FI100181B - Menetelmä uusien terapeuttisesti käyttökelpoisten kinoksaliiniyhdistei den valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten kinoksaliiniyhdistei den valmistamiseksi Download PDF

Info

Publication number
FI100181B
FI100181B FI885151A FI885151A FI100181B FI 100181 B FI100181 B FI 100181B FI 885151 A FI885151 A FI 885151A FI 885151 A FI885151 A FI 885151A FI 100181 B FI100181 B FI 100181B
Authority
FI
Finland
Prior art keywords
mmol
compound
dione
hydrogen
mixture
Prior art date
Application number
FI885151A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI885151A (fi
FI885151A0 (fi
Inventor
Flemming Elmelund Nielsen
Tage Honore
Lars Naerum
Poul Jocobsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK586287A external-priority patent/DK586287D0/da
Priority claimed from DK142288A external-priority patent/DK142288D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of FI885151A0 publication Critical patent/FI885151A0/fi
Publication of FI885151A publication Critical patent/FI885151A/fi
Application granted granted Critical
Publication of FI100181B publication Critical patent/FI100181B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
FI885151A 1987-11-10 1988-11-09 Menetelmä uusien terapeuttisesti käyttökelpoisten kinoksaliiniyhdistei den valmistamiseksi FI100181B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK586287A DK586287D0 (da) 1987-11-10 1987-11-10 Quinoxalinforbindelser, deres fremstilling og anvendelse
DK586287 1987-11-10
DK142288A DK142288D0 (da) 1988-03-16 1988-03-16 Quinoxalinforbindelser, deres fremstilling og anvendelse
DK142288 1988-03-16

Publications (3)

Publication Number Publication Date
FI885151A0 FI885151A0 (fi) 1988-11-09
FI885151A FI885151A (fi) 1989-05-11
FI100181B true FI100181B (fi) 1997-10-15

Family

ID=26065733

Family Applications (1)

Application Number Title Priority Date Filing Date
FI885151A FI100181B (fi) 1987-11-10 1988-11-09 Menetelmä uusien terapeuttisesti käyttökelpoisten kinoksaliiniyhdistei den valmistamiseksi

Country Status (16)

Country Link
US (2) US4948794A (ja)
EP (1) EP0315959B1 (ja)
JP (1) JP2721520B2 (ja)
KR (1) KR970011279B1 (ja)
AT (1) ATE102192T1 (ja)
AU (1) AU618766B2 (ja)
CA (1) CA1321587C (ja)
DE (1) DE3888093T2 (ja)
ES (1) ES2061606T3 (ja)
FI (1) FI100181B (ja)
IE (1) IE64320B1 (ja)
IL (1) IL88155A0 (ja)
NO (2) NO179551C (ja)
NZ (1) NZ226916A (ja)
PH (1) PH25103A (ja)
PT (1) PT88964B (ja)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
DK716188D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
DK715888D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
DK69790D0 (da) * 1990-03-16 1990-03-16 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling af anvendelse
EP0556393B1 (en) * 1990-11-06 2000-07-26 Yamanouchi Pharmaceutical Co. Ltd. Fused pyrazine derivative
PT99864B (pt) 1990-12-21 1999-06-30 Schering Ag Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato
DK73091D0 (da) * 1991-04-22 1991-04-22 Novo Nordisk As Quinoxalinforbindelser, deres fremstilling og anvendelse
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
US5196421A (en) * 1991-06-05 1993-03-23 Eli Lilly And Company Excitatory amino acid receptor antagonists in methods for the use thereof
DK177191D0 (da) * 1991-10-23 1991-10-23 Novo Nordisk As Heterocyclic compounds and their preparation and use
US6057304A (en) * 1992-10-26 2000-05-02 Schering Aktiengesellschaft Quinoxaline-phosphonic acid derivatives
PT101004B (pt) * 1991-10-26 1999-10-29 Schering Ag Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
AU672617B2 (en) * 1992-06-22 1996-10-10 Regents Of The University Of California, The Glycine receptor antagonists and the use thereof
FR2696466B1 (fr) * 1992-10-02 1994-11-25 Rhone Poulenc Rorer Sa Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.
DK12293D0 (da) * 1993-02-02 1993-02-02 Novo Nordisk As Heterocykliske forbindelser og deres fremstilling og anvendelse
IL109397A0 (en) * 1993-04-28 1994-07-31 Schering Ag Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
DE4314592A1 (de) * 1993-04-28 1994-11-03 Schering Ag Benzo(f)chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
DE4340045A1 (de) * 1993-11-24 1995-06-01 Basf Ag Neue Chinoxaline und Arzneimittel daraus
AU688459B2 (en) * 1994-04-08 1998-03-12 Shionogi & Co., Ltd. Oxopyridinylquinoxaline derivative
DE4428152A1 (de) * 1994-06-22 1996-01-04 Basf Ag Neue Amido-chinoxalindione, ihrer Herstellung und Verwendung
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
DE4436852A1 (de) * 1994-10-14 1996-04-18 Basf Ag Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung
DE19521058A1 (de) * 1995-06-09 1996-12-12 Basf Ag Verfahren zur Herstellung von Aromaten enthaltenden Polyetherpolyolen
DE19545251A1 (de) * 1995-11-24 1997-05-28 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19624808A1 (de) 1996-06-21 1998-01-02 Basf Ag Pyrrolylchinoxalindione, ihre Herstellung und Verwendung
DE59712642D1 (de) * 1996-10-24 2006-06-08 Novartis Ag Substituierte aminoalkanphosphonsäuren
US5922715A (en) * 1997-02-18 1999-07-13 American Home Products Corporation 5-aminoalkoxy-1, 4-dihydroquinoxaline-2, 3-diones
EP0963372A1 (en) * 1997-02-18 1999-12-15 American Home Products Corporation 5-aminoalkoxy-1,4-dihydroquinoxaline-2,3-diones being dopamine agonists
JP4707261B2 (ja) * 2001-05-15 2011-06-22 日本エンバイロケミカルズ株式会社 キノキサリン系化合物および工業用殺菌組成物
EP1654221A2 (en) * 2003-06-10 2006-05-10 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
EP2338492A1 (en) 2009-12-24 2011-06-29 Universidad del Pais Vasco Methods and compositions for the treatment of alzheimer
CN103237794B (zh) 2010-07-29 2016-07-06 日本化学医药株式会社 P2x4受体拮抗剂
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions
US10890033B1 (en) 2017-12-10 2021-01-12 Watson, Incorporated Kelly bar with locking feature, related system and method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3431111A (en) * 1963-06-10 1969-03-04 Eastman Kodak Co Cyanine dyes
US3992378A (en) * 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
EP0008864A1 (en) * 1978-08-15 1980-03-19 FISONS plc Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them
EP0030795A3 (en) * 1979-12-06 1981-09-09 Imperial Chemical Industries Plc Quinoxaline derivatives, processes therefor, pharmaceutical compositions, and benzene derivatives
DE3165028D1 (de) * 1980-05-09 1984-08-30 Usv Pharma Corp Triazaloquinoxalin-1,4-diones
US4659713A (en) * 1984-10-01 1987-04-21 International Minerals & Chemical Corp. Quinoxalinedione compounds useful for controlling coccidiosis
US4812458A (en) * 1986-09-16 1989-03-14 A/S Ferrosan 6,7-disubstituted-2,3-dihydroxyquinoxaline compounds, pharmaceutical compositions thereof, and their use as neuroleptics
DK146787A (da) * 1987-03-23 1988-09-24 Ferrosan Heterocykliske forbindelser, deres fremstilling og anvendelse
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser

Also Published As

Publication number Publication date
FI885151A (fi) 1989-05-11
NO884729D0 (no) 1988-10-24
PT88964A (pt) 1988-12-01
DE3888093D1 (de) 1994-04-07
NO307252B1 (no) 2000-03-06
JPH01153680A (ja) 1989-06-15
NO179551C (no) 1996-10-30
US5026704A (en) 1991-06-25
PT88964B (pt) 1993-02-26
ES2061606T3 (es) 1994-12-16
AU2494988A (en) 1989-05-11
FI885151A0 (fi) 1988-11-09
DE3888093T2 (de) 1994-06-09
KR970011279B1 (ko) 1997-07-09
KR890008113A (ko) 1989-07-08
IL88155A0 (en) 1989-06-30
NO963412L (no) 1989-05-11
NO884729L (no) 1989-05-11
EP0315959A3 (en) 1989-12-27
CA1321587C (en) 1993-08-24
US4948794A (en) 1990-08-14
EP0315959B1 (en) 1994-03-02
AU618766B2 (en) 1992-01-09
IE883209L (en) 1989-05-10
ATE102192T1 (de) 1994-03-15
PH25103A (en) 1991-02-19
NO179551B (no) 1996-07-22
EP0315959A2 (en) 1989-05-17
NZ226916A (en) 1991-01-29
IE64320B1 (en) 1995-07-26
JP2721520B2 (ja) 1998-03-04

Similar Documents

Publication Publication Date Title
FI100181B (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten kinoksaliiniyhdistei den valmistamiseksi
EP0348872B1 (en) Fused dihydroxyquinoxalines and their use as glutamate antagonists
US5955461A (en) Quinoxalinedione derivatives, their production and use in pharmaceutical agents
IL92464A (en) Quinoxaline compounds their preparation and pharmaceutical compositions containing them
EP0377112B1 (en) Quinoxaline compounds and their preparation and use
SK281518B6 (sk) Deriváty chinoxalínu, spôsob ich výroby a ich použitie v liečivách
JPH0656799A (ja) キノキサリン−２，３−（１ｈ，４ｈ）−ジオン
FI106719B (fi) Menetelmä terapeuttisesti käyttökelpoisten [1,2,4]triatsolo[4,3-a]kinoksaliini-1,4-dionien ja -4-onien valmistamiseksi
JPH06510056A (ja) 新規なイサチンオキシム誘導体類、その製造および使用
KR100304177B1 (ko) (1,2,4)트리아졸로(4,3-a)퀴녹살린화합물,이의제조방법및이를함유하는약제학적조성물_
US6197771B1 (en) Glutamate (ampa/kainate) receptor antagonists: N-substituted fused azacycloalkylquinoxalinediones
AU692524B2 (en) Imidazol {1, 2-9} quinoxalinone derivatives and the preparation and use
EP0511152A2 (en) Quinoxaline compounds, their preparation and use
DK164317B (da) Quinoxalin-2,3-dion-forbindelser, fremgangsmaade til deres fremstilling og farmaceutiske praeparater hvori forbindelserne indgaar
SK282635B6 (sk) [1,2,4]Triazolo[4,3-a]chinoxalinónové zlúčeniny, farmaceutický prostriedok, spôsob prípravy [1,2,4]triazolo[4,3-a] chinoxalinónových zlúčenín a ich použitie
JPH07324084A (ja) オキソピリジニルキノキサリン誘導体
HRP940949A2 (en) Novel quinoxalines and drugs prepared therefrom

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: NOVO NORDISK A/S