ES8700249A1 - Procedimiento para preparar derivados de acido 4-fenil-1,3-dioxan-cis-5-ilalquenoico - Google Patents

Procedimiento para preparar derivados de acido 4-fenil-1,3-dioxan-cis-5-ilalquenoico

Info

Publication number
ES8700249A1
ES8700249A1 ES528575A ES528575A ES8700249A1 ES 8700249 A1 ES8700249 A1 ES 8700249A1 ES 528575 A ES528575 A ES 528575A ES 528575 A ES528575 A ES 528575A ES 8700249 A1 ES8700249 A1 ES 8700249A1
Authority
ES
Spain
Prior art keywords
optionally substituted
dioxan
txa2
hydroxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528575A
Other languages
English (en)
Other versions
ES528575A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES528575A0 publication Critical patent/ES528575A0/es
Publication of ES8700249A1 publication Critical patent/ES8700249A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DEL ACIDO 4-HIDROXIFENIL-1,3-DIOXAN-CIS-5-ILALQUENOICO DE FORMULA (I) EN DONDE RA Y RB SON AMBOS HIDROGENO, METILO, ETILO O TRIFLUORMETILO (O RA ES TRIFLUORMETILO, CLOROMETILO, 2-CLOROETILO O PENTAFLUORFENILO Y RB ES HIDROGENO), RC ES HIDROXI, METANOSULFONAMIDO O ETANOSULFONAMIDO, N ESA 1, A ES VINILENO, Y ES TRIMETILENO, EL ANILLO BENCENICO B LLEVA UN SUSTITUYENTE HIDROXI Y LOS SUSTITUYENTES EN LAS POSICIONES 4 Y 5 DEL ANILLO DIOXANO ESTAN EN POSICION CIS-RELATIVA. CONSISTE EN DESPROTEGER EL DERIVADO CORRESPONDIENTE DEL COMPUESTO (I), EN EL QUE EL SUSTITUYENTE HIDROXI DEL ANILLO BENCENICO ESTA PROTEGIDO POR UN GRUPO TRIMETILSILILO, ALQUILO O ACILO, METOXI O ETOXI, POR REACCION CON METANO- O ETANO-SULFONAMIDA O UNA SAL ALCALINA DE LA MISMA. APLICABLES EN LA PREVENCION O EL TRATAMIENTO DE ENFERMEDADES ISQUEMICAS DEL CORAZON Y ENFERMEDADES CEREBROVASCULARES Y VASCULARES.
ES528575A 1982-05-12 1983-12-30 Procedimiento para preparar derivados de acido 4-fenil-1,3-dioxan-cis-5-ilalquenoico Expired ES8700249A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8213702 1982-05-12

Publications (2)

Publication Number Publication Date
ES528575A0 ES528575A0 (es) 1986-10-16
ES8700249A1 true ES8700249A1 (es) 1986-10-16

Family

ID=10530304

Family Applications (4)

Application Number Title Priority Date Filing Date
ES522331A Expired ES8407038A1 (es) 1982-05-12 1983-05-12 Un derivado de acido 4-fenil-1,3-dioxan-cis-5-ilalquenoico.
ES528576A Expired ES8700250A1 (es) 1982-05-12 1983-12-30 Procedimiento para preparar derivados de acido 4-hidroxifenil-1,3-dioxan-cis-5-ilalquenoico
ES528575A Expired ES8700249A1 (es) 1982-05-12 1983-12-30 Procedimiento para preparar derivados de acido 4-fenil-1,3-dioxan-cis-5-ilalquenoico
ES528577A Expired ES8608507A1 (es) 1982-05-12 1983-12-30 Procedimiento para preparar acidos 4-fenil-1,3-dioxan-cis-5-ilalquenoicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES522331A Expired ES8407038A1 (es) 1982-05-12 1983-05-12 Un derivado de acido 4-fenil-1,3-dioxan-cis-5-ilalquenoico.
ES528576A Expired ES8700250A1 (es) 1982-05-12 1983-12-30 Procedimiento para preparar derivados de acido 4-hidroxifenil-1,3-dioxan-cis-5-ilalquenoico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES528577A Expired ES8608507A1 (es) 1982-05-12 1983-12-30 Procedimiento para preparar acidos 4-fenil-1,3-dioxan-cis-5-ilalquenoicos

Country Status (32)

Country Link
US (3) US4567197A (es)
EP (1) EP0094239B1 (es)
JP (1) JPS58222081A (es)
KR (1) KR880002001B1 (es)
AR (1) AR240817A1 (es)
AT (1) ATE28329T1 (es)
AU (1) AU562056B2 (es)
CA (4) CA1258464A (es)
CS (2) CS245795B2 (es)
CY (1) CY1453A (es)
DD (2) DD212515A5 (es)
DE (1) DE3372483D1 (es)
DK (1) DK163431C (es)
ES (4) ES8407038A1 (es)
FI (1) FI80027C (es)
GB (1) GB8310407D0 (es)
GR (1) GR78138B (es)
HK (1) HK17889A (es)
HU (1) HU198705B (es)
IE (1) IE55114B1 (es)
IL (1) IL68628A0 (es)
KE (1) KE3823A (es)
MW (1) MW1583A1 (es)
NO (1) NO162383B (es)
NZ (1) NZ204202A (es)
PH (1) PH21691A (es)
PL (3) PL140462B1 (es)
PT (1) PT76684B (es)
SG (1) SG57088G (es)
SU (1) SU1277893A3 (es)
ZA (1) ZA833179B (es)
ZW (1) ZW10083A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8310407D0 (en) * 1982-05-12 1983-05-25 Ici Plc 1 3 - dioxan -5- ylalkenoic acids
FR2551446B1 (fr) * 1983-08-31 1987-03-20 Elf Aquitaine Compositions de resines ayant une resistance amelioree au choc renfermant un polymere thermoplastique, un additif choc du type copolymere greffe, et eventuellement d'autres additifs, et copolymere greffe correspondant, a caractere d'additif choc
GB8330120D0 (en) * 1983-11-11 1983-12-21 Ici Plc Chemical process
GB8330097D0 (en) * 1983-11-11 1983-12-21 Ici Plc Cyclic ethers
GB8330094D0 (en) * 1983-11-11 1983-12-21 Ici Plc Diphenyl compounds
GB8417314D0 (en) * 1984-07-06 1984-08-08 Ici Plc Carboxylic acid derivatives
GB8511890D0 (en) * 1985-05-10 1985-06-19 Ici Plc Benzene derivatives
DE3685775T2 (de) * 1985-05-10 1993-01-21 Ici Plc Alkenderivate.
GB8511894D0 (en) * 1985-05-10 1985-06-19 Ici Plc Phenol derivatives
GB8511895D0 (en) * 1985-05-10 1985-06-19 Ici Plc Heterocyclic compounds
HU198706B (en) * 1985-05-10 1989-11-28 Ici Plc Process for producing 1,3-dioxan-ethers and pharmaceutical compositions containing them
GB8511892D0 (en) * 1985-05-10 1985-06-19 Ici Plc Fluoralkane derivatives
GB8511897D0 (en) * 1985-05-10 1985-06-19 Ici Plc Carboxylic acids
GB8511891D0 (en) * 1985-05-10 1985-06-19 Ici Plc Alkenoic acids
ATE56967T1 (de) * 1985-11-12 1990-10-15 Ici Plc Amidderivate.
GB8611174D0 (en) * 1986-05-08 1986-06-18 Ici Plc Amide derivatives
GB8531892D0 (en) * 1985-12-30 1986-02-05 Ici Plc Carboxylic acids
DE3603662A1 (de) * 1986-02-06 1987-08-13 Basf Ag Acetalisierte oder ketalisierte dihydroxyaldehyde, verfahren zu ihrer herstellung und diese enthaltende loesungen
GB8626296D0 (en) * 1986-11-04 1986-12-03 Ici Plc Therapeutic agents
GB8626297D0 (en) * 1986-11-04 1986-12-03 Ici Plc Pharmaceutical compositions
GB8709794D0 (en) * 1987-04-24 1987-05-28 Ici Plc Heterocyclic acids
GB8901201D0 (en) * 1988-02-16 1989-03-15 Ici Plc Pyridine derivatives
US5248780A (en) * 1988-02-16 1993-09-28 Imperial Chemical Industries, Plc Pyridyl substituted alkenoic acid derivatives
EP0346511A1 (en) * 1988-06-15 1989-12-20 Fujisawa Pharmaceutical Co., Ltd. Oxygen-containing hererocyclic compound, processes for their preparation and pharmaceutical compositions comprising them
IE81170B1 (en) * 1988-10-21 2000-05-31 Zeneca Ltd Pyridine derivatives
CN1034120C (zh) * 1988-10-21 1997-02-26 曾尼卡有限公司 制备二噁烷链烯酸衍生物的方法
GB9021571D0 (en) * 1990-10-04 1990-11-21 Ici Plc Heterocyclic acids
US5925795A (en) * 1996-09-16 1999-07-20 Zeneca Limited Processes for the preparation of aryl-β-diketones, arylpyrimidine ketones and crop protection intermediates
GB0413970D0 (en) * 2004-06-22 2004-07-28 Syngenta Participations Ag Chemical compounds
CA2637803A1 (en) * 2006-01-18 2007-12-06 Evolva Sa Ppar modulators
EP2124558A4 (en) * 2007-01-18 2010-07-14 Evolva Sa SUBSTITUTED 1, 3-DIOXANES AND THEIR USE
CA2676435C (en) * 2007-01-18 2015-03-24 Evolva Sa Substituted 1,3-dioxanes useful as ppar modulators
CA2871545A1 (en) * 2012-05-18 2013-11-21 Sanofi Benzo[1,3]dioxine derivatives and their use as lpar5 antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4243592A (en) * 1979-03-12 1981-01-06 The Upjohn Company 9,11-Dideoxy-10-oxa-TXB compounds
GB8310407D0 (en) * 1982-05-12 1983-05-25 Ici Plc 1 3 - dioxan -5- ylalkenoic acids
GB8417314D0 (en) * 1984-07-06 1984-08-08 Ici Plc Carboxylic acid derivatives

Also Published As

Publication number Publication date
EP0094239B1 (en) 1987-07-15
KR880002001B1 (ko) 1988-10-11
DK163431C (da) 1992-07-20
SU1277893A3 (ru) 1986-12-15
DD219769A5 (de) 1985-03-13
CA1268772A (en) 1990-05-08
PL140274B1 (en) 1987-04-30
CS333683A2 (en) 1985-09-17
EP0094239A3 (en) 1984-12-12
US5166377A (en) 1992-11-24
CS245783B2 (en) 1986-10-16
GR78138B (es) 1984-09-26
GB8310407D0 (en) 1983-05-25
NZ204202A (en) 1986-05-09
DK211883A (da) 1983-11-13
PL250098A1 (en) 1985-07-02
PT76684B (en) 1986-01-14
IL68628A0 (en) 1984-05-31
ES8608507A1 (es) 1986-06-16
FI831664A0 (fi) 1983-05-12
JPH0378389B2 (es) 1991-12-13
KR840004739A (ko) 1984-10-24
HU198705B (en) 1989-11-28
DK163431B (da) 1992-03-02
FI831664L (fi) 1983-11-13
ZA833179B (en) 1984-04-25
ATE28329T1 (de) 1987-08-15
FI80027C (fi) 1990-04-10
DE3372483D1 (de) 1987-08-20
PL140462B1 (en) 1987-04-30
ES522331A0 (es) 1984-08-16
NO162383B (no) 1989-09-11
PT76684A (en) 1983-06-01
CA1258464A (en) 1989-08-15
PL241920A1 (en) 1985-03-26
EP0094239A2 (en) 1983-11-16
MW1583A1 (en) 1985-02-13
CA1268771C (es) 1990-05-08
NO831679L (no) 1983-11-14
CS245795B2 (en) 1986-10-16
ES8700250A1 (es) 1986-10-16
PH21691A (en) 1988-01-13
US4745198A (en) 1988-05-17
DD212515A5 (de) 1984-08-15
IE55114B1 (en) 1990-06-06
HK17889A (en) 1989-03-10
ZW10083A1 (en) 1984-11-28
FI80027B (fi) 1989-12-29
KE3823A (en) 1988-10-21
ES8407038A1 (es) 1984-08-16
SG57088G (en) 1989-01-27
ES528575A0 (es) 1986-10-16
PL140463B1 (en) 1987-04-30
CY1453A (en) 1989-07-21
IE831005L (en) 1983-11-12
ES528577A0 (es) 1986-06-16
AU1422383A (en) 1983-11-17
ES528576A0 (es) 1986-10-16
PL250099A1 (en) 1985-07-02
US4567197A (en) 1986-01-28
DK211883D0 (da) 1983-05-11
JPS58222081A (ja) 1983-12-23
CA1268771A (en) 1990-05-08
AR240817A2 (es) 1991-02-28
AR240817A1 (es) 1991-02-28
CA1269109A (en) 1990-05-15
AU562056B2 (en) 1987-05-28
CS725784A2 (en) 1985-09-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401