ES8504690A1 - Un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido w-guanidino-graso-amido)-2-alcoxietanamida - Google Patents

Un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido w-guanidino-graso-amido)-2-alcoxietanamida

Info

Publication number
ES8504690A1
ES8504690A1 ES526501A ES526501A ES8504690A1 ES 8504690 A1 ES8504690 A1 ES 8504690A1 ES 526501 A ES526501 A ES 526501A ES 526501 A ES526501 A ES 526501A ES 8504690 A1 ES8504690 A1 ES 8504690A1
Authority
ES
Spain
Prior art keywords
aminobutyl
guanidino
aminopropyl
amido
omega
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526501A
Other languages
English (en)
Other versions
ES526501A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES8504690A1 publication Critical patent/ES8504690A1/es
Publication of ES526501A0 publication Critical patent/ES526501A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA N-4-(3-AMINOPROPIL)-AMINOBUTIL-2-(ACIDO BVB-GUANIDINO-GRASO-AMIDO)-2-ALCOXIETANAMIDA, DE FORMULA GENERAL (I), EN LA QUE Y REPRESENTA UN RADICAL; R REPRESENTA UN GRUPO ALCOHILO DE 1 A 4 ATOMOS DE CARBONO; Y N REPRESENTA UN NUMERO ENTERO COMPRENDIDO ENTRE 1 Y 8, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN HACER REACCIONAR UNA N-4-(3-AMINOPROPIL)AMINOBUTIL-2-(ACIDO BVB-GUANIDINO-GRASO-AMIDO)-2-HIDROXIETANAMIDA, DE FORMULA GENERAL (II) O UNA DE SUS SALES, CON UN ALCOHOL ALIFATICO MONO O DIVALENTE.DE APLICACION COMO ANTIBIOTICO CARCINOSTATICO.
ES526501A 1981-10-08 1983-10-14 Un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido w-guanidino-graso-amido)-2-alcoxietanamida Granted ES526501A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56159503A JPS5862152A (ja) 1981-10-08 1981-10-08 Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法

Publications (2)

Publication Number Publication Date
ES8504690A1 true ES8504690A1 (es) 1985-04-16
ES526501A0 ES526501A0 (es) 1985-04-16

Family

ID=15695187

Family Applications (2)

Application Number Title Priority Date Filing Date
ES516258A Expired ES8402558A1 (es) 1981-10-08 1982-10-06 "un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido-guanidino-graso-amido)-etanamida sustituida en posicion 2".
ES526501A Granted ES526501A0 (es) 1981-10-08 1983-10-14 Un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido w-guanidino-graso-amido)-2-alcoxietanamida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES516258A Expired ES8402558A1 (es) 1981-10-08 1982-10-06 "un procedimiento para preparar una n-(4-(3-aminopropil)-aminobutil)-2-(acido-guanidino-graso-amido)-etanamida sustituida en posicion 2".

Country Status (19)

Country Link
US (3) US4518532A (es)
JP (1) JPS5862152A (es)
KR (1) KR870000656B1 (es)
AT (1) AT393680B (es)
AU (1) AU554489B2 (es)
BE (1) BE894651A (es)
CA (1) CA1187513A (es)
CH (1) CH653015A5 (es)
CS (1) CS268654B2 (es)
DE (1) DE3236725A1 (es)
DK (1) DK166080C (es)
ES (2) ES8402558A1 (es)
FR (1) FR2514350B1 (es)
GB (1) GB2111480B (es)
HU (1) HU187417B (es)
IT (1) IT1189373B (es)
NL (1) NL193107C (es)
SE (1) SE452006B (es)
YU (1) YU44678B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS60181056A (ja) * 1984-02-29 1985-09-14 Takara Shuzo Co Ltd Ν−〔４−（３−アミノプロピル）アミノブチル〕−２，２−ジヒドロキシエタンアミドの製造法
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
JPH0742268B2 (ja) * 1985-08-27 1995-05-10 財団法人微生物化学研究会 フエニレン基を有するスパガリン類縁化合物及びその製造法
ES2039213T3 (es) * 1986-04-04 1993-09-16 Microbial Chemistry Research Foundation Procedimiento para producir nuevos compuestos relacionados con espergualina.
JP2605762B2 (ja) * 1986-12-10 1997-04-30 武田薬品工業株式会社 δ−ハイドロキシ−β−リジン誘導体およびその製造法
US5061787A (en) * 1988-06-24 1991-10-29 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compounds and compositions
JPH0776204B2 (ja) * 1988-07-01 1995-08-16 寳酒造株式会社 スパガリン類の精製法
US4990536A (en) * 1989-04-03 1991-02-05 Nippon Kayaku Kabushiki Kaisha Immunopotentiator and spergualin-related compound therefor
JPH078846B2 (ja) * 1989-05-29 1995-02-01 寳酒造株式会社 塩酸デオキシスパガリンのβ型結晶及びその製造方法
US5162581A (en) * 1989-05-29 1992-11-10 Takaru Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
YU48230B (sh) * 1989-05-29 1997-08-22 Takara Shuzo Co.Ltd. Kristalni deoksispergvalin i postupak za njegovo pripremanje
US5196453A (en) * 1989-05-29 1993-03-23 Takara Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
DE69104291T2 (de) * 1990-07-20 1995-05-18 Nippon Kayaku Kk Spergulinähnliche Verbindungen und ihre Verwendung.
WO1994004140A1 (en) * 1992-08-19 1994-03-03 Nippon Kayaku Kabushiki Kaisha Antiprotozoan drug
CA2183917A1 (en) * 1995-09-26 1997-03-27 Xuebao Wang Preparation of optically active (s)-(-) and (r)-(+)- deoxyspergualin and novel intermediates thereof
CA2320900C (en) 1998-03-19 2009-10-27 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
US6656917B1 (en) * 1999-06-30 2003-12-02 Marker Gene Technologies, Inc. Compositions and methods for targeted enzymatic release of cell regulatory compounds
US8716558B2 (en) 1999-06-30 2014-05-06 Marker Gene Technologies, Inc. Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase
EP1516597A4 (en) * 2002-06-27 2010-11-10 Microport Medical Shanghai Co MEDICINES ELUTIONSSTENT
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
MX342120B (es) 2010-07-09 2016-09-14 William Owen Wilkison Combinación de sistema de liberación prolongada/inmediata para productos farmacéuticos de vida media corta como el remogliflozin.
PL3702374T3 (pl) 2012-02-15 2022-11-21 Cydex Pharmaceuticals, Inc. Sposób wytwarzania pochodnych cyklodekstryny
US9493582B2 (en) 2012-02-28 2016-11-15 Cydex Pharmaceuticals, Inc. Alkylated cyclodextrin compositions and processes for preparing and using the same
KR102112119B1 (ko) 2012-10-22 2020-05-19 사이덱스 파마슈티칼스, 인크. 알킬화된 시클로덱스트린 조성물 및 이의 제조 및 사용 방법
US10851184B2 (en) 2014-08-22 2020-12-01 Cydex Pharmaceuticals, Inc. Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2051495B1 (es) * 1969-04-02 1974-08-30 Taiho Pharmaceutical Co Ltd
JPS5748957A (en) * 1980-09-08 1982-03-20 Microbial Chem Res Found Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient
JPS57192347A (en) * 1981-05-18 1982-11-26 Microbial Chem Res Found N-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide and its synthesis
JPS57185254A (en) * 1981-05-11 1982-11-15 Microbial Chem Res Found Novel carcinostatic substances and their preparation
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
US4525299A (en) * 1983-05-10 1985-06-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same

Also Published As

Publication number Publication date
US4983328A (en) 1991-01-08
IT1189373B (it) 1988-02-04
HU187417B (en) 1986-01-28
YU44678B (en) 1990-12-31
DE3236725C2 (es) 1991-01-24
DK445182A (da) 1983-04-09
AU554489B2 (en) 1986-08-21
SE452006B (sv) 1987-11-09
NL193107B (nl) 1998-07-01
ES526501A0 (es) 1985-04-16
AT393680B (de) 1991-11-25
AU8912182A (en) 1983-04-14
ATA369682A (de) 1991-05-15
CS268654B2 (en) 1990-04-11
DK166080B (da) 1993-03-08
ES516258A0 (es) 1984-02-01
NL193107C (nl) 1998-11-03
GB2111480A (en) 1983-07-06
JPS6123183B2 (es) 1986-06-04
FR2514350A1 (fr) 1983-04-15
KR840001952A (ko) 1984-06-07
US4518532A (en) 1985-05-21
ES8402558A1 (es) 1984-02-01
CA1187513A (en) 1985-05-21
BE894651A (fr) 1983-01-31
IT8249228A0 (it) 1982-10-07
NL8203874A (nl) 1983-05-02
KR870000656B1 (ko) 1987-04-04
SE8205698D0 (sv) 1982-10-06
GB2111480B (en) 1985-03-13
YU227682A (en) 1985-06-30
SE8205698L (sv) 1983-04-09
US4658058A (en) 1987-04-14
DK166080C (da) 1993-08-02
DE3236725A1 (de) 1983-04-28
JPS5862152A (ja) 1983-04-13
CS717982A2 (en) 1989-08-14
CH653015A5 (de) 1985-12-13
FR2514350B1 (fr) 1985-10-25

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