BE900942A - NOUVEAUX DERIVES DE LA VINYL-6 FURO-(3,4-c)-PYRIDINE, LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES. - Google Patents

NOUVEAUX DERIVES DE LA VINYL-6 FURO-(3,4-c)-PYRIDINE, LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES.

Info

Publication number
BE900942A
BE900942A BE0/213926A BE213926A BE900942A BE 900942 A BE900942 A BE 900942A BE 0/213926 A BE0/213926 A BE 0/213926A BE 213926 A BE213926 A BE 213926A BE 900942 A BE900942 A BE 900942A
Authority
BE
Belgium
Prior art keywords
preparation
furo
pharmaceutical compositions
pyridine derivatives
new vinyl
Prior art date
Application number
BE0/213926A
Other languages
English (en)
Inventor
A Esanu
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of BE900942A publication Critical patent/BE900942A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Abstract

Un procédé de préparation du nouveau dérivé de formule (I) consiste à faire réagir dans un solvant polaire, en proportions équimoléculaires le dérivé chlorométhl-6 benzoxy-7 de formule (II) sur la triphénylphosphine, en présence d'une quantité molaire double de diméthylformamide, à l'ébullition puis à soumettre le composé obtenu à un traitement par un acide pour libérer le groupement OH en position 7. Les dérivés présentent une action diurétique.
BE0/213926A 1983-11-16 1984-10-30 NOUVEAUX DERIVES DE LA VINYL-6 FURO-(3,4-c)-PYRIDINE, LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES. BE900942A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838330517A GB8330517D0 (en) 1983-11-16 1983-11-16 6-vinyl-furo-(3,4-c)pyridine derivatives

Publications (1)

Publication Number Publication Date
BE900942A true BE900942A (fr) 1985-02-15

Family

ID=10551816

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/213926A BE900942A (fr) 1983-11-16 1984-10-30 NOUVEAUX DERIVES DE LA VINYL-6 FURO-(3,4-c)-PYRIDINE, LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES.

Country Status (25)

Country Link
US (1) US4569939A (fr)
JP (1) JPS60112793A (fr)
AT (1) AT391867B (fr)
BE (1) BE900942A (fr)
CA (1) CA1257271A (fr)
CH (1) CH660738A5 (fr)
DE (1) DE3442035A1 (fr)
DK (1) DK157870C (fr)
DZ (1) DZ701A1 (fr)
ES (1) ES537665A0 (fr)
FI (1) FI79852C (fr)
FR (2) FR2554817B1 (fr)
GB (2) GB8330517D0 (fr)
HK (1) HK36087A (fr)
IE (1) IE58005B1 (fr)
IT (1) IT1213246B (fr)
LU (1) LU85635A1 (fr)
MA (1) MA20259A1 (fr)
MY (1) MY101721A (fr)
NL (1) NL8403353A (fr)
OA (1) OA07864A (fr)
PT (1) PT79511B (fr)
SE (1) SE458116B (fr)
SG (1) SG6687G (fr)
ZA (1) ZA848130B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8402740D0 (en) * 1984-02-02 1984-03-07 Scras Furo-(3 4-c)-pyridine derivatives
GB8422379D0 (en) * 1984-09-05 1984-10-10 Scras Derivatives
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
GB8917168D0 (en) * 1989-07-27 1989-09-13 Scras Asymmetric synthesis of furo(3,4-c)pyridine derivatives
US5130252A (en) * 1990-05-14 1992-07-14 Synthetech, Inc. Resolution of furopyridine enantiomers and synthetic precursors thereof
DE59203008D1 (de) * 1991-04-24 1995-08-31 Ciba Geigy Ag Fliessfähige wässrige Dispersionen von Polycarbonsäure-Korrosionsinhibitoren.
US6339085B1 (en) 1999-03-08 2002-01-15 The University Of Manitoba Therapeutics for cardiovascular and related diseases
US6489345B1 (en) 1999-07-13 2002-12-03 Medicure, Inc. Treatment of diabetes and related pathologies
EP1872797A3 (fr) * 1999-08-24 2008-04-02 Medicure International Inc. Traitement des pathologies cardiovasculaires et associées
JP2003525303A (ja) 2000-02-29 2003-08-26 メディキュア インターナショナル インコーポレイテッド 心臓保護ホスホン酸塩およびマロン酸塩
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
EP1278526A2 (fr) 2000-03-28 2003-01-29 Medicure International Inc. Traitement d'une maladie vasculaire cerebrale
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
ATE364595T1 (de) 2000-07-07 2007-07-15 Medicure Int Inc Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
EP1773370A1 (fr) * 2004-07-07 2007-04-18 Medicure International Inc. Polytherapies faisant intervenir des inhibiteurs d'agregation plaquettaire
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
WO2006050598A1 (fr) * 2004-10-28 2006-05-18 Medicure International Inc. Analogues de pyridoxine à double activité anti-plaquettes et anti-coagulantes
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
WO2007059631A1 (fr) * 2005-11-28 2007-05-31 Medicure International Inc. Dosage selectionne pour le traitement de pathologies cardiovasculaires et apparentees

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2008582B (en) * 1977-11-25 1982-04-28 Scras Pyridine derivative
ZA786269B (en) * 1977-11-25 1979-10-31 Scras New pyridine derivative,its preparation and use
IN156817B (fr) * 1981-02-10 1985-11-09 Scras

Also Published As

Publication number Publication date
SE8405710L (sv) 1985-05-17
IT1213246B (it) 1989-12-14
MY101721A (en) 1992-01-17
PT79511B (en) 1986-09-08
CH660738A5 (fr) 1987-06-15
FI844279L (fi) 1985-05-17
FI844279A0 (fi) 1984-11-01
DK542584D0 (da) 1984-11-15
FI79852C (fi) 1990-03-12
GB8426490D0 (en) 1984-11-28
DE3442035A1 (de) 1985-05-30
IE842930L (en) 1985-05-16
PT79511A (en) 1984-12-01
NL8403353A (nl) 1985-06-17
CA1257271A (fr) 1989-07-11
DK157870C (da) 1990-08-06
ES8600299A1 (es) 1985-09-16
HK36087A (en) 1987-05-08
FR2554719A1 (fr) 1985-05-17
IT8423565A0 (it) 1984-11-14
DK542584A (da) 1985-05-17
OA07864A (fr) 1986-11-20
FR2554817A1 (fr) 1985-05-17
GB2149782B (en) 1986-10-22
DZ701A1 (fr) 2004-09-13
ES537665A0 (es) 1985-09-16
SE458116B (sv) 1989-02-27
JPS60112793A (ja) 1985-06-19
ZA848130B (en) 1985-06-26
FR2554817B1 (fr) 1986-04-18
SG6687G (en) 1987-06-05
AT391867B (de) 1990-12-10
GB2149782A (en) 1985-06-19
FI79852B (fi) 1989-11-30
US4569939A (en) 1986-02-11
FR2554719B1 (fr) 1986-06-06
MA20259A1 (fr) 1985-07-01
SE8405710D0 (sv) 1984-11-14
DK157870B (da) 1990-02-26
GB8330517D0 (en) 1983-12-21
ATA364384A (de) 1990-06-15
LU85635A1 (fr) 1985-06-04
IE58005B1 (en) 1993-06-02
JPH0314315B2 (fr) 1991-02-26

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SOC.DE CONSEILS DE RECHERCHES ET D APPLICATIONS S

Effective date: 19981031