ES8500060A1 - Un metodo de producir una solucion de insulina. - Google Patents

Un metodo de producir una solucion de insulina.

Info

Publication number
ES8500060A1
ES8500060A1 ES519533A ES519533A ES8500060A1 ES 8500060 A1 ES8500060 A1 ES 8500060A1 ES 519533 A ES519533 A ES 519533A ES 519533 A ES519533 A ES 519533A ES 8500060 A1 ES8500060 A1 ES 8500060A1
Authority
ES
Spain
Prior art keywords
insulin
solutions
hexamer
insulin preparations
stabilized insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519533A
Other languages
English (en)
Spanish (es)
Other versions
ES519533A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Industri AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri AS filed Critical Novo Industri AS
Publication of ES519533A0 publication Critical patent/ES519533A0/es
Publication of ES8500060A1 publication Critical patent/ES8500060A1/es
Expired legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
    • H05K13/06—Wiring by machine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
ES519533A 1982-02-05 1983-02-04 Un metodo de producir una solucion de insulina. Expired ES8500060A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK49182 1982-02-05

Publications (2)

Publication Number Publication Date
ES519533A0 ES519533A0 (es) 1984-10-16
ES8500060A1 true ES8500060A1 (es) 1984-10-16

Family

ID=8094159

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519533A Expired ES8500060A1 (es) 1982-02-05 1983-02-04 Un metodo de producir una solucion de insulina.

Country Status (22)

Country Link
US (1) US4476118A (OSRAM)
JP (1) JPS58192818A (OSRAM)
AT (1) AT382780B (OSRAM)
AU (1) AU549981B2 (OSRAM)
BE (1) BE895832A (OSRAM)
CA (1) CA1203476A (OSRAM)
CH (1) CH657530A5 (OSRAM)
DE (1) DE3303860A1 (OSRAM)
ES (1) ES8500060A1 (OSRAM)
FI (1) FI78616C (OSRAM)
FR (1) FR2521009B1 (OSRAM)
GB (1) GB2114573B (OSRAM)
GR (1) GR77388B (OSRAM)
IE (1) IE54548B1 (OSRAM)
IT (1) IT1178455B (OSRAM)
LU (1) LU84632A1 (OSRAM)
NL (1) NL187269C (OSRAM)
NO (1) NO161204C (OSRAM)
NZ (1) NZ203189A (OSRAM)
PT (1) PT76195B (OSRAM)
SE (1) SE460948B (OSRAM)
ZA (1) ZA83742B (OSRAM)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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DE3576120D1 (de) * 1984-06-09 1990-04-05 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
JP2520262B2 (ja) * 1987-08-21 1996-07-31 春幸 川原 パツチテスト材料
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
CA2236579C (en) * 1995-11-13 2009-06-30 Minimed, Inc. Methods and compositions for the delivery of monomeric proteins
EP0891419A4 (en) * 1996-03-12 2000-03-01 Life Technologies Inc NUTRIENT ADDITIVE FOR HEMATOPOETIC CELL CULTURES
ATE264871T1 (de) * 1996-07-26 2004-05-15 Aventis Pharma Gmbh Insulinderivate mit erhöhter zinkbindung
AR012894A1 (es) * 1997-06-13 2000-11-22 Lilly Co Eli Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma.
EP1283051B1 (en) * 1997-06-13 2006-06-14 Eli Lilly And Company Stable insulin formulations
DE69816325T2 (de) * 1997-11-12 2004-04-22 Alza Corp., Palo Alto Gepufferte arzneistoffformulierungen zur transdermalen verabreichung durch elektrotransport
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
CN1210058C (zh) * 1998-10-16 2005-07-13 诺沃挪第克公司 用于肺送递的稳定的浓缩胰岛素制剂
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
DK1265630T3 (da) * 2000-03-24 2006-10-09 Genentech Inc Anvendelse af insulin til behandling af brusksygdomme
JP4147234B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
JP5599543B2 (ja) 2002-05-07 2014-10-01 ノヴォ ノルディスク アー／エス 単量体インスリン及びアシル化インスリンを含む可溶性製剤
ATE378063T1 (de) * 2002-12-20 2007-11-15 Novo Nordisk As Pharmazeutische zusammensetzungen mit insulin und insulin-hexamer-liganden
US20050065066A1 (en) * 2002-12-20 2005-03-24 Kaarsholm Niels Christian Stabilised insulin compositions
WO2004096266A1 (en) * 2003-05-02 2004-11-11 Novo Nordisk A/S Improved physical stability of insulin formulations
JP4463814B2 (ja) * 2003-08-05 2010-05-19 ノボ ノルディスク アクティーゼルスカブ 新規のインスリン誘導体
KR101276754B1 (ko) * 2004-07-19 2013-06-19 바이오콘 리미티드 인슐린―올리고머 접합체，제형 및 이들의 용도
DK1969004T3 (da) * 2005-12-28 2011-11-28 Novo Nordisk As Insulinsammensætninger og metode til at lave en sammensætning
US20090136538A1 (en) * 2006-05-22 2009-05-28 Jan Jezek Stable vaccine formulation
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
PL3050568T3 (pl) 2007-03-13 2021-06-14 Jds Therapeutics, Llc Sposoby i kompozycje do przedłużonego uwalniania chromu
EP2167032B1 (en) * 2007-06-13 2019-08-07 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
WO2009002867A2 (en) 2007-06-26 2008-12-31 Nutrition 21, Inc. Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
EP2209800B1 (en) * 2007-11-16 2013-07-24 Novo Nordisk A/S Stable pharmaceutical compositions comprising liraglutide and degludec
EP2328607A1 (en) * 2008-07-16 2011-06-08 Arecor Limited Stable formulation of a therapeutic protein
EP2341940A1 (en) * 2008-07-16 2011-07-13 Arecor Limited The stabilisation of proteins
WO2010049488A1 (en) * 2008-10-30 2010-05-06 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
DK2632478T3 (da) 2010-10-27 2019-10-07 Novo Nordisk As Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
US8933022B2 (en) 2011-03-01 2015-01-13 Jds Therapeutics, Llc Methods and compositions for the treatment and prevention Hypoglycemia and related disorders
DK2919804T3 (en) 2012-11-13 2018-05-14 Adocia Rapidly acting insulin formulation comprising a substituted anionic compound
CA2889165A1 (en) * 2012-12-19 2014-06-26 Wockhardt Limited A stable aqueous composition comprising human insulin or an analogue or derivative thereof
AU2013368990B2 (en) 2012-12-26 2017-05-18 Wockhardt Limited Pharmaceutical composition
TWI641381B (zh) * 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
EP2991672A1 (en) 2013-04-30 2016-03-09 Novo Nordisk A/S Novel administration regime
EP3077414B1 (en) * 2013-12-04 2020-06-17 Merck Sharp & Dohme Corp. Method for preparing crystalline insulin
TW201630622A (zh) 2014-12-16 2016-09-01 美國禮來大藥廠 速效胰島素組合物
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
EP3413900A1 (en) 2016-02-11 2018-12-19 Nutrition 21, LLC Chromium containing compositions for improving health and fitness
AU2017334289B2 (en) * 2016-09-29 2023-04-20 Arecor Limited Novel formulations
CR20190522A (es) 2017-06-01 2020-01-15 Lilly Co Eli Composiciones de insulina de rápida acción
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
US12343383B2 (en) 2019-07-12 2025-07-01 Novo Nordisk A/S High concentration insulin formulation
CN120142500B (zh) * 2025-02-28 2025-10-10 中国计量科学研究院 一种具有互换性的活性人胰岛素溶液标准物质及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2882202A (en) * 1950-04-05 1959-04-14 Novo Terapeutisk Labor As Insulin crystal preparations and methods of producing them
US2787575A (en) * 1950-11-22 1957-04-02 Organon Zinc-glycine-insulin composition and production thereof
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
DE1044360B (de) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) * 1954-02-18 1957-01-10 Dr Dr Guenther Weitzel Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) * 1957-06-08 1962-10-16 Novo Terapeutisk Labor As Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) * 1957-08-10 1961-12-26 Novo Terapeutish Lab A S Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
FR1263220A (fr) * 1958-08-01 1961-06-09 Novo Terapeutisk Labor As Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
DE2459515C3 (de) * 1974-12-17 1982-02-11 Hoechst Ag, 6000 Frankfurt Arzneimittelzubereitungen mit antidiabetischer Wirkung
DE3064888D1 (en) * 1979-04-30 1983-10-27 Hoechst Ag Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
DK80781A (da) * 1980-02-29 1981-08-30 Hospital For Sick Children Oploesninger af polypeptider
ES8403723A1 (es) * 1982-03-03 1984-04-16 Nordisk Insulinlab Procedimiento de producir preparaciones de insulina.

Also Published As

Publication number Publication date
IE830220L (en) 1983-08-05
GB8303133D0 (en) 1983-03-09
AU549981B2 (en) 1986-02-20
NL187269C (nl) 1991-08-01
US4476118A (en) 1984-10-09
SE460948B (sv) 1989-12-11
ES519533A0 (es) 1984-10-16
PT76195B (en) 1986-01-27
GR77388B (OSRAM) 1984-09-11
LU84632A1 (fr) 1983-09-08
ATA38983A (de) 1986-09-15
AT382780B (de) 1987-04-10
FR2521009B1 (fr) 1987-07-17
NL187269B (nl) 1991-03-01
SE8300598D0 (sv) 1983-02-04
FI78616C (fi) 1989-09-11
GB2114573B (en) 1985-05-01
DE3303860A1 (de) 1983-08-18
ZA83742B (en) 1983-11-30
AU1113683A (en) 1983-08-11
BE895832A (fr) 1983-08-04
DE3303860C2 (OSRAM) 1989-12-28
IT8319420A0 (it) 1983-02-04
PT76195A (en) 1983-03-01
FI830375L (fi) 1983-08-06
NO830385L (no) 1983-08-08
GB2114573A (en) 1983-08-24
FI78616B (fi) 1989-05-31
JPS58192818A (ja) 1983-11-10
CA1203476A (en) 1986-04-22
SE8300598L (sv) 1983-08-06
IE54548B1 (en) 1989-11-08
NO161204B (no) 1989-04-10
NL8300440A (nl) 1983-09-01
IT1178455B (it) 1987-09-09
CH657530A5 (de) 1986-09-15
NO161204C (no) 1989-07-19
NZ203189A (en) 1985-07-31
JPH0367056B2 (OSRAM) 1991-10-21
FR2521009A1 (fr) 1983-08-12
FI830375A0 (fi) 1983-02-03

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