ES8607308A1 - Procedimiento de preparar nuevos derivados de 1,3-dihidro-6-(1-hidroxi-2-dimetilaminometil-alil)-7-hidroxi-furo-(3,4-c)-piridina - Google Patents

Procedimiento de preparar nuevos derivados de 1,3-dihidro-6-(1-hidroxi-2-dimetilaminometil-alil)-7-hidroxi-furo-(3,4-c)-piridina

Info

Publication number
ES8607308A1
ES8607308A1 ES540080A ES540080A ES8607308A1 ES 8607308 A1 ES8607308 A1 ES 8607308A1 ES 540080 A ES540080 A ES 540080A ES 540080 A ES540080 A ES 540080A ES 8607308 A1 ES8607308 A1 ES 8607308A1
Authority
ES
Spain
Prior art keywords
pyridine derivatives
furo
same
compositions containing
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540080A
Other languages
English (en)
Other versions
ES540080A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of ES540080A0 publication Critical patent/ES540080A0/es
Publication of ES8607308A1 publication Critical patent/ES8607308A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

UN PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS DE 1,3-DIHIDRO-6-(1-HIDROXI-2-DIMETILAMINOMETIL-ALIL)-7-HIDROXI-FURO-(3,4-C)-PIRIDINA DE LA FORMULA GENERAL (I). COMPRENDE HACER REACCIONAR UN DERIVADO DE 6-FORMIL-7-BENCILOXI-FURO-(3,4-C)-PIRIDINA DE LA FORMULA (II) CON BROMURO DE 1-DIMETILAMINOMETIL-VINILMAGNESIO A EBULLICION, EN UN DISOLVENTE NO POLAR E HIDROLIZAR EL GRUPO 7-BENCILOXI DEL COMPUESTO INTERMEDIO RESULTANTE MEDIANTE TRATAMIENTO CON UN ACIDO.
ES540080A 1984-02-02 1985-02-01 Procedimiento de preparar nuevos derivados de 1,3-dihidro-6-(1-hidroxi-2-dimetilaminometil-alil)-7-hidroxi-furo-(3,4-c)-piridina Expired ES8607308A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848402740A GB8402740D0 (en) 1984-02-02 1984-02-02 Furo-(3 4-c)-pyridine derivatives

Publications (2)

Publication Number Publication Date
ES540080A0 ES540080A0 (es) 1986-05-16
ES8607308A1 true ES8607308A1 (es) 1986-05-16

Family

ID=10555953

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540080A Expired ES8607308A1 (es) 1984-02-02 1985-02-01 Procedimiento de preparar nuevos derivados de 1,3-dihidro-6-(1-hidroxi-2-dimetilaminometil-alil)-7-hidroxi-furo-(3,4-c)-piridina

Country Status (24)

Country Link
US (1) US4581362A (es)
JP (1) JPS60181088A (es)
AT (1) AT391700B (es)
BE (1) BE901545A (es)
CA (1) CA1300148C (es)
CH (1) CH663023A5 (es)
DE (1) DE3503435A1 (es)
DK (1) DK158951C (es)
DZ (1) DZ743A1 (es)
ES (1) ES8607308A1 (es)
FI (1) FI82051C (es)
FR (2) FR2559152B1 (es)
GB (1) GB8402740D0 (es)
HK (1) HK92587A (es)
IE (1) IE58229B1 (es)
IT (1) IT1200587B (es)
LU (1) LU85744A1 (es)
MA (1) MA20342A1 (es)
NL (1) NL8500241A (es)
NO (1) NO160369C (es)
OA (1) OA07947A (es)
PT (1) PT79913B (es)
SE (2) SE460903B (es)
ZA (1) ZA85508B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
GB8907480D0 (en) * 1989-04-03 1989-05-17 Scaras Societe De Conseils De Separation of insomers of furo(3,4-c)pyridine derivatives
US5130252A (en) * 1990-05-14 1992-07-14 Synthetech, Inc. Resolution of furopyridine enantiomers and synthetic precursors thereof
JPH054664A (ja) * 1991-06-21 1993-01-14 Yoozuri:Kk 運搬等用の包装体及び包装方法
ES2790358T3 (es) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular
PL3738434T3 (pl) 2011-12-28 2024-03-04 Global Blood Therapeutics, Inc. Związki pośrednie do otrzymywania podstawionych związków benzaldehydowych i sposoby ich zastosowania do zwiększania natlenienia tkanek
CA2902711C (en) 2013-03-15 2021-07-06 Global Blood Therapeutics, Inc. Substituted pyridinyl-6-methoxy-2-hydroxybenzaldehyde derivatives and pharmaceutical compositions thereof useful for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
KR20190041548A (ko) 2013-03-15 2019-04-22 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
PE20160179A1 (es) 2014-02-07 2016-05-20 Global Blood Therapeutics Inc Polimorfos cristalinos de la base libre de 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)piridin-3-il)metoxi)benzaldehido
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
TW201731509A (zh) 2015-12-04 2017-09-16 全球血液治療公司 針對２-羥基-６-（（２-（１-異丙基-１ｈ-吡唑-５-基）吡啶-３-基）甲氧基）-苯甲醛之劑量方案
AR108435A1 (es) 2016-05-12 2018-08-22 Global Blood Therapeutics Inc Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
WO2020072377A1 (en) 2018-10-01 2020-04-09 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA786269B (en) * 1977-11-25 1979-10-31 Scras New pyridine derivative,its preparation and use
IN156817B (es) * 1981-02-10 1985-11-09 Scras
GB8330517D0 (en) * 1983-11-16 1983-12-21 Scras 6-vinyl-furo-(3,4-c)pyridine derivatives
GB8330658D0 (en) * 1983-11-17 1983-12-29 Scras 7-carboxymethoxy-furo-(3,4-c)-pyridine derivatives

Also Published As

Publication number Publication date
FR2559152A1 (fr) 1985-08-09
ATA27585A (de) 1990-05-15
US4581362A (en) 1986-04-08
NO850399L (no) 1985-08-05
FR2559062B1 (fr) 1987-05-22
ZA85508B (en) 1985-11-27
ES540080A0 (es) 1986-05-16
JPH0240069B2 (es) 1990-09-10
GB8402740D0 (en) 1984-03-07
DK45585D0 (da) 1985-02-01
FR2559062A1 (fr) 1985-08-09
CA1300148C (en) 1992-05-05
CH663023A5 (fr) 1987-11-13
PT79913A (en) 1985-03-01
LU85744A1 (fr) 1985-07-24
NO160369B (no) 1989-01-02
FR2559152B1 (fr) 1987-05-22
JPS60181088A (ja) 1985-09-14
PT79913B (en) 1986-11-10
BE901545A (fr) 1985-07-22
DK158951C (da) 1990-12-31
DK45585A (da) 1985-08-03
DE3503435A1 (de) 1985-08-08
IE58229B1 (en) 1993-08-11
DE3503435C2 (es) 1991-11-07
IE850241L (en) 1985-08-02
NL8500241A (nl) 1985-09-02
OA07947A (fr) 1987-01-31
SE8500460D0 (sv) 1985-02-01
AT391700B (de) 1990-11-12
NO160369C (no) 1989-04-12
FI82051B (fi) 1990-09-28
HK92587A (en) 1987-12-11
FI850275L (fi) 1985-08-03
DK158951B (da) 1990-08-06
SE460903B (sv) 1989-12-04
FI82051C (fi) 1991-01-10
IT1200587B (it) 1989-01-27
MA20342A1 (fr) 1985-10-01
SE8500460L (sv) 1985-08-03
DZ743A1 (fr) 2004-09-13
IT8519327A0 (it) 1985-02-01
FI850275A0 (fi) 1985-01-22

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