YU45884B - Postupak za dobivanje supstituisanih penem derivata - Google Patents

Postupak za dobivanje supstituisanih penem derivata

Info

Publication number
YU45884B
YU45884B YU79883A YU79883A YU45884B YU 45884 B YU45884 B YU 45884B YU 79883 A YU79883 A YU 79883A YU 79883 A YU79883 A YU 79883A YU 45884 B YU45884 B YU 45884B
Authority
YU
Yugoslavia
Prior art keywords
formula
group
hydroxy
compound
amino
Prior art date
Application number
YU79883A
Other languages
English (en)
Other versions
YU79883A (en
Inventor
M. Alpegiani
A. Bedeschi
M. Foglio
G. Franceschi
E. Perrone
Original Assignee
Farmitalia Carlo Erba S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba S.P.A. filed Critical Farmitalia Carlo Erba S.P.A.
Publication of YU79883A publication Critical patent/YU79883A/xx
Publication of YU45884B publication Critical patent/YU45884B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

POSTUPAK ZA DOBIVANJE SUPSTITUISANIH PENEM DERIVATA,formule (I): u kojoj je R1 vodonik ili organska grupa; R2 je vodonik ili karboksi zaštitna grupa; i Y je a) grupa - S-Het gde je Het opciono supstituisani zasićeni ili nezasićeni heterociklični prsten koji sadrži najmanje jedan heteroatom izabran od O, S i N; b) formiloksi ili C2-C6 karboksilna aciloksi grupa gde acil grupa može biti nesupstituisan ili supstituisana sa halogenom, C2-C6 karboksilnom acil, amino, hidroksi ili merkapto grupom i gde amino, hidroksi i merkapto grupe mogu opciono biti u zaštićenom obliku; c) C1-C12 alkoksi ili C1-C12 alkiltio grupa pri čemu su obe opciono supstituisane sa jednim ili više supstituenata izabranih od halogena, formil, C2-C6 acil, amino, hidroksi i merkapto grupe, gde amino, hidroksi i merkapto grupe mogu biti opciono u zaštićenom obliku; d) opciono supstituisana piridil grupa; ili e) azido, i njihovih farmaceutski ili veterinarski prihvatljivih soli, naznače n time, što obuhvata reakciju jedinjenja formule (II): u kojoj su R1 i R2 kao što je definisano gore i L je hlor, brom ili slobodna ili aktivirana hidroksi grupa, sa jedinjenjem formule (III) Y - H u kojoj je Y kao što je definisano gore, ili sa njegovim reaktivnim derivatom i, prema potrebi, konverziju dobivenog jedinjenja formule (I) u drugo jedinjenje formule (I) i/ili, prema potrebi, salifikaciju slobodnog jedinjenja formule (I) ili, prema potrebi, dobivanje slobodnog jedinjenja formule (I) iz njegove soli i/ili, prema potrebi, odvajanje smeše izomera formule (I) u pojedinačne izomere. Prijava sadrži još 10 patentnih zahteva.
YU79883A 1982-04-08 1983-04-05 Postupak za dobivanje supstituisanih penem derivata YU45884B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8210410 1982-04-08

Publications (2)

Publication Number Publication Date
YU79883A YU79883A (en) 1985-12-31
YU45884B true YU45884B (sh) 1992-09-07

Family

ID=10529606

Family Applications (1)

Application Number Title Priority Date Filing Date
YU79883A YU45884B (sh) 1982-04-08 1983-04-05 Postupak za dobivanje supstituisanih penem derivata

Country Status (29)

Country Link
US (2) US4577016A (sh)
JP (1) JPS58185591A (sh)
KR (1) KR840004434A (sh)
AT (1) AT381943B (sh)
AU (1) AU563030B2 (sh)
BE (1) BE896401A (sh)
CA (1) CA1269364A (sh)
CH (1) CH655933A5 (sh)
CS (1) CS235317B2 (sh)
DE (1) DE3312393A1 (sh)
DK (1) DK153583A (sh)
ES (2) ES521277A0 (sh)
FI (1) FI77866C (sh)
FR (1) FR2524889B1 (sh)
GR (1) GR77451B (sh)
HU (1) HU194888B (sh)
IE (1) IE54940B1 (sh)
IL (1) IL68307A (sh)
IT (1) IT1212083B (sh)
LU (1) LU84738A1 (sh)
NL (1) NL8301169A (sh)
NO (2) NO831160L (sh)
NZ (1) NZ203788A (sh)
PH (1) PH21161A (sh)
PT (1) PT76506B (sh)
SE (1) SE454176B (sh)
SU (1) SU1299512A3 (sh)
YU (1) YU45884B (sh)
ZA (1) ZA832385B (sh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051110A (ja) * 1983-08-01 1985-03-22 Nippon Nohyaku Co Ltd 家畜のケト−ジス治療剤
GB8416652D0 (en) * 1984-06-29 1984-08-01 Erba Farmitalia Penem derivatives
GB8416651D0 (en) * 1984-06-29 1984-08-01 Erba Farmitalia Penem derivatives
US4663451A (en) * 1985-05-09 1987-05-05 Farmitalia Carlo Erba S.P.A. Process for the synthesis of penems and penams
GB8509180D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
CA1339860C (en) * 1985-06-17 1998-05-12 Tsunehiko Soga Derivatives of penem
GB8605549D0 (en) * 1986-03-06 1986-04-09 Erba Farmitalia Penem derivatives
US4992543A (en) * 1988-10-19 1991-02-12 Pfizer Inc. Penem derivatives
US5191075A (en) * 1988-10-19 1993-03-02 Pfizer Inc Process for the preparation of penems
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6414156B2 (en) * 1998-10-21 2002-07-02 Bristol-Myers Squibb Company Process for preparing azacycloalkanoylaminothiazoles
US6392053B2 (en) 1999-12-15 2002-05-21 Bristol-Myers Squibb Company Process for preparing arylacetylaminothiazoles

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
AT365594B (de) * 1978-11-24 1982-01-25 Erba Farmitalia Verfahren zur herstellung von neuen 7-oxo-4-thia1-aza-bicyclo-(3,2,0)heptanderivaten
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
US4282150A (en) * 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
EP0013067A1 (en) * 1978-12-22 1980-07-09 Beecham Group Plc Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes
ZA80993B (en) * 1979-02-24 1981-02-25 Erba Farmitalia -lactam-containing antibacterial agents and -lactamase inhibitors and preparation thereof
GB2043639B (en) * 1979-02-24 1983-07-20 Erba Farmitalia 3-optionally substituted methyl-2-penem derivatives
US4269771A (en) * 1979-04-06 1981-05-26 Farmitalia Carlo Erba Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
US4386029A (en) * 1979-10-29 1983-05-31 Beecham Group Limited Process for the preparation of antibiotics
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS57179190A (en) * 1981-04-27 1982-11-04 Yamanouchi Pharmaceut Co Ltd Novel penem compound
US4558042A (en) * 1981-05-06 1985-12-10 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
AT379399B (de) * 1981-12-11 1985-12-27 Erba Farmitalia Verfahren zur herstellung von optisch aktiven penemen
GB2118181B (en) * 1982-04-08 1986-07-30 Erba Farmitalia Substituted penem derivatives and new process for their preparation
US4435412A (en) * 1982-11-29 1984-03-06 Schering Corporation 5R,6S,8R-2-(1-Methyl-2-imidazolylmethylthio)-6-(1-hydroxyethyl)penem-3-carboxylic acid
FI77459C (fi) * 1982-12-08 1989-03-10 Erba Farmitalia Foerfarande foer framstaellning av (5r)-penemderivat.
JPS59152387A (ja) * 1983-02-10 1984-08-31 Shionogi & Co Ltd 新規ペネム化合物

Also Published As

Publication number Publication date
LU84738A1 (fr) 1983-11-17
CH655933A5 (de) 1986-05-30
US4577016A (en) 1986-03-18
PT76506A (en) 1983-05-01
FR2524889A1 (fr) 1983-10-14
CS235317B2 (en) 1985-05-15
FI831148A0 (fi) 1983-04-05
AU563030B2 (en) 1987-06-25
DK153583A (da) 1983-10-09
AT381943B (de) 1986-12-10
NL8301169A (nl) 1983-11-01
ES528017A0 (es) 1985-06-16
US4729990A (en) 1988-03-08
FI831148L (fi) 1983-10-09
NO842177L (no) 1983-10-10
KR840004434A (ko) 1984-10-15
AU1317883A (en) 1983-10-13
FI77866C (fi) 1989-05-10
ZA832385B (en) 1983-12-28
IE54940B1 (en) 1990-03-28
IE830794L (en) 1983-10-08
YU79883A (en) 1985-12-31
IL68307A (en) 1986-12-31
IL68307A0 (en) 1983-07-31
DE3312393A1 (de) 1983-10-13
DK153583D0 (da) 1983-04-06
HU194888B (en) 1988-03-28
FI77866B (fi) 1989-01-31
ES8506022A1 (es) 1985-06-16
SE8301924L (sv) 1983-11-04
NZ203788A (en) 1986-06-11
ES8405798A1 (es) 1984-06-16
JPS58185591A (ja) 1983-10-29
SU1299512A3 (ru) 1987-03-23
PT76506B (en) 1986-02-06
BE896401A (fr) 1983-10-07
SE454176B (sv) 1988-04-11
SE8301924D0 (sv) 1983-04-07
PH21161A (en) 1987-08-05
IT8320495A0 (it) 1983-04-07
NO831160L (no) 1983-10-10
IT1212083B (it) 1989-11-08
FR2524889B1 (fr) 1986-01-10
ES521277A0 (es) 1984-06-16
GR77451B (sh) 1984-09-24
ATA119483A (de) 1986-05-15
CA1269364A (en) 1990-05-22

Similar Documents

Publication Publication Date Title
LU90317I2 (fr) Tacrolimus et ses sels et dérivés pharmaceutiquement acceptables
FI965126A (fi) Tri-substituoidut PDE IV -inhibiittoreina hyödylliset fenyylijohdannaiset
NZ240676A (en) Heterocyclic compounds substituted by a (piperidin-4-yl)-1-oxoalkyl group and pharmaceutical compositions thereof
YU45884B (sh) Postupak za dobivanje supstituisanih penem derivata
NO980154L (no) Sykliske GMP-spesifikke fosfodiesteraseinhibitorer
SE8107273L (sv) 2-oxoazetidinderivat, sett att framstella democh anvendning derav
DE3167774D1 (en) 4-substituted-2-oxoazetidine compounds, processes for their preparation, and their use for preparing antibiotics
RU2058313C1 (ru) Производные (2-имидазолин-2-ил)-тиено или фуро(3,2-в) пиридин карбоновой кислоты, гербицидная композиция, ингредиенты для их получения
YU46147B (sh) Postupak za dobijanje karbapenem derivata
ES2069345T3 (es) Analogos heterociclicos de amida-prostaglandina 7-oxabiciclo-heptil-sustituidos utiles en el tratamiento de enfermedades tromboticas y vasoespasticas.
DE3274740D1 (de) Ailanthone derivatives
ES8303357A1 (es) Un procedimiento para la preparacion de derivados de piridazinona.
JPS5555187A (en) Indole derivative
RS49832B (sr) Postupak za dobijanje aminskih derivata alkiloksifuranona, dobijanje jedinjenja i upotreba ovih jedinjenja
GB1011113A (en) Improvements in or relating to intermediates for the production of ergot alkaloids of the peptide type
ES8702399A1 (es) Un procedimiento para preparar derivdos de 1,5-benzoxatiepina
YU45568B (sh) Postupak za dobivanje beta-laktamskih antibiotika
HUT59412A (en) Thieno/3,2-b/pyran-5,7-dione derivatives, process for their application and for the production of these compounds and their intermediates, as well as endoparasiticidal and herbicidal compositions comprising such compounds
JPS5283363A (en) Synthesis of novel isoindoline derivative pigment
YU46919B (sh) Postupak za dobijanje derivata l-alanil-l-prolina
JPS5748933A (en) Preparation of bicyclo 3.3.0 octane derivative
JPS5473797A (en) Pyride 3.2.1-jk carbazole derivative
FR2390956A1 (fr) Derives substitues de la quinolizidine et de l'indolizidine, leur procede de preparation et agents therapeutiques contenant lesdits derives
NO952939L (no) Nye substituerte tiosemikarbazontioner
ES469922A1 (es) Un procedimiento para la preparacion de un derivado del 1,1-dioxido del acido penicilanico