DE3888093T2 - Chinoxalinverbindungen und deren Herstellung und Verwendung. - Google Patents

Chinoxalinverbindungen und deren Herstellung und Verwendung.

Info

Publication number
DE3888093T2
DE3888093T2 DE3888093T DE3888093T DE3888093T2 DE 3888093 T2 DE3888093 T2 DE 3888093T2 DE 3888093 T DE3888093 T DE 3888093T DE 3888093 T DE3888093 T DE 3888093T DE 3888093 T2 DE3888093 T2 DE 3888093T2
Authority
DE
Germany
Prior art keywords
alkyl
halogen
hydrogen
compounds
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3888093T
Other languages
English (en)
Other versions
DE3888093D1 (de
Inventor
Tage Honore
Poul Jacobsen
Flemming Elmelund
Lars Naerum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK586287A external-priority patent/DK586287D0/da
Priority claimed from DK142288A external-priority patent/DK142288D0/da
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of DE3888093D1 publication Critical patent/DE3888093D1/de
Application granted granted Critical
Publication of DE3888093T2 publication Critical patent/DE3888093T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
    • C07D241/52—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DE3888093T 1987-11-10 1988-11-08 Chinoxalinverbindungen und deren Herstellung und Verwendung. Expired - Fee Related DE3888093T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK586287A DK586287D0 (da) 1987-11-10 1987-11-10 Quinoxalinforbindelser, deres fremstilling og anvendelse
DK142288A DK142288D0 (da) 1988-03-16 1988-03-16 Quinoxalinforbindelser, deres fremstilling og anvendelse

Publications (2)

Publication Number Publication Date
DE3888093D1 DE3888093D1 (de) 1994-04-07
DE3888093T2 true DE3888093T2 (de) 1994-06-09

Family

ID=26065733

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3888093T Expired - Fee Related DE3888093T2 (de) 1987-11-10 1988-11-08 Chinoxalinverbindungen und deren Herstellung und Verwendung.

Country Status (16)

Country Link
US (2) US4948794A (de)
EP (1) EP0315959B1 (de)
JP (1) JP2721520B2 (de)
KR (1) KR970011279B1 (de)
AT (1) ATE102192T1 (de)
AU (1) AU618766B2 (de)
CA (1) CA1321587C (de)
DE (1) DE3888093T2 (de)
ES (1) ES2061606T3 (de)
FI (1) FI100181B (de)
IE (1) IE64320B1 (de)
IL (1) IL88155A0 (de)
NO (2) NO179551C (de)
NZ (1) NZ226916A (de)
PH (1) PH25103A (de)
PT (1) PT88964B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser
DK716188D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
DK715888D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Quinoxalinforbindelser, deres fremstilling og anvendelse
DK69790D0 (da) * 1990-03-16 1990-03-16 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling af anvendelse
JP2550456B2 (ja) * 1990-11-06 1996-11-06 山之内製薬株式会社 縮合ピラジン誘導体
PT99864B (pt) 1990-12-21 1999-06-30 Schering Ag Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato
DK73091D0 (da) * 1991-04-22 1991-04-22 Novo Nordisk As Quinoxalinforbindelser, deres fremstilling og anvendelse
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
US5196421A (en) * 1991-06-05 1993-03-23 Eli Lilly And Company Excitatory amino acid receptor antagonists in methods for the use thereof
DK177191D0 (da) * 1991-10-23 1991-10-23 Novo Nordisk As Heterocyclic compounds and their preparation and use
PT101004B (pt) * 1991-10-26 1999-10-29 Schering Ag Derivados da quinoxalina, processo para a sua preparacao e composicoes farmaceuticas que os contem
US6057304A (en) 1992-10-26 2000-05-02 Schering Aktiengesellschaft Quinoxaline-phosphonic acid derivatives
DE4217952A1 (de) * 1992-05-30 1993-12-02 Basf Ag Chinoxalin-2,3(1H,4H)-dione
WO1994000124A1 (en) * 1992-06-22 1994-01-06 Eckard Weber Glycine receptor antagonists and the use thereof
FR2696466B1 (fr) * 1992-10-02 1994-11-25 Rhone Poulenc Rorer Sa Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.
DK12293D0 (da) * 1993-02-02 1993-02-02 Novo Nordisk As Heterocykliske forbindelser og deres fremstilling og anvendelse
IL109397A0 (en) * 1993-04-28 1994-07-31 Schering Ag Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
DE4314592A1 (de) * 1993-04-28 1994-11-03 Schering Ag Benzo(f)chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
US5631373A (en) * 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
DE4340045A1 (de) * 1993-11-24 1995-06-01 Basf Ag Neue Chinoxaline und Arzneimittel daraus
AU688459B2 (en) * 1994-04-08 1998-03-12 Shionogi & Co., Ltd. Oxopyridinylquinoxaline derivative
DE4428152A1 (de) * 1994-06-22 1996-01-04 Basf Ag Neue Amido-chinoxalindione, ihrer Herstellung und Verwendung
US5597922A (en) * 1994-07-29 1997-01-28 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Glycine receptor antagonist pharmacophore
DE4436852A1 (de) * 1994-10-14 1996-04-18 Basf Ag Pyrrolyl-tetrahydrobenzochinoxalindione, ihre Herstellung und Verwendung
DE19521058A1 (de) * 1995-06-09 1996-12-12 Basf Ag Verfahren zur Herstellung von Aromaten enthaltenden Polyetherpolyolen
DE19545251A1 (de) * 1995-11-24 1997-05-28 Schering Ag Neue Chinoxalindionderivate, deren Herstellung und Verwendung in Arzneimitteln
DE19624808A1 (de) 1996-06-21 1998-01-02 Basf Ag Pyrrolylchinoxalindione, ihre Herstellung und Verwendung
PT934326E (pt) * 1996-10-24 2006-08-31 Novartis Ag Acidos aminoalcanofosfonicos substituidos
US5922715A (en) * 1997-02-18 1999-07-13 American Home Products Corporation 5-aminoalkoxy-1, 4-dihydroquinoxaline-2, 3-diones
EP0963372A1 (de) * 1997-02-18 1999-12-15 American Home Products Corporation 5-aminoalkoxy-1,4-dihydrochinoxalin-2,3-dione als dopamin agonsisten
JP4707261B2 (ja) * 2001-05-15 2011-06-22 日本エンバイロケミカルズ株式会社 キノキサリン系化合物および工業用殺菌組成物
JP2007500245A (ja) * 2003-06-10 2007-01-11 スミスクライン ビーチャム コーポレーション 化合物
EP2338492A1 (de) 2009-12-24 2011-06-29 Universidad del Pais Vasco Verfahren und Zusammensetzung zur Behandlung von Alzheimer
CN103237794B (zh) 2010-07-29 2016-07-06 日本化学医药株式会社 P2x4受体拮抗剂
EP3427729A1 (de) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid zur behandlung von epileptischen erkrankungen, störungen oder zuständen
US10890033B1 (en) 2017-12-10 2021-01-12 Watson, Incorporated Kelly bar with locking feature, related system and method

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3431111A (en) * 1963-06-10 1969-03-04 Eastman Kodak Co Cyanine dyes
US3992378A (en) * 1973-12-26 1976-11-16 Eli Lilly And Company Fluoralkyl quinoxadinediones
EP0008864A1 (de) * 1978-08-15 1980-03-19 FISONS plc Pyridopyrazin- und Chinoxalinderivate, Verfahren zu ihrer Herstellung, und sie enthaltende pharmazeutische Zusammensetzungen
EP0030795A3 (de) * 1979-12-06 1981-09-09 Imperial Chemical Industries Plc Chinoxalinderivate, Verfahren zu ihrer Herstellung, pharmazeutische Zusammensetzungen und Benzenderivate
DE3165028D1 (de) * 1980-05-09 1984-08-30 Usv Pharma Corp Triazaloquinoxalin-1,4-diones
US4659713A (en) * 1984-10-01 1987-04-21 International Minerals & Chemical Corp. Quinoxalinedione compounds useful for controlling coccidiosis
US4812458A (en) * 1986-09-16 1989-03-14 A/S Ferrosan 6,7-disubstituted-2,3-dihydroxyquinoxaline compounds, pharmaceutical compositions thereof, and their use as neuroleptics
DK146787A (da) * 1987-03-23 1988-09-24 Ferrosan Heterocykliske forbindelser, deres fremstilling og anvendelse
NO179551C (no) * 1987-11-10 1996-10-30 Novo Nordisk As Analogifremgangsmåte for fremstilling av terapeutisk virksomme kinoxalinforbindelser

Also Published As

Publication number Publication date
US5026704A (en) 1991-06-25
US4948794A (en) 1990-08-14
DE3888093D1 (de) 1994-04-07
NO963412L (no) 1989-05-11
EP0315959A2 (de) 1989-05-17
NO307252B1 (no) 2000-03-06
ES2061606T3 (es) 1994-12-16
IE883209L (en) 1989-05-10
FI885151A0 (fi) 1988-11-09
FI885151A (fi) 1989-05-11
JP2721520B2 (ja) 1998-03-04
PT88964A (pt) 1988-12-01
AU2494988A (en) 1989-05-11
CA1321587C (en) 1993-08-24
IE64320B1 (en) 1995-07-26
NO179551B (no) 1996-07-22
EP0315959A3 (en) 1989-12-27
PH25103A (en) 1991-02-19
JPH01153680A (ja) 1989-06-15
AU618766B2 (en) 1992-01-09
NO884729L (no) 1989-05-11
EP0315959B1 (de) 1994-03-02
NO179551C (no) 1996-10-30
NZ226916A (en) 1991-01-29
FI100181B (fi) 1997-10-15
PT88964B (pt) 1993-02-26
KR970011279B1 (ko) 1997-07-09
NO884729D0 (no) 1988-10-24
IL88155A0 (en) 1989-06-30
KR890008113A (ko) 1989-07-08
ATE102192T1 (de) 1994-03-15

Similar Documents

Publication Publication Date Title
DE3888093D1 (de) Chinoxalinverbindungen und deren Herstellung und Verwendung.
DE68916626D1 (de) Chinoxalin-Verbindungen, ihre Herstellung und Verwendung.
DE68917708T2 (de) Chinoxalin-Verbindungen, ihre Herstellung und Verwendung.
DE3788612D1 (de) Chinoxalin-Verbindungen und deren Herstellung und Verwendung.
FI862062A0 (fi) Foerfarande foer framstaellning av oxadiazolyl-imidazobensodiazepinfoereningar.
DK620688A (da) Quinoxalinforbindelser, deres fremstilling og anvendelse

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee