ES8306730A1 - Un procedimiento de preparacion de nuevos derivados de 4h-1,2,4-triazol - Google Patents
Un procedimiento de preparacion de nuevos derivados de 4h-1,2,4-triazolInfo
- Publication number
- ES8306730A1 ES8306730A1 ES504887A ES504887A ES8306730A1 ES 8306730 A1 ES8306730 A1 ES 8306730A1 ES 504887 A ES504887 A ES 504887A ES 504887 A ES504887 A ES 504887A ES 8306730 A1 ES8306730 A1 ES 8306730A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- alkyl
- aryl
- bis
- triazole derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/38—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 4H-1,2,4-TRIAZOL, DE FORMULA GENERAL (I), EN LA CUAL R , R , R Y R , IDENTICOS O DIFERENTES, REPRESENTAN UN ATOMO DE HIDROGENO, UN RADICAL HIDROXILO O UN RADICAL ALCOHILO, Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. COMPRENDE LAS SIGUIENTES ETAPAS: PRIMERA, SE HACE REACCIONAR UN COMPUESTO DE FORMULA (II), EN LA QUE R , R , R Y R TIENEN LOS SIGNIFICADOS YA INDICADOS, CON HIDRACINA PARA OBTENER UN COMPUESTO DE FORMULA (III); SEGUNDA, DICHO COMPUESTO DE FORMULA (III) SE HACE REACCIONAR CON UN ACIDO O CON UN DERIVADO FUNCIONAL DE ACIDO XCO H, EN EL CUAL X REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL ALCOHILO, PARA OBTENER UN COMPUESTO DE FORMULA (IV); Y POR ULTIMO, DICHO COMPUESTO DE FORMULA (IV) SE CICLISA POR CALENTAMIENTO PARA OBTENER UN COMPUESTO DE FORMULA (I). DE APLICACION EN COMPOSICIONES FARMACEUTICAS POR SU ACTIVIDAD ANALGESICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8018354A FR2488891A1 (fr) | 1980-08-22 | 1980-08-22 | Nouveaux derives du 4h-1,2,4-triazole, leur procede de preparation et leur application comme medicament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8306730A1 true ES8306730A1 (es) | 1983-06-01 |
| ES504887A0 ES504887A0 (es) | 1983-06-01 |
Family
ID=9245357
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES504887A Granted ES504887A0 (es) | 1980-08-22 | 1981-08-21 | Un procedimiento de preparacion de nuevos derivados de 4h-1,2,4-triazol |
| ES515419A Granted ES515419A0 (es) | 1980-08-22 | 1982-09-01 | Un procedimiento de preparacion de nuevos derivados de 4h-1,2,4-triazol. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES515419A Granted ES515419A0 (es) | 1980-08-22 | 1982-09-01 | Un procedimiento de preparacion de nuevos derivados de 4h-1,2,4-triazol. |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US4512997A (es) |
| JP (1) | JPS5770875A (es) |
| AT (1) | AT378957B (es) |
| AU (1) | AU543946B2 (es) |
| BE (1) | BE890035A (es) |
| CA (1) | CA1208226A (es) |
| CH (1) | CH649994A5 (es) |
| DE (1) | DE3133185A1 (es) |
| DK (1) | DK370781A (es) |
| ES (2) | ES504887A0 (es) |
| FI (1) | FI72971C (es) |
| FR (1) | FR2488891A1 (es) |
| GB (1) | GB2082581B (es) |
| GR (1) | GR75329B (es) |
| HU (1) | HU185647B (es) |
| IE (1) | IE51510B1 (es) |
| IT (1) | IT1171477B (es) |
| LU (1) | LU83576A1 (es) |
| NL (1) | NL8103903A (es) |
| OA (2) | OA06889A (es) |
| PH (2) | PH19890A (es) |
| PT (1) | PT73544B (es) |
| SE (1) | SE454173B (es) |
| ZA (1) | ZA815689B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2488891A1 (fr) * | 1980-08-22 | 1982-02-26 | Roussel Uclaf | Nouveaux derives du 4h-1,2,4-triazole, leur procede de preparation et leur application comme medicament |
| FR2539127B1 (fr) * | 1983-01-10 | 1985-08-23 | Roussel Uclaf | Nouveaux derives du 4h-1,2,4-triazole, leur procede de preparation et leur application comme medicaments |
| US5278180A (en) * | 1984-09-24 | 1994-01-11 | Roussel Uclaf | 4,5-bis(aryl) 4H-1,2,4-triazoles derivatives and analgesic use |
| FR2570699B1 (fr) * | 1984-09-24 | 1987-08-28 | Roussel Uclaf | Nouveau procede de preparation de derives du 4h-1,2,4-triazole, nouveaux triazoles ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| US6362342B1 (en) * | 1999-06-29 | 2002-03-26 | Lion Bioscience Ag | Triazole compounds and methods of making same |
| AU2001259298A1 (en) | 2000-05-02 | 2001-11-12 | Advanced Medicine, Inc. | Polyacid glycopeptide derivatives |
| WO2003066050A1 (en) | 2002-02-07 | 2003-08-14 | The Curators Of The University Of Missouri | Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds |
| CN110785867B (zh) | 2017-04-26 | 2023-05-02 | Oti照明公司 | 用于图案化表面上覆层的方法和包括图案化覆层的装置 |
| US11751415B2 (en) | 2018-02-02 | 2023-09-05 | Oti Lumionics Inc. | Materials for forming a nucleation-inhibiting coating and devices incorporating same |
| CN116456753A (zh) | 2019-03-07 | 2023-07-18 | Oti照明公司 | 一种光电子器件 |
| KR20220009961A (ko) | 2019-04-18 | 2022-01-25 | 오티아이 루미오닉스 인크. | 핵 생성 억제 코팅 형성용 물질 및 이를 포함하는 디바이스 |
| KR20220017918A (ko) | 2019-05-08 | 2022-02-14 | 오티아이 루미오닉스 인크. | 핵 생성 억제 코팅 형성용 물질 및 이를 포함하는 디바이스 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1796403A (en) * | 1931-03-17 | Schaft | ||
| US3681374A (en) * | 1970-08-11 | 1972-08-01 | Asahi Chemical Ind | Synthetic nacreous triazole crystals and method for production thereof |
| SU508198A3 (ru) * | 1971-07-22 | 1976-03-25 | Группо Лепетит С.П.А. (Фирма) | Способ получени производных 1,2,4-триазола |
| AU7528974A (en) * | 1973-11-13 | 1976-06-10 | Commonwealth Scientific And Industrial Research Organization | Triazoles |
| FR2269938A2 (en) * | 1974-05-08 | 1975-12-05 | Delalande Sa | 5-Hydroxymethyl-3,4-diphenyl-1,2,4-triazoles - with anticholinergic, bronchodilator, antidepressant, analgesic, vasodilator activity, etc. |
| JPS56125376A (en) * | 1980-03-07 | 1981-10-01 | Mitsubishi Chem Ind Ltd | Triazole derivative |
| FR2488891A1 (fr) * | 1980-08-22 | 1982-02-26 | Roussel Uclaf | Nouveaux derives du 4h-1,2,4-triazole, leur procede de preparation et leur application comme medicament |
-
1980
- 1980-08-22 FR FR8018354A patent/FR2488891A1/fr active Granted
-
1981
- 1981-07-23 SE SE8104515A patent/SE454173B/sv not_active IP Right Cessation
- 1981-08-17 HU HU812391A patent/HU185647B/hu not_active IP Right Cessation
- 1981-08-17 PH PH26054A patent/PH19890A/en unknown
- 1981-08-18 ZA ZA815689A patent/ZA815689B/xx unknown
- 1981-08-20 GR GR65834A patent/GR75329B/el unknown
- 1981-08-20 PT PT73544A patent/PT73544B/pt unknown
- 1981-08-21 IT IT49147/81A patent/IT1171477B/it active
- 1981-08-21 ES ES504887A patent/ES504887A0/es active Granted
- 1981-08-21 FI FI812585A patent/FI72971C/fi not_active IP Right Cessation
- 1981-08-21 GB GB8125631A patent/GB2082581B/en not_active Expired
- 1981-08-21 JP JP56130408A patent/JPS5770875A/ja active Granted
- 1981-08-21 IE IE1923/81A patent/IE51510B1/en unknown
- 1981-08-21 LU LU83576A patent/LU83576A1/fr unknown
- 1981-08-21 CA CA000384388A patent/CA1208226A/fr not_active Expired
- 1981-08-21 BE BE0/205731A patent/BE890035A/fr not_active IP Right Cessation
- 1981-08-21 DE DE19813133185 patent/DE3133185A1/de not_active Ceased
- 1981-08-21 AU AU74426/81A patent/AU543946B2/en not_active Ceased
- 1981-08-21 CH CH5409/81A patent/CH649994A5/fr not_active IP Right Cessation
- 1981-08-21 NL NL8103903A patent/NL8103903A/nl not_active Application Discontinuation
- 1981-08-21 DK DK370781A patent/DK370781A/da not_active Application Discontinuation
- 1981-08-22 OA OA57482A patent/OA06889A/xx unknown
- 1981-08-24 AT AT0368281A patent/AT378957B/de not_active IP Right Cessation
-
1982
- 1982-09-01 ES ES515419A patent/ES515419A0/es active Granted
-
1983
- 1983-09-22 OA OA58106A patent/OA07537A/xx unknown
- 1983-11-17 US US06/552,747 patent/US4512997A/en not_active Expired - Fee Related
-
1984
- 1984-02-21 US US06/582,051 patent/US4659729A/en not_active Expired - Fee Related
- 1984-11-08 PH PH31425A patent/PH21567A/en unknown
-
1986
- 1986-08-14 US US06/896,858 patent/US4727084A/en not_active Expired - Fee Related
Also Published As
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