ES8601998A1 - Procedimiento de preparacion de derivados de 1,3-dihidro-6-metil-7-hidroxi-furo-(3,4-c)-piridina - Google Patents
Procedimiento de preparacion de derivados de 1,3-dihidro-6-metil-7-hidroxi-furo-(3,4-c)-piridinaInfo
- Publication number
- ES8601998A1 ES8601998A1 ES531285A ES531285A ES8601998A1 ES 8601998 A1 ES8601998 A1 ES 8601998A1 ES 531285 A ES531285 A ES 531285A ES 531285 A ES531285 A ES 531285A ES 8601998 A1 ES8601998 A1 ES 8601998A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- furo
- compositions containing
- same
- pyridine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GJVNMIQVQXYJCP-UHFFFAOYSA-N furo[3,4-c]pyridine Chemical class C1=NC=CC2=[C]OC=C21 GJVNMIQVQXYJCP-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- GFEZPGADIMGWOH-UHFFFAOYSA-N 6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol Chemical class CC1=NC=C2COCC2=C1O GFEZPGADIMGWOH-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003509 tertiary alcohols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8309165 | 1983-04-05 | ||
| GB838327815A GB8327815D0 (en) | 1983-10-18 | 1983-10-18 | Furo-(3 4-c)-pyridine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8601998A1 true ES8601998A1 (es) | 1985-11-01 |
| ES531285A0 ES531285A0 (es) | 1985-11-01 |
Family
ID=26285725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES531285A Granted ES531285A0 (es) | 1983-04-05 | 1984-04-04 | Procedimiento de preparacion de derivados de 1,3-dihidro-6-metil-7-hidroxi-furo-(3,4-c)-piridina |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4581363A (OSRAM) |
| JP (1) | JPS59193888A (OSRAM) |
| KR (1) | KR900005518B1 (OSRAM) |
| AU (1) | AU582113B2 (OSRAM) |
| CA (1) | CA1257269A (OSRAM) |
| CH (1) | CH660191A5 (OSRAM) |
| DE (1) | DE3412885C2 (OSRAM) |
| DK (1) | DK157931C (OSRAM) |
| DZ (1) | DZ629A1 (OSRAM) |
| EG (1) | EG18150A (OSRAM) |
| ES (1) | ES531285A0 (OSRAM) |
| FI (1) | FI76804C (OSRAM) |
| FR (2) | FR2543956B1 (OSRAM) |
| GR (1) | GR79577B (OSRAM) |
| HK (1) | HK11187A (OSRAM) |
| IE (1) | IE57424B1 (OSRAM) |
| IL (1) | IL71243A (OSRAM) |
| IN (1) | IN160104B (OSRAM) |
| IT (1) | IT1173770B (OSRAM) |
| LU (1) | LU85262A1 (OSRAM) |
| MA (1) | MA20084A1 (OSRAM) |
| MX (1) | MX167397B (OSRAM) |
| MY (1) | MY8600664A (OSRAM) |
| NL (1) | NL190328C (OSRAM) |
| NO (1) | NO161802C (OSRAM) |
| NZ (1) | NZ207552A (OSRAM) |
| OA (1) | OA07699A (OSRAM) |
| PT (1) | PT78361B (OSRAM) |
| SE (1) | SE458362B (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4735950A (en) * | 1983-04-05 | 1988-04-05 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S) | Furo-(3,4-C)-pyridine derivatives and therapeutic composition containing the same |
| GB8427218D0 (en) * | 1984-10-27 | 1984-12-05 | Scras | Pyridine derivatives |
| GB8808001D0 (en) * | 1988-04-06 | 1988-05-05 | Scras | Stereospecific preparative process for furol(3,4-c)pyridine derivatives |
| DE3990349T1 (de) * | 1988-04-06 | 1990-04-26 | Scras | Stereospezifisches verfahren zur herstellung von enantiomeren von furo(3,4-c)pyridin, so erhaltene verbindungen und therapeutische zusammensetzungen auf basis dieser verbindungen |
| GB8917168D0 (en) * | 1989-07-27 | 1989-09-13 | Scras | Asymmetric synthesis of furo(3,4-c)pyridine derivatives |
| US5130252A (en) * | 1990-05-14 | 1992-07-14 | Synthetech, Inc. | Resolution of furopyridine enantiomers and synthetic precursors thereof |
| US6043259A (en) * | 1998-07-09 | 2000-03-28 | Medicure Inc. | Treatment of cardiovascular and related pathologies |
| BR0008857A (pt) | 1999-03-08 | 2001-12-18 | Medicure Inc | Análogos de piridoxal para distúrbios da vitaminab-6 |
| US6489345B1 (en) * | 1999-07-13 | 2002-12-03 | Medicure, Inc. | Treatment of diabetes and related pathologies |
| JP2003507418A (ja) * | 1999-08-24 | 2003-02-25 | メディキュア インターナショナル インコーポレイテッド | 心血管疾患とその関連疾患の治療 |
| US7442689B2 (en) * | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
| EP1268498B1 (en) | 2000-02-29 | 2005-04-13 | Medicure International Inc. | Cardioprotective phosphonates |
| US6586414B2 (en) | 2000-03-28 | 2003-07-01 | Medicure International Inc. | Treatment of cerebrovascular disease |
| AU2001272263B2 (en) | 2000-07-07 | 2005-12-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: cardiovascular therapeutics |
| US6897228B2 (en) * | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
| US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
| US20040121988A1 (en) * | 2001-03-28 | 2004-06-24 | Medicure International Inc. | Treatment of cerebrovascular disease |
| US20040186077A1 (en) * | 2003-03-17 | 2004-09-23 | Medicure International Inc. | Novel heteroaryl phosphonates as cardioprotective agents |
| WO2006002549A1 (en) * | 2004-07-07 | 2006-01-12 | Medicure International Inc. | Combination therapies employing platelet aggregation drugs |
| US20070060549A1 (en) * | 2004-08-10 | 2007-03-15 | Friesen Albert D | Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders |
| EP1817288A4 (en) * | 2004-10-28 | 2009-08-26 | Medicure Int Inc | DUAL ANTIPLÄTTCHEN / ANTIKOAGULANS PYRIDOXINANALOGE |
| US20060094749A1 (en) * | 2004-10-28 | 2006-05-04 | Medicure International Inc. | Substituted pyridoxines as anti-platelet agents |
| US7459468B2 (en) * | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
| JP2009517411A (ja) * | 2005-11-28 | 2009-04-30 | メディキュア インターナショナル インコーポレーテッド | 心血管及び関連病状の処置のための調剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA786269B (en) * | 1977-11-25 | 1979-10-31 | Scras | New pyridine derivative,its preparation and use |
| GB2008582B (en) * | 1977-11-25 | 1982-04-28 | Scras | Pyridine derivative |
| IN156817B (OSRAM) * | 1981-02-10 | 1985-11-09 | Scras |
-
1984
- 1984-03-13 IN IN229/DEL/84A patent/IN160104B/en unknown
- 1984-03-14 IL IL71243A patent/IL71243A/xx not_active IP Right Cessation
- 1984-03-19 GR GR74143A patent/GR79577B/el unknown
- 1984-03-19 NZ NZ207552A patent/NZ207552A/en unknown
- 1984-03-21 LU LU85262A patent/LU85262A1/fr unknown
- 1984-03-21 CH CH1419/84A patent/CH660191A5/fr not_active IP Right Cessation
- 1984-03-26 US US06/593,700 patent/US4581363A/en not_active Expired - Lifetime
- 1984-03-28 FR FR8404806A patent/FR2543956B1/fr not_active Expired
- 1984-03-28 FR FR8404807A patent/FR2543829B1/fr not_active Expired
- 1984-03-30 NL NLAANVRAGE8401013,A patent/NL190328C/xx not_active IP Right Cessation
- 1984-03-30 FI FI841273A patent/FI76804C/fi not_active IP Right Cessation
- 1984-04-01 DZ DZ847143A patent/DZ629A1/fr active
- 1984-04-02 MA MA20305A patent/MA20084A1/fr unknown
- 1984-04-03 EG EG221/84A patent/EG18150A/xx active
- 1984-04-03 PT PT78361A patent/PT78361B/pt not_active IP Right Cessation
- 1984-04-03 SE SE8401841A patent/SE458362B/sv not_active IP Right Cessation
- 1984-04-04 NO NO841322A patent/NO161802C/no unknown
- 1984-04-04 AU AU26401/84A patent/AU582113B2/en not_active Ceased
- 1984-04-04 DK DK178084A patent/DK157931C/da not_active IP Right Cessation
- 1984-04-04 ES ES531285A patent/ES531285A0/es active Granted
- 1984-04-04 IE IE826/84A patent/IE57424B1/en not_active IP Right Cessation
- 1984-04-04 MX MX008342A patent/MX167397B/es unknown
- 1984-04-04 KR KR1019840001772A patent/KR900005518B1/ko not_active Expired
- 1984-04-05 CA CA000451348A patent/CA1257269A/en not_active Expired
- 1984-04-05 IT IT20396/84A patent/IT1173770B/it active
- 1984-04-05 JP JP59066853A patent/JPS59193888A/ja active Granted
- 1984-04-05 DE DE843412885A patent/DE3412885C2/de not_active Expired - Lifetime
- 1984-04-05 OA OA58272A patent/OA07699A/xx unknown
-
1986
- 1986-12-30 MY MY664/86A patent/MY8600664A/xx unknown
-
1987
- 1987-02-05 HK HK111/87A patent/HK11187A/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000601 |