ES475173A1 - Procedimiento para la fabricacion de quinazolinas. - Google Patents

Procedimiento para la fabricacion de quinazolinas.

Info

Publication number
ES475173A1
ES475173A1 ES475173A ES475173A ES475173A1 ES 475173 A1 ES475173 A1 ES 475173A1 ES 475173 A ES475173 A ES 475173A ES 475173 A ES475173 A ES 475173A ES 475173 A1 ES475173 A1 ES 475173A1
Authority
ES
Spain
Prior art keywords
group
image
carbon atoms
hydrogen atom
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES475173A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Yuka Pharmaceutical Co Ltd
Original Assignee
Mitsubishi Yuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP13310577A external-priority patent/JPS5466691A/ja
Priority claimed from JP2089178A external-priority patent/JPS54125688A/ja
Application filed by Mitsubishi Yuka Pharmaceutical Co Ltd filed Critical Mitsubishi Yuka Pharmaceutical Co Ltd
Publication of ES475173A1 publication Critical patent/ES475173A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la fabricación de quinazolinas utilizables como antihipertensivos, caracterizado por proceder a la preparación de: *** ver imagen 01 en la que R1 es un átomo de hidrógeno o un grupo alquilo que posee 1-5 átomos de carbono; R2 es un grupo de la fórmula *** ver imagen 02 en el cual Y es un átomo de hidrógeno, un grupo alquilo de 1-5 átomos de carbono, un grupo alcoxy de 1-5 átomos de carbono, un grupo alqueniloxi, un grupo metilendioxi, un grupo nitro, un átomo de halógeno, un grupo trifluorometilo, un grupo aciloxi, un grupo hidroxi, un grupo amino no sustituido o sustituido o un núcleo bencénico condensado y m es un dígito comprendido entre 1 y 3 ambos inclusive.
ES475173A 1977-11-08 1978-11-07 Procedimiento para la fabricacion de quinazolinas. Expired ES475173A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13310577A JPS5466691A (en) 1977-11-08 1977-11-08 Novel quinazoline derivative and manufacture
JP2089178A JPS54125688A (en) 1978-02-27 1978-02-27 Novel quinazoline derivative*its manufacture and antihypertensive drug

Publications (1)

Publication Number Publication Date
ES475173A1 true ES475173A1 (es) 1979-04-16

Family

ID=26357889

Family Applications (1)

Application Number Title Priority Date Filing Date
ES475173A Expired ES475173A1 (es) 1977-11-08 1978-11-07 Procedimiento para la fabricacion de quinazolinas.

Country Status (8)

Country Link
US (1) US4189484A (es)
DE (1) DE2848263A1 (es)
DK (1) DK495578A (es)
ES (1) ES475173A1 (es)
FR (1) FR2407928A1 (es)
GB (1) GB2008106A (es)
NL (1) NL7811050A (es)
SE (1) SE7811492L (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0022481A1 (en) * 1979-06-21 1981-01-21 Mitsubishi Yuka Pharmaceutical Co., Ltd. 5,6-Alkylenepyrimidine derivatives, processes for preparing the same and pharmaceutical compositions
FR2468595B2 (fr) * 1979-10-30 1986-03-14 Synthelabo Amides d'alkylene diamines, leur preparation et leur application en therapeutique
US4426382A (en) * 1980-02-13 1984-01-17 Sankyo Company Limited 4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use
DE3264718D1 (en) * 1981-03-05 1985-08-22 Pfizer Piperazinoquinazoline antihypertensives, processes for preparing them, pharmaceutical compositions containing them, and immunogenic protein conjugates formed from them
CS236097B1 (en) * 1983-06-01 1985-05-15 Jan Koenig Acylderivatives of 2-piperazinochinazoline and method of their preparation
DE3346675A1 (de) * 1983-12-23 1985-07-04 Beiersdorf Ag, 2000 Hamburg Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte
JPH0647540B2 (ja) * 1985-07-16 1994-06-22 エーザイ株式会社 虚血性心疾患・不整脈治療・予防剤
WO1987002035A1 (en) * 1985-10-04 1987-04-09 Maggioni-Winthrop S.P.A. Fused cycloaliphatic aminoalcohols
EP0367888A1 (en) * 1988-11-08 1990-05-16 ISTITUTO LUSO FARMACO D'ITALIA S.p.A. 2,2-Disubstituted 2,3-dihydro-1,4-benzodioxin derivatives having hypotensive activity
GB9708917D0 (en) * 1997-05-01 1997-06-25 Pfizer Ltd Compounds useful in therapy
WO2007039170A1 (en) * 2005-09-23 2007-04-12 European Molecular Biology Laboratory (Embl) Antagonists of topoisomerase activity and their use in inhibiting pathological conditions
US9260441B2 (en) 2012-03-28 2016-02-16 Intervet Inc. Heteroaryl compounds with cyclic bridging unit
US11944624B2 (en) * 2017-07-06 2024-04-02 Case Western Reserve University Peptide and small molecule agonists of EphA and their uses
FR3164690A1 (fr) 2024-07-19 2026-01-23 Stellantis Auto Sas Vehicule automobile avec boucle dynamique de faisceau de cables de porte-moyeu de roue protegee

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines

Also Published As

Publication number Publication date
NL7811050A (nl) 1979-05-10
GB2008106A (en) 1979-05-31
US4189484A (en) 1980-02-19
SE7811492L (sv) 1979-05-09
FR2407928A1 (fr) 1979-06-01
DE2848263A1 (de) 1979-05-10
DK495578A (da) 1979-05-09

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