BE901545A - Nouveaux derives de la furo-(3,4-c)-pyridine substitues en position 6, un procede pour leur preparation et compositions therapeutiques a base de ces derives. - Google Patents

Nouveaux derives de la furo-(3,4-c)-pyridine substitues en position 6, un procede pour leur preparation et compositions therapeutiques a base de ces derives.

Info

Publication number
BE901545A
BE901545A BE0/214370A BE214370A BE901545A BE 901545 A BE901545 A BE 901545A BE 0/214370 A BE0/214370 A BE 0/214370A BE 214370 A BE214370 A BE 214370A BE 901545 A BE901545 A BE 901545A
Authority
BE
Belgium
Prior art keywords
derivatives
preparation
furo
therapeutic compositions
compositions based
Prior art date
Application number
BE0/214370A
Other languages
English (en)
Inventor
A Esanu
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of BE901545A publication Critical patent/BE901545A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Nouveaux dérivés répondant à la formule générale 1, un procédé de préparation de ces corps consistant à faire réagir, dans un solvant non polaire, en proportions équimoléculaires, le dérivé formyle-6 benzyloxy-7 de formule 2 sur le bromure de diméthylaminoéthyle-1 vinylmagnésium, à l'ébullition, puis à hydrolyser le groupement benzyloxy-7 par un traitement acide pour libérer le groupement OH en position 7, les dérivés présentent une activité anti-dépressive.
BE0/214370A 1984-02-02 1985-01-22 Nouveaux derives de la furo-(3,4-c)-pyridine substitues en position 6, un procede pour leur preparation et compositions therapeutiques a base de ces derives. BE901545A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848402740A GB8402740D0 (en) 1984-02-02 1984-02-02 Furo-(3 4-c)-pyridine derivatives

Publications (1)

Publication Number Publication Date
BE901545A true BE901545A (fr) 1985-07-22

Family

ID=10555953

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214370A BE901545A (fr) 1984-02-02 1985-01-22 Nouveaux derives de la furo-(3,4-c)-pyridine substitues en position 6, un procede pour leur preparation et compositions therapeutiques a base de ces derives.

Country Status (24)

Country Link
US (1) US4581362A (fr)
JP (1) JPS60181088A (fr)
AT (1) AT391700B (fr)
BE (1) BE901545A (fr)
CA (1) CA1300148C (fr)
CH (1) CH663023A5 (fr)
DE (1) DE3503435A1 (fr)
DK (1) DK158951C (fr)
DZ (1) DZ743A1 (fr)
ES (1) ES8607308A1 (fr)
FI (1) FI82051C (fr)
FR (2) FR2559062B1 (fr)
GB (1) GB8402740D0 (fr)
HK (1) HK92587A (fr)
IE (1) IE58229B1 (fr)
IT (1) IT1200587B (fr)
LU (1) LU85744A1 (fr)
MA (1) MA20342A1 (fr)
NL (1) NL8500241A (fr)
NO (1) NO160369C (fr)
OA (1) OA07947A (fr)
PT (1) PT79913B (fr)
SE (2) SE8500460L (fr)
ZA (1) ZA85508B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
GB8907480D0 (en) * 1989-04-03 1989-05-17 Scaras Societe De Conseils De Separation of insomers of furo(3,4-c)pyridine derivatives
US5130252A (en) * 1990-05-14 1992-07-14 Synthetech, Inc. Resolution of furopyridine enantiomers and synthetic precursors thereof
JPH054664A (ja) * 1991-06-21 1993-01-14 Yoozuri:Kk 運搬等用の包装体及び包装方法
PT3738434T (pt) 2011-12-28 2023-11-13 Global Blood Therapeutics Inc Intermediários para obter compostos de benzaldeído substituído e métodos para a sua utilização no aumento da oxigenação de tecidos
ES2790358T3 (es) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
CA2902711C (fr) 2013-03-15 2021-07-06 Global Blood Therapeutics, Inc. Derives de pyridinyl-6-methoxy-2-hydroxybenzaldehyde substitues et compositions pharmaceutiques de ceux-ci pour utilisation dans la modulation de l'hemoglobine
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
SG10201802911RA (en) 2013-03-15 2018-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN111454200A (zh) 2013-03-15 2020-07-28 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
SI3102208T1 (sl) 2014-02-07 2021-07-30 Global Blood Therapeutics, Inc. Kristalinični polimorf proste baze 2-hidroksi-6-((2-(1-izopropil-1H-pirazol-5-IL)piridin-3-IL)metoksi)- benzaldehida
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
MA43373A (fr) 2015-12-04 2018-10-10 Global Blood Therapeutics Inc Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde
TWI752307B (zh) 2016-05-12 2022-01-11 美商全球血液治療公司 新穎化合物及製造化合物之方法
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA786269B (en) * 1977-11-25 1979-10-31 Scras New pyridine derivative,its preparation and use
IN156817B (fr) * 1981-02-10 1985-11-09 Scras
GB8330517D0 (en) * 1983-11-16 1983-12-21 Scras 6-vinyl-furo-(3,4-c)pyridine derivatives
GB8330658D0 (en) * 1983-11-17 1983-12-29 Scras 7-carboxymethoxy-furo-(3,4-c)-pyridine derivatives

Also Published As

Publication number Publication date
FR2559062B1 (fr) 1987-05-22
FI82051B (fi) 1990-09-28
LU85744A1 (fr) 1985-07-24
MA20342A1 (fr) 1985-10-01
FR2559152A1 (fr) 1985-08-09
OA07947A (fr) 1987-01-31
FI850275A0 (fi) 1985-01-22
PT79913B (en) 1986-11-10
ATA27585A (de) 1990-05-15
US4581362A (en) 1986-04-08
DK158951C (da) 1990-12-31
ZA85508B (en) 1985-11-27
NO160369B (no) 1989-01-02
NO160369C (no) 1989-04-12
SE8500460D0 (sv) 1985-02-01
SE8500460L (sv) 1985-08-03
IE58229B1 (en) 1993-08-11
GB8402740D0 (en) 1984-03-07
SE460903B (sv) 1989-12-04
IT1200587B (it) 1989-01-27
HK92587A (en) 1987-12-11
AT391700B (de) 1990-11-12
DK45585D0 (da) 1985-02-01
DZ743A1 (fr) 2004-09-13
FR2559062A1 (fr) 1985-08-09
DK158951B (da) 1990-08-06
IE850241L (en) 1985-08-02
CA1300148C (fr) 1992-05-05
IT8519327A0 (it) 1985-02-01
NO850399L (no) 1985-08-05
JPS60181088A (ja) 1985-09-14
JPH0240069B2 (fr) 1990-09-10
FI82051C (fi) 1991-01-10
FR2559152B1 (fr) 1987-05-22
NL8500241A (nl) 1985-09-02
DE3503435C2 (fr) 1991-11-07
CH663023A5 (fr) 1987-11-13
PT79913A (en) 1985-03-01
ES8607308A1 (es) 1986-05-16
FI850275L (fi) 1985-08-03
DE3503435A1 (de) 1985-08-08
DK45585A (da) 1985-08-03
ES540080A0 (es) 1986-05-16

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RE Patent lapsed

Owner name: SOC.CONSEILS DE RECHERCHES ET D APPLICATIONS SCIE

Effective date: 19990131