565546A (en) * | 1943-04-13 | 1944-11-15 | Leslie Frederick Reeve | A pneumatically operated pickup unit for use in electric organs and the like |
FI894035A (fi) * | 1988-09-07 | 1990-03-08 | Orion Yhtymae Oy | Foerfarande foer framstaellning av nya substituerade pyridazinoner. |
GB8903130D0 (en) * | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
GB2251615B (en) * | 1991-01-03 | 1995-02-08 | Orion Yhtymae Oy | (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile |
GB2266841A (en) * | 1992-05-06 | 1993-11-17 | Orion Yhtymae Oy | Compounds for use as anti-ischemic medicaments |
GB9606474D0 (en) * | 1996-03-27 | 1996-06-05 | Orion Yhytmo Oy | Method for obtaining pure enantiomers of a pyridazinone derivative |
GB9614098D0 (en) * | 1996-07-05 | 1996-09-04 | Orion Yhtymae Oy | Transdermal delivery of levosimendan |
GB9915179D0 (en) * | 1999-06-29 | 1999-09-01 | Orion Corp | A method for the treatment or prevention of coronary graft vasospasm |
-
1998
- 1998-06-18 FI FI981428A patent/FI104718B/fi not_active IP Right Cessation
-
1999
- 1999-06-16 AR ARP990102890A patent/AR018879A1/es active IP Right Grant
- 1999-06-18 WO PCT/FI1999/000539 patent/WO1999065888A2/en active IP Right Grant
- 1999-06-18 EA EA200100055A patent/EA002854B1/ru not_active IP Right Cessation
- 1999-06-18 JP JP2000554714A patent/JP4550279B2/ja not_active Expired - Lifetime
- 1999-06-18 AT AT99931312T patent/ATE253566T1/de not_active IP Right Cessation
- 1999-06-18 AU AU47863/99A patent/AU755699B2/en not_active Expired
- 1999-06-18 ID IDW20010086A patent/ID29239A/id unknown
- 1999-06-18 CA CA002334864A patent/CA2334864C/en not_active Expired - Lifetime
- 1999-06-18 BR BR9911230-2A patent/BR9911230A/pt not_active Application Discontinuation
- 1999-06-18 DE DE69912604T patent/DE69912604D1/de not_active Expired - Lifetime
- 1999-06-18 ES ES99931312T patent/ES2211113T3/es not_active Expired - Lifetime
- 1999-06-18 CZ CZ20004555A patent/CZ298659B6/cs not_active IP Right Cessation
- 1999-06-18 EP EP99931312A patent/EP1087956B1/en not_active Expired - Lifetime
- 1999-06-18 HU HU0102020A patent/HU229582B1/hu unknown
- 1999-06-18 PL PL347577A patent/PL201772B1/pl unknown
- 1999-06-18 US US09/719,806 patent/US6340764B1/en not_active Expired - Lifetime
- 1999-06-18 MX MXPA00012436A patent/MXPA00012436A/es active IP Right Grant
- 1999-06-18 NZ NZ508557A patent/NZ508557A/en not_active IP Right Cessation
- 1999-06-18 RS YUP-767/00A patent/RS49929B/sr unknown
- 1999-06-18 CN CN99807544A patent/CN1129590C/zh not_active Expired - Lifetime
- 1999-06-18 IL IL13996499A patent/IL139964A/xx not_active IP Right Cessation
- 1999-06-18 SK SK1872-2000A patent/SK284353B6/sk not_active IP Right Cessation
- 1999-06-18 KR KR1020007014413A patent/KR100661772B1/ko not_active IP Right Cessation
-
2000
- 2000-11-28 ZA ZA200006993A patent/ZA200006993B/en unknown
- 2000-12-15 HR HR20000866A patent/HRP20000866B1/xx not_active IP Right Cessation
- 2000-12-15 NO NO20006444A patent/NO325393B1/no not_active IP Right Cessation
-
2001
- 2001-05-05 HK HK01103183A patent/HK1032779A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |