AR240817A2 - Procedimiento para la fabricacion de un derivado de acido (4-fenil-1,3-dioxan-cis-5-il) alquenoico - Google Patents
Procedimiento para la fabricacion de un derivado de acido (4-fenil-1,3-dioxan-cis-5-il) alquenoicoInfo
- Publication number
- AR240817A2 AR240817A2 AR29300283A AR29300283A AR240817A2 AR 240817 A2 AR240817 A2 AR 240817A2 AR 29300283 A AR29300283 A AR 29300283A AR 29300283 A AR29300283 A AR 29300283A AR 240817 A2 AR240817 A2 AR 240817A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- nitro
- formula
- substitute
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
UN PROCEDIMIENTO PARA LA FABRICACION DE UN DERIVADO DEL ACIDO (4-FENIL-1,3-DIOXAN-CIS-5-IL) ALQUENOICO DE FORMULA (I), DONDE RA Y RB PUEDEN SER: A) H, ALQUILO O ALQUILO CON GRUPOS HALOGENOS; B) UNO DE LOS DOS ES H O ALQUILO Y EL OTRO ES BENCILO, NAFTILO, O FENILO CON SUSTITUYENTE EN POSICION 2, 3 O 4 SELECCIONADO ENTRE HALOGENO, ALQUILO, ALCOXI, ALQUILEN-DIOXI, TRIFLUORMETILO, CIANO, NITRO, HIDROXI, ALCANOIL-OXI, ALQUIL-TIO, ALCANO-SULFONILO, ALCANOIL-AMINO Y OXAPOLIMETILENO; O PENTAFLUORFENILO, O FENILO CON DOS SUSTITUYENTES HALOGENO O ALQUILO EN LAS POSICIONES 2 Y 4 O 3 Y 4; C) UNO DE LOS DOS ES H Y EL OTRO ES ALQUILO O ALQUENILO O D) JUNTOS FORMAN UN POLIMETILENO INSUSTITUIDO O CON UN SUSTITUYENTE ALQUILO, RC ES HIDROXI, ALCOXI O ALCANOSULFONAMIDO; EL ANILLO BENCENICO B ES TAL O LLEVA UN SUSTITUYENTE LOCALIZADO EN LA POSICION 2 SELECCIONADO ENTRE HALOGENO, ALQUILO, ALCOXI, HIDROXI, ALCANOILOXI, ALCANOILAMINO Y TRIFLUORMETILO, LLEVA UN SUSTITUYENTE TRIFLUORMETILO O HALOGENO EN LA POSICION 3, O EL ANILLO BENCENICO B ES 2,6-DIFLUORFENILO, 4-METILFENILO, 4-NITROFENILO O 4-FLUORFENILO; N ES 1 O 2; A ES ETILENO O VINILENO; Y ES ETILENO, TRIMETILENO O TETRAMETILENO, LOS SUSTITUYENTES EN LAS POSICIONES 4 KY 5 DEL ANILLO DIOXANO TIENEN ESTEREOQUIMICA RELATIVA CIS; O PARA AQUELLOS COMPUESTOS EN LOS QUE RC ES HIDROXI, UNA SAL DE LOS MISMOS CON UNA BASE QUE DA UN CATION FISIOLOGICAMENTE ESTABLE. EL METODO CONSISTE EN HACER REACCIONAR UN ALDEHIDO DE LA FORMULA (II) CON EL REACTIVO DE WITTIG DE LA FORMULA (III) DONDE RD ES ALQUILO Y M+ ES UN CATION DE METAL ALCALINO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8213702 | 1982-05-12 | ||
GB838310407A GB8310407D0 (en) | 1982-05-12 | 1983-04-18 | 1 3 - dioxan -5- ylalkenoic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
AR240817A2 true AR240817A2 (es) | 1991-02-28 |
AR240817A1 AR240817A1 (es) | 1991-02-28 |
Family
ID=10530304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR293002A AR240817A1 (es) | 1982-05-12 | 1983-05-12 | Procedimiento para la fabricacion de un derivado de acido (4-fenil-1,3-dioxan-cis-5-il) alquenoico |
Country Status (32)
Country | Link |
---|---|
US (3) | US4567197A (es) |
EP (1) | EP0094239B1 (es) |
JP (1) | JPS58222081A (es) |
KR (1) | KR880002001B1 (es) |
AR (1) | AR240817A1 (es) |
AT (1) | ATE28329T1 (es) |
AU (1) | AU562056B2 (es) |
CA (4) | CA1258464A (es) |
CS (2) | CS245783B2 (es) |
CY (1) | CY1453A (es) |
DD (2) | DD212515A5 (es) |
DE (1) | DE3372483D1 (es) |
DK (1) | DK163431C (es) |
ES (4) | ES522331A0 (es) |
FI (1) | FI80027C (es) |
GB (1) | GB8310407D0 (es) |
GR (1) | GR78138B (es) |
HK (1) | HK17889A (es) |
HU (1) | HU198705B (es) |
IE (1) | IE55114B1 (es) |
IL (1) | IL68628A0 (es) |
KE (1) | KE3823A (es) |
MW (1) | MW1583A1 (es) |
NO (1) | NO162383B (es) |
NZ (1) | NZ204202A (es) |
PH (1) | PH21691A (es) |
PL (3) | PL140463B1 (es) |
PT (1) | PT76684B (es) |
SG (1) | SG57088G (es) |
SU (1) | SU1277893A3 (es) |
ZA (1) | ZA833179B (es) |
ZW (1) | ZW10083A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8310407D0 (en) * | 1982-05-12 | 1983-05-25 | Ici Plc | 1 3 - dioxan -5- ylalkenoic acids |
FR2551446B1 (fr) * | 1983-08-31 | 1987-03-20 | Elf Aquitaine | Compositions de resines ayant une resistance amelioree au choc renfermant un polymere thermoplastique, un additif choc du type copolymere greffe, et eventuellement d'autres additifs, et copolymere greffe correspondant, a caractere d'additif choc |
GB8330120D0 (en) * | 1983-11-11 | 1983-12-21 | Ici Plc | Chemical process |
GB8330094D0 (en) * | 1983-11-11 | 1983-12-21 | Ici Plc | Diphenyl compounds |
GB8330097D0 (en) * | 1983-11-11 | 1983-12-21 | Ici Plc | Cyclic ethers |
GB8417314D0 (en) * | 1984-07-06 | 1984-08-08 | Ici Plc | Carboxylic acid derivatives |
GB8511891D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Alkenoic acids |
GB8511897D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Carboxylic acids |
GB8511890D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Benzene derivatives |
HU198706B (en) * | 1985-05-10 | 1989-11-28 | Ici Plc | Process for producing 1,3-dioxan-ethers and pharmaceutical compositions containing them |
GB8511894D0 (en) | 1985-05-10 | 1985-06-19 | Ici Plc | Phenol derivatives |
GB8511892D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Fluoralkane derivatives |
US4824858A (en) * | 1985-05-10 | 1989-04-25 | Imperial Chemical Industries Plc | 1,3-Dioxolane-5-yl-hexenoic acid derivatives |
GB8511895D0 (en) * | 1985-05-10 | 1985-06-19 | Ici Plc | Heterocyclic compounds |
ATE56967T1 (de) * | 1985-11-12 | 1990-10-15 | Ici Plc | Amidderivate. |
GB8611174D0 (en) * | 1986-05-08 | 1986-06-18 | Ici Plc | Amide derivatives |
GB8531892D0 (en) * | 1985-12-30 | 1986-02-05 | Ici Plc | Carboxylic acids |
DE3603662A1 (de) * | 1986-02-06 | 1987-08-13 | Basf Ag | Acetalisierte oder ketalisierte dihydroxyaldehyde, verfahren zu ihrer herstellung und diese enthaltende loesungen |
GB8626297D0 (en) * | 1986-11-04 | 1986-12-03 | Ici Plc | Pharmaceutical compositions |
GB8626296D0 (en) * | 1986-11-04 | 1986-12-03 | Ici Plc | Therapeutic agents |
GB8709794D0 (en) * | 1987-04-24 | 1987-05-28 | Ici Plc | Heterocyclic acids |
US5248780A (en) * | 1988-02-16 | 1993-09-28 | Imperial Chemical Industries, Plc | Pyridyl substituted alkenoic acid derivatives |
GB8901201D0 (en) * | 1988-02-16 | 1989-03-15 | Ici Plc | Pyridine derivatives |
EP0346511A1 (en) * | 1988-06-15 | 1989-12-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxygen-containing hererocyclic compound, processes for their preparation and pharmaceutical compositions comprising them |
IE81170B1 (en) * | 1988-10-21 | 2000-05-31 | Zeneca Ltd | Pyridine derivatives |
CN1034120C (zh) * | 1988-10-21 | 1997-02-26 | 曾尼卡有限公司 | 制备二噁烷链烯酸衍生物的方法 |
GB9021571D0 (en) * | 1990-10-04 | 1990-11-21 | Ici Plc | Heterocyclic acids |
US5925795A (en) * | 1996-09-16 | 1999-07-20 | Zeneca Limited | Processes for the preparation of aryl-β-diketones, arylpyrimidine ketones and crop protection intermediates |
GB0413970D0 (en) * | 2004-06-22 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
EP2363127A1 (en) * | 2006-01-18 | 2011-09-07 | Evolva SA | PPAR Modulators |
EP2120567A4 (en) * | 2007-01-18 | 2011-11-09 | Evolva Sa | SUBSTITUTED 1,3-DIOXANE PRODRUGS AND USES THEREOF |
US20100273824A1 (en) * | 2007-01-18 | 2010-10-28 | Evolva Sa | Substituted 1,3-dioxanes and their uses |
SI2850070T1 (en) * | 2012-05-18 | 2018-01-31 | Sanofi | Benzo (1,3) dioxin derivatives and their use as LPAR5 antagonists |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4243592A (en) * | 1979-03-12 | 1981-01-06 | The Upjohn Company | 9,11-Dideoxy-10-oxa-TXB compounds |
GB8310407D0 (en) * | 1982-05-12 | 1983-05-25 | Ici Plc | 1 3 - dioxan -5- ylalkenoic acids |
GB8417314D0 (en) * | 1984-07-06 | 1984-08-08 | Ici Plc | Carboxylic acid derivatives |
-
1983
- 1983-04-18 GB GB838310407A patent/GB8310407D0/en active Pending
- 1983-04-29 ZW ZW100/83A patent/ZW10083A1/xx unknown
- 1983-05-02 IE IE1005/83A patent/IE55114B1/en not_active IP Right Cessation
- 1983-05-04 MW MW15/83A patent/MW1583A1/xx unknown
- 1983-05-04 ZA ZA833179A patent/ZA833179B/xx unknown
- 1983-05-04 AU AU14223/83A patent/AU562056B2/en not_active Ceased
- 1983-05-06 US US06/492,247 patent/US4567197A/en not_active Expired - Fee Related
- 1983-05-09 DE DE8383302613T patent/DE3372483D1/de not_active Expired
- 1983-05-09 AT AT83302613T patent/ATE28329T1/de not_active IP Right Cessation
- 1983-05-09 HU HU831588A patent/HU198705B/hu not_active IP Right Cessation
- 1983-05-09 EP EP83302613A patent/EP0094239B1/en not_active Expired
- 1983-05-09 IL IL68628A patent/IL68628A0/xx not_active IP Right Cessation
- 1983-05-11 PL PL1983250099A patent/PL140463B1/pl unknown
- 1983-05-11 PL PL1983250098A patent/PL140462B1/pl unknown
- 1983-05-11 GR GR71324A patent/GR78138B/el unknown
- 1983-05-11 NO NO831679A patent/NO162383B/no unknown
- 1983-05-11 DK DK211883A patent/DK163431C/da not_active IP Right Cessation
- 1983-05-11 CA CA000427937A patent/CA1258464A/en not_active Expired
- 1983-05-11 SU SU833596399A patent/SU1277893A3/ru active
- 1983-05-11 NZ NZ204202A patent/NZ204202A/en unknown
- 1983-05-11 PL PL1983241920A patent/PL140274B1/pl unknown
- 1983-05-11 PH PH28883A patent/PH21691A/en unknown
- 1983-05-12 ES ES522331A patent/ES522331A0/es active Granted
- 1983-05-12 CS CS833336A patent/CS245783B2/cs unknown
- 1983-05-12 AR AR293002A patent/AR240817A1/es active
- 1983-05-12 CS CS847257A patent/CS245795B2/cs unknown
- 1983-05-12 DD DD83250869A patent/DD212515A5/de not_active IP Right Cessation
- 1983-05-12 PT PT76684A patent/PT76684B/pt not_active IP Right Cessation
- 1983-05-12 FI FI831664A patent/FI80027C/fi not_active IP Right Cessation
- 1983-05-12 JP JP58083438A patent/JPS58222081A/ja active Granted
- 1983-05-12 DD DD83264391A patent/DD219769A5/de not_active IP Right Cessation
- 1983-05-12 KR KR1019830002053A patent/KR880002001B1/ko not_active IP Right Cessation
- 1983-12-30 ES ES528577A patent/ES8608507A1/es not_active Expired
- 1983-12-30 ES ES528576A patent/ES8700250A1/es not_active Expired
- 1983-12-30 ES ES528575A patent/ES8700249A1/es not_active Expired
-
1985
- 1985-11-12 US US06/797,204 patent/US4745198A/en not_active Expired - Fee Related
-
1988
- 1988-02-09 US US07/153,928 patent/US5166377A/en not_active Expired - Fee Related
- 1988-08-18 KE KE3823A patent/KE3823A/xx unknown
- 1988-08-31 SG SG570/88A patent/SG57088G/en unknown
-
1989
- 1989-03-02 HK HK178/89A patent/HK17889A/xx unknown
- 1989-05-24 CA CA000600592A patent/CA1268772A/en not_active Expired - Fee Related
- 1989-05-24 CA CA000600591A patent/CA1268771A/en not_active Expired - Fee Related
- 1989-05-24 CA CA000600593A patent/CA1269109A/en not_active Expired - Fee Related
- 1989-07-21 CY CY1453A patent/CY1453A/xx unknown
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