ES8600300A1 - Procedimiento para preparar nuevos derivados de 1, 3-dihidro-6-metilfuro-(3, 4-c)-piridina - Google Patents
Procedimiento para preparar nuevos derivados de 1, 3-dihidro-6-metilfuro-(3, 4-c)-piridinaInfo
- Publication number
- ES8600300A1 ES8600300A1 ES537666A ES537666A ES8600300A1 ES 8600300 A1 ES8600300 A1 ES 8600300A1 ES 537666 A ES537666 A ES 537666A ES 537666 A ES537666 A ES 537666A ES 8600300 A1 ES8600300 A1 ES 8600300A1
- Authority
- ES
- Spain
- Prior art keywords
- furo
- derivatives
- pyridine derivatives
- carboxymethoxy
- antihistaminic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE 1,3-DIHIDRO-6-METIL-FURO-(3,4-C)-PIRIDINA.COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON BROMOACETATO DE ETILO, EN PRESENCIA DE DIMETILFORMAMIDA Y A UNA TEMPERATURA ENTRE 10 Y 70JC, PARA OBTENER UN ESTER; Y B) HIDROLIZAR EL ESTER CON HIDROXIDO SODICO, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO, A1 Y A2, H UN GRUPO HIDROXICARBONADO SATURADO O INSATURADO DE CADENA LINEAL DE C 1 A 5, UN GRUPO HETEROCICLICO DE C 6 EN EL ANILLO Y OTROS Y R H O HAL.SE UTILIZAN COMO AGENTES ANTI-HISTAMINICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838330658A GB8330658D0 (en) | 1983-11-17 | 1983-11-17 | 7-carboxymethoxy-furo-(3,4-c)-pyridine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8600300A1 true ES8600300A1 (es) | 1985-09-16 |
ES537666A0 ES537666A0 (es) | 1985-09-16 |
Family
ID=10551897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES537666A Granted ES537666A0 (es) | 1983-11-17 | 1984-11-15 | Procedimiento para preparar nuevos derivados de 1, 3-dihidro-6-metilfuro-(3, 4-c)-piridina |
Country Status (24)
Country | Link |
---|---|
US (1) | US4569938A (es) |
JP (1) | JPS60116685A (es) |
AT (1) | AT391868B (es) |
BE (1) | BE900941A (es) |
CA (1) | CA1257272A (es) |
CH (1) | CH660737A5 (es) |
DE (1) | DE3441975A1 (es) |
DK (1) | DK157932C (es) |
DZ (1) | DZ702A1 (es) |
ES (1) | ES537666A0 (es) |
FI (1) | FI80701C (es) |
FR (2) | FR2555181B1 (es) |
GB (2) | GB8330658D0 (es) |
HK (1) | HK77987A (es) |
IE (1) | IE58097B1 (es) |
IT (1) | IT1177185B (es) |
LU (1) | LU85634A1 (es) |
MA (1) | MA20263A1 (es) |
MY (1) | MY100665A (es) |
NL (1) | NL8403318A (es) |
OA (1) | OA07865A (es) |
SE (1) | SE458277B (es) |
SG (1) | SG52687G (es) |
ZA (1) | ZA848128B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8402740D0 (en) * | 1984-02-02 | 1984-03-07 | Scras | Furo-(3 4-c)-pyridine derivatives |
GB8808001D0 (en) * | 1988-04-06 | 1988-05-05 | Scras | Stereospecific preparative process for furol(3,4-c)pyridine derivatives |
GB8907480D0 (en) * | 1989-04-03 | 1989-05-17 | Scaras Societe De Conseils De | Separation of insomers of furo(3,4-c)pyridine derivatives |
US5130252A (en) * | 1990-05-14 | 1992-07-14 | Synthetech, Inc. | Resolution of furopyridine enantiomers and synthetic precursors thereof |
ES2250112T3 (es) | 1999-03-08 | 2006-04-16 | Medicure Inc. | Analogos de piridoxal para el tratamiento de trastornos causados por carencia de vitamina b6. |
CA2376029A1 (en) | 1999-07-13 | 2001-01-18 | Medicure Inc. | Use of pyridoxin derivatives for the treatment of diabetes and related complications |
WO2001013900A2 (en) * | 1999-08-24 | 2001-03-01 | Medicure International Inc. | Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds |
US7442689B2 (en) * | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
ATE293119T1 (de) | 2000-02-29 | 2005-04-15 | Medicure Int Inc | Cardioprotektive phosphonate |
AU784840B2 (en) | 2000-03-28 | 2006-07-06 | Medicure International Inc. | Treatment of cerebrovascular disease |
US6897228B2 (en) * | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
EP1299358B1 (en) | 2000-07-07 | 2007-06-13 | Medicure International Inc. | Pyridoxine and pyridoxal analogues as cardiovascular therapeutics |
US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
US20040121988A1 (en) * | 2001-03-28 | 2004-06-24 | Medicure International Inc. | Treatment of cerebrovascular disease |
US20040186077A1 (en) * | 2003-03-17 | 2004-09-23 | Medicure International Inc. | Novel heteroaryl phosphonates as cardioprotective agents |
AU2005259735A1 (en) * | 2004-07-07 | 2006-01-12 | Medicure International Inc. | Combination therapies employing platelet aggregation drugs |
US20070060549A1 (en) * | 2004-08-10 | 2007-03-15 | Friesen Albert D | Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders |
US7459468B2 (en) * | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
AU2005304220A1 (en) * | 2004-10-28 | 2006-05-18 | Medicure International Inc. | Dual antiplatelet/anticoagulant pyridoxine analogs |
US20060094749A1 (en) * | 2004-10-28 | 2006-05-04 | Medicure International Inc. | Substituted pyridoxines as anti-platelet agents |
US20070105817A1 (en) * | 2005-11-09 | 2007-05-10 | Jim Page | Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension |
AU2006317440A1 (en) * | 2005-11-28 | 2007-05-31 | Medicure International Inc. | Selected dosage for the treatment of cardiovascular and related pathologies |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT297442B (de) * | 1970-04-01 | 1972-03-27 | Unilever Nv | Verfahren zum Reinigen, Entfetten, Entzundern und Beizen von Metallen |
GB2008582B (en) * | 1977-11-25 | 1982-04-28 | Scras | Pyridine derivative |
ZA786269B (en) * | 1977-11-25 | 1979-10-31 | Scras | New pyridine derivative,its preparation and use |
IN156817B (es) * | 1981-02-10 | 1985-11-09 | Scras |
-
1983
- 1983-11-17 GB GB838330658A patent/GB8330658D0/en active Pending
-
1984
- 1984-10-17 ZA ZA848128A patent/ZA848128B/xx unknown
- 1984-10-19 GB GB08426489A patent/GB2149781B/en not_active Expired
- 1984-10-26 CH CH5127/84A patent/CH660737A5/fr not_active IP Right Cessation
- 1984-10-30 BE BE0/213925A patent/BE900941A/fr not_active IP Right Cessation
- 1984-11-01 NL NL8403318A patent/NL8403318A/nl not_active Application Discontinuation
- 1984-11-05 US US06/668,394 patent/US4569938A/en not_active Expired - Lifetime
- 1984-11-07 LU LU85634A patent/LU85634A1/fr unknown
- 1984-11-08 MA MA20487A patent/MA20263A1/fr unknown
- 1984-11-08 FI FI844383A patent/FI80701C/fi not_active IP Right Cessation
- 1984-11-14 IT IT23564/84A patent/IT1177185B/it active
- 1984-11-14 DZ DZ847329A patent/DZ702A1/fr active
- 1984-11-14 CA CA000467829A patent/CA1257272A/en not_active Expired
- 1984-11-15 ES ES537666A patent/ES537666A0/es active Granted
- 1984-11-16 DK DK545684A patent/DK157932C/da not_active IP Right Cessation
- 1984-11-16 OA OA58442A patent/OA07865A/xx unknown
- 1984-11-16 SE SE8405754A patent/SE458277B/sv not_active IP Right Cessation
- 1984-11-16 IE IE294784A patent/IE58097B1/en not_active IP Right Cessation
- 1984-11-16 DE DE19843441975 patent/DE3441975A1/de active Granted
- 1984-11-16 FR FR8417478A patent/FR2555181B1/fr not_active Expired
- 1984-11-16 FR FR8417479A patent/FR2555049B1/fr not_active Expired
- 1984-11-16 JP JP59240900A patent/JPS60116685A/ja active Granted
- 1984-11-19 AT AT0365584A patent/AT391868B/de not_active IP Right Cessation
-
1987
- 1987-06-17 SG SG52687A patent/SG52687G/en unknown
- 1987-07-01 MY MYPI87000926A patent/MY100665A/en unknown
- 1987-10-22 HK HK779/87A patent/HK77987A/xx not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20041102 |