CS264257B2 - Process for preparing new derivatives of cephalosporine - Google Patents

Process for preparing new derivatives of cephalosporine Download PDF

Info

Publication number
CS264257B2
CS264257B2 CS832190A CS219083A CS264257B2 CS 264257 B2 CS264257 B2 CS 264257B2 CS 832190 A CS832190 A CS 832190A CS 219083 A CS219083 A CS 219083A CS 264257 B2 CS264257 B2 CS 264257B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
formula
cephem
ethyl
carboxylate
Prior art date
Application number
CS832190A
Other languages
Czech (cs)
English (en)
Other versions
CS219083A2 (en
Inventor
Hajime Kamachi
Jun Okumura
Takayuki Naito
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CS219083A2 publication Critical patent/CS219083A2/cs
Publication of CS264257B2 publication Critical patent/CS264257B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS832190A 1982-03-29 1983-03-29 Process for preparing new derivatives of cephalosporine CS264257B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/363,313 US4457929A (en) 1982-03-29 1982-03-29 3-Quaternary ammonium methyl)-substituted cephalosporin derivatives

Publications (2)

Publication Number Publication Date
CS219083A2 CS219083A2 (en) 1988-09-16
CS264257B2 true CS264257B2 (en) 1989-06-13

Family

ID=23429716

Family Applications (1)

Application Number Title Priority Date Filing Date
CS832190A CS264257B2 (en) 1982-03-29 1983-03-29 Process for preparing new derivatives of cephalosporine

Country Status (33)

Country Link
US (1) US4457929A (es)
JP (1) JPS58198490A (es)
KR (1) KR900005047B1 (es)
AT (1) AT383129B (es)
AU (1) AU564971B2 (es)
BE (1) BE896292A (es)
CA (1) CA1213883A (es)
CH (1) CH655118A5 (es)
CS (1) CS264257B2 (es)
DD (1) DD210279A5 (es)
DE (1) DE3311300A1 (es)
DK (1) DK161024C (es)
EG (1) EG16029A (es)
ES (2) ES8600312A1 (es)
FI (1) FI74974C (es)
FR (1) FR2523973B1 (es)
GB (1) GB2117770B (es)
GR (1) GR77907B (es)
HU (1) HU189676B (es)
IE (1) IE54791B1 (es)
IL (1) IL68244A0 (es)
IT (1) IT1164634B (es)
LU (1) LU84717A1 (es)
MY (1) MY8700944A (es)
NL (1) NL8301053A (es)
NZ (1) NZ203360A (es)
OA (1) OA07354A (es)
PH (1) PH18959A (es)
PT (1) PT76460B (es)
SE (1) SE453092B (es)
SU (3) SU1205772A3 (es)
YU (1) YU43654B (es)
ZA (1) ZA832156B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963542A (en) * 1976-09-08 1990-10-16 Takeda Chemical Industries, Ltd. Cephalosporin derivatives
US6331308B1 (en) 1981-10-26 2001-12-18 Battelle Memorial Institute Method and apparatus for providing long term protection from intrusion by insects and other cold blooded animals
US6060076A (en) * 1981-10-26 2000-05-09 Battelle Memorial Institute Method and apparatus for providing long term protection from intrusion by insects and other cold blooded animals
US6099850A (en) * 1981-10-26 2000-08-08 Battelle Memorial Institute Termite and boring insect barrier for the protection of wooden structures
US5925368A (en) * 1981-10-26 1999-07-20 Battelle Memorial Institute Protection of wooden objects in direct contact with soil from pest invasion
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3409431A1 (de) * 1983-10-08 1985-04-18 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3419012A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
DE3581891D1 (de) * 1984-11-12 1991-04-04 Banyu Pharma Co Ltd Cephalosporinderivate.
EP0182633A3 (en) * 1984-11-20 1987-09-02 Ici Pharma Cephalosporin derivatives
US4883868A (en) * 1984-12-27 1989-11-28 Banyu Pharmaceutical Co., Ltd. 7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
JPH068300B2 (ja) * 1985-08-02 1994-02-02 萬有製薬株式会社 新規セフアロスポリン誘導体
IE862850L (en) * 1985-11-21 1987-05-21 Inst Animal Health Ltd Intermediates for the preparation of beta-lactam antibiotics
US4814328A (en) * 1986-03-19 1989-03-21 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, and antibacterial agents
IL84128A (en) * 1986-10-13 1992-12-01 Eisai Co Ltd 3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
US5244890A (en) * 1988-06-06 1993-09-14 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
US6852328B1 (en) 1989-09-01 2005-02-08 Battelle Memorial Institute K1-53 Method and device for protection of wooden objects proximate soil from pest invasion
US6572872B2 (en) 1989-09-01 2003-06-03 Battelle Memorial Institute Method and apparatus for providing long term protection from intrusion by insects and other cold blooded animals
US6319511B1 (en) 1989-09-01 2001-11-20 Battelle Memorial Institute Termite and boring insect barrier for the protection of wooden structures
GB9107973D0 (en) * 1991-04-15 1991-05-29 Fujisawa Pharmaceutical Co New cephem compounds and process for preparation thereof
US5985304A (en) 1998-02-25 1999-11-16 Battelle Memorial Institute Barrier preventing wood pest access to wooden structures
KR100380323B1 (ko) * 2000-01-26 2003-04-16 한국과학기술연구원 Ｎ-메틸-ｎ-(3-메틸-1,3-티아졸리움-2-일)아미노기를함유한 신규한 세팔로스포린 화합물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
GB1536281A (en) * 1975-06-09 1978-12-20 Takeda Chemical Industries Ltd Cephem compounds
DE2760484C2 (es) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
CA1131618A (en) * 1978-10-27 1982-09-14 Cynthia H. O'callaghan Cephalosporin compounds
JPS5559196A (en) * 1978-10-27 1980-05-02 Glaxo Group Ltd Cephalosporin compound
GR78245B (es) * 1980-09-12 1984-09-26 Ciba Geigy Ag

Also Published As

Publication number Publication date
GB2117770B (en) 1985-10-09
FI831013L (fi) 1983-09-30
FI831013A0 (fi) 1983-03-24
GB2117770A (en) 1983-10-19
DD210279A5 (de) 1984-06-06
GB8308519D0 (en) 1983-05-05
PT76460A (en) 1983-04-01
IE830687L (en) 1983-09-29
DK95383D0 (da) 1983-02-25
YU43654B (en) 1989-10-31
SE453092B (sv) 1988-01-11
KR840004119A (ko) 1984-10-06
AU564971B2 (en) 1987-09-03
YU71683A (en) 1986-02-28
ES520983A0 (es) 1985-10-01
DE3311300C2 (es) 1991-05-16
CH655118A5 (de) 1986-03-27
DK161024C (da) 1991-10-28
PT76460B (en) 1986-03-11
FR2523973B1 (fr) 1986-09-12
NZ203360A (en) 1985-08-16
AU1186483A (en) 1983-10-06
CA1213883A (en) 1986-11-12
GR77907B (es) 1984-09-25
CS219083A2 (en) 1988-09-16
ZA832156B (en) 1984-08-29
LU84717A1 (fr) 1983-12-05
DE3311300A1 (de) 1983-09-29
IL68244A0 (en) 1983-06-15
SU1373325A3 (ru) 1988-02-07
MY8700944A (en) 1987-12-31
ATA110983A (de) 1986-10-15
IE54791B1 (en) 1990-02-14
BE896292A (fr) 1983-09-28
HU189676B (en) 1986-07-28
SE8301726L (sv) 1983-11-25
FR2523973A1 (fr) 1983-09-30
SU1313351A3 (ru) 1987-05-23
OA07354A (fr) 1984-08-31
PH18959A (en) 1985-11-26
US4457929A (en) 1984-07-03
DK161024B (da) 1991-05-21
ES527661A0 (es) 1985-04-16
IT1164634B (it) 1987-04-15
FI74974C (fi) 1988-04-11
IT8348006A0 (it) 1983-03-28
SE8301726D0 (sv) 1983-03-28
JPS58198490A (ja) 1983-11-18
DK95383A (da) 1983-09-30
ES8504205A1 (es) 1985-04-16
EG16029A (en) 1987-03-30
ES8600312A1 (es) 1985-10-01
NL8301053A (nl) 1983-10-17
AT383129B (de) 1987-05-25
SU1205772A3 (ru) 1986-01-15
KR900005047B1 (ko) 1990-07-18
FI74974B (fi) 1987-12-31

Similar Documents

Publication Publication Date Title
CS264257B2 (en) Process for preparing new derivatives of cephalosporine
JPS59172493A (ja) 化合物
JPH0326197B2 (es)
JPH0365350B2 (es)
EP0197409B1 (en) Cephalosporin derivatives
RU2056425C1 (ru) Производные цефалоспорина или их фармацевтически приемлемые кислотно-аддитивные соли и способы их получения
KR870001986B1 (ko) 세팔로스포린 유도체의 제조방법
JPH05132488A (ja) 新規セフアロスポリン誘導体
US5281589A (en) 3-fused pyridiniummethyl cephalosporins
DE69132580T2 (de) 7-Acyl-3-(substituierte carbamoyloxy) Cephem Verbindungen, Verfahren zu ihrer Herstellung und Anwendung
JPH01261392A (ja) アシル誘導体及びその製造方法
US5142041A (en) Cephalosporin intermediates
JPH0461000B2 (es)
JP2934809B2 (ja) 新規なセファロスポリン系抗生剤およびその製造方法
DE69902462T2 (de) Cephalosporin-derivate, verfahren zu ihrer herstellung und diese enthaltende antimikrobielle mittel
KR0154901B1 (ko) 신규 세팔로스포린계 항생제(v)
JPH07508274A (ja) アルファロスポリンおよび１−カルバ−１−デチアセファロスポリン
US4474954A (en) Intermediates for cephalosporin derivatives
KR0154899B1 (ko) 신규 세팔로스포린계 항생제(iii)
KR0154902B1 (ko) 신규 세팔로스포린계 항생제(iv)
EP0589914A1 (en) Novel 3-fused pyridiniummethyl cephalosporins
EP0481441A2 (en) Novel cephem compounds, their preparation processes and antibacterial agents
JPH06206886A (ja) セフェム化合物、その製造方法及び該化合物を含む医薬
JPS62226986A (ja) 新規セフアロスポリン誘導体
JPH02134384A (ja) セファロスポリン化合物及びその製造法