ES8205412A1 - Procedimiento para preparar nuevos derivados de la indolo- benzoxazina - Google Patents
Procedimiento para preparar nuevos derivados de la indolo- benzoxazinaInfo
- Publication number
- ES8205412A1 ES8205412A1 ES501000A ES501000A ES8205412A1 ES 8205412 A1 ES8205412 A1 ES 8205412A1 ES 501000 A ES501000 A ES 501000A ES 501000 A ES501000 A ES 501000A ES 8205412 A1 ES8205412 A1 ES 8205412A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- preparation
- hydrogen
- optionally substituted
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA INDOLOBENZOXAZINA, ASI COMO DE SUS SALES DE ADICION DE ACIDOS ORGANICOS, DE FORMULA (I), EN LA QUE R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCON DE REDUCCION DE UN COMPUESTOS E FORMULA (II), CON UN HIDRURO METALICO, TAL COMO HIDRURO DE LITIO Y ALUMINIO, EN PRESENCIA DE UN ACIDO E LEWIS, EN UN ESTER COMO DISOLVENTE, SEGUIDA DE LA REACCION CON CLORURO DE CLOROACETILO CICLISION DEL PRODUCTO OBTENIDO CON AYUDA DE HIDRURO SODICO, REDUCCION CON HIRURO DE LITIO Y ALIMINIO, REACCION CON UN AGENTE DE METILACION O UN HALOGENURO DE FORMULA R-HAL, EN LA QUE HAL ES UN HALOGENO, Y FINALMENTE HIDROGENACION DEL PRODUCTO OBTENIDO CON HIDROGENO EN PRESENCIA DE PALADIO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8007544A FR2479830A1 (fr) | 1980-04-03 | 1980-04-03 | Nouveaux derives de l'indolobenzoxazine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
Publications (2)
Publication Number | Publication Date |
---|---|
ES501000A0 ES501000A0 (es) | 1982-06-01 |
ES8205412A1 true ES8205412A1 (es) | 1982-06-01 |
Family
ID=9240505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES501000A Expired ES8205412A1 (es) | 1980-04-03 | 1981-04-02 | Procedimiento para preparar nuevos derivados de la indolo- benzoxazina |
Country Status (11)
Country | Link |
---|---|
US (1) | US4318910A (es) |
EP (1) | EP0037784B1 (es) |
JP (1) | JPS56154486A (es) |
AT (1) | ATE8786T1 (es) |
AU (1) | AU541530B2 (es) |
CA (1) | CA1162539A (es) |
DE (1) | DE3165179D1 (es) |
ES (1) | ES8205412A1 (es) |
FR (1) | FR2479830A1 (es) |
HU (1) | HU183349B (es) |
ZA (1) | ZA812104B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2522658A1 (fr) * | 1982-03-05 | 1983-09-09 | Roussel Uclaf | Application a titre de medicaments de derives du trans 4-amino benz (c,d) indol-5-ol ainsi que de leurs sels, compositions les renfermant, nouveaux derives et leur procede de preparation |
FR2526797A1 (fr) * | 1982-05-12 | 1983-11-18 | Roussel Uclaf | Nouveaux derives de l'acide 9-oxalysergique, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
US4766212A (en) * | 1983-02-15 | 1988-08-23 | Merrell Dow Pharmaceuticals Inc. | 2H-[1]benzoxepino[5,4-b]-1,4-oxazine derivatives |
US4552956A (en) * | 1984-08-15 | 1985-11-12 | Eli Lilly And Company | Partially hydrogenated pyrazolo, pyrimido and thiazolo[1,4]benzoxazines |
US4587336A (en) * | 1984-08-15 | 1986-05-06 | Eli Lilly And Company | Partially hydrogenated intermediate pyrazolo, pyrimido and thiazolo[1,4]benzoxazines |
FR2594828B1 (fr) * | 1986-02-24 | 1988-07-01 | Roussel Uclaf | Derives du tetrahydrobenz (c,d) indole, leurs sels, procede de preparation, application a titre de medicaments, compositions les renfermant et intermediaires |
US5466689A (en) * | 1993-02-08 | 1995-11-14 | Takeda Chemical Industries, Ltd. | Morpholine derivatives and their use |
CN112194667B (zh) * | 2020-11-06 | 2021-08-17 | 湖南科技大学 | 取代1,4-苯并噁嗪并二氮卓类化合物及其制备方法和用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4238486A (en) * | 1979-11-23 | 1980-12-09 | Merck & Co., Inc. | Indolobenzoxazines |
FR2476649A1 (fr) * | 1980-02-26 | 1981-08-28 | Roussel Uclaf | Nouveaux derives du cycloheptindole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
-
1980
- 1980-04-03 FR FR8007544A patent/FR2479830A1/fr active Granted
-
1981
- 1981-03-03 HU HU81524A patent/HU183349B/hu not_active IP Right Cessation
- 1981-03-23 US US06/246,169 patent/US4318910A/en not_active Expired - Lifetime
- 1981-03-30 ZA ZA00812104A patent/ZA812104B/xx unknown
- 1981-04-02 AU AU69027/81A patent/AU541530B2/en not_active Ceased
- 1981-04-02 ES ES501000A patent/ES8205412A1/es not_active Expired
- 1981-04-02 CA CA000374492A patent/CA1162539A/fr not_active Expired
- 1981-04-03 EP EP81400538A patent/EP0037784B1/fr not_active Expired
- 1981-04-03 DE DE8181400538T patent/DE3165179D1/de not_active Expired
- 1981-04-03 AT AT81400538T patent/ATE8786T1/de active
- 1981-04-03 JP JP4950181A patent/JPS56154486A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
US4318910A (en) | 1982-03-09 |
FR2479830A1 (fr) | 1981-10-09 |
FR2479830B1 (es) | 1982-04-02 |
CA1162539A (fr) | 1984-02-21 |
JPS56154486A (en) | 1981-11-30 |
AU541530B2 (en) | 1985-01-10 |
DE3165179D1 (en) | 1984-09-06 |
EP0037784A1 (fr) | 1981-10-14 |
ES501000A0 (es) | 1982-06-01 |
ZA812104B (en) | 1982-04-28 |
EP0037784B1 (fr) | 1984-08-01 |
JPH0360835B2 (es) | 1991-09-17 |
HU183349B (en) | 1984-04-28 |
AU6902781A (en) | 1981-10-08 |
ATE8786T1 (de) | 1984-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970401 |