ES8402558A1 - "un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido-guanidino-graso-amido)-etanamida sustituida en posicion 2". - Google Patents

"un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido-guanidino-graso-amido)-etanamida sustituida en posicion 2".

Info

Publication number
ES8402558A1
ES8402558A1 ES516258A ES516258A ES8402558A1 ES 8402558 A1 ES8402558 A1 ES 8402558A1 ES 516258 A ES516258 A ES 516258A ES 516258 A ES516258 A ES 516258A ES 8402558 A1 ES8402558 A1 ES 8402558A1
Authority
ES
Spain
Prior art keywords
aminobutyl
guanidino
aminopropyl
amido
omega
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516258A
Other languages
English (en)
Other versions
ES516258A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES8402558A1 publication Critical patent/ES8402558A1/es
Publication of ES516258A0 publication Critical patent/ES516258A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN N-4-(3-AMINOPROPIL)-AMINOB UTIL-2-(ACIDO BVB-GUANIDINO-GRASO-AMIDO)-ETANAMIDA SUSTITUIDA EN POSICION 2.CONSISTE EN: A) CONDENSACION DE UNA AMIDA DE UN ACIDO BVB-GUANIDINO-GRASO DE FORMULA (II) CON UNA DIHIDROXIETANAMIDA DE FORMULA (III) EN PRESENCIA DE AGUA CON CANTIDAD DE 2 A 60 MOLES POR MOL DE COMPUESTO DE FORMULA (II), CON 0,5 A 4 MOLES COMPUESTO DE FORMULA (IV) POR MOL DE COMPUESTO DE FORMULA (II). SE OBTIENE UN COMPUESTO DE FORMULA (IV), Y B) ALCOHILIZACION DEL COMPUESTO DE FORMULA (IV) CON UN ALCOHOL ALIFATICO DE FORMULA R1-OH, OBTENIENDOSELOS COMPUESTOS DE FORMULA (I), EN LA QUE Y, REPRESENTE -CH2-CH2-, -CHFCH- Y EN LA QUE R, REPRESENTE UN GRUPO ALCOHILO DE C 1 A 4, O UN GRUPO BENCILO Y N ES NUMERO QUE VARIA ENTRE 1 A 8.SE UTILIZAN COMO CARCINOSTATICOS DEBIDO A SU BAJA TOXICIDAD.
ES516258A 1981-10-08 1982-10-06 "un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido-guanidino-graso-amido)-etanamida sustituida en posicion 2". Granted ES516258A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56159503A JPS5862152A (ja) 1981-10-08 1981-10-08 Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法

Publications (2)

Publication Number Publication Date
ES8402558A1 true ES8402558A1 (es) 1984-02-01
ES516258A0 ES516258A0 (es) 1984-02-01

Family

ID=15695187

Family Applications (2)

Application Number Title Priority Date Filing Date
ES516258A Granted ES516258A0 (es) 1981-10-08 1982-10-06 "un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido-guanidino-graso-amido)-etanamida sustituida en posicion 2".
ES526501A Expired ES8504690A1 (es) 1981-10-08 1983-10-14 Un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido w-guanidino-graso-amido)-2-alcoxietanamida

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES526501A Expired ES8504690A1 (es) 1981-10-08 1983-10-14 Un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido w-guanidino-graso-amido)-2-alcoxietanamida

Country Status (19)

Country Link
US (3) US4518532A (es)
JP (1) JPS5862152A (es)
KR (1) KR870000656B1 (es)
AT (1) AT393680B (es)
AU (1) AU554489B2 (es)
BE (1) BE894651A (es)
CA (1) CA1187513A (es)
CH (1) CH653015A5 (es)
CS (1) CS268654B2 (es)
DE (1) DE3236725A1 (es)
DK (1) DK166080C (es)
ES (2) ES516258A0 (es)
FR (1) FR2514350B1 (es)
GB (1) GB2111480B (es)
HU (1) HU187417B (es)
IT (1) IT1189373B (es)
NL (1) NL193107C (es)
SE (1) SE452006B (es)
YU (1) YU44678B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS60181056A (ja) * 1984-02-29 1985-09-14 Takara Shuzo Co Ltd Ν−〔４−（３−アミノプロピル）アミノブチル〕−２，２−ジヒドロキシエタンアミドの製造法
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
JPH0742268B2 (ja) * 1985-08-27 1995-05-10 財団法人微生物化学研究会 フエニレン基を有するスパガリン類縁化合物及びその製造法
ES2039213T3 (es) * 1986-04-04 1993-09-16 Microbial Chemistry Research Foundation Procedimiento para producir nuevos compuestos relacionados con espergualina.
JP2605762B2 (ja) * 1986-12-10 1997-04-30 武田薬品工業株式会社 δ−ハイドロキシ−β−リジン誘導体およびその製造法
US5061787A (en) * 1988-06-24 1991-10-29 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compounds and compositions
JPH0776204B2 (ja) * 1988-07-01 1995-08-16 寳酒造株式会社 スパガリン類の精製法
US4990536A (en) * 1989-04-03 1991-02-05 Nippon Kayaku Kabushiki Kaisha Immunopotentiator and spergualin-related compound therefor
US5196453A (en) * 1989-05-29 1993-03-23 Takara Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
US5162581A (en) * 1989-05-29 1992-11-10 Takaru Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
JPH078846B2 (ja) * 1989-05-29 1995-02-01 寳酒造株式会社 塩酸デオキシスパガリンのβ型結晶及びその製造方法
YU48230B (sh) * 1989-05-29 1997-08-22 Takara Shuzo Co.Ltd. Kristalni deoksispergvalin i postupak za njegovo pripremanje
DE69104291T2 (de) * 1990-07-20 1995-05-18 Nippon Kayaku Kk Spergulinähnliche Verbindungen und ihre Verwendung.
WO1994004140A1 (en) * 1992-08-19 1994-03-03 Nippon Kayaku Kabushiki Kaisha Antiprotozoan drug
CA2183917A1 (en) * 1995-09-26 1997-03-27 Xuebao Wang Preparation of optically active (s)-(-) and (r)-(+)- deoxyspergualin and novel intermediates thereof
AP1224A (en) 1998-03-19 2003-11-14 Bristol Myers Squibb Co Biphasic controlled release delivery system for high solubility pharmaceuticals and method.
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
US8716558B2 (en) 1999-06-30 2014-05-06 Marker Gene Technologies, Inc. Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase
US6656917B1 (en) * 1999-06-30 2003-12-02 Marker Gene Technologies, Inc. Compositions and methods for targeted enzymatic release of cell regulatory compounds
JP2005531391A (ja) * 2002-06-27 2005-10-20 微創医療器械（上海）有限公司 薬剤放出ステント
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
MY161846A (en) 2010-07-09 2017-05-15 James Trinca Green Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin
US9751957B2 (en) 2012-02-15 2017-09-05 Cydex Pharmaceuticals, Inc. Manufacturing process for cyclodextrin derivatives
CN104704007A (zh) 2012-02-28 2015-06-10 锡德克斯药物公司 烷基化环糊精组合物及其制备和使用方法
WO2014066274A1 (en) 2012-10-22 2014-05-01 Cydex Pharmaceuticals, Inc. Alkylated cyclodextrin compositions and processes for preparing and using the same
FI3183295T3 (fi) 2014-08-22 2023-09-25 Cydex Pharmaceuticals Inc Fraktioidut alkyloidut syklodekstriinikoostumukset ja menetelmät niiden valmistamiseksi ja käyttämiseksi

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2051495B1 (es) * 1969-04-02 1974-08-30 Taiho Pharmaceutical Co Ltd
JPS5748957A (en) * 1980-09-08 1982-03-20 Microbial Chem Res Found Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient
JPS57185254A (en) * 1981-05-11 1982-11-15 Microbial Chem Res Found Novel carcinostatic substances and their preparation
JPS57192347A (en) * 1981-05-18 1982-11-26 Microbial Chem Res Found N-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide and its synthesis
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
US4525299A (en) * 1983-05-10 1985-06-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same

Also Published As

Publication number Publication date
HU187417B (en) 1986-01-28
IT8249228A0 (it) 1982-10-07
NL8203874A (nl) 1983-05-02
AT393680B (de) 1991-11-25
DK445182A (da) 1983-04-09
IT1189373B (it) 1988-02-04
YU227682A (en) 1985-06-30
JPS5862152A (ja) 1983-04-13
BE894651A (fr) 1983-01-31
US4983328A (en) 1991-01-08
SE452006B (sv) 1987-11-09
NL193107C (nl) 1998-11-03
SE8205698L (sv) 1983-04-09
KR840001952A (ko) 1984-06-07
ES526501A0 (es) 1985-04-16
JPS6123183B2 (es) 1986-06-04
CS717982A2 (en) 1989-08-14
AU8912182A (en) 1983-04-14
DK166080C (da) 1993-08-02
US4518532A (en) 1985-05-21
CS268654B2 (en) 1990-04-11
GB2111480A (en) 1983-07-06
ES516258A0 (es) 1984-02-01
US4658058A (en) 1987-04-14
CH653015A5 (de) 1985-12-13
DE3236725A1 (de) 1983-04-28
FR2514350B1 (fr) 1985-10-25
ES8504690A1 (es) 1985-04-16
GB2111480B (en) 1985-03-13
ATA369682A (de) 1991-05-15
YU44678B (en) 1990-12-31
DK166080B (da) 1993-03-08
NL193107B (nl) 1998-07-01
AU554489B2 (en) 1986-08-21
FR2514350A1 (fr) 1983-04-15
KR870000656B1 (ko) 1987-04-04
SE8205698D0 (sv) 1982-10-06
DE3236725C2 (es) 1991-01-24
CA1187513A (en) 1985-05-21

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