ES8405798A1 - Un procedimiento para la preparacion de derivados de penem sustituidos. - Google Patents

Un procedimiento para la preparacion de derivados de penem sustituidos.

Info

Publication number
ES8405798A1
ES8405798A1 ES521277A ES521277A ES8405798A1 ES 8405798 A1 ES8405798 A1 ES 8405798A1 ES 521277 A ES521277 A ES 521277A ES 521277 A ES521277 A ES 521277A ES 8405798 A1 ES8405798 A1 ES 8405798A1
Authority
ES
Spain
Prior art keywords
group
preparation
penem derivatives
hydrogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521277A
Other languages
English (en)
Other versions
ES521277A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES521277A0 publication Critical patent/ES521277A0/es
Publication of ES8405798A1 publication Critical patent/ES8405798A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PENEM SUSTITUIDOS.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER DERIVADOS DE PENEM SUSTITUIDOS DE FORMULA (I), DONDE R1 ES HIDROGENO O UN GRUPO ORGANICO; R2 ES HIDROGENO O GRUPO PROTECTOR DE CARBOXI; Y ES UN GRUPO -S-HET, UN GRUPO PIRIDILO SUSTITUIDO O UN AZIDO; HET ES UN ANILLO HETEROCICLICO SATURADO O INSATURADO; Y L ES CLORO, BROMO O UN GRUPO HIDROXI LIBRE O ACTIVADO. LA REACCION SE REALIZA A TEMPERATURA ENTRE -40JC Y 40JC Y EN PRESENCIA DEUN DISOLVENTE ORGANICO TAL COMO TETRAHIDROFURANO, ACETONA Y OTROS.TIENE APLICACIONES FARMACEUTICAS Y VETERINARIAS POR PRESENTAR UNA ELEVADA ACTIVIDAD ANTIBACTERIANA CONTRA BACTERIAS GRAM-POSITIVO, GRAM-NEGATIVO Y MICROORGANISMOS PRODUCTORES DE BETA-LACTAMASAS.
ES521277A 1982-04-08 1983-04-06 Un procedimiento para la preparacion de derivados de penem sustituidos. Expired ES8405798A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8210410 1982-04-08

Publications (2)

Publication Number Publication Date
ES521277A0 ES521277A0 (es) 1984-06-16
ES8405798A1 true ES8405798A1 (es) 1984-06-16

Family

ID=10529606

Family Applications (2)

Application Number Title Priority Date Filing Date
ES521277A Expired ES8405798A1 (es) 1982-04-08 1983-04-06 Un procedimiento para la preparacion de derivados de penem sustituidos.
ES528017A Expired ES8506022A1 (es) 1982-04-08 1983-12-13 Un procedimiento para la preparacion de derivados de penem sustituidos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES528017A Expired ES8506022A1 (es) 1982-04-08 1983-12-13 Un procedimiento para la preparacion de derivados de penem sustituidos.

Country Status (29)

Country Link
US (2) US4577016A (es)
JP (1) JPS58185591A (es)
KR (1) KR840004434A (es)
AT (1) AT381943B (es)
AU (1) AU563030B2 (es)
BE (1) BE896401A (es)
CA (1) CA1269364A (es)
CH (1) CH655933A5 (es)
CS (1) CS235317B2 (es)
DE (1) DE3312393A1 (es)
DK (1) DK153583A (es)
ES (2) ES8405798A1 (es)
FI (1) FI77866C (es)
FR (1) FR2524889B1 (es)
GR (1) GR77451B (es)
HU (1) HU194888B (es)
IE (1) IE54940B1 (es)
IL (1) IL68307A (es)
IT (1) IT1212083B (es)
LU (1) LU84738A1 (es)
NL (1) NL8301169A (es)
NO (2) NO831160L (es)
NZ (1) NZ203788A (es)
PH (1) PH21161A (es)
PT (1) PT76506B (es)
SE (1) SE454176B (es)
SU (1) SU1299512A3 (es)
YU (1) YU45884B (es)
ZA (1) ZA832385B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051110A (ja) * 1983-08-01 1985-03-22 Nippon Nohyaku Co Ltd 家畜のケト−ジス治療剤
GB8416652D0 (en) * 1984-06-29 1984-08-01 Erba Farmitalia Penem derivatives
GB8416651D0 (en) * 1984-06-29 1984-08-01 Erba Farmitalia Penem derivatives
US4663451A (en) * 1985-05-09 1987-05-05 Farmitalia Carlo Erba S.P.A. Process for the synthesis of penems and penams
GB8509180D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
CA1339860C (en) * 1985-06-17 1998-05-12 Tsunehiko Soga Derivatives of penem
GB8605549D0 (en) * 1986-03-06 1986-04-09 Erba Farmitalia Penem derivatives
US5191075A (en) * 1988-10-19 1993-03-02 Pfizer Inc Process for the preparation of penems
US4992543A (en) * 1988-10-19 1991-02-12 Pfizer Inc. Penem derivatives
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6414156B2 (en) 1998-10-21 2002-07-02 Bristol-Myers Squibb Company Process for preparing azacycloalkanoylaminothiazoles
US6392053B2 (en) 1999-12-15 2002-05-21 Bristol-Myers Squibb Company Process for preparing arylacetylaminothiazoles

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4331677A (en) * 1978-11-24 1982-05-25 Farmitalia Carlo Erba S.P.A. 7-Oxo-4-1-aza-bicyclo-[3,2,0]-heptane derivatives
US4282150A (en) * 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
EP0013067A1 (en) * 1978-12-22 1980-07-09 Beecham Group Plc Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes
ZA80993B (en) * 1979-02-24 1981-02-25 Erba Farmitalia -lactam-containing antibacterial agents and -lactamase inhibitors and preparation thereof
FI75163C (fi) * 1979-02-24 1988-05-09 Erba Farmitalia Foerfarande foer framstaellning av nya penemkarboxylsyror eller -estrar.
US4269771A (en) * 1979-04-06 1981-05-26 Farmitalia Carlo Erba Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
US4386029A (en) * 1979-10-29 1983-05-31 Beecham Group Limited Process for the preparation of antibiotics
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS57179190A (en) * 1981-04-27 1982-11-04 Yamanouchi Pharmaceut Co Ltd Novel penem compound
US4558042A (en) * 1981-05-06 1985-12-10 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
AT379399B (de) * 1981-12-11 1985-12-27 Erba Farmitalia Verfahren zur herstellung von optisch aktiven penemen
GB2118181B (en) * 1982-04-08 1986-07-30 Erba Farmitalia Substituted penem derivatives and new process for their preparation
US4435412A (en) * 1982-11-29 1984-03-06 Schering Corporation 5R,6S,8R-2-(1-Methyl-2-imidazolylmethylthio)-6-(1-hydroxyethyl)penem-3-carboxylic acid
AU563157B2 (en) * 1982-12-08 1987-07-02 Farmitalia Carlo Erba S.P.A. 2-thiacephems and (5r) penems derivatives
JPS59152387A (ja) * 1983-02-10 1984-08-31 Shionogi & Co Ltd 新規ペネム化合物

Also Published As

Publication number Publication date
BE896401A (fr) 1983-10-07
FR2524889B1 (fr) 1986-01-10
YU45884B (sh) 1992-09-07
ES521277A0 (es) 1984-06-16
NO842177L (no) 1983-10-10
PT76506B (en) 1986-02-06
IE54940B1 (en) 1990-03-28
FI831148A0 (fi) 1983-04-05
SE8301924L (sv) 1983-11-04
SU1299512A3 (ru) 1987-03-23
FI77866C (fi) 1989-05-10
JPS58185591A (ja) 1983-10-29
KR840004434A (ko) 1984-10-15
HU194888B (en) 1988-03-28
GR77451B (es) 1984-09-24
DK153583A (da) 1983-10-09
DE3312393A1 (de) 1983-10-13
FR2524889A1 (fr) 1983-10-14
AU563030B2 (en) 1987-06-25
IT8320495A0 (it) 1983-04-07
IT1212083B (it) 1989-11-08
PT76506A (en) 1983-05-01
FI77866B (fi) 1989-01-31
ATA119483A (de) 1986-05-15
LU84738A1 (fr) 1983-11-17
DK153583D0 (da) 1983-04-06
NO831160L (no) 1983-10-10
SE454176B (sv) 1988-04-11
NZ203788A (en) 1986-06-11
CS235317B2 (en) 1985-05-15
AT381943B (de) 1986-12-10
IE830794L (en) 1983-10-08
ZA832385B (en) 1983-12-28
NL8301169A (nl) 1983-11-01
CH655933A5 (de) 1986-05-30
US4577016A (en) 1986-03-18
ES528017A0 (es) 1985-06-16
YU79883A (en) 1985-12-31
IL68307A0 (en) 1983-07-31
US4729990A (en) 1988-03-08
PH21161A (en) 1987-08-05
ES8506022A1 (es) 1985-06-16
SE8301924D0 (sv) 1983-04-07
CA1269364A (en) 1990-05-22
AU1317883A (en) 1983-10-13
IL68307A (en) 1986-12-31
FI831148L (fi) 1983-10-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612