AU554489B2 - N-(4-(3-aminopropyl)aminobutyl)-2-(omega-guanidino- fatty-acid-amido)-2-substituted ethanamides - Google Patents

N-(4-(3-aminopropyl)aminobutyl)-2-(omega-guanidino- fatty-acid-amido)-2-substituted ethanamides

Info

Publication number
AU554489B2
AU554489B2 AU89121/82A AU8912182A AU554489B2 AU 554489 B2 AU554489 B2 AU 554489B2 AU 89121/82 A AU89121/82 A AU 89121/82A AU 8912182 A AU8912182 A AU 8912182A AU 554489 B2 AU554489 B2 AU 554489B2
Authority
AU
Australia
Prior art keywords
ethanamides
aminobutyl
guanidino
aminopropyl
amido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU89121/82A
Other languages
English (en)
Other versions
AU8912182A (en
Inventor
Akio Fujii
Hironobu Iinuma
Daishiro Ikeda
Shinichi Kondo
Teruya Nakamura
Tomio Takeuchi
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of AU8912182A publication Critical patent/AU8912182A/en
Application granted granted Critical
Publication of AU554489B2 publication Critical patent/AU554489B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU89121/82A 1981-10-08 1982-10-05 N-(4-(3-aminopropyl)aminobutyl)-2-(omega-guanidino- fatty-acid-amido)-2-substituted ethanamides Expired AU554489B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56159503A JPS5862152A (ja) 1981-10-08 1981-10-08 Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JP56-159503 1981-10-08

Publications (2)

Publication Number Publication Date
AU8912182A AU8912182A (en) 1983-04-14
AU554489B2 true AU554489B2 (en) 1986-08-21

Family

ID=15695187

Family Applications (1)

Application Number Title Priority Date Filing Date
AU89121/82A Expired AU554489B2 (en) 1981-10-08 1982-10-05 N-(4-(3-aminopropyl)aminobutyl)-2-(omega-guanidino- fatty-acid-amido)-2-substituted ethanamides

Country Status (19)

Country Link
US (3) US4518532A (de)
JP (1) JPS5862152A (de)
KR (1) KR870000656B1 (de)
AT (1) AT393680B (de)
AU (1) AU554489B2 (de)
BE (1) BE894651A (de)
CA (1) CA1187513A (de)
CH (1) CH653015A5 (de)
CS (1) CS268654B2 (de)
DE (1) DE3236725A1 (de)
DK (1) DK166080C (de)
ES (2) ES516258A0 (de)
FR (1) FR2514350B1 (de)
GB (1) GB2111480B (de)
HU (1) HU187417B (de)
IT (1) IT1189373B (de)
NL (1) NL193107C (de)
SE (1) SE452006B (de)
YU (1) YU44678B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS60181056A (ja) * 1984-02-29 1985-09-14 Takara Shuzo Co Ltd Ν−〔４−（３−アミノプロピル）アミノブチル〕−２，２−ジヒドロキシエタンアミドの製造法
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法
JPS61129119A (ja) * 1984-11-13 1986-06-17 Microbial Chem Res Found 新規免疫抑制剤
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
JPH0742268B2 (ja) * 1985-08-27 1995-05-10 財団法人微生物化学研究会 フエニレン基を有するスパガリン類縁化合物及びその製造法
ATE64378T1 (de) * 1986-04-04 1991-06-15 Microbial Chem Res Found Spergualinaehnliche verbindungen und ihr herstellungsverfahren.
JP2605762B2 (ja) * 1986-12-10 1997-04-30 武田薬品工業株式会社 δ−ハイドロキシ−β−リジン誘導体およびその製造法
US5061787A (en) * 1988-06-24 1991-10-29 Nippon Kayaku Kabushiki Kaisha Novel spergualin-related compounds and compositions
JPH0776204B2 (ja) * 1988-07-01 1995-08-16 寳酒造株式会社 スパガリン類の精製法
US4990536A (en) * 1989-04-03 1991-02-05 Nippon Kayaku Kabushiki Kaisha Immunopotentiator and spergualin-related compound therefor
YU48230B (sh) * 1989-05-29 1997-08-22 Takara Shuzo Co.Ltd. Kristalni deoksispergvalin i postupak za njegovo pripremanje
US5162581A (en) * 1989-05-29 1992-11-10 Takaru Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
JPH078846B2 (ja) * 1989-05-29 1995-02-01 寳酒造株式会社 塩酸デオキシスパガリンのβ型結晶及びその製造方法
US5196453A (en) * 1989-05-29 1993-03-23 Takara Shuzo Co., Ltd. Crystalline deoxyspergualin, process for its preparation and suppository containing the same
EP0467280B1 (de) * 1990-07-20 1994-09-28 Nippon Kayaku Kabushiki Kaisha Spergulinähnliche Verbindungen und ihre Verwendung
WO1994004140A1 (en) * 1992-08-19 1994-03-03 Nippon Kayaku Kabushiki Kaisha Antiprotozoan drug
CA2183917A1 (en) * 1995-09-26 1997-03-27 Xuebao Wang Preparation of optically active (s)-(-) and (r)-(+)- deoxyspergualin and novel intermediates thereof
AP1224A (en) 1998-03-19 2003-11-14 Bristol Myers Squibb Co Biphasic controlled release delivery system for high solubility pharmaceuticals and method.
US20020142000A1 (en) * 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
US8716558B2 (en) 1999-06-30 2014-05-06 Marker Gene Technologies, Inc. Method of altering glycosylation of proteins in response to nojirimycin glucuronide in a plant cell expressing glucuronidase
US6656917B1 (en) 1999-06-30 2003-12-02 Marker Gene Technologies, Inc. Compositions and methods for targeted enzymatic release of cell regulatory compounds
EP1516597A4 (de) * 2002-06-27 2010-11-10 Microport Medical Shanghai Co Arzneimittel-elutionsstent
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
CA2804926C (en) 2010-07-09 2019-01-08 James Trinca Green Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin
HUE058834T2 (hu) 2012-02-15 2022-09-28 Cydex Pharmaceuticals Inc Elõállítási eljárás ciklodextrin-származékokhoz
RU2747757C2 (ru) 2012-02-28 2021-05-13 Сидекс Фармасьютикалс, Инк. Композиции алкилированного циклодекстрина и способы их получения и применения
WO2014066274A1 (en) 2012-10-22 2014-05-01 Cydex Pharmaceuticals, Inc. Alkylated cyclodextrin compositions and processes for preparing and using the same
FI3183295T3 (fi) 2014-08-22 2023-09-25 Cydex Pharmaceuticals Inc Fraktioidut alkyloidut syklodekstriinikoostumukset ja menetelmät niiden valmistamiseksi ja käyttämiseksi

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799988A (en) * 1969-04-02 1974-03-26 Taiho Pharmaceutical Co Ltd {107 -guanidino acid diamide derivatives and manufacturing the same
JPS5748957A (en) * 1980-09-08 1982-03-20 Microbial Chem Res Found Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient
JPS57185254A (en) * 1981-05-11 1982-11-15 Microbial Chem Res Found Novel carcinostatic substances and their preparation
JPS57192347A (en) * 1981-05-18 1982-11-26 Microbial Chem Res Found N-(4-(3-aminopropyl)aminobutyl)-2,2-dihydroxyethanamide and its synthesis
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
US4525299A (en) * 1983-05-10 1985-06-25 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same

Also Published As

Publication number Publication date
DK166080B (da) 1993-03-08
KR840001952A (ko) 1984-06-07
CS717982A2 (en) 1989-08-14
HU187417B (en) 1986-01-28
BE894651A (fr) 1983-01-31
KR870000656B1 (ko) 1987-04-04
DK445182A (da) 1983-04-09
JPS5862152A (ja) 1983-04-13
SE8205698L (sv) 1983-04-09
US4658058A (en) 1987-04-14
FR2514350A1 (fr) 1983-04-15
GB2111480A (en) 1983-07-06
GB2111480B (en) 1985-03-13
AU8912182A (en) 1983-04-14
ES8402558A1 (es) 1984-02-01
DK166080C (da) 1993-08-02
IT8249228A0 (it) 1982-10-07
YU227682A (en) 1985-06-30
NL193107B (nl) 1998-07-01
AT393680B (de) 1991-11-25
DE3236725C2 (de) 1991-01-24
ES516258A0 (es) 1984-02-01
IT1189373B (it) 1988-02-04
CH653015A5 (de) 1985-12-13
CA1187513A (en) 1985-05-21
ES526501A0 (es) 1985-04-16
SE8205698D0 (sv) 1982-10-06
SE452006B (sv) 1987-11-09
US4518532A (en) 1985-05-21
ES8504690A1 (es) 1985-04-16
NL8203874A (nl) 1983-05-02
YU44678B (en) 1990-12-31
JPS6123183B2 (de) 1986-06-04
CS268654B2 (en) 1990-04-11
ATA369682A (de) 1991-05-15
FR2514350B1 (fr) 1985-10-25
DE3236725A1 (de) 1983-04-28
NL193107C (nl) 1998-11-03
US4983328A (en) 1991-01-08

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired