ES8406422A1 - Procedimiento para preparar ureas y tioureas sustituidas - Google Patents
Procedimiento para preparar ureas y tioureas sustituidasInfo
- Publication number
- ES8406422A1 ES8406422A1 ES519246A ES519246A ES8406422A1 ES 8406422 A1 ES8406422 A1 ES 8406422A1 ES 519246 A ES519246 A ES 519246A ES 519246 A ES519246 A ES 519246A ES 8406422 A1 ES8406422 A1 ES 8406422A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- phenyl
- substituent
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000879 anti-atherosclerotic effect Effects 0.000 title abstract 2
- 235000013877 carbamide Nutrition 0.000 title abstract 2
- 150000003585 thioureas Chemical class 0.000 title abstract 2
- 150000003672 ureas Chemical class 0.000 title abstract 2
- -1 phenoxy, mercapto Chemical class 0.000 abstract 7
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004399 C1-C4 alkenyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000006277 halobenzyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000006178 methyl benzyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000005147 toluenesulfonyl group Chemical group C=1(C(=CC=CC1)S(=O)(=O)*)C 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/342,698 US4387105A (en) | 1982-01-26 | 1982-01-26 | Methods of treating atherosclerosis with dialkylureas and dialkylthioureas |
| US06/342,693 US4473579A (en) | 1982-01-26 | 1982-01-26 | Antiatherosclerotic tetrasubstituted ureas and thioureas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES519246A0 ES519246A0 (es) | 1984-08-01 |
| ES8406422A1 true ES8406422A1 (es) | 1984-08-01 |
Family
ID=26993144
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES519246A Expired ES8406422A1 (es) | 1982-01-26 | 1983-01-25 | Procedimiento para preparar ureas y tioureas sustituidas |
| ES531508A Granted ES531508A0 (es) | 1982-01-26 | 1984-04-11 | Procedimiento para preparar ureas y tioureas sustituidas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES531508A Granted ES531508A0 (es) | 1982-01-26 | 1984-04-11 | Procedimiento para preparar ureas y tioureas sustituidas. |
Country Status (20)
| Country | Link |
|---|---|
| KR (1) | KR890001808B1 (enExample) |
| AT (1) | AT391313B (enExample) |
| AU (1) | AU562699B2 (enExample) |
| CH (1) | CH654571A5 (enExample) |
| DE (1) | DE3247581A1 (enExample) |
| DK (1) | DK160869C (enExample) |
| ES (2) | ES8406422A1 (enExample) |
| FI (1) | FI85013C (enExample) |
| FR (1) | FR2521134B1 (enExample) |
| GB (1) | GB2113684B (enExample) |
| GR (1) | GR77186B (enExample) |
| HU (1) | HU200746B (enExample) |
| IE (1) | IE54683B1 (enExample) |
| IL (1) | IL67417A (enExample) |
| IT (1) | IT1203647B (enExample) |
| NL (1) | NL8300269A (enExample) |
| NO (1) | NO158417C (enExample) |
| PL (1) | PL143836B1 (enExample) |
| PT (1) | PT76138A (enExample) |
| SE (1) | SE462653B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2138804A (en) * | 1983-04-27 | 1984-10-31 | Sumitomo Chemical Co | Fungicidal N-phenylcarbamates |
| GB2149394B (en) * | 1983-07-19 | 1986-09-24 | American Cyanamid Co | Ureas |
| US4818899A (en) * | 1986-12-03 | 1989-04-04 | Minnesota Mining And Manufacturing Company | Second harmonic generation by carbamic acid derivatives |
| EP0344425B1 (en) * | 1988-03-30 | 1993-12-08 | Warner-Lambert Company | N-[[(2,6-disubstituted)phenyl]-N'- arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents |
| US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
| AU7317391A (en) * | 1990-02-14 | 1991-09-03 | Chugai Seiyaku Kabushiki Kaisha | Inhibitor of denatured ldl formation |
| US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
| HUT62558A (en) * | 1991-07-01 | 1993-05-28 | Sandoz Ag | Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same |
| ATE159715T1 (de) * | 1992-07-20 | 1997-11-15 | Eisai Co Ltd | Benzolderivate |
| EP1019367A1 (en) * | 1997-08-05 | 2000-07-19 | Novo Nordisk A/S | Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use |
| TW415942B (en) * | 1997-09-03 | 2000-12-21 | American Home Prod | Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents |
| US6455566B1 (en) | 1997-09-03 | 2002-09-24 | Wyeth | Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents |
| CA2284864A1 (en) * | 1998-01-21 | 1999-07-29 | Zymogenetics, Inc. | Dialkyl ureas as calcitonin mimetics |
| US8324396B2 (en) * | 2007-07-10 | 2012-12-04 | Amgen Inc. | Derivatives of urea and related diamines, methods for their manufacture, and uses therefor |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL212631A (enExample) * | 1949-12-06 | |||
| US2688039A (en) * | 1952-02-08 | 1954-08-31 | Ciba Pharm Prod Inc | Halogen-containing di-(substituted phenyl)-thioureas |
| US3326663A (en) * | 1964-09-25 | 1967-06-20 | Shell Oil Co | Herbicidal phenylureas |
| US3335142A (en) * | 1965-07-07 | 1967-08-08 | American Cyanamid Co | Process for the preparation of n, n'-disubstituted ureas |
| US3659012A (en) * | 1969-05-26 | 1972-04-25 | Lilly Co Eli | Methods of treating helminth infections with thiourea derivatives |
| US3728386A (en) * | 1970-07-27 | 1973-04-17 | Exxon Research Engineering Co | N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides |
| US3928437A (en) * | 1970-09-02 | 1975-12-23 | Ciba Geigy Corp | Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas |
| US3856952A (en) * | 1973-03-01 | 1974-12-24 | Pennwalt Corp | Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides |
| US3903130A (en) * | 1974-05-03 | 1975-09-02 | Stauffer Chemical Co | 1-Trifluormethylphenyl-3-dicyanophenyl urea |
| DE2928485A1 (de) * | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
-
1982
- 1982-12-05 IL IL67417A patent/IL67417A/xx not_active IP Right Cessation
- 1982-12-22 DE DE19823247581 patent/DE3247581A1/de not_active Withdrawn
- 1982-12-28 KR KR8205843A patent/KR890001808B1/ko not_active Expired
-
1983
- 1983-01-14 GR GR70261A patent/GR77186B/el unknown
- 1983-01-21 AU AU10681/83A patent/AU562699B2/en not_active Ceased
- 1983-01-24 GB GB08301863A patent/GB2113684B/en not_active Expired
- 1983-01-25 DK DK028683A patent/DK160869C/da not_active IP Right Cessation
- 1983-01-25 ES ES519246A patent/ES8406422A1/es not_active Expired
- 1983-01-25 FI FI830247A patent/FI85013C/fi not_active IP Right Cessation
- 1983-01-25 SE SE8300370A patent/SE462653B/sv not_active IP Right Cessation
- 1983-01-25 CH CH404/83A patent/CH654571A5/de not_active IP Right Cessation
- 1983-01-25 FR FR8301082A patent/FR2521134B1/fr not_active Expired
- 1983-01-25 NL NL8300269A patent/NL8300269A/nl not_active Application Discontinuation
- 1983-01-25 PL PL1983240284A patent/PL143836B1/pl unknown
- 1983-01-25 IT IT47605/83A patent/IT1203647B/it active
- 1983-01-25 PT PT76138A patent/PT76138A/pt not_active IP Right Cessation
- 1983-01-25 HU HU83227A patent/HU200746B/hu not_active IP Right Cessation
- 1983-01-25 NO NO830238A patent/NO158417C/no unknown
- 1983-01-25 IE IE146/83A patent/IE54683B1/en not_active IP Right Cessation
- 1983-01-25 AT AT0023983A patent/AT391313B/de not_active IP Right Cessation
-
1984
- 1984-04-11 ES ES531508A patent/ES531508A0/es active Granted
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8406422A1 (es) | Procedimiento para preparar ureas y tioureas sustituidas | |
| GB8922026D0 (en) | Novel anti-viral and cytotoxic agent | |
| IL135068A0 (en) | Stimulation of hematopoietic cells in vitro | |
| ES8107022A1 (es) | Un procedimiento para la preparacion de una composicion an- ticoccidial para su consumo por las especies avicolas | |
| GR3024181T3 (en) | N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors. | |
| DK377389A (da) | Heterocycliske n-arylsulfonamider, fremgangsmaade til deres fremstilling, midler indeholdende dem samt deres anvendelse som herbicider eller vaekstregulerende midler | |
| DE58905006D1 (de) | Harnstoffe. | |
| AU591132B2 (en) | E-isomers of N alpha-(2-cyano-2-alkoximinoacetyl)-amino acid derivatives and peptides | |
| TR199901834T2 (xx) | S�lfonil �releri ve adj�van bazl� kat� kar���mlar. | |
| ES484784A1 (es) | Procedimiento para la obtencion de n-benzoil-n'-terc.-alco- xicarbonilfenil-(tio)ureas sustituidas, de efecto insectici-da | |
| DE2961055D1 (en) | Novel n-substituted 2-oxo-3-benzothiazoline derivatives, their use as leguminous plant growth regulants, and plant growth regulating compositions containing said derivatives as the active ingredients | |
| GB2043062B (en) | N-(heterocyclyl)-acetanilide derivatives and herbicidal and plant growth regulating compositions containing them | |
| DE69903559D1 (de) | Verwendung von neuen zelltod inducierenden mitteln im synergismus mit interferon | |
| ES8506113A1 (es) | Un metodo de electrodepositar una superficie electroconductora que sirve como electrodo | |
| ES8500896A1 (es) | Procedimiento para la obtencion de 1-fenil-3-benzoil-(tio)-ureas | |
| ES8604914A1 (es) | Procedimiento para preparar derivados furanicos herbicidas | |
| IL71361A0 (en) | Urea derivatives,their preparation and their use as pesticides | |
| ES8802424A1 (es) | Procedimiento para preparar acido azabiciclo (3.3.0)-7-octen-3-carboxilico y sus derivados | |
| IL78080A0 (en) | Piperazinylmethyl-1,2,4-triazolylmethyl-carbinols,their preparation and their use as plant protecting agents | |
| WO1995016452A3 (en) | Use of macrophage depleting agents for prolonging the survival of non-autologus hematopoietic cell transplants and animal model assay systems | |
| AU683626B2 (en) | Antagonistic inhibitor for the proliferation of mesenchymal cells | |
| DE2963333D1 (en) | Novel n-substituted 2-oxo-3-benzothiazoline derivatives, their use as leguminous plant growth regulants, and plant growth regulating compositions containing said derivatives as the active ingredients | |
| ES8301908A1 (es) | Procedimiento para la obtencion de alofanatos n-sulfenilados. | |
| ES2038164T3 (es) | Una composicion herbicida. | |
| ES8604008A1 (es) | Procedimiento para la obtencion de productos herbicidas a base de derivados de dicloroquinolina |