ES8600312A1 - Un procedimiento para preparacion de nuevos derivados de cefalosporina. - Google Patents
Un procedimiento para preparacion de nuevos derivados de cefalosporina.Info
- Publication number
- ES8600312A1 ES8600312A1 ES520983A ES520983A ES8600312A1 ES 8600312 A1 ES8600312 A1 ES 8600312A1 ES 520983 A ES520983 A ES 520983A ES 520983 A ES520983 A ES 520983A ES 8600312 A1 ES8600312 A1 ES 8600312A1
- Authority
- ES
- Spain
- Prior art keywords
- ethyl
- quaternary ammonium
- ammonium methyl
- cephalosporin derivatives
- substituted cephalosporin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE CEFALOSPORINA.COMPRENDE: HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN DONDE B1 ES UN GRUPO PRODUCTOR DEL CARBOXILO Y B2 UN GRUPO PROTECTOR DEL AMINO, CON UNA AMINA TERCIARIA DE FORMULA (III), PARA OBTENER UN COMPUESTO DE FORMULA (IV); Y SEPARAR TODOS LOS GRUPOS PROTECTORES Y/O CONVERTIR EL COMPUESTO DE FORMULA (IV) EN UN COMPUESTO DE FORMULA (I), EN DONDE R2 Y R3 SON METILO O ETILO, R4 ES METILO, ETILO, N-PROPILO, ISOPROPILO U OTROS, Y SUS SALES NO TOXICAS Y FARMACEUTICAMENTE ACEPTABLES.SE UTILIZAN EN EL TRATAMIENTO DE LAS INFECCIONES BACTERIANAS EN LOS ANIMALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/363,313 US4457929A (en) | 1982-03-29 | 1982-03-29 | 3-Quaternary ammonium methyl)-substituted cephalosporin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES520983A0 ES520983A0 (es) | 1985-10-01 |
ES8600312A1 true ES8600312A1 (es) | 1985-10-01 |
Family
ID=23429716
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES520983A Expired ES8600312A1 (es) | 1982-03-29 | 1983-03-25 | Un procedimiento para preparacion de nuevos derivados de cefalosporina. |
ES527661A Granted ES527661A0 (es) | 1982-03-29 | 1983-11-30 | Un procedimiento para la preparacion de nuevos derivados de cefalosporina. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES527661A Granted ES527661A0 (es) | 1982-03-29 | 1983-11-30 | Un procedimiento para la preparacion de nuevos derivados de cefalosporina. |
Country Status (33)
Country | Link |
---|---|
US (1) | US4457929A (es) |
JP (1) | JPS58198490A (es) |
KR (1) | KR900005047B1 (es) |
AT (1) | AT383129B (es) |
AU (1) | AU564971B2 (es) |
BE (1) | BE896292A (es) |
CA (1) | CA1213883A (es) |
CH (1) | CH655118A5 (es) |
CS (1) | CS264257B2 (es) |
DD (1) | DD210279A5 (es) |
DE (1) | DE3311300A1 (es) |
DK (1) | DK161024C (es) |
EG (1) | EG16029A (es) |
ES (2) | ES8600312A1 (es) |
FI (1) | FI74974C (es) |
FR (1) | FR2523973B1 (es) |
GB (1) | GB2117770B (es) |
GR (1) | GR77907B (es) |
HU (1) | HU189676B (es) |
IE (1) | IE54791B1 (es) |
IL (1) | IL68244A0 (es) |
IT (1) | IT1164634B (es) |
LU (1) | LU84717A1 (es) |
MY (1) | MY8700944A (es) |
NL (1) | NL8301053A (es) |
NZ (1) | NZ203360A (es) |
OA (1) | OA07354A (es) |
PH (1) | PH18959A (es) |
PT (1) | PT76460B (es) |
SE (1) | SE453092B (es) |
SU (3) | SU1205772A3 (es) |
YU (1) | YU43654B (es) |
ZA (1) | ZA832156B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4963542A (en) * | 1976-09-08 | 1990-10-16 | Takeda Chemical Industries, Ltd. | Cephalosporin derivatives |
US6331308B1 (en) | 1981-10-26 | 2001-12-18 | Battelle Memorial Institute | Method and apparatus for providing long term protection from intrusion by insects and other cold blooded animals |
US6099850A (en) * | 1981-10-26 | 2000-08-08 | Battelle Memorial Institute | Termite and boring insect barrier for the protection of wooden structures |
US6060076A (en) * | 1981-10-26 | 2000-05-09 | Battelle Memorial Institute | Method and apparatus for providing long term protection from intrusion by insects and other cold blooded animals |
US5925368A (en) * | 1981-10-26 | 1999-07-20 | Battelle Memorial Institute | Protection of wooden objects in direct contact with soil from pest invasion |
US4525473A (en) * | 1983-03-30 | 1985-06-25 | Bristol-Myers Company | Cephalosporins |
DE3409431A1 (de) * | 1983-10-08 | 1985-04-18 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
DE3419012A1 (de) * | 1984-05-22 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien |
GB8424692D0 (en) * | 1984-10-01 | 1984-11-07 | Glaxo Group Ltd | Chemical compounds |
EP0182210B1 (en) * | 1984-11-12 | 1991-02-27 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
EP0182633A3 (en) * | 1984-11-20 | 1987-09-02 | Ici Pharma | Cephalosporin derivatives |
US4883868A (en) * | 1984-12-27 | 1989-11-28 | Banyu Pharmaceutical Co., Ltd. | 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives |
JPH068300B2 (ja) * | 1985-08-02 | 1994-02-02 | 萬有製薬株式会社 | 新規セフアロスポリン誘導体 |
IE862850L (en) * | 1985-11-21 | 1987-05-21 | Inst Animal Health Ltd | Intermediates for the preparation of beta-lactam antibiotics |
US4814328A (en) * | 1986-03-19 | 1989-03-21 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives, and antibacterial agents |
IL84128A (en) * | 1986-10-13 | 1992-12-01 | Eisai Co Ltd | 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them |
US5244890A (en) * | 1988-06-06 | 1993-09-14 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
US6319511B1 (en) | 1989-09-01 | 2001-11-20 | Battelle Memorial Institute | Termite and boring insect barrier for the protection of wooden structures |
US6572872B2 (en) | 1989-09-01 | 2003-06-03 | Battelle Memorial Institute | Method and apparatus for providing long term protection from intrusion by insects and other cold blooded animals |
US6852328B1 (en) | 1989-09-01 | 2005-02-08 | Battelle Memorial Institute K1-53 | Method and device for protection of wooden objects proximate soil from pest invasion |
GB9107973D0 (en) * | 1991-04-15 | 1991-05-29 | Fujisawa Pharmaceutical Co | New cephem compounds and process for preparation thereof |
US5985304A (en) | 1998-02-25 | 1999-11-16 | Battelle Memorial Institute | Barrier preventing wood pest access to wooden structures |
KR100380323B1 (ko) * | 2000-01-26 | 2003-04-16 | 한국과학기술연구원 | N-메틸-n-(3-메틸-1,3-티아졸리움-2-일)아미노기를함유한 신규한 세팔로스포린 화합물 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
GB1536281A (en) * | 1975-06-09 | 1978-12-20 | Takeda Chemical Industries Ltd | Cephem compounds |
DE2760484C2 (es) * | 1976-04-14 | 1992-12-03 | Takeda Chemical Industries, Ltd., Osaka, Jp | |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
JPS5559196A (en) * | 1978-10-27 | 1980-05-02 | Glaxo Group Ltd | Cephalosporin compound |
ES485433A1 (es) * | 1978-10-27 | 1980-07-01 | Glaxo Group Ltd | Un procedimiento para la preparacion de antibioticos de ce- falosporina |
GR78245B (es) * | 1980-09-12 | 1984-09-26 | Ciba Geigy Ag |
-
1982
- 1982-03-29 US US06/363,313 patent/US4457929A/en not_active Expired - Fee Related
-
1983
- 1983-02-17 CA CA000421782A patent/CA1213883A/en not_active Expired
- 1983-02-22 NZ NZ203360A patent/NZ203360A/en unknown
- 1983-02-25 AU AU11864/83A patent/AU564971B2/en not_active Ceased
- 1983-02-25 DK DK095383A patent/DK161024C/da not_active IP Right Cessation
- 1983-03-24 NL NL8301053A patent/NL8301053A/nl not_active Application Discontinuation
- 1983-03-24 FI FI831013A patent/FI74974C/fi not_active IP Right Cessation
- 1983-03-25 KR KR1019830001218A patent/KR900005047B1/ko not_active IP Right Cessation
- 1983-03-25 IL IL68244A patent/IL68244A0/xx not_active IP Right Cessation
- 1983-03-25 YU YU716/83A patent/YU43654B/xx unknown
- 1983-03-25 OA OA57952A patent/OA07354A/xx unknown
- 1983-03-25 FR FR8304964A patent/FR2523973B1/fr not_active Expired
- 1983-03-25 ES ES520983A patent/ES8600312A1/es not_active Expired
- 1983-03-25 ZA ZA832156A patent/ZA832156B/xx unknown
- 1983-03-28 IT IT48006/83A patent/IT1164634B/it active
- 1983-03-28 DE DE19833311300 patent/DE3311300A1/de active Granted
- 1983-03-28 PT PT76460A patent/PT76460B/pt not_active IP Right Cessation
- 1983-03-28 LU LU84717A patent/LU84717A1/fr unknown
- 1983-03-28 PH PH28713A patent/PH18959A/en unknown
- 1983-03-28 HU HU831048A patent/HU189676B/hu not_active IP Right Cessation
- 1983-03-28 SU SU833568301A patent/SU1205772A3/ru active
- 1983-03-28 CH CH1711/83A patent/CH655118A5/de not_active IP Right Cessation
- 1983-03-28 GR GR70902A patent/GR77907B/el unknown
- 1983-03-28 SE SE8301726A patent/SE453092B/sv not_active IP Right Cessation
- 1983-03-28 BE BE0/210418A patent/BE896292A/fr not_active IP Right Cessation
- 1983-03-28 GB GB08308519A patent/GB2117770B/en not_active Expired
- 1983-03-28 EG EG198/83A patent/EG16029A/xx active
- 1983-03-28 IE IE687/83A patent/IE54791B1/en not_active IP Right Cessation
- 1983-03-29 AT AT0110983A patent/AT383129B/de not_active IP Right Cessation
- 1983-03-29 JP JP58051693A patent/JPS58198490A/ja active Pending
- 1983-03-29 DD DD83249303A patent/DD210279A5/de not_active IP Right Cessation
- 1983-03-29 CS CS832190A patent/CS264257B2/cs unknown
- 1983-11-30 ES ES527661A patent/ES527661A0/es active Granted
-
1984
- 1984-04-02 SU SU843720792A patent/SU1373325A3/ru active
- 1984-04-02 SU SU843721669A patent/SU1313351A3/ru active
-
1987
- 1987-12-30 MY MY944/87A patent/MY8700944A/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970303 |