ATA369682A - Verfahren zur herstellung neuer n-(4-(3aminopropyl)-aminobutyl)-2-(w-guanidinofetts|ureamido)-2-substituierter ethanamide und ihrer salze - Google Patents
Verfahren zur herstellung neuer n-(4-(3aminopropyl)-aminobutyl)-2-(w-guanidinofetts|ureamido)-2-substituierter ethanamide und ihrer salzeInfo
- Publication number
- ATA369682A ATA369682A AT823696A AT369682A ATA369682A AT A369682 A ATA369682 A AT A369682A AT 823696 A AT823696 A AT 823696A AT 369682 A AT369682 A AT 369682A AT A369682 A ATA369682 A AT A369682A
- Authority
- AT
- Austria
- Prior art keywords
- ureamido
- guanidinofetts
- ethanamides
- aminobutyl
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56159503A JPS5862152A (ja) | 1981-10-08 | 1981-10-08 | Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA369682A true ATA369682A (de) | 1991-05-15 |
| AT393680B AT393680B (de) | 1991-11-25 |
Family
ID=15695187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0369682A AT393680B (de) | 1981-10-08 | 1982-10-06 | Verfahren zur herstellung neuer n-(4-(3aminopropyl)-aminobutyl)-2-(w-guanidinofetts|ureamido)-2-substituierter ethanamide und ihrer salze |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US4518532A (de) |
| JP (1) | JPS5862152A (de) |
| KR (1) | KR870000656B1 (de) |
| AT (1) | AT393680B (de) |
| AU (1) | AU554489B2 (de) |
| BE (1) | BE894651A (de) |
| CA (1) | CA1187513A (de) |
| CH (1) | CH653015A5 (de) |
| CS (1) | CS268654B2 (de) |
| DE (1) | DE3236725A1 (de) |
| DK (1) | DK166080C (de) |
| ES (2) | ES516258A0 (de) |
| FR (1) | FR2514350B1 (de) |
| GB (1) | GB2111480B (de) |
| HU (1) | HU187417B (de) |
| IT (1) | IT1189373B (de) |
| NL (1) | NL193107C (de) |
| SE (1) | SE452006B (de) |
| YU (1) | YU44678B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5862152A (ja) * | 1981-10-08 | 1983-04-13 | Microbial Chem Res Found | Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法 |
| JPS60181056A (ja) * | 1984-02-29 | 1985-09-14 | Takara Shuzo Co Ltd | Ν−〔４−（３−アミノプロピル）アミノブチル〕−２，２−ジヒドロキシエタンアミドの製造法 |
| JPS60185758A (ja) * | 1984-03-02 | 1985-09-21 | Microbial Chem Res Found | フエニレン基を有するスパガリン関連化合物およびその製造法 |
| JPS61129119A (ja) * | 1984-11-13 | 1986-06-17 | Microbial Chem Res Found | 新規免疫抑制剤 |
| JPS61165322A (ja) * | 1985-01-14 | 1986-07-26 | Microbial Chem Res Found | スパガリン類の注射用凍結乾燥製剤 |
| JPH0742268B2 (ja) * | 1985-08-27 | 1995-05-10 | 財団法人微生物化学研究会 | フエニレン基を有するスパガリン類縁化合物及びその製造法 |
| ES2039213T3 (es) * | 1986-04-04 | 1993-09-16 | Microbial Chemistry Research Foundation | Procedimiento para producir nuevos compuestos relacionados con espergualina. |
| JP2605762B2 (ja) * | 1986-12-10 | 1997-04-30 | 武田薬品工業株式会社 | δ−ハイドロキシ−β−リジン誘導体およびその製造法 |
| US5061787A (en) * | 1988-06-24 | 1991-10-29 | Nippon Kayaku Kabushiki Kaisha | Novel spergualin-related compounds and compositions |
| JPH0776204B2 (ja) * | 1988-07-01 | 1995-08-16 | 寳酒造株式会社 | スパガリン類の精製法 |
| US4990536A (en) * | 1989-04-03 | 1991-02-05 | Nippon Kayaku Kabushiki Kaisha | Immunopotentiator and spergualin-related compound therefor |
| US5196453A (en) * | 1989-05-29 | 1993-03-23 | Takara Shuzo Co., Ltd. | Crystalline deoxyspergualin, process for its preparation and suppository containing the same |
| US5162581A (en) * | 1989-05-29 | 1992-11-10 | Takaru Shuzo Co., Ltd. | Crystalline deoxyspergualin, process for its preparation and suppository containing the same |
| JPH078846B2 (ja) * | 1989-05-29 | 1995-02-01 | 寳酒造株式会社 | 塩酸デオキシスパガリンのβ型結晶及びその製造方法 |
| YU48230B (sh) * | 1989-05-29 | 1997-08-22 | Takara Shuzo Co.Ltd. | Kristalni deoksispergvalin i postupak za njegovo pripremanje |
| DE69104291T2 (de) * | 1990-07-20 | 1995-05-18 | Nippon Kayaku Kk | Spergulinähnliche Verbindungen und ihre Verwendung. |
| WO1994004140A1 (en) * | 1992-08-19 | 1994-03-03 | Nippon Kayaku Kabushiki Kaisha | Antiprotozoan drug |
| CA2183917A1 (en) * | 1995-09-26 | 1997-03-27 | Xuebao Wang | Preparation of optically active (s)-(-) and (r)-(+)- deoxyspergualin and novel intermediates thereof |
| AP1224A (en) | 1998-03-19 | 2003-11-14 | Bristol Myers Squibb Co | Biphasic controlled release delivery system for high solubility pharmaceuticals and method. |
| US20020142000A1 (en) * | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
| US8716558B2 (en) | 1999-06-30 | 2014-05-06 | Marker Gene Technologies, Inc. | Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase |
| US6656917B1 (en) * | 1999-06-30 | 2003-12-02 | Marker Gene Technologies, Inc. | Compositions and methods for targeted enzymatic release of cell regulatory compounds |
| JP2005531391A (ja) * | 2002-06-27 | 2005-10-20 | 微創医療器械（上海）有限公司 | 薬剤放出ステント |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| MY161846A (en) | 2010-07-09 | 2017-05-15 | James Trinca Green | Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin |
| US9751957B2 (en) | 2012-02-15 | 2017-09-05 | Cydex Pharmaceuticals, Inc. | Manufacturing process for cyclodextrin derivatives |
| CN104704007A (zh) | 2012-02-28 | 2015-06-10 | 锡德克斯药物公司 | 烷基化环糊精组合物及其制备和使用方法 |
| WO2014066274A1 (en) | 2012-10-22 | 2014-05-01 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
| FI3183295T3 (fi) | 2014-08-22 | 2023-09-25 | Cydex Pharmaceuticals Inc | Fraktioidut alkyloidut syklodekstriinikoostumukset ja menetelmät niiden valmistamiseksi ja käyttämiseksi |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2051495B1 (de) * | 1969-04-02 | 1974-08-30 | Taiho Pharmaceutical Co Ltd | |
| JPS5748957A (en) * | 1980-09-08 | 1982-03-20 | Microbial Chem Res Found | Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient |
| JPS57185254A (en) * | 1981-05-11 | 1982-11-15 | Microbial Chem Res Found | Novel carcinostatic substances and their preparation |
| JPS57192347A (en) * | 1981-05-18 | 1982-11-26 | Microbial Chem Res Found | N-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide and its synthesis |
| JPS5862152A (ja) * | 1981-10-08 | 1983-04-13 | Microbial Chem Res Found | Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法 |
| JPS5942356A (ja) * | 1982-09-02 | 1984-03-08 | Microbial Chem Res Found | スパガリン関連化合物およびその製造法 |
| US4525299A (en) * | 1983-05-10 | 1985-06-25 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same |
-
1981
- 1981-10-08 JP JP56159503A patent/JPS5862152A/ja active Granted
-
1982
- 1982-09-29 US US06/426,372 patent/US4518532A/en not_active Expired - Lifetime
- 1982-10-04 DE DE19823236725 patent/DE3236725A1/de active Granted
- 1982-10-05 AU AU89121/82A patent/AU554489B2/en not_active Expired
- 1982-10-06 CA CA000412980A patent/CA1187513A/en not_active Expired
- 1982-10-06 NL NL8203874A patent/NL193107C/nl not_active IP Right Cessation
- 1982-10-06 ES ES516258A patent/ES516258A0/es active Granted
- 1982-10-06 AT AT0369682A patent/AT393680B/de not_active IP Right Cessation
- 1982-10-06 SE SE8205698A patent/SE452006B/sv not_active IP Right Cessation
- 1982-10-07 CH CH5895/82A patent/CH653015A5/de not_active IP Right Cessation
- 1982-10-07 IT IT49228/82A patent/IT1189373B/it active
- 1982-10-07 GB GB08228636A patent/GB2111480B/en not_active Expired
- 1982-10-07 KR KR8204571A patent/KR870000656B1/ko active
- 1982-10-07 CS CS827179A patent/CS268654B2/cs unknown
- 1982-10-07 HU HU823215A patent/HU187417B/hu unknown
- 1982-10-07 DK DK445182A patent/DK166080C/da active
- 1982-10-08 FR FR8216894A patent/FR2514350B1/fr not_active Expired
- 1982-10-08 YU YU2276/82A patent/YU44678B/xx unknown
- 1982-10-08 BE BE0/209206A patent/BE894651A/fr unknown
-
1983
- 1983-10-14 ES ES526501A patent/ES8504690A1/es not_active Expired
-
1985
- 1985-04-15 US US06/723,169 patent/US4658058A/en not_active Expired - Lifetime
-
1988
- 1988-03-15 US US07/170,611 patent/US4983328A/en not_active Expired - Lifetime
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee | ||
| ELJ | Ceased due to non-payment of the annual fee |