ES8405794A1 - Procedimiento para la preparacion de nuevas piridobenzodiazepinonas - Google Patents

Procedimiento para la preparacion de nuevas piridobenzodiazepinonas

Info

Publication number
ES8405794A1
ES8405794A1 ES526556A ES526556A ES8405794A1 ES 8405794 A1 ES8405794 A1 ES 8405794A1 ES 526556 A ES526556 A ES 526556A ES 526556 A ES526556 A ES 526556A ES 8405794 A1 ES8405794 A1 ES 8405794A1
Authority
ES
Spain
Prior art keywords
compounds
methyl
pyridobenzodiazepinones
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526556A
Other languages
English (en)
Other versions
ES526556A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8405794A1 publication Critical patent/ES8405794A1/es
Publication of ES526556A0 publication Critical patent/ES526556A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PIRIDOBENZODIAZEPINONAS, DE FORMULA GENERAL (I), EN LA QUE X SIGNIFICA OXIGENO O EL GRUPO -NH; Y R SIGNIFICA UN RADICAL 1-METIL-4-PIPERIDINILO,4-METIL-1-PIPERAZINILO, 3BAB- O 3BBB-TROPANILO, EVENTUALMENTE SUSTITUIDO CON UN GRUPO METILO, Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR 5,11-DIHIDRO-6H-PIRIDO2,3-B1,4-BENZODIAZEPIN-6-ONA, CON UN DERIVADO DE ACIDO CLOROCARBONICO, DE FORMULA GENERAL (II) O CON UN ISOCIANATO DE FORMULA GENERAL: O F C F N - R, EN LAS QUE R Y X TIENEN LOS SIGNIFICADOSYA INDICADOS, EN PRESENCIA DE DISOLVENTES ORGANICOS.DE APLICACION EN FARMACIA Y MEDICINA POR SUS PROPIEDADES INHIBIDORAS DE ULCERAS.
ES526556A 1982-02-09 1983-10-19 Procedimiento para la preparacion de nuevas piridobenzodiazepinonas Granted ES526556A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823204401 DE3204401A1 (de) 1982-02-09 1982-02-09 Pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8405794A1 true ES8405794A1 (es) 1984-06-16
ES526556A0 ES526556A0 (es) 1984-06-16

Family

ID=6155156

Family Applications (2)

Application Number Title Priority Date Filing Date
ES519605A Granted ES519605A0 (es) 1982-02-09 1983-02-08 Procedimiento para la preparacion de nuevas piridobenzodiazepinonas.
ES526556A Granted ES526556A0 (es) 1982-02-09 1983-10-19 Procedimiento para la preparacion de nuevas piridobenzodiazepinonas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES519605A Granted ES519605A0 (es) 1982-02-09 1983-02-08 Procedimiento para la preparacion de nuevas piridobenzodiazepinonas.

Country Status (10)

Country Link
US (1) US4424222A (es)
EP (1) EP0085893B1 (es)
JP (1) JPS58148883A (es)
AT (1) ATE19777T1 (es)
AU (1) AU556962B2 (es)
DE (2) DE3204401A1 (es)
ES (2) ES519605A0 (es)
NZ (1) NZ203216A (es)
PH (1) PH24504A (es)
ZA (1) ZA83857B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE71097T1 (de) * 1985-06-27 1992-01-15 Thomae Gmbh Dr K In 11-stellung substituierte 5,11-dihydro-6hpyrido-(2,3-b>(1,4>benzodiazepin-6-one, verfahren zur ihrer herstellung und diese verbindungen enthaltende arzneimittel.
DE3643666A1 (de) * 1986-12-20 1988-06-30 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3820347A1 (de) * 1988-06-15 1989-12-21 Thomae Gmbh Dr K Verwendung von in 11-stellung substituierten 5,11-dihydro-6h-pyrido(2,3-b) (1,4)benzodiazepin-6-onen zur behandlung von bradycardien und bradyarrhythmien in der human- und veterinaermedizin
US8466144B2 (en) 2004-07-16 2013-06-18 Proteosys Ag Muscarinic antagonists with parp and sir modulating activity as cytoprotective agents
EP2387405A2 (en) 2009-01-13 2011-11-23 ProteoSys AG Pirenzepine as an agent in cancer treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795183B1 (de) 1968-08-20 1972-07-20 Thomae Gmbh Dr K 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel
DE2644121A1 (de) * 1976-09-30 1978-04-06 Thomae Gmbh Dr K Neue pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE2724434A1 (de) * 1977-05-31 1979-02-22 Thomae Gmbh Dr K Neue, in 11-stellung substituierte 5,11-dihydro-6h-pyrido eckige klammer auf 2,3-b eckige klammer zu eckige klammer auf 1,4 eckige klammer zu benzodiazepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
PH24504A (en) 1990-07-18
EP0085893A2 (de) 1983-08-17
DE3204401A1 (de) 1983-08-11
JPS58148883A (ja) 1983-09-05
ES8403482A1 (es) 1984-03-16
NZ203216A (en) 1985-09-13
ES519605A0 (es) 1984-03-16
EP0085893A3 (en) 1984-03-21
US4424222A (en) 1984-01-03
AU556962B2 (en) 1986-11-27
ZA83857B (en) 1984-10-31
AU1123183A (en) 1983-08-18
DE3363450D1 (en) 1986-06-19
EP0085893B1 (de) 1986-05-14
ES526556A0 (es) 1984-06-16
JPH0373550B2 (es) 1991-11-22
ATE19777T1 (de) 1986-05-15

Similar Documents

Publication Publication Date Title
ES8707732A1 (es) Procedimiento para preparar 1,2,4 triazolo 1,5-c quinazolinas
HUT38097A (en) Process for preparing substituted benzopyrans and pharmaceutical compositions containing them as active substances
ES8501390A1 (es) Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas
ES8405794A1 (es) Procedimiento para la preparacion de nuevas piridobenzodiazepinonas
ES8401946A1 (es) Procedimiento para la preparacion de sulfonilureas.
DE3378120D1 (en) Thiazaspiro derivatives, process for their preparation and pharmaceutical composition
IL86169A (en) Substituted quinoxalyl-imidazolidine-2,4-diones,processes for their preparation and pharmaceutical compositions containing them
DE3378980D1 (en) Benzazepine derivatives, process for their preparation and their use as pharmaceutical compounds
ATE23528T1 (de) +/- 2-((3,4-methylenedioxy)phenethyl)-5-((3carboxamido-4-hydroxy)-alpha-hydroxybenzyl)pyrrolidine, pharmazeutische zusammenstellungen die sie enthalten, verfahren zur herstellung und deren zwischenprodukte.
MA21434A1 (fr) Procede de preparation de derives thieno-imidazole substitues utilisables comme inhibiteurs de la secretion d'acidite gastrique.