ES472877A1 - Procedimiento para preparar derivados de 25-alquilcolesterol - Google Patents
Procedimiento para preparar derivados de 25-alquilcolesterolInfo
- Publication number
- ES472877A1 ES472877A1 ES472877A ES472877A ES472877A1 ES 472877 A1 ES472877 A1 ES 472877A1 ES 472877 A ES472877 A ES 472877A ES 472877 A ES472877 A ES 472877A ES 472877 A1 ES472877 A1 ES 472877A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- image
- carbon atoms
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 abstract 1
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003904 antiprotozoal agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los compuestos obtenidos por el proceso de la invención son útiles en virtud de sus valiosas propiedades farmacológicas. Así, por ejemplo, inhiben la actividad del beta-hidroxi-beta-metilglutaril coenzima A (HMG CoA) reductasa, un enzima que controla la velocidad a la cual se sintetiza colesterol en el hígado de mamíferos (uno de las dos principales fuentes de colesterol de suero). Los compuestos obtenidos según la invención inhiben la actividad de HMG CoA reductasa. Este tipo de actividad debe ser particularmente útil en el control de la hipercolesterolemia de tipo II, un estado heredado causado por una mutación dominante autosomal de un solo foco genético (Brown y Goldstein, Science 191, 150 (1976)).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82838577A | 1977-08-29 | 1977-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES472877A1 true ES472877A1 (es) | 1979-02-16 |
Family
ID=25251653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES472877A Expired ES472877A1 (es) | 1977-08-29 | 1978-08-28 | Procedimiento para preparar derivados de 25-alquilcolesterol |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5448751A (es) |
| AU (1) | AU520334B2 (es) |
| CA (1) | CA1113086A (es) |
| CH (1) | CH643566A5 (es) |
| DE (1) | DE2837414A1 (es) |
| ES (1) | ES472877A1 (es) |
| FR (1) | FR2401935A1 (es) |
| GB (1) | GB2009180B (es) |
| IT (1) | IT1106121B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4225525A (en) * | 1979-02-08 | 1980-09-30 | Hoffmann-La Roche Inc. | Vitamin D3 metabolite derivatives |
| US4230626A (en) * | 1979-07-30 | 1980-10-28 | G. D. Searle & Co. | 25-Halocholest-5-ene-3β,22-diols and esters thereof |
| US4329295A (en) * | 1981-06-29 | 1982-05-11 | G. D. Searle & Co. | 24-Cyclopropylcholene-3β, 22-diols and esters thereof |
| US4348328A (en) * | 1981-11-09 | 1982-09-07 | G.D. Searle & Co. | 25-Substituted-5α-cholestane-3β,22S-diol |
| IL105050A0 (en) * | 1992-03-27 | 1993-07-08 | Lilly Co Eli | Steroid derivatives |
| ES2188515T3 (es) | 1999-03-09 | 2003-07-01 | Akzo Nobel Nv | Derivados de 22r-hidroxicolesta-8,14-dieno con actividad inhibidora de la meiosis. |
| CN1498222A (zh) * | 2001-02-08 | 2004-05-19 | 芝加哥大学 | 类固醇衍生物 |
| US7078396B2 (en) | 2001-05-03 | 2006-07-18 | Arch Development Corporation | Method of treating disorder related to high cholesterol concentration |
| EP2459581A4 (en) | 2009-07-29 | 2012-12-26 | Univ Chicago | LIVER X-RECEPTOR AGONISTS |
-
1978
- 1978-08-28 DE DE19782837414 patent/DE2837414A1/de active Granted
- 1978-08-28 AU AU39318/78A patent/AU520334B2/en not_active Expired
- 1978-08-28 JP JP10480878A patent/JPS5448751A/ja active Granted
- 1978-08-28 IT IT50879/78A patent/IT1106121B/it active
- 1978-08-28 ES ES472877A patent/ES472877A1/es not_active Expired
- 1978-08-28 CA CA310,200A patent/CA1113086A/en not_active Expired
- 1978-08-28 CH CH906378A patent/CH643566A5/de not_active IP Right Cessation
- 1978-08-29 FR FR7824922A patent/FR2401935A1/fr active Granted
- 1978-08-29 GB GB7834881A patent/GB2009180B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2837414C2 (es) | 1987-09-03 |
| JPS5448751A (en) | 1979-04-17 |
| GB2009180A (en) | 1979-06-13 |
| CH643566A5 (de) | 1984-06-15 |
| FR2401935A1 (fr) | 1979-03-30 |
| JPS6259720B2 (es) | 1987-12-12 |
| IT7850879A0 (it) | 1978-08-28 |
| GB2009180B (en) | 1982-05-26 |
| AU3931878A (en) | 1980-03-06 |
| CA1113086A (en) | 1981-11-24 |
| AU520334B2 (en) | 1982-01-28 |
| IT1106121B (it) | 1985-11-11 |
| DE2837414A1 (de) | 1979-03-08 |
| FR2401935B1 (es) | 1981-07-10 |
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