ES8600938A1 - Un procedimiento para preparar el antigeno de superficie de la hepatitis b - Google Patents
Un procedimiento para preparar el antigeno de superficie de la hepatitis bInfo
- Publication number
- ES8600938A1 ES8600938A1 ES532730A ES532730A ES8600938A1 ES 8600938 A1 ES8600938 A1 ES 8600938A1 ES 532730 A ES532730 A ES 532730A ES 532730 A ES532730 A ES 532730A ES 8600938 A1 ES8600938 A1 ES 8600938A1
- Authority
- ES
- Spain
- Prior art keywords
- hepatitis
- preparation
- recombinant dna
- dna molecules
- surface antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
METODO DE PREPARACION DEL ANTIGENO DE SUPERFICIE DE LA HEPATITIS B. CONSISTE EN LA INSERCION DE CELULAS DE LEVADURA CORRESPONDIENTE A CEPAS DE S. CERAVISIAE DE UNA MOLECULA DE ADN RECOMBINANTE QUE COMPRENDE UNA SECUENCIA DE NUCLEOTIDOS QUE PUEDE CODIFICAR EL VIRUS DE LA HEPATITIS B Y UNA REGION REGULADORA DERIVADA DEL GEN ARG 3 DE LEVADURA EL CUAL PUEDE EFECTUAR LA TRANSCRIPCION DE LA SECUENCIA DEL CITADO VIRUS EN LEVADURA; CULTIVO DE LA LEVADURA Y RECOGIDA DEL VIRUS DE LA HEPATITIS B QUE SE PRODUCE. LA SECUENCIA DEL VIRUS ESTA SUSTITUIDA RESPECTO A LA REGION REGULADORA DE MODO QUE EL VIRUS SINTETIZADO POR LA EXPRESION ESTA SUSTANCIALMENTE EXENTO DE RESIDUOS DE AMINOACIDOS EXTRAÑOS. ESTE VIRUS TIENE APLICACION PARA LA PREPARACION DE VACUNAS DEL VIRUS DE LA HEPATITIS B.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41578982A | 1982-09-08 | 1982-09-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES532730A0 ES532730A0 (es) | 1985-10-16 |
ES8600938A1 true ES8600938A1 (es) | 1985-10-16 |
Family
ID=23647197
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES525439A Expired ES8506350A1 (es) | 1982-09-08 | 1983-09-07 | Un procedimiento para preparar una molecula de dna recombinante |
ES532731A Granted ES532731A0 (es) | 1982-09-08 | 1984-05-23 | Un procedimiento para preparar un vector que comprende la region reguladora arg3 de levadura y un sitio de restriccion proximo a ella |
ES532730A Expired ES8600938A1 (es) | 1982-09-08 | 1984-05-23 | Un procedimiento para preparar el antigeno de superficie de la hepatitis b |
ES532732A Expired ES8600939A1 (es) | 1982-09-08 | 1984-05-23 | Un procedimiento para preparar una vacuna para el virus de la hepatitis b |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES525439A Expired ES8506350A1 (es) | 1982-09-08 | 1983-09-07 | Un procedimiento para preparar una molecula de dna recombinante |
ES532731A Granted ES532731A0 (es) | 1982-09-08 | 1984-05-23 | Un procedimiento para preparar un vector que comprende la region reguladora arg3 de levadura y un sitio de restriccion proximo a ella |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532732A Expired ES8600939A1 (es) | 1982-09-08 | 1984-05-23 | Un procedimiento para preparar una vacuna para el virus de la hepatitis b |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0106828B1 (es) |
JP (5) | JPS5971694A (es) |
KR (1) | KR840006014A (es) |
AT (1) | ATE91718T1 (es) |
AU (4) | AU584580B2 (es) |
CA (1) | CA1222707A (es) |
CY (1) | CY1932A (es) |
DE (1) | DE3382704T2 (es) |
DK (1) | DK406483A (es) |
ES (4) | ES8506350A1 (es) |
FI (1) | FI833205A (es) |
GR (1) | GR78982B (es) |
HK (1) | HK1004570A1 (es) |
HU (1) | HU196625B (es) |
IE (1) | IE60387B1 (es) |
IL (1) | IL69202A (es) |
MA (1) | MA19895A1 (es) |
MY (1) | MY102920A (es) |
NO (1) | NO833198L (es) |
NZ (1) | NZ204952A (es) |
PT (1) | PT77265B (es) |
ZA (1) | ZA836658B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5936699A (ja) * | 1982-08-20 | 1984-02-28 | Chemo Sero Therapeut Res Inst | シヤトルベクタ− |
JPS5931799A (ja) * | 1982-08-16 | 1984-02-20 | Science & Tech Agency | B型肝炎ウイルス遺伝子を組込んだ組換えプラスミド |
WO1986007384A1 (en) * | 1985-06-03 | 1986-12-18 | Takeda Chemical Industries, Ltd. | Process for preparing hapatitis b virus surface antigen p31 |
WO1986001534A1 (en) * | 1984-09-04 | 1986-03-13 | Takeda Chemical Industries, Ltd. | Recombinant dna and its use |
WO1986003411A1 (en) * | 1984-12-12 | 1986-06-19 | Takeda Chemical Industries, Ltd. | Process for preparing novel protein |
US4683294A (en) * | 1985-04-03 | 1987-07-28 | Smith Kline Rit, S.A. | Process for the extraction and purification of proteins from culture media producing them |
DE3677851D1 (de) * | 1985-08-05 | 1991-04-11 | Merck & Co Inc | Verfahren zur steigerung der produktion von rekombinantem protein in hefearten der gattung saccharomyces. |
US4895800A (en) * | 1985-11-26 | 1990-01-23 | Phillips Petroleum Company | Yeast production of hepatitis B surface antigen |
EP0278940A3 (en) * | 1987-01-30 | 1988-12-07 | Smithkline Biologicals S.A. | Hepatitis b virus surface antigens and hybrid antigens containing them |
DE3883596T2 (de) * | 1987-03-09 | 1994-02-17 | Merck & Co Inc | Reinigung von rekombiniertem Hepatitis-B-Oberflächen-Antigen. |
NZ229260A (en) * | 1988-06-03 | 1994-02-25 | Merck & Co Inc | Hepatitis b virus, expression cassette for pre-s domain, host cells and |
US4962656A (en) * | 1989-06-30 | 1990-10-16 | The United States Of America As Represented By The United States Department Of Energy | Control and monitoring method and system for electromagnetic forming process |
LT3988B (en) | 1992-02-17 | 1996-06-25 | Fermentas Biotech Inst | Recombinant plasmides pfs19, pfps2-48 and pjlfds1 codingsynthesis of human hepatite b of surfice virus antigenes, methods fof producing thereof |
TW340132B (en) * | 1994-10-20 | 1998-09-11 | Ibm | Structure for use as an electrical interconnection means and process for preparing the same |
JP4028850B2 (ja) * | 2004-02-04 | 2007-12-26 | 株式会社名機製作所 | ディスク基板の成形用金型 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8105035A1 (es) * | 1978-12-22 | 1981-05-16 | Biogen Nv | Un metodo para producir al menos un polipeptido que muestra antigenicidad de hbv |
NZ199722A (en) * | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
GR76274B (es) * | 1981-08-04 | 1984-08-04 | Univ California | |
NZ201705A (en) * | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
GB2125047B (en) * | 1982-08-09 | 1986-02-19 | Ciba Geigy Ag | Yeast hybrid vectors and their use for the production of polypeptides |
-
1983
- 1983-07-12 AU AU16750/83A patent/AU584580B2/en not_active Ceased
- 1983-07-12 IL IL69202A patent/IL69202A/xx not_active IP Right Cessation
- 1983-07-19 NZ NZ204952A patent/NZ204952A/en unknown
- 1983-08-29 PT PT77265A patent/PT77265B/pt not_active IP Right Cessation
- 1983-08-31 GR GR72346A patent/GR78982B/el unknown
- 1983-09-06 DE DE83870090T patent/DE3382704T2/de not_active Expired - Fee Related
- 1983-09-06 KR KR1019830004194A patent/KR840006014A/ko not_active Application Discontinuation
- 1983-09-06 EP EP83870090A patent/EP0106828B1/fr not_active Expired - Lifetime
- 1983-09-06 AT AT83870090T patent/ATE91718T1/de not_active IP Right Cessation
- 1983-09-06 CY CY193283A patent/CY1932A/xx unknown
- 1983-09-07 FI FI833205A patent/FI833205A/fi not_active Application Discontinuation
- 1983-09-07 DK DK406483A patent/DK406483A/da not_active Application Discontinuation
- 1983-09-07 CA CA000436153A patent/CA1222707A/en not_active Expired
- 1983-09-07 NO NO833198A patent/NO833198L/no unknown
- 1983-09-07 MA MA20118A patent/MA19895A1/fr unknown
- 1983-09-07 IE IE209983A patent/IE60387B1/en not_active IP Right Cessation
- 1983-09-07 ZA ZA836658A patent/ZA836658B/xx unknown
- 1983-09-07 ES ES525439A patent/ES8506350A1/es not_active Expired
- 1983-09-07 JP JP58165829A patent/JPS5971694A/ja active Pending
- 1983-09-08 HU HU833136A patent/HU196625B/hu not_active IP Right Cessation
-
1984
- 1984-05-23 ES ES532731A patent/ES532731A0/es active Granted
- 1984-05-23 ES ES532730A patent/ES8600938A1/es not_active Expired
- 1984-05-23 ES ES532732A patent/ES8600939A1/es not_active Expired
-
1987
- 1987-09-29 MY MYPI87002209A patent/MY102920A/en unknown
-
1988
- 1988-05-06 AU AU15692/88A patent/AU1569288A/en not_active Abandoned
- 1988-10-05 JP JP63251724A patent/JPH02464A/ja active Pending
- 1988-10-05 JP JP63251723A patent/JPH02116A/ja active Pending
- 1988-10-05 JP JP63251725A patent/JP2522825B2/ja not_active Expired - Lifetime
-
1989
- 1989-03-14 AU AU31318/89A patent/AU3131889A/en not_active Abandoned
-
1991
- 1991-12-24 AU AU90014/91A patent/AU9001491A/en not_active Abandoned
-
1995
- 1995-09-26 JP JP7247478A patent/JP2702899B2/ja not_active Expired - Lifetime
-
1998
- 1998-04-28 HK HK98103620A patent/HK1004570A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8506350A1 (es) | Un procedimiento para preparar una molecula de dna recombinante | |
AP8600035A0 (en) | Hepatitis B surface antigen formed by recombinant DNA Techniques, vaccines, diagnostics, cell lines and methods of forming same. | |
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EP0291586A3 (en) | Recombinant hepatitis b surface antigen and vaccine containing it | |
UA27706C2 (uk) | Спосіб одержання гетерологічного поліпептиду | |
IL90035A (en) | Synthetic multimeric hepatitis b virus vaccine including both t cell and b cell determinants | |
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FI861559A (fi) | Menetelmä hepatitis B-viruksen pinta-antigeenin PreS1-PreS2-S-proteiinin koodaavan alueen koodaamia proteiineja käsittävän proteiinin valmistamiseksi sekä menetelmässä käytettävät yhdistelmä-DNA-vektorit ja -kontameerit sekä nisäkässolut | |
ES8602935A1 (es) | Un vector reversible | |
JPS6467191A (en) | Recombinant dna plasmid having integrated hepatitis b virus gene, transformed animal cell, hepatitis b viral surface antigen protein and production thereof | |
SU1380209A1 (ru) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК PUR 291-HAV 22, КОДИРУЮЩАЯ СИНТЕЗ ГИБРИДНОГО ПОЛИПЕПТИДА АНТИГЕННЫХ ДЕТЕРМИНАНТ ВИРУСА ГЕПАТИТА А С β -ГАЛАКТОЗИДАЗОЙ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970401 |